The Effect of Guided Imagery and Progressive Muscle Relaxation on Sedation in Patients Undergoing Noninvasive Mechanical Ventilation
This study included 80 patients with a mean age (± SD) of 59.59 ± 9.27 years. The Quade nonparametric ANCOVA revealed the significant impact of intervention on the post values of Total score (p-value < 0.001), Tolerance (p-value < 0.001), Calmness (p-value < 0.001), Ventilator synchrony (p-value < 0.001), face relaxation (p-value < 0.001), Consciousness (p-value = 0.009) and Awakeness (p-value = 0.020). The study findings demonstrated the effectiveness of relaxation program in promoting sedation in patients undergoing NIV. Accordingly, intensive care unit (ICU) nurses at our institution are encouraged to u...
Source: Journal of Pain and Palliative Care Pharmacotherapy - April 26, 2024 Category: Palliative Care Authors: Atefe Salimi Akinabadi Sorour Khari Mehdi Azizmohammad Looha Mitra Zandi Source Type: research
Antibody-Drug Conjugates in the Treatment of Genitourinary Cancers: An Updated Review of Data
In this study, we have thoroughly completed a narrative review of the current literature and summarized preclinical studies and clinical trials that evaluated the utility, activity, and toxicity of ADCs in GU cancers, the prospects of ADC development, and the ongoing clinical trials. Prospective clinical trials, retrospective studies, case reports, and scoping reviews were included.PMID:38668075 | DOI:10.3390/curroncol31040172 (Source: Current Oncology)
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Prathana Nathan Adnan Rajeh Meh Noor Gabriel Boldt Ricardo Fernandes Source Type: research
Developing innovative strategies of tumor ‑infiltrating lymphocyte therapy for tumor treatment
Oncol Rep. 2024 Jun;51(6):85. doi: 10.3892/or.2024.8744. Epub 2024 Apr 26.ABSTRACTCancer is the main cause of global mortality, and thus far, effective therapeutic strategies for cancer treatment are in high demand. Adoptive transfer of tumor‑infiltrating lymphocytes (TILs) represents a promising avenue in immunotherapy for the management of malignancies. The clinical safety and efficacy of TIL‑based therapy have been established through numerous rigorous clinical trials. However, the efficacy of TIL infusion in inducing an anti‑tumor response is limited to a subset of clinical patients with cancer. Therefore, there ...
Source: Oncology Reports - April 26, 2024 Category: Cancer & Oncology Authors: Zhongjie Yu Jianhua Shi Yuan Fang Yi Zhao Aotian Xu Ning Li Source Type: research
Microbiological assessment of success and failure in pulp revitalization: a randomized clinical trial using calcium hydroxide and chlorhexidine gluconate in traumatized immature necrotic teeth
CONCLUSIONS: There were no statistical differences in CH and CHD efficacy. At S5, microflora persisted in both successful and failed outcomes, but the abundance and diversity increased significantly only in the failed cases. The successful outcomes presented higher diversity and higher decreases of the primary microflora at S5 than the failed outcomes. The abundance and diversity increased significantly at S5 only in failed cases.PMID:38665416 | PMC:PMC11044761 | DOI:10.1080/20002297.2024.2343518 (Source: Journal of Oral Microbiology)
Source: Journal of Oral Microbiology - April 26, 2024 Category: Microbiology Authors: Alina Wikstr öm Nelly Romani Vestman Olena Rakhimova David Lazaro Gimeno Georgios Tsilingaridis Malin Brundin Source Type: research
Identifying time-resolved features of nocturnal sleep characteristics of narcolepsy using machine learning
J Sleep Res. 2024 Apr 26:e14216. doi: 10.1111/jsr.14216. Online ahead of print.ABSTRACTThe differential diagnosis of narcolepsy type 1, a rare, chronic, central disorder of hypersomnolence, is challenging due to overlapping symptoms with other hypersomnolence disorders. While recent years have seen significant growth in our understanding of nocturnal polysomnography narcolepsy type 1 features, there remains a need for improving methods to differentiate narcolepsy type 1 nighttime sleep features from those of individuals without narcolepsy type 1. We aimed to develop a machine learning framework for identifying sleep featur...
