Effect of cross-immunity in a two-strain cholera model with aquatic component
Math Biosci. 2023 Oct 10;365:109086. doi: 10.1016/j.mbs.2023.109086. Online ahead of print.ABSTRACTThe bacteria Vibrio cholerae relies heavily upon an aquatic reservoir as a transmission route with two distinct serotypes observed in many recent outbreaks. In this paper, we extend previously studied ordinary differential equation epidemiological models to create a two-strain SIRP (susceptible-infectious-recovered-pathogen) system which incorporates both partial cross-immunity between disease strains and environmental pathogen transmission. Of particular interest are undamped anti-phase periodic solutions, as these display a...
Source: Mathematical Biosciences - October 11, 2023 Category: Statistics Authors: Leah LeJeune Cameron Browne Source Type: research
Toxigenic < em > Vibrio cholerae < /em > strains in South-East Queensland, Australian river waterways
This study aimed to characterize recent surveillance of environmental NOVC strains isolated from Queensland River waterways to understand their virulence, antimicrobial resistance profile and to place genetic current V. cholerae strains from Australia in context with international strains. The findings from this study suggest the presence of unique toxigenic V. cholerae in Queensland river water systems that are of public health concern. Therefore, ongoing monitoring and genomic characterization of V. cholerae strains from the Queensland environment is important and would assist public health departments to track the sourc...
Source: Applied and Environmental Microbiology - October 6, 2023 Category: Microbiology Authors: Murari Bhandari Irani U Rathnayake Lawrence Ariotti Brett Heron Flavia Huygens Mitchelle Sullivan Amy V Jennison Source Type: research
Toxigenic < em > Vibrio cholerae < /em > strains in South-East Queensland, Australian river waterways
This study aimed to characterize recent surveillance of environmental NOVC strains isolated from Queensland River waterways to understand their virulence, antimicrobial resistance profile and to place genetic current V. cholerae strains from Australia in context with international strains. The findings from this study suggest the presence of unique toxigenic V. cholerae in Queensland river water systems that are of public health concern. Therefore, ongoing monitoring and genomic characterization of V. cholerae strains from the Queensland environment is important and would assist public health departments to track the sourc...
Source: Applied and Environmental Microbiology - October 6, 2023 Category: Microbiology Authors: Murari Bhandari Irani U Rathnayake Lawrence Ariotti Brett Heron Flavia Huygens Mitchelle Sullivan Amy V Jennison Source Type: research
Toxigenic < em > Vibrio cholerae < /em > strains in South-East Queensland, Australian river waterways
This study aimed to characterize recent surveillance of environmental NOVC strains isolated from Queensland River waterways to understand their virulence, antimicrobial resistance profile and to place genetic current V. cholerae strains from Australia in context with international strains. The findings from this study suggest the presence of unique toxigenic V. cholerae in Queensland river water systems that are of public health concern. Therefore, ongoing monitoring and genomic characterization of V. cholerae strains from the Queensland environment is important and would assist public health departments to track the sourc...
Source: Applied and Environmental Microbiology - October 6, 2023 Category: Microbiology Authors: Murari Bhandari Irani U Rathnayake Lawrence Ariotti Brett Heron Flavia Huygens Mitchelle Sullivan Amy V Jennison Source Type: research
Toxigenic < em > Vibrio cholerae < /em > strains in South-East Queensland, Australian river waterways
This study aimed to characterize recent surveillance of environmental NOVC strains isolated from Queensland River waterways to understand their virulence, antimicrobial resistance profile and to place genetic current V. cholerae strains from Australia in context with international strains. The findings from this study suggest the presence of unique toxigenic V. cholerae in Queensland river water systems that are of public health concern. Therefore, ongoing monitoring and genomic characterization of V. cholerae strains from the Queensland environment is important and would assist public health departments to track the sourc...
