Atypical B cells in chronic infectious diseases and systemic autoimmunity: puzzles with many missing pieces
Curr Opin Immunol. 2022 Jun 17;77:102227. doi: 10.1016/j.coi.2022.102227. Online ahead of print.ABSTRACTThe world's struggle to contain the SARS-CoV-2 epidemic, primarily through vaccination, has highlighted the importance of better understanding the biology of B cells that participate in defense against infectious diseases, both acute and chronic. Here, we focus on a population of human B cells, termed atypical B cells (ABCs), that comprise a distinct B-cell lineage that differentiates from naive B cells in an interferon-γ-driven process, and are infrequent in healthy individuals but significantly expanded in chronic inf...
Source: Current Opinion in Immunology - June 20, 2022 Category: Allergy & Immunology Authors: Abhijit A Ambegaonkar Prasida Holla Brian Lp Dizon Haewon Sohn Susan K Pierce Source Type: research

Inflammation, immunity, and antigen persistence in post-acute sequelae of SARS-CoV-2 infection
Curr Opin Immunol. 2022 May 24;77:102228. doi: 10.1016/j.coi.2022.102228. Online ahead of print.ABSTRACTSARS-CoV-2 infection is known to result in a range of symptoms with varying degrees of acute-phase severity. In a subset of individuals, an equally diverse collection of long-term sequelae has been reported after convalescence. As survivorship and therefore the number of individuals with 'long-COVID' continues to grow, an understanding of the prevalence, origins, and mechanisms of post-acute sequelae manifestation is critically needed. Here, we will explore proposed roles of the anti-SARS-CoV-2 immune response in the ons...
Source: Current Opinion in Immunology - June 20, 2022 Category: Allergy & Immunology Authors: Krista L Newell Adam T Waickman Source Type: research

Atypical B cells in chronic infectious diseases and systemic autoimmunity: puzzles with many missing pieces
Curr Opin Immunol. 2022 Jun 17;77:102227. doi: 10.1016/j.coi.2022.102227. Online ahead of print.ABSTRACTThe world's struggle to contain the SARS-CoV-2 epidemic, primarily through vaccination, has highlighted the importance of better understanding the biology of B cells that participate in defense against infectious diseases, both acute and chronic. Here, we focus on a population of human B cells, termed atypical B cells (ABCs), that comprise a distinct B-cell lineage that differentiates from naive B cells in an interferon-γ-driven process, and are infrequent in healthy individuals but significantly expanded in chronic inf...
Source: Current Opinion in Immunology - June 20, 2022 Category: Allergy & Immunology Authors: Abhijit A Ambegaonkar Prasida Holla Brian Lp Dizon Haewon Sohn Susan K Pierce Source Type: research

Inflammation, immunity, and antigen persistence in post-acute sequelae of SARS-CoV-2 infection
Curr Opin Immunol. 2022 May 24;77:102228. doi: 10.1016/j.coi.2022.102228. Online ahead of print.ABSTRACTSARS-CoV-2 infection is known to result in a range of symptoms with varying degrees of acute-phase severity. In a subset of individuals, an equally diverse collection of long-term sequelae has been reported after convalescence. As survivorship and therefore the number of individuals with 'long-COVID' continues to grow, an understanding of the prevalence, origins, and mechanisms of post-acute sequelae manifestation is critically needed. Here, we will explore proposed roles of the anti-SARS-CoV-2 immune response in the ons...
Source: Current Opinion in Immunology - June 20, 2022 Category: Allergy & Immunology Authors: Krista L Newell Adam T Waickman Source Type: research

Atypical B cells in chronic infectious diseases and systemic autoimmunity: puzzles with many missing pieces
Curr Opin Immunol. 2022 Jun 17;77:102227. doi: 10.1016/j.coi.2022.102227. Online ahead of print.ABSTRACTThe world's struggle to contain the SARS-CoV-2 epidemic, primarily through vaccination, has highlighted the importance of better understanding the biology of B cells that participate in defense against infectious diseases, both acute and chronic. Here, we focus on a population of human B cells, termed atypical B cells (ABCs), that comprise a distinct B-cell lineage that differentiates from naive B cells in an interferon-γ-driven process, and are infrequent in healthy individuals but significantly expanded in chronic inf...
Source: Current Opinion in Immunology - June 20, 2022 Category: Allergy & Immunology Authors: Abhijit A Ambegaonkar Prasida Holla Brian Lp Dizon Haewon Sohn Susan K Pierce Source Type: research