Source: Journal of Sleep Research - April 26, 2024 Category: Sleep Medicine Authors: Marco Vilela Brian Tracey Dmitri Volfson Lucie Barateau Alice Cai Derek L Buhl Yves Dauvilliers Source Type: research
Facilitators and barriers to adolescent participation in a TB clinical trial
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - April 26, 2024 Category: Respiratory Medicine Authors: Mangan, J.M. Hedges, K.N.C. Salerno, M.M. Tatum, K. Bouwkamp, B. Frick, M.W. McKenna, L. Muzanyi, G. Engle, M. Coetzee, J. Yvetot, J. Elskamp, M. Lamunu, D. Tizora, M.E. Theunissen Namutamba, D. Chaisson, R.E. Swindells, S. Nahid, P. Dorman, S.E. Kurbatov Tags: ORIGINAL ARTICLES Source Type: research
Thrombopoietin Agonism to Promote Platelet Engraftment Following Hematopoietic Stem Cell Transplantation: Promising, but Not Ready for Primetime
In this issue of TCT, Fu and colleagues report the results of a randomized clinical trial conducted in China comparing thrombopoietic support using recombinant human thrombopoietin (rhTPO) with observation to promote platelet engraftment in patients receiving haploidentical hematopoietic stem cell transplantation (HSCT) with post-transplantation cyclophosphamide for the treatment of severe aplastic anemia (SAA).1 The trial enrolled 55 patients, randomized 1:1 to rhTPO or observation. The authors report successful hematopoietic reconstitution in all patients, but significantly faster platelet engraftment in patients randomi...
Source: Biology of Blood and Marrow Transplantation - April 26, 2024 Category: Hematology Authors: Hanny Al-Samkari Tags: The Bottom Line Source Type: research
The impact of ankle –foot orthoses on mobility of dual-task walking in stroke patients? A cross-sectional two-factor factorial design clinical trial
. (Source: Neuropsychological Rehabilitation)
Source: Neuropsychological Rehabilitation - April 26, 2024 Category: Rehabilitation Authors: Rong ChenHuan ChenShilin LiPeihua CaoLonglong HeYijin ZhaoZijun HeZe GongGuozhi HuangQing Zenga Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, People ’s Republic of Chinab Clinical Research Center, Zhuj Source Type: research
Feasibility of exergaming for upper extremity rehabilitation in people with multiple sclerosis: prospective clinical trial
ConclusionThese results showed that our custom-made exergaming scenario could be feasible in upper extremity rehabilitation in MS. More research is needed to investigate its effectiveness in the rehabilitation of upper limbs. (Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - April 26, 2024 Category: Neurology Source Type: research
CAR T-cell therapy: a potential treatment strategy for pediatric midline gliomas
AbstractPediatric brain tumors are the primary cause of death in children with cancer. Diffuse midline glioma (DMG) and diffuse intrinsic pontine glioma (DIPG) are frequently unresectable due to their difficult access location, and 5-year survival remains less than 20%. Despite significant advances in tumor biology and genetics, treatment options remain limited and ineffective. Immunotherapy using T cells with a chimeric antigen receptor (CAR) that has been genetically engineered is quickly emerging as a new treatment option for these patients. High levels of expression were detected for both disialoganglioside (GD2) and B...
