Emerging resistome diversity in clinical Vibrio cholerae strains revealing their role as potential reservoirs of antimicrobial resistance
CONCLUSIONS: The study helped to examine the resistome of VC isolated from recent outbreaks to understand the underlying reason of sensitivity to most antibiotics and also to characterize the ARGs in their genome. It revealed that VC is a reservoir of signatures of resistance determinants and serving as precursors for severe AMR crisis in cholera. This is the first study, to our knowledge, which has scrutinized and presented systematically, information on prospective domains which bear the potential of serving as AMR determinants in VC with the help of bioinformatic tools. This pioneering approach may help in the predictio...
Source: Molecular Biology Reports - March 9, 2024 Category: Molecular Biology Authors: Rituparna De Asish K Mukhopadhyay Manisha Ghosh Surajit Basak Shanta Dutta Source Type: research
Emerging resistome diversity in clinical Vibrio cholerae strains revealing their role as potential reservoirs of antimicrobial resistance
CONCLUSIONS: The study helped to examine the resistome of VC isolated from recent outbreaks to understand the underlying reason of sensitivity to most antibiotics and also to characterize the ARGs in their genome. It revealed that VC is a reservoir of signatures of resistance determinants and serving as precursors for severe AMR crisis in cholera. This is the first study, to our knowledge, which has scrutinized and presented systematically, information on prospective domains which bear the potential of serving as AMR determinants in VC with the help of bioinformatic tools. This pioneering approach may help in the predictio...
Source: Molecular Biology Reports - March 9, 2024 Category: Molecular Biology Authors: Rituparna De Asish K Mukhopadhyay Manisha Ghosh Surajit Basak Shanta Dutta Source Type: research
PIRES2-EGFP/CTB-UreI vaccination activated a mixed Th1/Th2/Th17 immune system defense towards Helicobacter pylori infection in the BALB/c mice model
Vaccine. 2024 Mar 7:S0264-410X(24)00209-3. doi: 10.1016/j.vaccine.2024.02.050. Online ahead of print.ABSTRACTThe occurrence of gastritis, gastric ulcers, distal gastric cancer, and gastric mucosal lymphoma in humans is strongly associated with Helicobacter pylori (H. pylori). Vaccination is an effective preventive measure due to the increasing prevalence of antibiotic resistance. Fusion vaccination is a potentially practical approach. A fusion vaccine was created in this study by combining the cholera toxin B subunit (CTB) with the antigenic H. pylori urease I subunit (CTB-UreI). The CTB-UreI DNA vaccine was chemically clo...
Source: Vaccine - March 7, 2024 Category: Allergy & Immunology Authors: Sana Ghasemifar Omid Chabak Tohid Piri-Gharaghie Abbas Doosti Source Type: research
PIRES2-EGFP/CTB-UreI vaccination activated a mixed Th1/Th2/Th17 immune system defense towards Helicobacter pylori infection in the BALB/c mice model
Vaccine. 2024 Mar 7:S0264-410X(24)00209-3. doi: 10.1016/j.vaccine.2024.02.050. Online ahead of print.ABSTRACTThe occurrence of gastritis, gastric ulcers, distal gastric cancer, and gastric mucosal lymphoma in humans is strongly associated with Helicobacter pylori (H. pylori). Vaccination is an effective preventive measure due to the increasing prevalence of antibiotic resistance. Fusion vaccination is a potentially practical approach. A fusion vaccine was created in this study by combining the cholera toxin B subunit (CTB) with the antigenic H. pylori urease I subunit (CTB-UreI). The CTB-UreI DNA vaccine was chemically clo...
Source: Vaccine - March 7, 2024 Category: Allergy & Immunology Authors: Sana Ghasemifar Omid Chabak Tohid Piri-Gharaghie Abbas Doosti Source Type: research
< em > Vibrio cholerae < /em > virulence and its suppression through the quorum-sensing system
Crit Rev Microbiol. 2024 Mar 5:1-22. doi: 10.1080/1040841X.2024.2320823. Online ahead of print.ABSTRACTVibrio cholerae is a cholera-causing pathogen known to instigate severe contagious diarrhea that affects millions globally. Survival of vibrios depend on a combination of multicellular responses and adapt to changes that prevail in the environment. This process is achieved through a strong communication at the cellular level, the process has been recognized as quorum sensing (QS). The severity of infection is highly dependent on the QS of vibrios in the gut milieu. The quorum may exist in a low/high cell density (LCD/HCD)...