Source: Applied and Environmental Microbiology - October 6, 2023 Category: Microbiology Authors: Murari Bhandari Irani U Rathnayake Lawrence Ariotti Brett Heron Flavia Huygens Mitchelle Sullivan Amy V Jennison Source Type: research
Euvichol-plus vaccine campaign coverage during the 2017/2018 cholera outbreak in Lusaka district, Zambia: a cross-sectional descriptive study
Conclusion
These findings confirm the 2018 OCV campaign coverage and highlight the need for follow-up surveys to validate administrative coverage estimates using population-based methods. Reliance on health facility data alone may mask low coverage and prevent measures to improve programming. Future public health interventions should consider sociodemographic factors in order to achieve optimal vaccine coverage. (Source: BMJ Open)
Source: BMJ Open - October 5, 2023 Category: General Medicine Authors: Mukonka, V. M., Sialubanje, C., Matapo, B. B., Chewe, O., Ngomah, A. M., Ngosa, W., Hamoonga, R., Sinyange, N., Mzyece, H., Mazyanga, L., Bakyaita, N., Kapata, N. Tags: Open access, Epidemiology Source Type: research
Vaccination of Rabbits with a Cholera Conjugate Vaccine Comprising O-Specific Polysaccharide and a Recombinant Fragment of Tetanus Toxin Heavy Chain Induces Protective Immune Responses against Vibrio cholerae O1
Am J Trop Med Hyg. 2023 Oct 2:tpmd230259. doi: 10.4269/ajtmh.23-0259. Online ahead of print.ABSTRACTThere is a need for next-generation cholera vaccines that provide high-level and durable protection in young children in cholera-endemic areas. A cholera conjugate vaccine (CCV) is in development to address this need. This vaccine contains the O-specific polysaccharide (OSP) of Vibrio cholerae O1 conjugated via squaric acid chemistry to a recombinant fragment of the tetanus toxin heavy chain (OSP:rTTHc). This vaccine has been shown previously to be immunogenic and protective in mice and found to be safe in a recent preclinic...
Source: Am J Trop Med Hyg - October 2, 2023 Category: Infectious Diseases Authors: Meagan Kelly Suhi Jeon Jeesun Yun Byungman Lee Minchul Park Yoonhee Whang Chankyu Lee Richelle C Charles Taufiqur R Bhuiyan Firdausi Qadri Mohammad Kamruzzaman Somyoung Cho Willie F Vann Peng Xu Pavol Kov áč Ravi Ganapathy Julia Lynch Edward T Ryan Source Type: research
Vaccination of Rabbits with a Cholera Conjugate Vaccine Comprising O-Specific Polysaccharide and a Recombinant Fragment of Tetanus Toxin Heavy Chain Induces Protective Immune Responses against Vibrio cholerae O1
Am J Trop Med Hyg. 2023 Oct 2:tpmd230259. doi: 10.4269/ajtmh.23-0259. Online ahead of print.ABSTRACTThere is a need for next-generation cholera vaccines that provide high-level and durable protection in young children in cholera-endemic areas. A cholera conjugate vaccine (CCV) is in development to address this need. This vaccine contains the O-specific polysaccharide (OSP) of Vibrio cholerae O1 conjugated via squaric acid chemistry to a recombinant fragment of the tetanus toxin heavy chain (OSP:rTTHc). This vaccine has been shown previously to be immunogenic and protective in mice and found to be safe in a recent preclinic...
