Clinicopathological profile of head and neck cancers in Army Hospital of Nepal: a retrospective study
CONCLUSIONS: Head and neck cancers are not uncommon and majority of patients present late with advanced stage cancer. Hence, public awareness, early diagnosis with cost-effective treatment and regular follow-up are needed to improve outcomes of these patients in our society.PMID:38694395 | PMC:PMC11060235 | DOI:10.1097/MS9.0000000000001918 (Source: Annals of Medicine)
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Reeba Karki Anupama Marasini Rajeev Kumar Mahaseth Ranishma Bista Suman Raj Dongol Yuvraj Adhikari Source Type: research
Assessing the impact of lubricant on liquid-based Pap smear test outcomes: a randomized clinical trial
CONCLUSION: The use of lubricant gel in patients can reduce pain in patients during examination and testing, but does not affect the cytological and pathological results of patients.PMID:38694378 | PMC:PMC11060314 | DOI:10.1097/MS9.0000000000001803 (Source: Annals of Medicine)
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Mansooreh Yaraghi Sarvenaz Gharavi Ayda Najafian Vajihe Hazari Source Type: research
Effects of Narrative Exposure Therapy for Treating Depressive and Anxious Disorders: A Systematic Review and Meta-Analysis
CONCLUSION: This analysis showed that NET can alleviate depression and anxiety. It may thus be used in clinical settings to alleviate patients' negative feelings and aid their overall recovery.PMID:38695040 | DOI:10.30773/pi.2023.0281 (Source: Psychiatry Investigation)
Source: Psychiatry Investigation - May 2, 2024 Category: Psychiatry Authors: Chen Geng Miao Zhang Lily Zhang Hai Yin Suyun Wang Source Type: research
Effectiveness of autologous fibrin glue in preventing post-thoracotomy air leaks: a randomized controlled trial
CONCLUSIONS: The application of autologous fibrin glue during thoracotomy procedures significantly reduces postoperative air leaks and hospitalization duration without increasing complication rates. This finding suggests a beneficial role of fibrin glue in thoracic procedures requiring lung resection or decortication.PMID:38693984 | PMC:PMC11059015 | DOI:10.5114/kitp.2024.138579 (Source: Polish Journal of Cardio-Thoracic Surgery)
Source: Polish Journal of Cardio-Thoracic Surgery - May 2, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Fariba Zabihi Ali Mehri Ghazale Ahmadi Daryoush Hamidi Alamdari Mona Kabiri Azam Amirianfar Reza Rezaei Source Type: research
The establishment of a multiple myeloma clinical registry in the Asia-Pacific region: The Asia-Pacific Myeloma and Related Diseases Registry (APAC MRDR)
CONCLUSION: The APAC MRDR is providing 'real-world' data to participating sites, clinicians and policy-makers to explore factors influencing outcomes and survival, and to support high quality studies. It is already a valuable resource that will continue to grow and support research and clinical collaboration in MM and related diseases across the APAC region.PMID:38698331 | DOI:10.1186/s12874-024-02227-0 (Source: Cell Research)
Source: Cell Research - May 2, 2024 Category: Cytology Authors: Naomi Aoki Pin-Yen Chen Wenming Chen Wee Joo Chng Gin Gin Gan Yeow Tee Goh Jian Hou Jeffrey Huang Kihyun Kim Je Jung Lee Jin Lu Zoe K McQuilten Chang Ki Min Elizabeth Moore Laura Oliver Neil A Waters Cameron Wellard Erica M Wood Su-Peng Yeh Andrew Spencer Source Type: research
Population impacts of conditional financial incentives and a male-targeted digital decision support application on the HIV treatment cascade in rural KwaZulu Natal: findings from the HITS cluster randomized clinical trial
