From ownership to custodianship of tumor biopsy tissue in genomic testing: a mixed methods study of patient views
Oncologist. 2024 May 7:oyae074. doi: 10.1093/oncolo/oyae074. Online ahead of print.ABSTRACTTumor mutation profiling (MP) is often conducted on tissue from biopsies conducted for clinical purposes (diagnostic tissue). We aimed to explore the views of patients with cancer on who should own tumor biopsy tissue, pay for its storage, and decide on its future use; and determine their attitudes to and predictors of undergoing additional biopsies if required for research purposes. In this mixed methods, cross-sectional study, patients with advanced solid cancers enrolled in the Molecular Screening and Therapeutics Program (n = 397...
Source: Cancer Control - May 7, 2024 Category: Cancer & Oncology Authors: Megan C Best Phyllis Butow Jacqueline Savard Ainsley J Newson Rachel Campbell Sabina Vatter Christine E Napier Nicci Bartley Katherine Tucker Mandy L Ballinger David M Thomas PiGeOn Project Source Type: research
Association between pre-biologic T2-biomarker combinations and response to biologics in patients with severe asthma
CONCLUSIONS: The ability of higher baseline BEC, FeNO and their combination to predict biologic-associated lung function improvement may encourage earlier intervention in patients with impaired lung function or at risk of accelerated lung function decline.PMID:38711495 | PMC:PMC11070939 | DOI:10.3389/fimmu.2024.1361891 (Source: Cancer Control)
Source: Cancer Control - May 7, 2024 Category: Cancer & Oncology Authors: Celeste M Porsbjerg John Townend Celine Bergeron George C Christoff Gregory P Katsoulotos D ésirée Larenas-Linnemann Trung N Tran Riyad Al-Lehebi Sinthia Z Bosnic-Anticevich John Busby Mark Hew Konstantinos Kostikas Nikolaos G Papadopoulos Paul E Pfeffe Source Type: research
Safety and efficacy of autologous adipose tissue-derived stem cell transplantation in aging-related low-grade inflammation patients: a single-group, open-label, phase I clinical trial
CONCLUSION: AD-MSCs represent a potential intervention to prevent age-related inflammation in patients.TRIAL REGISTRATION: ClinicalTrials.gov number is NCT05827757, first registered on 13th Oct 2020.PMID:38715140 | DOI:10.1186/s13063-024-08128-3 (Source: Atherosclerosis)
Source: Atherosclerosis - May 7, 2024 Category: Cardiology Authors: Ngoc-Huynh Ton Nguyen Hao Thanh Phan Phong Minh Le Lan-Huong Thi Nguyen Thuy Thi Do Thien-Phuc Thanh Phan Trinh Van Le Thanh Minh Dang Chinh-Nhan Lu Phan Tung-Loan Thi Dang Nhung Hai Truong Source Type: research
Association between Usage of Prophylactic AYUSH Medicines and Disease Severity in COVID-19 Patients: A Retrospective Cohort Study
CONCLUSION: AYUSH prophylactics were associated with statistically significant levels of protection against COVID-19 disease severity. Amongst these, previous intake of homeopathy or Siddha medicines was associated with some protection against moderate/severe illness and with a somewhat quicker clinical recovery. Prospective studies with experimental research design are needed to validate the findings of this study.STUDY REGISTRATION: Clinical Trials Registry-India (CTRI/2020/08/027000).PMID:38714214 | DOI:10.1055/s-0044-1779693 (Source: Homeopathy)
Source: Homeopathy - May 7, 2024 Category: Complementary Medicine Authors: Anupriya Chaudhary Debadatta Nayak Swati Pandey Vipul Shastri Madhuri Kamble Vidya Pendse Vismay Prajapati Brijesh Vaidya Heenal Rohit Swaroopa Beedmani Nutan Presswala Tejaswini Patole Ramesh Bawaskar Vaishali Shinde Mohua Datta Gunjan Rai Umakanta Prust Source Type: research
From ownership to custodianship of tumor biopsy tissue in genomic testing: a mixed methods study of patient views
Oncologist. 2024 May 7:oyae074. doi: 10.1093/oncolo/oyae074. Online ahead of print.ABSTRACTTumor mutation profiling (MP) is often conducted on tissue from biopsies conducted for clinical purposes (diagnostic tissue). We aimed to explore the views of patients with cancer on who should own tumor biopsy tissue, pay for its storage, and decide on its future use; and determine their attitudes to and predictors of undergoing additional biopsies if required for research purposes. In this mixed methods, cross-sectional study, patients with advanced solid cancers enrolled in the Molecular Screening and Therapeutics Program (n = 397...
