Extracellular vesicles from oral mucosa stem cells promote lipid raft formation in human microglia through TLR4, P2X4R, and αVβ3/αVβ5 signaling pathways
Cell Biol Int. 2023 Dec 15. doi: 10.1002/cbin.12111. Online ahead of print.ABSTRACTTargeting of disease-associated microglia represents a promising therapeutic approach that can be used for the prevention or slowing down neurodegeneration. In this regard, the use of extracellular vesicles (EVs) represents a promising therapeutic approach. However, the molecular mechanisms by which EVs regulate microglial responses remain poorly understood. In the present study, we used EVs derived from human oral mucosa stem cells (OMSCs) to investigate the effects on the lipid raft formation and the phagocytic response of human microglial...
Source: Cell Biology International - December 15, 2023 Category: Cytology Authors: Diana Romenskaja Ugn ė Jonavičė Virginijus Tunaitis Augustas Pivori ūnas Source Type: research
Increased incidence of vibriosis in Maryland, U.S.A., 2006-2019
CONCLUSIONS: Long-term increases in Vibrio infections, notably V. vulnificus wound infections, are occurring in Maryland. This trend, along with increased rates in hospitalizations and average hospital durations, underscore the need to improve public awareness, water monitoring, post-harvest seafood interventions, and environmental forecasting ability.PMID:38101724 | DOI:10.1016/j.envres.2023.117940 (Source: Environmental Research)
Source: Environmental Research - December 15, 2023 Category: Environmental Health Authors: Michele E Morgado Kyle D Brumfield Clifford Mitchell Michelle M Boyle Rita R Colwell Amy R Sapkota Source Type: research
Extracellular vesicles from oral mucosa stem cells promote lipid raft formation in human microglia through TLR4, P2X4R, and αVβ3/αVβ5 signaling pathways
Cell Biol Int. 2023 Dec 15. doi: 10.1002/cbin.12111. Online ahead of print.ABSTRACTTargeting of disease-associated microglia represents a promising therapeutic approach that can be used for the prevention or slowing down neurodegeneration. In this regard, the use of extracellular vesicles (EVs) represents a promising therapeutic approach. However, the molecular mechanisms by which EVs regulate microglial responses remain poorly understood. In the present study, we used EVs derived from human oral mucosa stem cells (OMSCs) to investigate the effects on the lipid raft formation and the phagocytic response of human microglial...
Source: Cell Biology International - December 15, 2023 Category: Cytology Authors: Diana Romenskaja Ugn ė Jonavičė Virginijus Tunaitis Augustas Pivori ūnas Source Type: research
The overlooked bacterial pandemic
AbstractThe COVID-19 pandemic had a significant economic and health impact worldwide. It also reinforced the misperception that only viruses can pose a threat to human existence, overlooking that bacteria (e.g., plague and cholera) have severely haunted and shaped the course of human civilization. While the world is preparing for the next viral pandemic, it is again overlooking a silent one: antimicrobial resistance (AMR). This review proposes to show the impact of bacterial infections on civilization to remind the pandemic potential. The work will also discuss a few examples of how bacteria can mutate risking global sprea...
Source: Seminars in Immunopathology - December 11, 2023 Category: Pathology Source Type: research
Phytochemistry and pharmacology of plants in the genus Chaenomeles
The objective of this review is to provide a comprehensive and up-to-date summary of the available information on the genus Chaenomeles to serve as a valuable reference for further investigations.PMID:38062238 | DOI:10.1007/s12272-023-01475-w (Source: Archives of Pharmacal Research)
Source: Archives of Pharmacal Research - December 7, 2023 Category: Drugs & Pharmacology Authors: Ruoling Xu Mengting Kuang Ning Li Source Type: research
Excess mortality in northern Haiti during the 2010 cholera epidemic
In conclusion, addressing transportation and information needs could increase healthcare utilization and reduc e lives lost during an outbreak. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - December 6, 2023 Category: Tropical Medicine Authors: Macceau Medozile Source Type: research
Region-specific response of central microglial cells to sciatic nerve demyelination through sensory and motor pathways
Histol Histopathol. 2023 Nov 28:18681. doi: 10.14670/HH-18-681. Online ahead of print.ABSTRACTPeripheral nerve injury can cause changes in microglial cells on the spinal dorsal and ventral horns. This region-specific response implies that central microglial cells could be activated through both sensory and motor pathways. In order to further determine how peripheral nerve injury activates central microglial cells through neural pathways, the sciatic nerve was selected as the target for neural tract tracing and demyelination. Firstly, we used cholera toxin subunit B (CTB) to map the central sensory and motor territories of ...
