Vaccination of Rabbits with a Cholera Conjugate Vaccine Comprising O-Specific Polysaccharide and a Recombinant Fragment of Tetanus Toxin Heavy Chain Induces Protective Immune Responses against Vibrio cholerae O1
Am J Trop Med Hyg. 2023 Oct 2:tpmd230259. doi: 10.4269/ajtmh.23-0259. Online ahead of print.ABSTRACTThere is a need for next-generation cholera vaccines that provide high-level and durable protection in young children in cholera-endemic areas. A cholera conjugate vaccine (CCV) is in development to address this need. This vaccine contains the O-specific polysaccharide (OSP) of Vibrio cholerae O1 conjugated via squaric acid chemistry to a recombinant fragment of the tetanus toxin heavy chain (OSP:rTTHc). This vaccine has been shown previously to be immunogenic and protective in mice and found to be safe in a recent preclinic...
Source: Am J Trop Med Hyg - October 2, 2023 Category: Infectious Diseases Authors: Meagan Kelly Suhi Jeon Jeesun Yun Byungman Lee Minchul Park Yoonhee Whang Chankyu Lee Richelle C Charles Taufiqur R Bhuiyan Firdausi Qadri Mohammad Kamruzzaman Somyoung Cho Willie F Vann Peng Xu Pavol Kov áč Ravi Ganapathy Julia Lynch Edward T Ryan Source Type: research

Vaccination of Rabbits with a Cholera Conjugate Vaccine Comprising O-Specific Polysaccharide and a Recombinant Fragment of Tetanus Toxin Heavy Chain Induces Protective Immune Responses against Vibrio cholerae O1
Am J Trop Med Hyg. 2023 Oct 2:tpmd230259. doi: 10.4269/ajtmh.23-0259. Online ahead of print.ABSTRACTThere is a need for next-generation cholera vaccines that provide high-level and durable protection in young children in cholera-endemic areas. A cholera conjugate vaccine (CCV) is in development to address this need. This vaccine contains the O-specific polysaccharide (OSP) of Vibrio cholerae O1 conjugated via squaric acid chemistry to a recombinant fragment of the tetanus toxin heavy chain (OSP:rTTHc). This vaccine has been shown previously to be immunogenic and protective in mice and found to be safe in a recent preclinic...
Source: The American Journal of Tropical Medicine and Hygiene - October 2, 2023 Category: Tropical Medicine Authors: Meagan Kelly Suhi Jeon Jeesun Yun Byungman Lee Minchul Park Yoonhee Whang Chankyu Lee Richelle C Charles Taufiqur R Bhuiyan Firdausi Qadri Mohammad Kamruzzaman Somyoung Cho Willie F Vann Peng Xu Pavol Kov áč Ravi Ganapathy Julia Lynch Edward T Ryan Source Type: research

Vaccination of Rabbits with a Cholera Conjugate Vaccine Comprising O-Specific Polysaccharide and a Recombinant Fragment of Tetanus Toxin Heavy Chain Induces Protective Immune Responses against Vibrio cholerae O1
Am J Trop Med Hyg. 2023 Oct 2:tpmd230259. doi: 10.4269/ajtmh.23-0259. Online ahead of print.ABSTRACTThere is a need for next-generation cholera vaccines that provide high-level and durable protection in young children in cholera-endemic areas. A cholera conjugate vaccine (CCV) is in development to address this need. This vaccine contains the O-specific polysaccharide (OSP) of Vibrio cholerae O1 conjugated via squaric acid chemistry to a recombinant fragment of the tetanus toxin heavy chain (OSP:rTTHc). This vaccine has been shown previously to be immunogenic and protective in mice and found to be safe in a recent preclinic...
Source: Am J Trop Med Hyg - October 2, 2023 Category: Infectious Diseases Authors: Meagan Kelly Suhi Jeon Jeesun Yun Byungman Lee Minchul Park Yoonhee Whang Chankyu Lee Richelle C Charles Taufiqur R Bhuiyan Firdausi Qadri Mohammad Kamruzzaman Somyoung Cho Willie F Vann Peng Xu Pavol Kov áč Ravi Ganapathy Julia Lynch Edward T Ryan Source Type: research

Vaccination of Rabbits with a Cholera Conjugate Vaccine Comprising O-Specific Polysaccharide and a Recombinant Fragment of Tetanus Toxin Heavy Chain Induces Protective Immune Responses against Vibrio cholerae O1
Am J Trop Med Hyg. 2023 Oct 2:tpmd230259. doi: 10.4269/ajtmh.23-0259. Online ahead of print.ABSTRACTThere is a need for next-generation cholera vaccines that provide high-level and durable protection in young children in cholera-endemic areas. A cholera conjugate vaccine (CCV) is in development to address this need. This vaccine contains the O-specific polysaccharide (OSP) of Vibrio cholerae O1 conjugated via squaric acid chemistry to a recombinant fragment of the tetanus toxin heavy chain (OSP:rTTHc). This vaccine has been shown previously to be immunogenic and protective in mice and found to be safe in a recent preclinic...
Source: The American Journal of Tropical Medicine and Hygiene - October 2, 2023 Category: Tropical Medicine Authors: Meagan Kelly Suhi Jeon Jeesun Yun Byungman Lee Minchul Park Yoonhee Whang Chankyu Lee Richelle C Charles Taufiqur R Bhuiyan Firdausi Qadri Mohammad Kamruzzaman Somyoung Cho Willie F Vann Peng Xu Pavol Kov áč Ravi Ganapathy Julia Lynch Edward T Ryan Source Type: research

Vaccination of Rabbits with a Cholera Conjugate Vaccine Comprising O-Specific Polysaccharide and a Recombinant Fragment of Tetanus Toxin Heavy Chain Induces Protective Immune Responses against Vibrio cholerae O1
Am J Trop Med Hyg. 2023 Oct 2:tpmd230259. doi: 10.4269/ajtmh.23-0259. Online ahead of print.ABSTRACTThere is a need for next-generation cholera vaccines that provide high-level and durable protection in young children in cholera-endemic areas. A cholera conjugate vaccine (CCV) is in development to address this need. This vaccine contains the O-specific polysaccharide (OSP) of Vibrio cholerae O1 conjugated via squaric acid chemistry to a recombinant fragment of the tetanus toxin heavy chain (OSP:rTTHc). This vaccine has been shown previously to be immunogenic and protective in mice and found to be safe in a recent preclinic...
Source: Am J Trop Med Hyg - October 2, 2023 Category: Infectious Diseases Authors: Meagan Kelly Suhi Jeon Jeesun Yun Byungman Lee Minchul Park Yoonhee Whang Chankyu Lee Richelle C Charles Taufiqur R Bhuiyan Firdausi Qadri Mohammad Kamruzzaman Somyoung Cho Willie F Vann Peng Xu Pavol Kov áč Ravi Ganapathy Julia Lynch Edward T Ryan Source Type: research

Responding to cholera outbreaks in Somalia in 2017-2019
CONCLUSIONS: Periodic assessment of response to and preparedness for potential epidemics is essential to identify and close gaps within the health systems. Somalia's experience offers important lessons on preventing and controlling cholera outbreaks for countries experiencing complex humanitarian emergencies.PMID:37776135 | DOI:10.26719/emhj.23.096 (Source: Eastern Mediterranean Health Journal)
Source: Eastern Mediterranean Health Journal - September 30, 2023 Category: Middle East Health Authors: Mutaawe Lubogo Buliva Evans Abubakar Abdinasir Elnossery Sherein Tayyab Muhammad Ahmed Mohamed Aden Hussein Fayez Abdulrazeq Malik Mamunur Source Type: research