Phage predation, disease severity, and pathogen genetic diversity in cholera patients | Science
Despite an increasingly detailed picture of the molecular mechanisms of bacteriophage (phage) –bacterial interactions, we lack an understanding of how these interactions evolve and impact disease within patients. In this work, we report a year-long, ... (Source: Science: Current Issue)
Source: Science: Current Issue - April 18, 2024 Category: Science Source Type: research
A Review of Traditional Use, Constituent Analysis, Bioactivity, and Application of Volatile Oils from Elsholtzia
CONCLUSION: The contents of traditional use, constituent analysis, bioactivity, and application of volatile oils from Elsholtzia were reviewed in this paper. This will provide important research value and a scientific basis for the in-depth study of the plants of Elsholtzia in the future.PMID:38623976 | DOI:10.2174/0113862073301745240403051205 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 16, 2024 Category: Chemistry Authors: Dul Dram Jia-Zeng Guo Rong-Rui Wei Qin-Ge Ma Source Type: research
A Review of Traditional Use, Constituent Analysis, Bioactivity, and Application of Volatile Oils from Elsholtzia
CONCLUSION: The contents of traditional use, constituent analysis, bioactivity, and application of volatile oils from Elsholtzia were reviewed in this paper. This will provide important research value and a scientific basis for the in-depth study of the plants of Elsholtzia in the future.PMID:38623976 | DOI:10.2174/0113862073301745240403051205 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 16, 2024 Category: Chemistry Authors: Dul Dram Jia-Zeng Guo Rong-Rui Wei Qin-Ge Ma Source Type: research
In silico design of a novel multi-epitope vaccine against HCV infection through immunoinformatics approaches
This study is the first to present this epitopes-adjuvant combination. The vaccine had acceptable physicochemical characteristics. The vaccine's 3D structure was predicted and validated. The vaccine's binding stability with Toll-like receptor 2 (TLR2) and TLR4 was confirmed using molecular docking and molecular dynamics (MD) simulation. The immune simulation revealed the vaccine's efficacy by increasing the population of B and T cells in response to vaccination. In silico expression in Escherichia coli (E. coli) was also successful.PMID:38621559 | DOI:10.1016/j.ijbiomac.2024.131517 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 15, 2024 Category: Biochemistry Authors: Sajjad Ahmad Fatemeh Mobini Demneh Bushra Rehman Taghreed N Almanaa Nahid Akhtar Hamidreza Pazoki-Toroudi Ali Shojaeian Mahdi Ghatrehsamani Samira Sanami Source Type: research
In silico design of a novel multi-epitope vaccine against HCV infection through immunoinformatics approaches
This study is the first to present this epitopes-adjuvant combination. The vaccine had acceptable physicochemical characteristics. The vaccine's 3D structure was predicted and validated. The vaccine's binding stability with Toll-like receptor 2 (TLR2) and TLR4 was confirmed using molecular docking and molecular dynamics (MD) simulation. The immune simulation revealed the vaccine's efficacy by increasing the population of B and T cells in response to vaccination. In silico expression in Escherichia coli (E. coli) was also successful.PMID:38621559 | DOI:10.1016/j.ijbiomac.2024.131517 (Source: Cancer Control)
Source: Cancer Control - April 15, 2024 Category: Cancer & Oncology Authors: Sajjad Ahmad Fatemeh Mobini Demneh Bushra Rehman Taghreed N Almanaa Nahid Akhtar Hamidreza Pazoki-Toroudi Ali Shojaeian Mahdi Ghatrehsamani Samira Sanami Source Type: research
In Commemoration of Dr. Mostafa Pourtaghva Shahrestani, a Pioneer in Infectious Disease Research
Arch Iran Med. 2024 Feb 1;27(2):105-109. doi: 10.34172/aim.2024.16.ABSTRACTIt is important to honor the contributions of scientific leaders who have dedicated their lives to advancing knowledge and serving their country. One way is to document their experiences and personalities in a documentary format, which can serve as a historical record and an inspiration for future generations. Dr. Mostafa Pourtaghva Shahrestani, a renowned physician and specialist in infectious diseases and tropical medicine, has made significant contributions to public health in Iran. He has played a crucial role in controlling infectious diseases ...
Source: Archives of Iranian Medicine - April 15, 2024 Category: Middle East Health Authors: Fatemeh Bardestani Mohammad Ali Rad Mohammad Hossein Azizi Mohammad Mehdi Gouya Ehsan Mostafavi Source Type: research
In silico design of a novel multi-epitope vaccine against HCV infection through immunoinformatics approaches
This study is the first to present this epitopes-adjuvant combination. The vaccine had acceptable physicochemical characteristics. The vaccine's 3D structure was predicted and validated. The vaccine's binding stability with Toll-like receptor 2 (TLR2) and TLR4 was confirmed using molecular docking and molecular dynamics (MD) simulation. The immune simulation revealed the vaccine's efficacy by increasing the population of B and T cells in response to vaccination. In silico expression in Escherichia coli (E. coli) was also successful.PMID:38621559 | DOI:10.1016/j.ijbiomac.2024.131517 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 15, 2024 Category: Biochemistry Authors: Sajjad Ahmad Fatemeh Mobini Demneh Bushra Rehman Taghreed N Almanaa Nahid Akhtar Hamidreza Pazoki-Toroudi Ali Shojaeian Mahdi Ghatrehsamani Samira Sanami Source Type: research
In Commemoration of Dr. Mostafa Pourtaghva Shahrestani, a Pioneer in Infectious Disease Research
Arch Iran Med. 2024 Feb 1;27(2):105-109. doi: 10.34172/aim.2024.16.ABSTRACTIt is important to honor the contributions of scientific leaders who have dedicated their lives to advancing knowledge and serving their country. One way is to document their experiences and personalities in a documentary format, which can serve as a historical record and an inspiration for future generations. Dr. Mostafa Pourtaghva Shahrestani, a renowned physician and specialist in infectious diseases and tropical medicine, has made significant contributions to public health in Iran. He has played a crucial role in controlling infectious diseases ...