Source: Histology and Histopathology - December 5, 2023 Category: Cytology Authors: Shuang Wu Yuxin Su Yuqing Wang Jia Wang Dongsheng Xu Yihan Liu Kunwu Yang Junhong Gao Jingjing Cui Wanzhu Bai Source Type: research
Molecules, Vol. 28, Pages 7954: Unveiling the Anti-Cholera and Active Diabetic Renoprotective Compounds of Maqian Essential Oil: A Computational and Molecular Dynamics Study
In conclusion, based on a computational approach, our findings reveal that MQEO constituents have inhibitory activity against cholera toxin and are promising therapeutic agents for suppressing diabetic inflammation and for the treatment of diabetic nephropathy complications. (Source: Molecules)
Source: Molecules - December 5, 2023 Category: Chemistry Authors: Mahmoud Dahab Ping Zhang Samiah Hamad Al-Mijalli Emad M. Abdallah Tags: Article Source Type: research
Vaccine and malnutrition: A narrative review
J Family Med Prim Care. 2023 Sep;12(9):1808-1813. doi: 10.4103/jfmpc.jfmpc_596_23. Epub 2023 Sep 30.ABSTRACTNearly 45% of under 5 mortality is directly or indirectly linked to malnutrition. Infection adds to the increased mortality and morbidity in these groups. Vaccination is very important in these undernourished children protecting against life-threatening infections. The goal of vaccination is to produce long-term protection by generating memory cells and the generation of antibodies. Since malnutrition is a state of immunodeficiency, the immune response to vaccines in these children is a matter of concern. We did an e...
Source: Primary Care - November 29, 2023 Category: Primary Care Authors: Saroj K Tripathy Sarthak Das Archana Malik Source Type: research
Vaccine and malnutrition: A narrative review
J Family Med Prim Care. 2023 Sep;12(9):1808-1813. doi: 10.4103/jfmpc.jfmpc_596_23. Epub 2023 Sep 30.ABSTRACTNearly 45% of under 5 mortality is directly or indirectly linked to malnutrition. Infection adds to the increased mortality and morbidity in these groups. Vaccination is very important in these undernourished children protecting against life-threatening infections. The goal of vaccination is to produce long-term protection by generating memory cells and the generation of antibodies. Since malnutrition is a state of immunodeficiency, the immune response to vaccines in these children is a matter of concern. We did an e...
Source: Primary Care - November 29, 2023 Category: Primary Care Authors: Saroj K Tripathy Sarthak Das Archana Malik Source Type: research
Effectiveness of the Euvichol ® oral cholera vaccine at 2 years: a case-control and bias-indicator study in Haiti
Cholera accounts for a significant burden of morbidity and mortality, with recent years demonstrating an increase in the number of outbreaks globally.[1] As part of comprehensive cholera control efforts, the World Health Organization (WHO) recommends use of oral cholera vaccine (OCV) in endemic and epidemic settings.[2] A global stockpile of WHO pre-qualified OCVs was established in 2013 and has since supplied the majority of OCVs used in outbreak settings.[3] (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - November 22, 2023 Category: Infectious Diseases Authors: Wilfredo R. Matias, Yodeline Guillaume, Gertrude Cene Augustin, Kenia Vissieres, Ralph Ternier, Damien M. Slater, Jason B. Harris, Molly F. Franke, Louise C. Ivers Source Type: research
GSE247770 RNAseq of VP882 phage activation in V. cholerae
Contributors : Marcel Sprenger ; Malte Siemers ; Kai PapenfortSeries Type : Expression profiling by high throughput sequencingOrganism : Vibrio choleraeMany, if not all, bacteria use quorum sensing (QS) to control gene expression and collective behaviours, and more recently QS has also been discovered in bacteriophages (phages). Phages can produce communication molecules of their own, or “listen in” on the host’s communication processes, in order to switch between lytic and lysogenic modes of infection. In this project, we studied the interaction of Vibrio cholerae, the causative agent of cholera disease, with the...
Source: GEO: Gene Expression Omnibus - November 20, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Vibrio cholerae Source Type: research
GSE247769 RNAseq of VP882 and VP882 ∆vpdS phage activation in V. cholerae
Contributors : Marcel Sprenger ; Malte Siemers ; Kai PapenfortSeries Type : Expression profiling by high throughput sequencingOrganism : Vibrio choleraeMany, if not all, bacteria use quorum sensing (QS) to control gene expression and collective behaviours, and more recently QS has also been discovered in bacteriophages (phages). Phages can produce communication molecules of their own, or “listen in” on the host’s communication processes, in order to switch between lytic and lysogenic modes of infection. In this project, we studied the interaction of Vibrio cholerae, the causative agent of cholera disease, with the...
Source: GEO: Gene Expression Omnibus - November 20, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Vibrio cholerae Source Type: research