Source: The American Journal of Tropical Medicine and Hygiene - October 2, 2023 Category: Tropical Medicine Authors: Meagan Kelly Suhi Jeon Jeesun Yun Byungman Lee Minchul Park Yoonhee Whang Chankyu Lee Richelle C Charles Taufiqur R Bhuiyan Firdausi Qadri Mohammad Kamruzzaman Somyoung Cho Willie F Vann Peng Xu Pavol Kov áč Ravi Ganapathy Julia Lynch Edward T Ryan Source Type: research
Vaccination of Rabbits with a Cholera Conjugate Vaccine Comprising O-Specific Polysaccharide and a Recombinant Fragment of Tetanus Toxin Heavy Chain Induces Protective Immune Responses against Vibrio cholerae O1
Am J Trop Med Hyg. 2023 Oct 2:tpmd230259. doi: 10.4269/ajtmh.23-0259. Online ahead of print.ABSTRACTThere is a need for next-generation cholera vaccines that provide high-level and durable protection in young children in cholera-endemic areas. A cholera conjugate vaccine (CCV) is in development to address this need. This vaccine contains the O-specific polysaccharide (OSP) of Vibrio cholerae O1 conjugated via squaric acid chemistry to a recombinant fragment of the tetanus toxin heavy chain (OSP:rTTHc). This vaccine has been shown previously to be immunogenic and protective in mice and found to be safe in a recent preclinic...
Source: Am J Trop Med Hyg - October 2, 2023 Category: Infectious Diseases Authors: Meagan Kelly Suhi Jeon Jeesun Yun Byungman Lee Minchul Park Yoonhee Whang Chankyu Lee Richelle C Charles Taufiqur R Bhuiyan Firdausi Qadri Mohammad Kamruzzaman Somyoung Cho Willie F Vann Peng Xu Pavol Kov áč Ravi Ganapathy Julia Lynch Edward T Ryan Source Type: research
Vaccination of Rabbits with a Cholera Conjugate Vaccine Comprising O-Specific Polysaccharide and a Recombinant Fragment of Tetanus Toxin Heavy Chain Induces Protective Immune Responses against Vibrio cholerae O1
Am J Trop Med Hyg. 2023 Oct 2:tpmd230259. doi: 10.4269/ajtmh.23-0259. Online ahead of print.ABSTRACTThere is a need for next-generation cholera vaccines that provide high-level and durable protection in young children in cholera-endemic areas. A cholera conjugate vaccine (CCV) is in development to address this need. This vaccine contains the O-specific polysaccharide (OSP) of Vibrio cholerae O1 conjugated via squaric acid chemistry to a recombinant fragment of the tetanus toxin heavy chain (OSP:rTTHc). This vaccine has been shown previously to be immunogenic and protective in mice and found to be safe in a recent preclinic...
Source: The American Journal of Tropical Medicine and Hygiene - October 2, 2023 Category: Tropical Medicine Authors: Meagan Kelly Suhi Jeon Jeesun Yun Byungman Lee Minchul Park Yoonhee Whang Chankyu Lee Richelle C Charles Taufiqur R Bhuiyan Firdausi Qadri Mohammad Kamruzzaman Somyoung Cho Willie F Vann Peng Xu Pavol Kov áč Ravi Ganapathy Julia Lynch Edward T Ryan Source Type: research
Vaccination of Rabbits with a Cholera Conjugate Vaccine Comprising O-Specific Polysaccharide and a Recombinant Fragment of Tetanus Toxin Heavy Chain Induces Protective Immune Responses against Vibrio cholerae O1
Am J Trop Med Hyg. 2023 Oct 2:tpmd230259. doi: 10.4269/ajtmh.23-0259. Online ahead of print.ABSTRACTThere is a need for next-generation cholera vaccines that provide high-level and durable protection in young children in cholera-endemic areas. A cholera conjugate vaccine (CCV) is in development to address this need. This vaccine contains the O-specific polysaccharide (OSP) of Vibrio cholerae O1 conjugated via squaric acid chemistry to a recombinant fragment of the tetanus toxin heavy chain (OSP:rTTHc). This vaccine has been shown previously to be immunogenic and protective in mice and found to be safe in a recent preclinic...
