Increased iron utilization and oxidative stress tolerance in a < em > Vibrio cholerae flrA < /em > mutant confers resistance to amoeba predation
This study explores how a mutant of V. cholerae adapts to acquire essential nutrients and survive predation. Here, we observed that up-regulation of iron acquisition genes and genes regulating resistance to oxidative stress enhances pathogen fitness. Our data show that V. cholerae can defend predation to overcome nutrient limitation and oxidative stress, resulting in an enhanced survival inside the protozoan hosts.PMID:37882527 | DOI:10.1128/aem.01095-23 (Source: Applied and Environmental Microbiology)
Source: Applied and Environmental Microbiology - October 26, 2023 Category: Microbiology Authors: M Mozammel Hoque Parisa Noorian Gustavo Espinoza-Vergara Srijon Adhikary Joyce To Scott A Rice Diane McDougald Source Type: research
Increased iron utilization and oxidative stress tolerance in a < em > Vibrio cholerae flrA < /em > mutant confers resistance to amoeba predation
This study explores how a mutant of V. cholerae adapts to acquire essential nutrients and survive predation. Here, we observed that up-regulation of iron acquisition genes and genes regulating resistance to oxidative stress enhances pathogen fitness. Our data show that V. cholerae can defend predation to overcome nutrient limitation and oxidative stress, resulting in an enhanced survival inside the protozoan hosts.PMID:37882527 | DOI:10.1128/aem.01095-23 (Source: Applied and Environmental Microbiology)
Source: Applied and Environmental Microbiology - October 26, 2023 Category: Microbiology Authors: M Mozammel Hoque Parisa Noorian Gustavo Espinoza-Vergara Srijon Adhikary Joyce To Scott A Rice Diane McDougald Source Type: research
Comparative secretomic and proteomic analysis reveal multiple defensive strategies developed by Vibrio cholerae against the heavy metal (Cd2+, Ni2+, Pb2+, and Zn2+) stresses
In this study, we investigated for the first time the response of such V. cholerae isolates (n = 3) toward the heavy metal (Cd2+, Ni2+, Pb2+, and Zn2+) stresses by comparative secretomic and proteomic analyses. The results showed that sublethal concentrations of the Pb2+ (200 μg/mL), Cd2+ (12.5 μg/mL), and Zn2+ (50 μg/mL) stresses for 2 h significantly decreased the bacterial cell membrane fluidity, but increased cell surface hydrophobicity and inner membrane permeability, whereas the Ni2+ (50 μg/mL) stress increased cell membrane fluidity (p < 0.05). The comparative secretomic and proteomic analys...
Source: Frontiers in Microbiology - October 26, 2023 Category: Microbiology Source Type: research
Study on association factors of intestinal infectious diseases based-Bayesian spatio-temporal model
CONCLUSIONS: This research systematically and quantitatively studied the effect of socioeconomic and meteorological factors on IIDs, which provided causal clues for future studies and guided government planning.PMID:37875791 | DOI:10.1186/s12879-023-08665-3 (Source: Cancer Control)
Source: Cancer Control - October 24, 2023 Category: Cancer & Oncology Authors: Yancen Zhan Hua Gu Xiuyang Li Source Type: research
Post-epidemic health system recovery: A comparative case study analysis of routine immunization programs in the Republics of Haiti and Liberia
This study suggests that embedding in-country expertise within outbreak response structures, respecting governmental autonomy, aligning post-epidemic recovery plans and policies, and integrating outbreak response assets into robust systems of primary care contribute to higher, more equitable levels of routine immunization coverage in resource-constrained settings recovering from epidemics. (Source: PLoS One)
Source: PLoS One - October 17, 2023 Category: Biomedical Science Authors: Sanjana J. Ravi Source Type: research
Enhancing preparedness for reducing transmission and globalisation of Antimicrobial Resistance at the Ardh Kumbh Mela 2025, the world's largest recurring religious mass gathering
Recurrent mass gathering religious and sporting events pose substantial public health challenges for host countries since they attract millions of local and international travellers from all continents. [1,2] Past outbreaks of meningococcal disease associated with the Hajj pilgrimage, cholera at the Kumbh Mela, and of influenza at the Winter Olympics highlighted the importance of public health preparedness prior to, during and after the event. [1,2,3,4] The importation, local spread, and globalisation of antimicrobial resistance (AMR) is an important, but neglected, global public health issue associated with mass gathering...
