Structure-function of type I and III interferons
Curr Opin Immunol. 2024 Apr 10;86:102413. doi: 10.1016/j.coi.2024.102413. Online ahead of print.ABSTRACTType I and type III interferons (IFNs) are major components in activating the innate immune response. Common to both are two distinct receptor chains (IFNAR1/IFNAR2 and IFNLR1/IL10R2), which form ternary complexes upon binding their respective ligands. This results in close proximity of the intracellularly associated kinases JAK1 and TYK2, which cross phosphorylate each other, the associated receptor chains, and signal transducer and activator of transcriptions, with the latter activating IFN-stimulated genes. While ther...
Source: Current Opinion in Immunology - April 12, 2024 Category: Allergy & Immunology Authors: Nicole A de Weerd Aleksandra K Kurowska Juan L Mendoza Gideon Schreiber Source Type: research
Structure-function of type I and III interferons
Curr Opin Immunol. 2024 Apr 10;86:102413. doi: 10.1016/j.coi.2024.102413. Online ahead of print.ABSTRACTType I and type III interferons (IFNs) are major components in activating the innate immune response. Common to both are two distinct receptor chains (IFNAR1/IFNAR2 and IFNLR1/IL10R2), which form ternary complexes upon binding their respective ligands. This results in close proximity of the intracellularly associated kinases JAK1 and TYK2, which cross phosphorylate each other, the associated receptor chains, and signal transducer and activator of transcriptions, with the latter activating IFN-stimulated genes. While ther...
Source: Current Opinion in Immunology - April 12, 2024 Category: Allergy & Immunology Authors: Nicole A de Weerd Aleksandra K Kurowska Juan L Mendoza Gideon Schreiber Source Type: research
Structure-function of type I and III interferons
Curr Opin Immunol. 2024 Apr 10;86:102413. doi: 10.1016/j.coi.2024.102413. Online ahead of print.ABSTRACTType I and type III interferons (IFNs) are major components in activating the innate immune response. Common to both are two distinct receptor chains (IFNAR1/IFNAR2 and IFNLR1/IL10R2), which form ternary complexes upon binding their respective ligands. This results in close proximity of the intracellularly associated kinases JAK1 and TYK2, which cross phosphorylate each other, the associated receptor chains, and signal transducer and activator of transcriptions, with the latter activating IFN-stimulated genes. While ther...
Source: Current Opinion in Immunology - April 12, 2024 Category: Allergy & Immunology Authors: Nicole A de Weerd Aleksandra K Kurowska Juan L Mendoza Gideon Schreiber Source Type: research
Structure-function of type I and III interferons
Curr Opin Immunol. 2024 Apr 10;86:102413. doi: 10.1016/j.coi.2024.102413. Online ahead of print.ABSTRACTType I and type III interferons (IFNs) are major components in activating the innate immune response. Common to both are two distinct receptor chains (IFNAR1/IFNAR2 and IFNLR1/IL10R2), which form ternary complexes upon binding their respective ligands. This results in close proximity of the intracellularly associated kinases JAK1 and TYK2, which cross phosphorylate each other, the associated receptor chains, and signal transducer and activator of transcriptions, with the latter activating IFN-stimulated genes. While ther...
Source: Current Opinion in Immunology - April 12, 2024 Category: Allergy & Immunology Authors: Nicole A de Weerd Aleksandra K Kurowska Juan L Mendoza Gideon Schreiber Source Type: research
Role of type-I and type-III interferons in gastrointestinal homeostasis and pathogenesis
Curr Opin Immunol. 2024 Mar 21;86:102412. doi: 10.1016/j.coi.2024.102412. Online ahead of print.ABSTRACTInterferon (IFN) was discovered based on interference with virus production, and three types of IFN are now defined. Since its discovery, IFN's roles have expanded beyond viruses to diverse pathogen types, tissue homeostasis, and inflammatory disease. The gastrointestinal (GI) tract is arguably the tissue where the roles of IFN types are most distinct, with a particularly prominent role for type-III IFN in antiviral protection of the intestinal epithelium. Current studies continue to deepen our understanding of the type-...
