Molecules, Vol. 28, Pages 7954: Unveiling the Anti-Cholera and Active Diabetic Renoprotective Compounds of Maqian Essential Oil: A Computational and Molecular Dynamics Study
In conclusion, based on a computational approach, our findings reveal that MQEO constituents have inhibitory activity against cholera toxin and are promising therapeutic agents for suppressing diabetic inflammation and for the treatment of diabetic nephropathy complications. (Source: Molecules)
Source: Molecules - December 5, 2023 Category: Chemistry Authors: Mahmoud Dahab Ping Zhang Samiah Hamad Al-Mijalli Emad M. Abdallah Tags: Article Source Type: research
Vaccine and malnutrition: A narrative review
J Family Med Prim Care. 2023 Sep;12(9):1808-1813. doi: 10.4103/jfmpc.jfmpc_596_23. Epub 2023 Sep 30.ABSTRACTNearly 45% of under 5 mortality is directly or indirectly linked to malnutrition. Infection adds to the increased mortality and morbidity in these groups. Vaccination is very important in these undernourished children protecting against life-threatening infections. The goal of vaccination is to produce long-term protection by generating memory cells and the generation of antibodies. Since malnutrition is a state of immunodeficiency, the immune response to vaccines in these children is a matter of concern. We did an e...
Source: Primary Care - November 29, 2023 Category: Primary Care Authors: Saroj K Tripathy Sarthak Das Archana Malik Source Type: research
Vaccine and malnutrition: A narrative review
J Family Med Prim Care. 2023 Sep;12(9):1808-1813. doi: 10.4103/jfmpc.jfmpc_596_23. Epub 2023 Sep 30.ABSTRACTNearly 45% of under 5 mortality is directly or indirectly linked to malnutrition. Infection adds to the increased mortality and morbidity in these groups. Vaccination is very important in these undernourished children protecting against life-threatening infections. The goal of vaccination is to produce long-term protection by generating memory cells and the generation of antibodies. Since malnutrition is a state of immunodeficiency, the immune response to vaccines in these children is a matter of concern. We did an e...
Source: Primary Care - November 29, 2023 Category: Primary Care Authors: Saroj K Tripathy Sarthak Das Archana Malik Source Type: research
Effectiveness of the Euvichol ® oral cholera vaccine at 2 years: a case-control and bias-indicator study in Haiti
Cholera accounts for a significant burden of morbidity and mortality, with recent years demonstrating an increase in the number of outbreaks globally.[1] As part of comprehensive cholera control efforts, the World Health Organization (WHO) recommends use of oral cholera vaccine (OCV) in endemic and epidemic settings.[2] A global stockpile of WHO pre-qualified OCVs was established in 2013 and has since supplied the majority of OCVs used in outbreak settings.[3] (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - November 22, 2023 Category: Infectious Diseases Authors: Wilfredo R. Matias, Yodeline Guillaume, Gertrude Cene Augustin, Kenia Vissieres, Ralph Ternier, Damien M. Slater, Jason B. Harris, Molly F. Franke, Louise C. Ivers Source Type: research
GSE247770 RNAseq of VP882 phage activation in V. cholerae
Contributors : Marcel Sprenger ; Malte Siemers ; Kai PapenfortSeries Type : Expression profiling by high throughput sequencingOrganism : Vibrio choleraeMany, if not all, bacteria use quorum sensing (QS) to control gene expression and collective behaviours, and more recently QS has also been discovered in bacteriophages (phages). Phages can produce communication molecules of their own, or “listen in” on the host’s communication processes, in order to switch between lytic and lysogenic modes of infection. In this project, we studied the interaction of Vibrio cholerae, the causative agent of cholera disease, with the...
Source: GEO: Gene Expression Omnibus - November 20, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Vibrio cholerae Source Type: research
GSE247769 RNAseq of VP882 and VP882 ∆vpdS phage activation in V. cholerae
Contributors : Marcel Sprenger ; Malte Siemers ; Kai PapenfortSeries Type : Expression profiling by high throughput sequencingOrganism : Vibrio choleraeMany, if not all, bacteria use quorum sensing (QS) to control gene expression and collective behaviours, and more recently QS has also been discovered in bacteriophages (phages). Phages can produce communication molecules of their own, or “listen in” on the host’s communication processes, in order to switch between lytic and lysogenic modes of infection. In this project, we studied the interaction of Vibrio cholerae, the causative agent of cholera disease, with the...
Source: GEO: Gene Expression Omnibus - November 20, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Vibrio cholerae Source Type: research
GSE247768 RIPseq of VP882 phage activation in V. cholerae
Contributors : Marcel Sprenger ; Malte Siemers ; Kai PapenfortSeries Type : OtherOrganism : Vibrio choleraeMany, if not all, bacteria use quorum sensing (QS) to control gene expression and collective behaviours, and more recently QS has also been discovered in bacteriophages (phages). Phages can produce communication molecules of their own, or “listen in” on the host’s communication processes, in order to switch between lytic and lysogenic modes of infection. In this project, we studied the interaction of Vibrio cholerae, the causative agent of cholera disease, with the lysogenic vibriophage VP882. The lytic cycle...