Source: Critical Reviews in Microbiology - March 5, 2024 Category: Microbiology Authors: Anusree Sajeevan Thandavarayan Ramamurthy Adline Princy Solomon Source Type: research
Facility capacity and provider knowledge for cholera surveillance and diarrhoea case management in cholera hotspots in the Democratic Republic of Congo - a mixed-methods study
CONCLUSIONS: Increasing awareness of cholera case definitions in this context could help improve cholera surveillance and control. Increased support and supervision, especially for private providers, could help ensure facilities are equipped to provide safe care. More nuanced aspects of case management should be emphasised in provider training.PMID:38441883 | DOI:10.1080/16549716.2024.2317774 (Source: Global Health Action)
Source: Global Health Action - March 5, 2024 Category: International Medicine & Public Health Authors: Mattias Schedwin Aur élie Bisumba Furaha Kelly Elimian Carina King Espoir Bwenge Malembaka Marc K Yambayamba Thorkild Tyllesk är Tobias Alfv én Simone E Carter Placide Welo Okitayemba Mala Ali Mapatano Helena Hildenwall Source Type: research
< em > Vibrio cholerae < /em > virulence and its suppression through the quorum-sensing system
Crit Rev Microbiol. 2024 Mar 5:1-22. doi: 10.1080/1040841X.2024.2320823. Online ahead of print.ABSTRACTVibrio cholerae is a cholera-causing pathogen known to instigate severe contagious diarrhea that affects millions globally. Survival of vibrios depend on a combination of multicellular responses and adapt to changes that prevail in the environment. This process is achieved through a strong communication at the cellular level, the process has been recognized as quorum sensing (QS). The severity of infection is highly dependent on the QS of vibrios in the gut milieu. The quorum may exist in a low/high cell density (LCD/HCD)...
Source: Critical Reviews in Microbiology - March 5, 2024 Category: Microbiology Authors: Anusree Sajeevan Thandavarayan Ramamurthy Adline Princy Solomon Source Type: research
Facility capacity and provider knowledge for cholera surveillance and diarrhoea case management in cholera hotspots in the Democratic Republic of Congo - a mixed-methods study
CONCLUSIONS: Increasing awareness of cholera case definitions in this context could help improve cholera surveillance and control. Increased support and supervision, especially for private providers, could help ensure facilities are equipped to provide safe care. More nuanced aspects of case management should be emphasised in provider training.PMID:38441883 | PMC:PMC10916892 | DOI:10.1080/16549716.2024.2317774 (Source: Global Health Action)
Source: Global Health Action - March 5, 2024 Category: International Medicine & Public Health Authors: Mattias Schedwin Aur élie Bisumba Furaha Kelly Elimian Carina King Espoir Bwenge Malembaka Marc K Yambayamba Thorkild Tyllesk är Tobias Alfv én Simone E Carter Placide Welo Okitayemba Mala Ali Mapatano Helena Hildenwall Source Type: research
< em > Vibrio cholerae < /em > virulence and its suppression through the quorum-sensing system
Crit Rev Microbiol. 2024 Mar 5:1-22. doi: 10.1080/1040841X.2024.2320823. Online ahead of print.ABSTRACTVibrio cholerae is a cholera-causing pathogen known to instigate severe contagious diarrhea that affects millions globally. Survival of vibrios depend on a combination of multicellular responses and adapt to changes that prevail in the environment. This process is achieved through a strong communication at the cellular level, the process has been recognized as quorum sensing (QS). The severity of infection is highly dependent on the QS of vibrios in the gut milieu. The quorum may exist in a low/high cell density (LCD/HCD)...
Source: Critical Reviews in Microbiology - March 5, 2024 Category: Microbiology Authors: Anusree Sajeevan Thandavarayan Ramamurthy Adline Princy Solomon Source Type: research
Facility capacity and provider knowledge for cholera surveillance and diarrhoea case management in cholera hotspots in the Democratic Republic of Congo - a mixed-methods study
CONCLUSIONS: Increasing awareness of cholera case definitions in this context could help improve cholera surveillance and control. Increased support and supervision, especially for private providers, could help ensure facilities are equipped to provide safe care. More nuanced aspects of case management should be emphasised in provider training.PMID:38441883 | PMC:PMC10916892 | DOI:10.1080/16549716.2024.2317774 (Source: Global Health Action)
Source: Global Health Action - March 5, 2024 Category: International Medicine & Public Health Authors: Mattias Schedwin Aur élie Bisumba Furaha Kelly Elimian Carina King Espoir Bwenge Malembaka Marc K Yambayamba Thorkild Tyllesk är Tobias Alfv én Simone E Carter Placide Welo Okitayemba Mala Ali Mapatano Helena Hildenwall Source Type: research
< em > Vibrio cholerae < /em > virulence and its suppression through the quorum-sensing system
Crit Rev Microbiol. 2024 Mar 5:1-22. doi: 10.1080/1040841X.2024.2320823. Online ahead of print.ABSTRACTVibrio cholerae is a cholera-causing pathogen known to instigate severe contagious diarrhea that affects millions globally. Survival of vibrios depend on a combination of multicellular responses and adapt to changes that prevail in the environment. This process is achieved through a strong communication at the cellular level, the process has been recognized as quorum sensing (QS). The severity of infection is highly dependent on the QS of vibrios in the gut milieu. The quorum may exist in a low/high cell density (LCD/HCD)...