Source: Am J Trop Med Hyg - October 2, 2023 Category: Infectious Diseases Authors: Meagan Kelly Suhi Jeon Jeesun Yun Byungman Lee Minchul Park Yoonhee Whang Chankyu Lee Richelle C Charles Taufiqur R Bhuiyan Firdausi Qadri Mohammad Kamruzzaman Somyoung Cho Willie F Vann Peng Xu Pavol Kov áč Ravi Ganapathy Julia Lynch Edward T Ryan Source Type: research
Vaccination of Rabbits with a Cholera Conjugate Vaccine Comprising O-Specific Polysaccharide and a Recombinant Fragment of Tetanus Toxin Heavy Chain Induces Protective Immune Responses against Vibrio cholerae O1
Am J Trop Med Hyg. 2023 Oct 2:tpmd230259. doi: 10.4269/ajtmh.23-0259. Online ahead of print.ABSTRACTThere is a need for next-generation cholera vaccines that provide high-level and durable protection in young children in cholera-endemic areas. A cholera conjugate vaccine (CCV) is in development to address this need. This vaccine contains the O-specific polysaccharide (OSP) of Vibrio cholerae O1 conjugated via squaric acid chemistry to a recombinant fragment of the tetanus toxin heavy chain (OSP:rTTHc). This vaccine has been shown previously to be immunogenic and protective in mice and found to be safe in a recent preclinic...
Source: The American Journal of Tropical Medicine and Hygiene - October 2, 2023 Category: Tropical Medicine Authors: Meagan Kelly Suhi Jeon Jeesun Yun Byungman Lee Minchul Park Yoonhee Whang Chankyu Lee Richelle C Charles Taufiqur R Bhuiyan Firdausi Qadri Mohammad Kamruzzaman Somyoung Cho Willie F Vann Peng Xu Pavol Kov áč Ravi Ganapathy Julia Lynch Edward T Ryan Source Type: research
Vaccination of Rabbits with a Cholera Conjugate Vaccine Comprising O-Specific Polysaccharide and a Recombinant Fragment of Tetanus Toxin Heavy Chain Induces Protective Immune Responses against Vibrio cholerae O1
Am J Trop Med Hyg. 2023 Oct 2:tpmd230259. doi: 10.4269/ajtmh.23-0259. Online ahead of print.ABSTRACTThere is a need for next-generation cholera vaccines that provide high-level and durable protection in young children in cholera-endemic areas. A cholera conjugate vaccine (CCV) is in development to address this need. This vaccine contains the O-specific polysaccharide (OSP) of Vibrio cholerae O1 conjugated via squaric acid chemistry to a recombinant fragment of the tetanus toxin heavy chain (OSP:rTTHc). This vaccine has been shown previously to be immunogenic and protective in mice and found to be safe in a recent preclinic...
Source: Am J Trop Med Hyg - October 2, 2023 Category: Infectious Diseases Authors: Meagan Kelly Suhi Jeon Jeesun Yun Byungman Lee Minchul Park Yoonhee Whang Chankyu Lee Richelle C Charles Taufiqur R Bhuiyan Firdausi Qadri Mohammad Kamruzzaman Somyoung Cho Willie F Vann Peng Xu Pavol Kov áč Ravi Ganapathy Julia Lynch Edward T Ryan Source Type: research
Responding to cholera outbreaks in Somalia in 2017-2019
CONCLUSIONS: Periodic assessment of response to and preparedness for potential epidemics is essential to identify and close gaps within the health systems. Somalia's experience offers important lessons on preventing and controlling cholera outbreaks for countries experiencing complex humanitarian emergencies.PMID:37776135 | DOI:10.26719/emhj.23.096 (Source: Eastern Mediterranean Health Journal)
Source: Eastern Mediterranean Health Journal - September 30, 2023 Category: Middle East Health Authors: Mutaawe Lubogo Buliva Evans Abubakar Abdinasir Elnossery Sherein Tayyab Muhammad Ahmed Mohamed Aden Hussein Fayez Abdulrazeq Malik Mamunur Source Type: research