Source: International Journal of Infectious Diseases - October 16, 2023 Category: Infectious Diseases Authors: Avinash Sharma, Bhavuk Gupta, Eskild Petersen, Shui Shan Lee, Alimuddin Zumla Tags: Editorial Source Type: research
Tafluprost promotes axon regeneration after optic nerve crush via Zn < sup > 2+ < /sup > -mTOR pathway
CONCLUSIONS: Our results suggest that Tafluprost promoted axon regeneration via regulation of the Zn2+-mTOR pathway, and provide novel research directions for glaucomatous optic nerve injury mechanisms.PMID:37832634 | DOI:10.1016/j.neuropharm.2023.109746 (Source: Neuropharmacology)
Source: Neuropharmacology - October 13, 2023 Category: Drugs & Pharmacology Authors: Siting Wu Canying Liu Jiahui Tang Caiqing Wu Qi Zhang Zhe Liu Jiaxu Han Jingfei Xue Jicheng Lin Yuze Chen Jinpeng Yang Yehong Zhuo Yiqing Li Source Type: research
Tafluprost promotes axon regeneration after optic nerve crush via Zn < sup > 2+ < /sup > -mTOR pathway
CONCLUSIONS: Our results suggest that Tafluprost promoted axon regeneration via regulation of the Zn2+-mTOR pathway, and provide novel research directions for glaucomatous optic nerve injury mechanisms.PMID:37832634 | DOI:10.1016/j.neuropharm.2023.109746 (Source: Neuropharmacology)
Source: Neuropharmacology - October 13, 2023 Category: Drugs & Pharmacology Authors: Siting Wu Canying Liu Jiahui Tang Caiqing Wu Qi Zhang Zhe Liu Jiaxu Han Jingfei Xue Jicheng Lin Yuze Chen Jinpeng Yang Yehong Zhuo Yiqing Li Source Type: research
Effect of cross-immunity in a two-strain cholera model with aquatic component
Math Biosci. 2023 Oct 9:109086. doi: 10.1016/j.mbs.2023.109086. Online ahead of print.ABSTRACTThe bacteria Vibrio cholerae relies heavily upon an aquatic reservoir as a transmission route with two distinct serotypes observed in many recent outbreaks. In this paper, we extend previously studied ordinary differential equation epidemiological models to create a two-strain SIRP (susceptible-infectious-recovered-pathogen) system which incorporates both partial cross-immunity between disease strains and environmental pathogen transmission. Of particular interest are undamped anti-phase periodic solutions, as these display a type...
Source: Mathematical Biosciences - October 11, 2023 Category: Statistics Authors: Leah LeJeune Cameron Browne Source Type: research
Effect of cross-immunity in a two-strain cholera model with aquatic component
Math Biosci. 2023 Oct 9:109086. doi: 10.1016/j.mbs.2023.109086. Online ahead of print.ABSTRACTThe bacteria Vibrio cholerae relies heavily upon an aquatic reservoir as a transmission route with two distinct serotypes observed in many recent outbreaks. In this paper, we extend previously studied ordinary differential equation epidemiological models to create a two-strain SIRP (susceptible-infectious-recovered-pathogen) system which incorporates both partial cross-immunity between disease strains and environmental pathogen transmission. Of particular interest are undamped anti-phase periodic solutions, as these display a type...
Source: Mathematical Biosciences - October 11, 2023 Category: Statistics Authors: Leah LeJeune Cameron Browne Source Type: research
Effect of cross-immunity in a two-strain cholera model with aquatic component
Math Biosci. 2023 Oct 10;365:109086. doi: 10.1016/j.mbs.2023.109086. Online ahead of print.ABSTRACTThe bacteria Vibrio cholerae relies heavily upon an aquatic reservoir as a transmission route with two distinct serotypes observed in many recent outbreaks. In this paper, we extend previously studied ordinary differential equation epidemiological models to create a two-strain SIRP (susceptible-infectious-recovered-pathogen) system which incorporates both partial cross-immunity between disease strains and environmental pathogen transmission. Of particular interest are undamped anti-phase periodic solutions, as these display a...
Source: Mathematical Biosciences - October 11, 2023 Category: Statistics Authors: Leah LeJeune Cameron Browne Source Type: research
Effect of cross-immunity in a two-strain cholera model with aquatic component
Math Biosci. 2023 Oct 10;365:109086. doi: 10.1016/j.mbs.2023.109086. Online ahead of print.ABSTRACTThe bacteria Vibrio cholerae relies heavily upon an aquatic reservoir as a transmission route with two distinct serotypes observed in many recent outbreaks. In this paper, we extend previously studied ordinary differential equation epidemiological models to create a two-strain SIRP (susceptible-infectious-recovered-pathogen) system which incorporates both partial cross-immunity between disease strains and environmental pathogen transmission. Of particular interest are undamped anti-phase periodic solutions, as these display a...
Source: Mathematical Biosciences - October 11, 2023 Category: Statistics Authors: Leah LeJeune Cameron Browne Source Type: research
Effect of cross-immunity in a two-strain cholera model with aquatic component
Math Biosci. 2023 Oct 10;365:109086. doi: 10.1016/j.mbs.2023.109086. Online ahead of print.ABSTRACTThe bacteria Vibrio cholerae relies heavily upon an aquatic reservoir as a transmission route with two distinct serotypes observed in many recent outbreaks. In this paper, we extend previously studied ordinary differential equation epidemiological models to create a two-strain SIRP (susceptible-infectious-recovered-pathogen) system which incorporates both partial cross-immunity between disease strains and environmental pathogen transmission. Of particular interest are undamped anti-phase periodic solutions, as these display a...
Source: Mathematical Biosciences - October 11, 2023 Category: Statistics Authors: Leah LeJeune Cameron Browne Source Type: research
Effect of cross-immunity in a two-strain cholera model with aquatic component
Math Biosci. 2023 Oct 10;365:109086. doi: 10.1016/j.mbs.2023.109086. Online ahead of print.ABSTRACTThe bacteria Vibrio cholerae relies heavily upon an aquatic reservoir as a transmission route with two distinct serotypes observed in many recent outbreaks. In this paper, we extend previously studied ordinary differential equation epidemiological models to create a two-strain SIRP (susceptible-infectious-recovered-pathogen) system which incorporates both partial cross-immunity between disease strains and environmental pathogen transmission. Of particular interest are undamped anti-phase periodic solutions, as these display a...
Source: Mathematical Biosciences - October 11, 2023 Category: Statistics Authors: Leah LeJeune Cameron Browne Source Type: research