Source: Archives of Iranian Medicine - April 15, 2024 Category: Middle East Health Authors: Fatemeh Bardestani Mohammad Ali Rad Mohammad Hossein Azizi Mohammad Mehdi Gouya Ehsan Mostafavi Source Type: research
Early use of oral cholera vaccines as a prime control measure during outbreaks: Necessary but not sufficient
The objective of the outbreak investigation was to identify associated risk factors that would help institute appropriate control measures.MATERIAL AND METHODS: A case control study design was chosen to identify the risk factors for cholera in Gadarif State.RESULTS: Multi-variate analysis of identified two risk factors and three preventive factors for cholera in Gadarif City.RISK FACTORS: Buying foods or drinks from street vendors (OR = 71.36), 95 % CI: 16.58-307.14), living in an urban setting (Gadarif City) (OR = 5.38), 95 % CI: 2.10-13.81); and the preventive factors were: Washing hands with water after defecation but w...
Source: Vaccine - April 9, 2024 Category: Allergy & Immunology Authors: Hassan E El Bushra Ahmed A A Haroun Mohammad Dauod Altaf Humayoon Gardiwal Ali Muhammad Raja Mohamed A Alkhidir Source Type: research
Early use of oral cholera vaccines as a prime control measure during outbreaks: Necessary but not sufficient
The objective of the outbreak investigation was to identify associated risk factors that would help institute appropriate control measures.MATERIAL AND METHODS: A case control study design was chosen to identify the risk factors for cholera in Gadarif State.RESULTS: Multi-variate analysis of identified two risk factors and three preventive factors for cholera in Gadarif City.RISK FACTORS: Buying foods or drinks from street vendors (OR = 71.36), 95 % CI: 16.58-307.14), living in an urban setting (Gadarif City) (OR = 5.38), 95 % CI: 2.10-13.81); and the preventive factors were: Washing hands with water after defecation but w...
Source: Vaccine - April 9, 2024 Category: Allergy & Immunology Authors: Hassan E El Bushra Ahmed A A Haroun Mohammad Dauod Altaf Humayoon Gardiwal Ali Muhammad Raja Mohamed A Alkhidir Source Type: research
Genomic characteristics of clinical non-toxigenic Vibrio cholerae isolates in Switzerland: a cross-sectional study
CONCLUSIONS: V. cholerae infections in Switzerland are rare and predominantly caused by lowly virulent ctxAB-negative and tcpA-negative strains. As V. cholerae is not endemic in Switzerland, cases are assumed to be acquired predominantly during travel. This assumption was supported by the phylogenetic diversity of the analysed isolates.PMID:38579327 | DOI:10.57187/s.3437 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Natalie Meyer Roger Stephan Nicole Cernela Jule Anna Horlbog Michael Biggel Source Type: research
Genomic characteristics of clinical non-toxigenic Vibrio cholerae isolates in Switzerland: a cross-sectional study
CONCLUSIONS: V. cholerae infections in Switzerland are rare and predominantly caused by lowly virulent ctxAB-negative and tcpA-negative strains. As V. cholerae is not endemic in Switzerland, cases are assumed to be acquired predominantly during travel. This assumption was supported by the phylogenetic diversity of the analysed isolates.PMID:38579327 | DOI:10.57187/s.3437 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Natalie Meyer Roger Stephan Nicole Cernela Jule Anna Horlbog Michael Biggel Source Type: research
Genomic characteristics of clinical non-toxigenic Vibrio cholerae isolates in Switzerland: a cross-sectional study
CONCLUSIONS: V. cholerae infections in Switzerland are rare and predominantly caused by lowly virulent ctxAB-negative and tcpA-negative strains. As V. cholerae is not endemic in Switzerland, cases are assumed to be acquired predominantly during travel. This assumption was supported by the phylogenetic diversity of the analysed isolates.PMID:38579327 | DOI:10.57187/s.3437 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Natalie Meyer Roger Stephan Nicole Cernela Jule Anna Horlbog Michael Biggel Source Type: research
Analyses of drinking water quality during a protracted cholera epidemic in Malawi - a cross-sectional study of key physicochemical and microbiological parameters
This study assessed drinking water quality in 17 cholera-affected Malawi districts from February to April 2023. Six hundred and thirty-three records were analysed. The median counts/100 ml for thermotolerant coliform was 98 (interquartile range (IQR): 4-100) and that for Escherichia coli was 0 (IQR: 0-9). The drinking water in all (except one) districts was contaminated by thermotolerant coliform, while six districts had their drinking water sources contaminated by E. coli. The percentage of contaminated drinking water sources was significantly higher in shallow unprotected wells (80.0% for E. coli and 95.0% for thermotole...
Source: Journal of Water and Health - April 1, 2024 Category: Environmental Health Authors: Alex Yao Sokemawu Freeman Aaron Ganizani Annie Chauma Mwale Innocent Kauta Manda James Chitete Gift Phiri Bashil Stambuli Elias Chimulambe Mougabe Koslengar Neema Rusibamayila Kimambo Alisa Bita Rebecca Racheal Apolot Hamid Mponda Randy George Mungwira Ge Source Type: research