Source: Current Opinion in Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Austin P Wright Timothy J Nice Source Type: research
Role of type-I and type-III interferons in gastrointestinal homeostasis and pathogenesis
Curr Opin Immunol. 2024 Mar 21;86:102412. doi: 10.1016/j.coi.2024.102412. Online ahead of print.ABSTRACTInterferon (IFN) was discovered based on interference with virus production, and three types of IFN are now defined. Since its discovery, IFN's roles have expanded beyond viruses to diverse pathogen types, tissue homeostasis, and inflammatory disease. The gastrointestinal (GI) tract is arguably the tissue where the roles of IFN types are most distinct, with a particularly prominent role for type-III IFN in antiviral protection of the intestinal epithelium. Current studies continue to deepen our understanding of the type-...
Source: Current Opinion in Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Austin P Wright Timothy J Nice Source Type: research
Role of type-I and type-III interferons in gastrointestinal homeostasis and pathogenesis
Curr Opin Immunol. 2024 Mar 21;86:102412. doi: 10.1016/j.coi.2024.102412. Online ahead of print.ABSTRACTInterferon (IFN) was discovered based on interference with virus production, and three types of IFN are now defined. Since its discovery, IFN's roles have expanded beyond viruses to diverse pathogen types, tissue homeostasis, and inflammatory disease. The gastrointestinal (GI) tract is arguably the tissue where the roles of IFN types are most distinct, with a particularly prominent role for type-III IFN in antiviral protection of the intestinal epithelium. Current studies continue to deepen our understanding of the type-...
Source: Current Opinion in Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Austin P Wright Timothy J Nice Source Type: research
Role of type-I and type-III interferons in gastrointestinal homeostasis and pathogenesis
Curr Opin Immunol. 2024 Mar 21;86:102412. doi: 10.1016/j.coi.2024.102412. Online ahead of print.ABSTRACTInterferon (IFN) was discovered based on interference with virus production, and three types of IFN are now defined. Since its discovery, IFN's roles have expanded beyond viruses to diverse pathogen types, tissue homeostasis, and inflammatory disease. The gastrointestinal (GI) tract is arguably the tissue where the roles of IFN types are most distinct, with a particularly prominent role for type-III IFN in antiviral protection of the intestinal epithelium. Current studies continue to deepen our understanding of the type-...
Source: Current Opinion in Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Austin P Wright Timothy J Nice Source Type: research
Role of type-I and type-III interferons in gastrointestinal homeostasis and pathogenesis
Curr Opin Immunol. 2024 Mar 21;86:102412. doi: 10.1016/j.coi.2024.102412. Online ahead of print.ABSTRACTInterferon (IFN) was discovered based on interference with virus production, and three types of IFN are now defined. Since its discovery, IFN's roles have expanded beyond viruses to diverse pathogen types, tissue homeostasis, and inflammatory disease. The gastrointestinal (GI) tract is arguably the tissue where the roles of IFN types are most distinct, with a particularly prominent role for type-III IFN in antiviral protection of the intestinal epithelium. Current studies continue to deepen our understanding of the type-...
Source: Current Opinion in Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Austin P Wright Timothy J Nice Source Type: research
Role of type-I and type-III interferons in gastrointestinal homeostasis and pathogenesis
Curr Opin Immunol. 2024 Mar 21;86:102412. doi: 10.1016/j.coi.2024.102412. Online ahead of print.ABSTRACTInterferon (IFN) was discovered based on interference with virus production, and three types of IFN are now defined. Since its discovery, IFN's roles have expanded beyond viruses to diverse pathogen types, tissue homeostasis, and inflammatory disease. The gastrointestinal (GI) tract is arguably the tissue where the roles of IFN types are most distinct, with a particularly prominent role for type-III IFN in antiviral protection of the intestinal epithelium. Current studies continue to deepen our understanding of the type-...