Source: Acta Neurologica Belgica - April 26, 2024 Category: Neurology Source Type: research
Shining a spotlight on the inclusion of disabled participants in clinical trials: a mixed methods study
It is crucial to include a wide range of the population in clinical trials for the outcome to be applicable in real-world settings. Existing literature indicates that under-served groups, including disabled pe... (Source: Trials)
Source: Trials - April 26, 2024 Category: General Medicine Authors: Yoshiko Sakuma, Marie L. E. Miller, Daphne S. Babalis, Alex Baker, Meena Reddi, Aisha Anjum, Jane Bruton, Kathryn N Jones, Umm Zeinab Mulla and Henock Taddese Tags: Research Source Type: research
Evaluation of the internet-based intervention “Selfapy” in participants with unipolar depression and the impact on quality of life: a randomized, parallel group study
ConclusionSelfapy proved to positively affect psychological and physical QOL in a sample of participants suffering from depressive disorders and can therefore be considered an effective and highly scalable therapeutic tool. The pattern of results might partly be attributable to effects of the COVID-19 pandemic and public health measures that coincided with the trial.Trial registration: German Clinical Trials Register (DRKS): DRKS00017191. Registered June 14th, 2019,https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00017191. (Source: Quality of Life Research)
Source: Quality of Life Research - April 25, 2024 Category: Health Management Source Type: research
CBT More Effective Than Mindfulness for Prolonged Grief Symptoms Over Time, Study Finds
Both grief-focused cognitive-behavioral therapy (CBT) and mindfulness-based cognitive therapy improved patients ’ symptoms of prolonged grief disorder immediately after 11 weeks of treatment, according to astudy published yesterday inJAMA Psychiatry. Grief-focused CBT, however, was more effective in reducing patients ’ symptom severity six months after treatment ended.“[B]etween 15% and 25% of patients with prolonged grief disorder offered grief-focused cognitive behavior therapy decline to participate in treatment, and between 17% and 50% may not respond to treatment,” wrote Richard A. Bryant, Ph.D., of the Univer...
Source: Psychiatr News - April 25, 2024 Category: Psychiatry Tags: cognitive behavior therapy JAMA Psychiatry meditation mindfulness-based cognitive therapy Ph.D. prolonged grief disorder Randomized Clinical Trial Richard A. Bryant University of New South Wales Source Type: research
Human Infrapatellar Fat Pad Mesenchymal Stem Cell-derived Extracellular Vesicles Purified by Anion Exchange Chromatography Suppress Osteoarthritis Progression in a Mouse Model
CONCLUSION: Using an OA mouse model, we found that infrapatellar fat pad-derived MSC-extracellular vesicles could delay OA progression via alleviating pain and suppressing cartilage degeneration, osteophyte formation, and synovial inflammation. The autologous origin of extracellular vesicles and scalable purification method make our strategy potentially viable for clinical translation.CLINICAL RELEVANCE: Infrapatellar fat pad-derived MSC-extracellular vesicles isolated by anion exchange chromatography can suppress OA progression in a mouse model. Further studies with large-animal models, larger animal groups, and subsequen...
Source: Cell Research - April 25, 2024 Category: Cytology Authors: Qisong Liu Jianqun Wu Hua Wang Zhaofeng Jia Guangheng Li Source Type: research
Pediatric Endocrine Society Statement on Considerations for Use of Teplizumab (Tzield ™) in Clinical Practice
We present considerations on all aspects of teplizumab administration, utilizing evidence where possible and providing a spectrum of expert opinions on unknown aspects. We discuss patient selection and prescreening, highlighting the safety and considerations for monitoring and treatment of side effects. We propose a schedule of events, a protocol for administration and discuss practice management aspects. We advocate for the need for further long-term systematic surveillance studies to continue evaluating the efficacy and safety of teplizumab.PMID:38663372 | DOI:10.1159/000538775 (Source: Cell Research)
Source: Cell Research - April 25, 2024 Category: Cytology Authors: Shilpa Mehta Anna Ryabets-Lienhard Neha Patel Emily Breidbart Ingrid Libman Michael J Haller Kimber M Simmons Emily K Sims Linda A DiMeglio Stephen E Gitelman Kurt J Griffin Ksenia N Tonyushkina Source Type: research