Inflammation, immunity, and antigen persistence in post-acute sequelae of SARS-CoV-2 infection
Curr Opin Immunol. 2022 May 24;77:102228. doi: 10.1016/j.coi.2022.102228. Online ahead of print.ABSTRACTSARS-CoV-2 infection is known to result in a range of symptoms with varying degrees of acute-phase severity. In a subset of individuals, an equally diverse collection of long-term sequelae has been reported after convalescence. As survivorship and therefore the number of individuals with 'long-COVID' continues to grow, an understanding of the prevalence, origins, and mechanisms of post-acute sequelae manifestation is critically needed. Here, we will explore proposed roles of the anti-SARS-CoV-2 immune response in the ons...
Source: Current Opinion in Immunology - June 20, 2022 Category: Allergy & Immunology Authors: Krista L Newell Adam T Waickman Source Type: research

Atypical B cells in chronic infectious diseases and systemic autoimmunity: puzzles with many missing pieces
Curr Opin Immunol. 2022 Jun 17;77:102227. doi: 10.1016/j.coi.2022.102227. Online ahead of print.ABSTRACTThe world's struggle to contain the SARS-CoV-2 epidemic, primarily through vaccination, has highlighted the importance of better understanding the biology of B cells that participate in defense against infectious diseases, both acute and chronic. Here, we focus on a population of human B cells, termed atypical B cells (ABCs), that comprise a distinct B-cell lineage that differentiates from naive B cells in an interferon-γ-driven process, and are infrequent in healthy individuals but significantly expanded in chronic inf...
Source: Current Opinion in Immunology - June 20, 2022 Category: Allergy & Immunology Authors: Abhijit A Ambegaonkar Prasida Holla Brian Lp Dizon Haewon Sohn Susan K Pierce Source Type: research

Inflammation, immunity, and antigen persistence in post-acute sequelae of SARS-CoV-2 infection
Curr Opin Immunol. 2022 May 24;77:102228. doi: 10.1016/j.coi.2022.102228. Online ahead of print.ABSTRACTSARS-CoV-2 infection is known to result in a range of symptoms with varying degrees of acute-phase severity. In a subset of individuals, an equally diverse collection of long-term sequelae has been reported after convalescence. As survivorship and therefore the number of individuals with 'long-COVID' continues to grow, an understanding of the prevalence, origins, and mechanisms of post-acute sequelae manifestation is critically needed. Here, we will explore proposed roles of the anti-SARS-CoV-2 immune response in the ons...
Source: Current Opinion in Immunology - June 20, 2022 Category: Allergy & Immunology Authors: Krista L Newell Adam T Waickman Source Type: research

Atypical B cells in chronic infectious diseases and systemic autoimmunity: puzzles with many missing pieces
Curr Opin Immunol. 2022 Jun 17;77:102227. doi: 10.1016/j.coi.2022.102227. Online ahead of print.ABSTRACTThe world's struggle to contain the SARS-CoV-2 epidemic, primarily through vaccination, has highlighted the importance of better understanding the biology of B cells that participate in defense against infectious diseases, both acute and chronic. Here, we focus on a population of human B cells, termed atypical B cells (ABCs), that comprise a distinct B-cell lineage that differentiates from naive B cells in an interferon-γ-driven process, and are infrequent in healthy individuals but significantly expanded in chronic inf...
Source: Current Opinion in Immunology - June 20, 2022 Category: Allergy & Immunology Authors: Abhijit A Ambegaonkar Prasida Holla Brian Lp Dizon Haewon Sohn Susan K Pierce Source Type: research

Inflammation, immunity, and antigen persistence in post-acute sequelae of SARS-CoV-2 infection
Curr Opin Immunol. 2022 May 24;77:102228. doi: 10.1016/j.coi.2022.102228. Online ahead of print.ABSTRACTSARS-CoV-2 infection is known to result in a range of symptoms with varying degrees of acute-phase severity. In a subset of individuals, an equally diverse collection of long-term sequelae has been reported after convalescence. As survivorship and therefore the number of individuals with 'long-COVID' continues to grow, an understanding of the prevalence, origins, and mechanisms of post-acute sequelae manifestation is critically needed. Here, we will explore proposed roles of the anti-SARS-CoV-2 immune response in the ons...
Source: Current Opinion in Immunology - June 20, 2022 Category: Allergy & Immunology Authors: Krista L Newell Adam T Waickman Source Type: research