Source: Current Opinion in Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Austin P Wright Timothy J Nice Source Type: research
Role of type-I and type-III interferons in gastrointestinal homeostasis and pathogenesis
Curr Opin Immunol. 2024 Mar 21;86:102412. doi: 10.1016/j.coi.2024.102412. Online ahead of print.ABSTRACTInterferon (IFN) was discovered based on interference with virus production, and three types of IFN are now defined. Since its discovery, IFN's roles have expanded beyond viruses to diverse pathogen types, tissue homeostasis, and inflammatory disease. The gastrointestinal (GI) tract is arguably the tissue where the roles of IFN types are most distinct, with a particularly prominent role for type-III IFN in antiviral protection of the intestinal epithelium. Current studies continue to deepen our understanding of the type-...
Source: Current Opinion in Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Austin P Wright Timothy J Nice Source Type: research
Role of type-I and type-III interferons in gastrointestinal homeostasis and pathogenesis
Curr Opin Immunol. 2024 Mar 21;86:102412. doi: 10.1016/j.coi.2024.102412. Online ahead of print.ABSTRACTInterferon (IFN) was discovered based on interference with virus production, and three types of IFN are now defined. Since its discovery, IFN's roles have expanded beyond viruses to diverse pathogen types, tissue homeostasis, and inflammatory disease. The gastrointestinal (GI) tract is arguably the tissue where the roles of IFN types are most distinct, with a particularly prominent role for type-III IFN in antiviral protection of the intestinal epithelium. Current studies continue to deepen our understanding of the type-...
Source: Current Opinion in Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Austin P Wright Timothy J Nice Source Type: research
Role of type-I and type-III interferons in gastrointestinal homeostasis and pathogenesis
Curr Opin Immunol. 2024 Mar 21;86:102412. doi: 10.1016/j.coi.2024.102412. Online ahead of print.ABSTRACTInterferon (IFN) was discovered based on interference with virus production, and three types of IFN are now defined. Since its discovery, IFN's roles have expanded beyond viruses to diverse pathogen types, tissue homeostasis, and inflammatory disease. The gastrointestinal (GI) tract is arguably the tissue where the roles of IFN types are most distinct, with a particularly prominent role for type-III IFN in antiviral protection of the intestinal epithelium. Current studies continue to deepen our understanding of the type-...
Source: Current Opinion in Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Austin P Wright Timothy J Nice Source Type: research
Role of type-I and type-III interferons in gastrointestinal homeostasis and pathogenesis
Curr Opin Immunol. 2024 Mar 21;86:102412. doi: 10.1016/j.coi.2024.102412. Online ahead of print.ABSTRACTInterferon (IFN) was discovered based on interference with virus production, and three types of IFN are now defined. Since its discovery, IFN's roles have expanded beyond viruses to diverse pathogen types, tissue homeostasis, and inflammatory disease. The gastrointestinal (GI) tract is arguably the tissue where the roles of IFN types are most distinct, with a particularly prominent role for type-III IFN in antiviral protection of the intestinal epithelium. Current studies continue to deepen our understanding of the type-...
Source: Current Opinion in Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Austin P Wright Timothy J Nice Source Type: research
Role of type-I and type-III interferons in gastrointestinal homeostasis and pathogenesis
Curr Opin Immunol. 2024 Mar 21;86:102412. doi: 10.1016/j.coi.2024.102412. Online ahead of print.ABSTRACTInterferon (IFN) was discovered based on interference with virus production, and three types of IFN are now defined. Since its discovery, IFN's roles have expanded beyond viruses to diverse pathogen types, tissue homeostasis, and inflammatory disease. The gastrointestinal (GI) tract is arguably the tissue where the roles of IFN types are most distinct, with a particularly prominent role for type-III IFN in antiviral protection of the intestinal epithelium. Current studies continue to deepen our understanding of the type-...
Source: Current Opinion in Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Austin P Wright Timothy J Nice Source Type: research