CONCLUSIONS: Small CFIs can contribute to achieve the first step of the HIV care cascade. However, neither CFIs nor EPIC-HIV was sufficient to increase the number of people on ART. Additional evidence is needed to confirm the impact of EPIC-HIV on viral suppression.PMID:38695099 | DOI:10.1002/jia2.26248 (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - May 2, 2024 Category: Infectious Diseases Authors: Maxime Inghels Hae-Young Kim Thulile Mathenjwa Maryam Shahmanesh Janet Seeley Sally Wyke Philippa Matthews Oluwafemi Adeagbo Dickman Gareta Nuala McGrath H Manisha Yapa Ann Blandford Thembelihle Zuma Adrian Dobra Till B ärnighausen Frank Tanser Source Type: research
A narrative review of the comparative safety of disease-modifying anti-rheumatic drugs used for the treatment of rheumatoid arthritis
Expert Opin Drug Saf. 2024 May 2. doi: 10.1080/14740338.2024.2348575. Online ahead of print.ABSTRACTINTRODUCTION: Disease modifying anti-rheumatic drugs (DMARDs) have improved the outcomes of patients with rheumatoid arthritis (RA). DMARDs are classified into three categories: conventional synthetic DMARDs, biological DMARDs (including biosimilars), and targeted synthetic DMARDs. DMARDs, by way of their effect on the immune system, are associated with increased risk of adverse events, including infections, malignancies, cardiovascular disease, gastrointestinal perforations, and other less common events.AREAS COVERED: In th...
Source: Expert Opinion on Drug Safety - May 2, 2024 Category: Drugs & Pharmacology Authors: Rouhin Sen Maria Riofrio Jasvinder A Singh Source Type: research
Intraocular inflammation as a Major Adverse Event of Anti-vascular endothelial growth factor therapy for neovascular age-related macular degeneration: from clinical trials to real-world practice
Expert Opin Drug Saf. 2024 May 2. doi: 10.1080/14740338.2024.2351468. Online ahead of print.NO ABSTRACTPMID:38696228 | DOI:10.1080/14740338.2024.2351468 (Source: Expert Opinion on Drug Safety)
Source: Expert Opinion on Drug Safety - May 2, 2024 Category: Drugs & Pharmacology Authors: Jae Hui Kim Source Type: research
Effectiveness of autologous fibrin glue in preventing post-thoracotomy air leaks: a randomized controlled trial
CONCLUSIONS: The application of autologous fibrin glue during thoracotomy procedures significantly reduces postoperative air leaks and hospitalization duration without increasing complication rates. This finding suggests a beneficial role of fibrin glue in thoracic procedures requiring lung resection or decortication.PMID:38693984 | PMC:PMC11059015 | DOI:10.5114/kitp.2024.138579 (Source: Polish Journal of Cardio-Thoracic Surgery)
Source: Polish Journal of Cardio-Thoracic Surgery - May 2, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Fariba Zabihi Ali Mehri Ghazale Ahmadi Daryoush Hamidi Alamdari Mona Kabiri Azam Amirianfar Reza Rezaei Source Type: research
Turkish translation and transcultural validity and reliability of an assessment tool for spasticity: Leg Activity Measure (Leg A)
CONCLUSIONS: Tr-LegA is a valid and reliable multidimensional scale for passive and active function and quality of life in patients with lower limb spasticity.THE CLINICAL TRIAL NUMBER: NCT05182411.PMID:38695372 | DOI:10.1080/01616412.2024.2340878 (Source: Neurological Research)
Source: Neurological Research - May 2, 2024 Category: Neurology Authors: Zekiye İpek Katırcı Kırmacı Hatice Adig üzel Yusuf Şinasi Kırmacı Emel Ta şvuran Horata Deniz Tuncel Berkta ş Suat Erel Source Type: research
A comprehensive review on ethnomedicinal, phytochemical and pharmacological properties of genus Bistorta (L.) scop
The objective of this review is to present up-to-date information from the scientific literature about the phytochemistry, pharmacology, and toxicology of Bistorta. At present, there is a lack of a comprehensive review that consolidates the various scientific studies conducted on the genus Bistorta. To address this knowledge gap, a global review has been compiled on the genus Bistorta, which emphasizes ethnomedicinal, phytochemistry, and pharmacology. To gather information about Bistorta, relevant keywords were used to search internet databases including Google scholar, PubMed, ResearchGate, Web of Science, Europe PMC, CNK...