New insights and approaches for analyses of immunopeptidomes
Curr Opin Immunol. 2022 Jun 15;77:102216. doi: 10.1016/j.coi.2022.102216. Online ahead of print.ABSTRACTHuman leucocyte antigen (HLA) molecules play a key role in health and disease by presenting antigen to T-lymphocytes for immunosurveillance. Immunopeptidomics involves the study of the collection of peptides presented within the antigen-binding groove of HLA molecules. Identifying their nature and diversity is crucial to understanding immunosurveillance especially during infection or for the recognition and potential eradication of tumours. This review discusses recent advances in the isolation, identification, and quant...
Source: Current Opinion in Immunology - June 18, 2022 Category: Allergy & Immunology Authors: Patricia T Illing Sri H Ramarathinam Anthony W Purcell Source Type: research

New insights and approaches for analyses of immunopeptidomes
Curr Opin Immunol. 2022 Jun 15;77:102216. doi: 10.1016/j.coi.2022.102216. Online ahead of print.ABSTRACTHuman leucocyte antigen (HLA) molecules play a key role in health and disease by presenting antigen to T-lymphocytes for immunosurveillance. Immunopeptidomics involves the study of the collection of peptides presented within the antigen-binding groove of HLA molecules. Identifying their nature and diversity is crucial to understanding immunosurveillance especially during infection or for the recognition and potential eradication of tumours. This review discusses recent advances in the isolation, identification, and quant...
Source: Current Opinion in Immunology - June 18, 2022 Category: Allergy & Immunology Authors: Patricia T Illing Sri H Ramarathinam Anthony W Purcell Source Type: research

Tissue-specific proteasomes in generation of MHC class I peptides and CD8 < sup > + < /sup > T cells
Curr Opin Immunol. 2022 Jun 8;77:102217. doi: 10.1016/j.coi.2022.102217. Online ahead of print.ABSTRACTThymoproteasomes and immunoproteasomes are two types of tissue-specific proteasomes, which contribute to the production of major histocompatibility complex (MHC) class I (MHC-I)-associated peptides that are important for the development and function of CD8+ cytotoxic T cells. Thymoproteasomes are specifically expressed by cortical thymic epithelial cells and are important for MHC-I-dependent positive selection of developing thymocytes, whereas immunoproteasomes are abundant in many other cells, including hematopoietic cel...
Source: Current Opinion in Immunology - June 11, 2022 Category: Allergy & Immunology Authors: Mami Matsuda-Lennikov Izumi Ohigashi Yousuke Takahama Source Type: research

Tissue-specific proteasomes in generation of MHC class I peptides and CD8 < sup > + < /sup > T cells
Curr Opin Immunol. 2022 Jun 8;77:102217. doi: 10.1016/j.coi.2022.102217. Online ahead of print.ABSTRACTThymoproteasomes and immunoproteasomes are two types of tissue-specific proteasomes, which contribute to the production of major histocompatibility complex (MHC) class I (MHC-I)-associated peptides that are important for the development and function of CD8+ cytotoxic T cells. Thymoproteasomes are specifically expressed by cortical thymic epithelial cells and are important for MHC-I-dependent positive selection of developing thymocytes, whereas immunoproteasomes are abundant in many other cells, including hematopoietic cel...
Source: Current Opinion in Immunology - June 11, 2022 Category: Allergy & Immunology Authors: Mami Matsuda-Lennikov Izumi Ohigashi Yousuke Takahama Source Type: research

Tissue-specific proteasomes in generation of MHC class I peptides and CD8 < sup > + < /sup > T cells
Curr Opin Immunol. 2022 Jun 8;77:102217. doi: 10.1016/j.coi.2022.102217. Online ahead of print.ABSTRACTThymoproteasomes and immunoproteasomes are two types of tissue-specific proteasomes, which contribute to the production of major histocompatibility complex (MHC) class I (MHC-I)-associated peptides that are important for the development and function of CD8+ cytotoxic T cells. Thymoproteasomes are specifically expressed by cortical thymic epithelial cells and are important for MHC-I-dependent positive selection of developing thymocytes, whereas immunoproteasomes are abundant in many other cells, including hematopoietic cel...
Source: Current Opinion in Immunology - June 11, 2022 Category: Allergy & Immunology Authors: Mami Matsuda-Lennikov Izumi Ohigashi Yousuke Takahama Source Type: research