Source: GEO: Gene Expression Omnibus - November 20, 2023 Category: Genetics & Stem Cells Tags: Other Vibrio cholerae Source Type: research
GSE247767 RILseq of VP882 phage activation in V. cholerae
Contributors : Marcel Sprenger ; Malte Siemers ; Kai PapenfortSeries Type : OtherOrganism : Vibrio choleraeMany, if not all, bacteria use quorum sensing (QS) to control gene expression and collective behaviours, and more recently QS has also been discovered in bacteriophages (phages). Phages can produce communication molecules of their own, or “listen in” on the host’s communication processes, in order to switch between lytic and lysogenic modes of infection. In this project, we studied the interaction of Vibrio cholerae, the causative agent of cholera disease, with the lysogenic vibriophage VP882. The lytic cycle...
Source: GEO: Gene Expression Omnibus - November 20, 2023 Category: Genetics & Stem Cells Tags: Other Vibrio cholerae Source Type: research
Recent advances in enterotoxin vaccine adjuvants
Curr Opin Immunol. 2023 Nov 15;85:102398. doi: 10.1016/j.coi.2023.102398. Online ahead of print.ABSTRACTEnterotoxin adjuvants have been researched for their ability to promote immunity to co-delivered antigens. Outside of cholera vaccines, however, these proteins have yet to be included in any currently licensed vaccines. They include molecules derived from the bacterial toxins of Vibrio cholerae, cholera toxin, or Escherichia coli, heat-labile toxin, such as detoxified mutants or subunits. This class of adjuvants is distinguished by their delivery possibilities, which include parenteral injection, skin applications, or di...
Source: Current Opinion in Immunology - November 17, 2023 Category: Allergy & Immunology Authors: Jessica W Crothers Elizabeth B Norton Source Type: research
Recent advances in enterotoxin vaccine adjuvants
Curr Opin Immunol. 2023 Nov 15;85:102398. doi: 10.1016/j.coi.2023.102398. Online ahead of print.ABSTRACTEnterotoxin adjuvants have been researched for their ability to promote immunity to co-delivered antigens. Outside of cholera vaccines, however, these proteins have yet to be included in any currently licensed vaccines. They include molecules derived from the bacterial toxins of Vibrio cholerae, cholera toxin, or Escherichia coli, heat-labile toxin, such as detoxified mutants or subunits. This class of adjuvants is distinguished by their delivery possibilities, which include parenteral injection, skin applications, or di...
Source: Current Opinion in Immunology - November 17, 2023 Category: Allergy & Immunology Authors: Jessica W Crothers Elizabeth B Norton Source Type: research
Recent advances in enterotoxin vaccine adjuvants
Curr Opin Immunol. 2023 Nov 15;85:102398. doi: 10.1016/j.coi.2023.102398. Online ahead of print.ABSTRACTEnterotoxin adjuvants have been researched for their ability to promote immunity to co-delivered antigens. Outside of cholera vaccines, however, these proteins have yet to be included in any currently licensed vaccines. They include molecules derived from the bacterial toxins of Vibrio cholerae, cholera toxin, or Escherichia coli, heat-labile toxin, such as detoxified mutants or subunits. This class of adjuvants is distinguished by their delivery possibilities, which include parenteral injection, skin applications, or di...
Source: Current Opinion in Immunology - November 17, 2023 Category: Allergy & Immunology Authors: Jessica W Crothers Elizabeth B Norton Source Type: research
Recent advances in enterotoxin vaccine adjuvants
Curr Opin Immunol. 2023 Nov 15;85:102398. doi: 10.1016/j.coi.2023.102398. Online ahead of print.ABSTRACTEnterotoxin adjuvants have been researched for their ability to promote immunity to co-delivered antigens. Outside of cholera vaccines, however, these proteins have yet to be included in any currently licensed vaccines. They include molecules derived from the bacterial toxins of Vibrio cholerae, cholera toxin, or Escherichia coli, heat-labile toxin, such as detoxified mutants or subunits. This class of adjuvants is distinguished by their delivery possibilities, which include parenteral injection, skin applications, or di...
Source: Current Opinion in Immunology - November 17, 2023 Category: Allergy & Immunology Authors: Jessica W Crothers Elizabeth B Norton Source Type: research
Recent advances in enterotoxin vaccine adjuvants
Curr Opin Immunol. 2023 Nov 15;85:102398. doi: 10.1016/j.coi.2023.102398. Online ahead of print.ABSTRACTEnterotoxin adjuvants have been researched for their ability to promote immunity to co-delivered antigens. Outside of cholera vaccines, however, these proteins have yet to be included in any currently licensed vaccines. They include molecules derived from the bacterial toxins of Vibrio cholerae, cholera toxin, or Escherichia coli, heat-labile toxin, such as detoxified mutants or subunits. This class of adjuvants is distinguished by their delivery possibilities, which include parenteral injection, skin applications, or di...
Source: Current Opinion in Immunology - November 17, 2023 Category: Allergy & Immunology Authors: Jessica W Crothers Elizabeth B Norton Source Type: research
Recent advances in enterotoxin vaccine adjuvants
Curr Opin Immunol. 2023 Nov 15;85:102398. doi: 10.1016/j.coi.2023.102398. Online ahead of print.ABSTRACTEnterotoxin adjuvants have been researched for their ability to promote immunity to co-delivered antigens. Outside of cholera vaccines, however, these proteins have yet to be included in any currently licensed vaccines. They include molecules derived from the bacterial toxins of Vibrio cholerae, cholera toxin, or Escherichia coli, heat-labile toxin, such as detoxified mutants or subunits. This class of adjuvants is distinguished by their delivery possibilities, which include parenteral injection, skin applications, or di...
Source: Current Opinion in Immunology - November 17, 2023 Category: Allergy & Immunology Authors: Jessica W Crothers Elizabeth B Norton Source Type: research