Source: The Oncologist - May 7, 2024 Category: Cancer & Oncology Authors: Megan C Best Phyllis Butow Jacqueline Savard Ainsley J Newson Rachel Campbell Sabina Vatter Christine E Napier Nicci Bartley Katherine Tucker Mandy L Ballinger David M Thomas PiGeOn Project Source Type: research
Plasma Metabolic Profiles-Based Prediction of Induction Chemotherapy Efficacy in Nasopharyngeal Carcinoma: Results of a Bidirectional Clinical Trial
CONCLUSION: In this study, we found that dysregulation of plasma lipoprotein may result in resistance to IC in NPC patients. The prediction model constructed based on the plasma metabolites' profile as good predictive capabilities and potential for real-world generalization. This discovery has implications for the development of treatment strategies and may offer insight into potential targets for enhancing the effectiveness of IC.PMID:38713248 | DOI:10.1158/1078-0432.CCR-23-3608 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - May 7, 2024 Category: Cancer & Oncology Authors: Tingxi Tang Zhenhua Zhou Min Chen Nan Li Jianda Sun Zekai Chen Ting Xiao Xiaoqing Wang Longshan Zhang Yingqiao Wang Hanbin Zhang Xiuting Zheng Bei Chen Feng Ye Jian Guan Source Type: research
Variation in incidence rates of outcomes relevant to vaccine safety monitoring in a US commercially insured population by case identification algorithm
CONCLUSIONS: For many cardiac/cerebrovascular outcomes, rates were similar regardless of the algorithm. For other outcomes, rates varied substantially by algorithm. Using multiple algorithms to ascertain outcomes in claims data can be informative about the extent of uncertainty due to outcome misclassification.PMID:38714442 | DOI:10.1016/j.vaccine.2024.04.095 (Source: Vaccine)
Source: Vaccine - May 7, 2024 Category: Allergy & Immunology Authors: Christopher L Crowe Jill Dreyfus Stephan Lanes Haechung Chung Wendy Watson Source Type: research
[ < sup > 18 < /sup > F]AlF-NOTA-PCP2: a novel PET/CT tracer for enhanced PD-L1 heterogeneity imaging and comparative analysis with [ < sup > 18 < /sup > F]AlF-NOTA-WL12 in glioblastoma xenografts
CONCLUSION: [18F]AlF-NOTA-PCP2 distinguishes itself as an exceptionally sensitive PET/CT tracer, adept at non-invasively and accurately quantifying PD-L1 expression and its spatial heterogeneity in tumors, especially in GBM. Its favorable pharmacokinetic properties, safety profile, and high affinity for PD-L1 highlight its potential for enhancing the precision of cancer immunotherapy and guiding individualized treatment strategies. While promising, its clinical translation, especially in brain imaging, necessitates further validation in clinical trials.PMID:38713298 | DOI:10.1007/s00259-024-06743-5 (Source: Molecular Medicine)
Source: Molecular Medicine - May 7, 2024 Category: Molecular Biology Authors: Yong Wang Yang Zhang Yunhao Chen Shijie Wang Wei Liu Zhiguo Liu Man Hu Source Type: research
Content Validity of the Modified Functional Scale for the Assessment and Rating of Ataxia (f-SARA) Instrument in Spinocerebellar Ataxia
Cerebellum. 2024 May 7. doi: 10.1007/s12311-024-01700-2. Online ahead of print.ABSTRACTThe functional Scale for the Assessment and Rating of Ataxia (f-SARA) assesses Gait, Stance, Sitting, and Speech. It was developed as a potentially clinically meaningful measure of spinocerebellar ataxia (SCA) progression for clinical trial use. Here, we evaluated content validity of the f-SARA. Qualitative interviews were conducted among individuals with SCA1 (n = 1) and SCA3 (n = 6) and healthcare professionals (HCPs) with SCA expertise (USA, n = 5; Europe, n = 3). Interviews evaluated symptoms and signs of SCA and relevance of f-SARA ...