Source: Critical Reviews in Microbiology - March 5, 2024 Category: Microbiology Authors: Anusree Sajeevan Thandavarayan Ramamurthy Adline Princy Solomon Source Type: research
Facility capacity and provider knowledge for cholera surveillance and diarrhoea case management in cholera hotspots in the Democratic Republic of Congo - a mixed-methods study
CONCLUSIONS: Increasing awareness of cholera case definitions in this context could help improve cholera surveillance and control. Increased support and supervision, especially for private providers, could help ensure facilities are equipped to provide safe care. More nuanced aspects of case management should be emphasised in provider training.PMID:38441883 | PMC:PMC10916892 | DOI:10.1080/16549716.2024.2317774 (Source: Global Health Action)
Source: Global Health Action - March 5, 2024 Category: International Medicine & Public Health Authors: Mattias Schedwin Aur élie Bisumba Furaha Kelly Elimian Carina King Espoir Bwenge Malembaka Marc K Yambayamba Thorkild Tyllesk är Tobias Alfv én Simone E Carter Placide Welo Okitayemba Mala Ali Mapatano Helena Hildenwall Source Type: research
< em > Vibrio cholerae < /em > virulence and its suppression through the quorum-sensing system
Crit Rev Microbiol. 2024 Mar 5:1-22. doi: 10.1080/1040841X.2024.2320823. Online ahead of print.ABSTRACTVibrio cholerae is a cholera-causing pathogen known to instigate severe contagious diarrhea that affects millions globally. Survival of vibrios depend on a combination of multicellular responses and adapt to changes that prevail in the environment. This process is achieved through a strong communication at the cellular level, the process has been recognized as quorum sensing (QS). The severity of infection is highly dependent on the QS of vibrios in the gut milieu. The quorum may exist in a low/high cell density (LCD/HCD)...
Source: Critical Reviews in Microbiology - March 5, 2024 Category: Microbiology Authors: Anusree Sajeevan Thandavarayan Ramamurthy Adline Princy Solomon Source Type: research
Facility capacity and provider knowledge for cholera surveillance and diarrhoea case management in cholera hotspots in the Democratic Republic of Congo - a mixed-methods study
CONCLUSIONS: Increasing awareness of cholera case definitions in this context could help improve cholera surveillance and control. Increased support and supervision, especially for private providers, could help ensure facilities are equipped to provide safe care. More nuanced aspects of case management should be emphasised in provider training.PMID:38441883 | PMC:PMC10916892 | DOI:10.1080/16549716.2024.2317774 (Source: Global Health Action)
Source: Global Health Action - March 5, 2024 Category: International Medicine & Public Health Authors: Mattias Schedwin Aur élie Bisumba Furaha Kelly Elimian Carina King Espoir Bwenge Malembaka Marc K Yambayamba Thorkild Tyllesk är Tobias Alfv én Simone E Carter Placide Welo Okitayemba Mala Ali Mapatano Helena Hildenwall Source Type: research
< em > Vibrio cholerae < /em > virulence and its suppression through the quorum-sensing system
Crit Rev Microbiol. 2024 Mar 5:1-22. doi: 10.1080/1040841X.2024.2320823. Online ahead of print.ABSTRACTVibrio cholerae is a cholera-causing pathogen known to instigate severe contagious diarrhea that affects millions globally. Survival of vibrios depend on a combination of multicellular responses and adapt to changes that prevail in the environment. This process is achieved through a strong communication at the cellular level, the process has been recognized as quorum sensing (QS). The severity of infection is highly dependent on the QS of vibrios in the gut milieu. The quorum may exist in a low/high cell density (LCD/HCD)...
Source: Critical Reviews in Microbiology - March 5, 2024 Category: Microbiology Authors: Anusree Sajeevan Thandavarayan Ramamurthy Adline Princy Solomon Source Type: research