Source: Fitoterapia - May 2, 2024 Category: Biochemistry Authors: Hanan Javid Ishrat Shaheen Roof Ul Qadir Junaid Ahmad Magray Bilal Ahmad Wani Irshad A Nawchoo Shabana Gulzar Source Type: research
Emerging therapies for overactive bladder: preclinical, phase I and phase II studies
Expert Opin Investig Drugs. 2024 May 2. doi: 10.1080/13543784.2024.2349285. Online ahead of print.ABSTRACTINTRODUCTION: Overactive bladder syndrome is a common chronic condition with a significant impact on quality of life and economic burden. Persistence with pharmacologic therapy has been limited by efficacy and side effects. A greater understanding of the pathophysiology of overactive bladder has led to the initial evaluation of several drugs affecting ion channels, the autonomic nervous system, and enzymes which may provide useful alternatives for the management of overactive bladder.AREAS COVERED: A comprehensive revi...
Source: Expert Opinion on Investigational Drugs - May 2, 2024 Category: Drugs & Pharmacology Authors: Samantha Gibson Pamela Ellsworth Source Type: research
Electrocatalytic Formal C(sp2)-H Alkylations via Nickel-Catalyzed Cross-Electrophile Coupling with Versatile Arylsulfonium Salts
Angew Chem Int Ed Engl. 2024 May 2:e202401198. doi: 10.1002/anie.202401198. Online ahead of print.ABSTRACTProducing sp3-hybridized carbon-enriched molecules is of particular interest due to their high success rate in clinical trials. The installation of aliphatic chains onto aromatic scaffolds was accomplished by nickel-catalyzed C(sp2)-C(sp3) cross-electrophile coupling with arylsulfonium salts. Thus, simple non-prefunctionalized arenes could be alkylated through the formation of aryldibenzothiophenium salts. The reaction employs an electrochemical approach to avoid potentially hazardous chemical redox agents, and importa...
Source: Angewandte Chemie - May 2, 2024 Category: Chemistry Authors: Takuya Michiyuki Simon L Hom ölle Neeraj Kumar Pandit Lutz Ackermann Source Type: research
Miniaturized inkjet-printed flexible ion-selective sensing electrodes with the addition of graphene in PVC layer for fast response real-time monitoring applications
Talanta. 2024 Apr 23;275:126107. doi: 10.1016/j.talanta.2024.126107. Online ahead of print.ABSTRACTIn this letter, we propose a miniaturization scheme of inkjet printed ionic sensing electrodes by adding graphene into the ion-selective PVC film not only to reduce the impedance of the ionic liquid layer of the electrode but also to increase the electrode capacitance for the reduction of the response time. Based on the scheme, we present a fully inkjet-printed electrochemical ion-selective sensor comprising a working electrode and reference electrode, which are inkjet-printed Ag NPs/PEDOT:PSS-graphene/PVC-graphene and Ag/AgC...
Source: Talanta - May 2, 2024 Category: Chemistry Authors: Kun-Lin Tsou Yu-Ting Cheng Source Type: research
A randomized study of subconjonctival bevacizumab (Avastin ®) injection for corneal neovascularization
CONCLUSION: This study shows the efficacy of subconjunctival bevacizumab injection in the reduction of neovascularized corneal surface area versus placebo, but only when the neovascularization has been present less than 1year. Nevertheless, the study did not attain the statistical power to pass the threshold of significance.PMID:38696862 | DOI:10.1016/j.jfo.2024.104152 (Source: Journal Francais d Ophtalmologie)
Source: Journal Francais d Ophtalmologie - May 2, 2024 Category: Opthalmology Authors: M Rocher Y Benayoun S Quilbe S Laribi P Fournie N Leveziel M-C Trone T Bourcier P-Y Robert Source Type: research