Source: Cerebellum - May 7, 2024 Category: Neuroscience Authors: Michele Potashman Katja Rudell Ivanna Pavisic Naomi Suminski Rinchen Doma Maggie Heinrich Linda Abetz-Webb Melissa Wolfe Beiner Sheng-Han Kuo Liana S Rosenthal Theresa Zesiwicz Terry D Fife Bart P van de Warrenburg Giovanni Ristori Matthis Synofzik Susan Source Type: research
The application of neuronavigated rTMS of the supplementary motor area and rhythmic speech training for stuttering intervention
CONCLUSIONS AND IMPLICATIONS: The findings of this study indicate that stimulating the SMA reduced stuttering, only in the production of tongue twisters that may require greater motor control and coordination. Furthermore, it indicates that rhythmic speech might help alleviate negative beliefs and anxiety related to stuttering. This research contributes to our understanding of neuromodulation in stuttering treatment and the role of the SMA in speech motor control and emphasises the need for more research on the potential benefits and limitations of applying rTMS in this condition.WHAT THIS PAPER ADDS: What is already known...
Source: International Journal of Language and Communication Disorders - May 7, 2024 Category: Speech-Language Pathology Authors: Mehdi Bakhtiar Tegan Wai Yee Yeung Angela Choi Source Type: research
Gallstone Dissolution Effects of Combination Therapy with n-3 Polyunsaturated Fatty Acids and Ursodeoxycholic Acid: A Randomized, Prospective, Preliminary Clinical Trial
CONCLUSIONS: : UDCA plus PUFA therapy dissolves cholesterol gallstones more effectively than UDCA monotherapy, without significant complications. Further prospective, large-scale studies of this combination therapy are warranted.PMID:38712398 | DOI:10.5009/gnl230494 (Source: Gut and Liver)
Source: Gut and Liver - May 7, 2024 Category: Gastroenterology Authors: See Young Lee Sung Ill Jang Jae Hee Cho Min Young Do Su Yeon Lee Arong Choi Hye Sun Lee Juyeon Yang Dong Ki Lee Source Type: research
GSE266219 Clinical and Immunological Responses to Combined JAK Inhibition and PD-1 immunotherapy for Lung Cancer Patients
Contributors : Divij Mathew ; Andy MinnSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPersistent inflammation driven by cytokines like type-one interferon (IFN-I) can cause immunosuppression. We show that administration of the JAK1 inhibitor itacitinib after anti-PD1 immunotherapy improves immune function and anti-tumor responses in mice, and results in high response rates (67%) in a phase-2 clinical trial for metastatic non-small cell lung cancer. Patients who failed to respond to initial anti-PD1 immunotherapy but responded after addition of itacitinib had multiple features of po...
Source: GEO: Gene Expression Omnibus - May 7, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Gender Disparities in Valvular Heart Disease and Treatment in the Aging Population
AbstractPurpose of ReviewAs the presence of valvular heart disease increases with age and women have a longer life-expectancy than men, gender disparities for patients with valvular heart disease (VHD) are exacerbated in the aging population. In this article, we review the differences in presentation, pathophysiology, treatment, and outcomes between men and women with VHD and examine available data as to how these differences may impact the aging population.Recent FindingsAvailable data demonstrate significant gender-related differences in clinical presentation, treatment, and outcomes for patients with valvular heart dise...
Source: Current Geriatrics Reports - May 7, 2024 Category: Geriatrics Source Type: research
Left Ventricular Unloading in Extracorporeal Membrane Oxygenation: A Clinical Perspective Derived from Basic Cardiovascular Physiology
AbstractPurpose of ReviewTo present an abridged overview of the literature and pathophysiological background of adjunct interventional left ventricular unloading strategies during veno-arterial extracorporeal membrane oxygenation (V-A ECMO). From a clinical perspective, the mechanistic complexity of such combined mechanical circulatory support often requires in-depth physiological reasoning at the bedside, which remains a cornerstone of daily practice for optimal patient-specific V-A ECMO care.Recent FindingsRecent conventional clinical trials have not convincingly shown the superiority of V-A ECMO in acute myocardial infa...
Source: Current Cardiology Reports - May 7, 2024 Category: Cardiology Source Type: research
Acupuncture for the treatment of the pain-fatigue-sleep disturbance-numbness/tingling symptom cluster in breast cancer survivors: a feasibility trial
ConclusionThis study demonstrated that acupuncture was safe and feasible, justifying a powered randomized control trial. Preliminary findings suggest beneficial effects of acupuncture for the management of the pain-fatigue-sleep disturbance-numbness/tingling symptom cluster for women with breast cancer. TCM syndromes identified in this trial may be used to guide acupuncture treatment protocols.Clinical trial registration: This trial was registered with the Australian New Zealand Clinical Trials Registry (ACTRN12622000590763) on 21 April 2022. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - May 7, 2024 Category: Cancer & Oncology Source Type: research
