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Prediction of extranodal extension in oropharyngeal cancer patients and carcinoma of unknown primary: value of metabolic tumor imaging with hybrid PET compared with MRI and CT
ConclusionsCT achieved the best specificity, while MRI had the best sensitivity to detect ENE. Nodal metabolic tumor parameters differed significantly between ENE-positive/negative and p16-positive/negative patients. Hence, quantitative data obtained by metabolic imaging might predict presence of ENE and, therefore, could be helpful in customizing therapy management. (Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - December 5, 2022 Category: ENT & OMF Source Type: research

Real-world histopathological approach to malignancy of undefined primary origin (MUO) to diagnose cancers of unknown primary (CUPs)
AbstractThe aim of this study is to envisage a streamlined pathological workup to rule out CUPs in patients presenting with MUOs. Sixty-four MUOs were classified using standard histopathology. Clinical data, immunocytochemical markers, and results of molecular analysis were recorded. MUOs were histologically subdivided in clear-cut carcinomas (40 adenocarcinomas, 11 squamous, and 3 neuroendocrine carcinomas) and unclear-carcinoma features (5 undifferentiated and 5 sarcomatoid tumors). Cytohistology of 7/40 adenocarcinomas suggested an early metastatic cancer per se. In 33/40 adenocarcinomas, CK7/CK20 expression pattern, ge...
Source: Virchows Archiv - November 8, 2022 Category: Pathology Source Type: research

A rare but very serious disease: Tumors metastasizing to the thyroid in the light of cases
CONCLUSION: Thyroidal metastases are rare; however, they must be suspected in patients with a previous history of non-thyroid malignancy and a thyroid nodule. The prognosis is quite poor and the overall survival of the patient depends on the type and location of the primary tumor. The most common primary tumors metastasizing to the thyroid are kidney, lung, and head and neck malignancies, and surgery/chemotherapy may be beneficial.PMID:36327570 | DOI:10.1016/j.tice.2022.101958 (Source: Tissue and Cell)
Source: Tissue and Cell - November 3, 2022 Category: Cytology Authors: Hilal Balta Nevin Kocaman Ozlem Ucer Source Type: research

Clinical analysis of extrapulmonary neuroendocrine carcinoma: a retrospective and single institution experience
Conclusion: EPNEC occurs in various organs and has poor prognosis. L ong-term survival may be possible with surgical resection in cases with early-stage disease or tumor shrinkage due to chemotherapy. (Source: Chemotherapy)
Source: Chemotherapy - November 3, 2022 Category: Cancer & Oncology Source Type: research

Clinical Analysis of Extrapulmonary Neuroendocrine Carcinoma: A Retrospective and Single Institution Experience
Conclusion: EPNEC occurs in various organs and has poor prognosis. Long-term survival may be possible with surgical resection in cases with early-stage disease or tumor shrinkage due to chemotherapy. (Source: Chemotherapy)
Source: Chemotherapy - November 3, 2022 Category: Cancer & Oncology Source Type: research

CUP-syndrome: Inguinal high grade serous ovarian carcinoma lymph node metastases with unknown primary origin – a case report and literature review
ConclusionsInguinal node metastasis is a rare but not unusual occurrence in HGSC. A reasonable level of suspicion should be maintained in patients with inguinal adenopathy and high CA125 values, especially in women with a history of gynecologic surgery, even in the absence of negative imaging for an ovarian origin. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - October 10, 2022 Category: Cancer & Oncology Source Type: research

The Complementary Role of PET to Pathology in Differentiating the Primary Origin of a Malignant Skin Nodule from Liver or Lung
We present a case of malignant abdominal wall nodule initially diagnosed as metastasis from hepatocellular carcinoma through excisional biopsy and immunohistochemical (IHC) staining. Dual-tracer positron emission tomography/computed tomography (PET/CT) with11C-acetate and18F-FDG, however, showed metabolic findings in favor of metastasis from lung origin, which was finally confirmed by ensuing a lung biopsy with additional IHC stains. This case illustrates the complementary molecular role of PET to pathology, particularly when dual-tracer or multi-tracer PET is used in conjunction with pathology methods for cross referencin...
Source: Nuclear Medicine and Molecular Imaging - October 10, 2022 Category: Nuclear Medicine Source Type: research

Carcinoma of Unknown Primary Origin: Application of Immunohistochemistry With Emphasis to Different Cytokeratin 7 and 20 Staining Patterns
Conclusion: The IHC analysis may improve the diagnosis of CUPs. However, the origin of some cases remains unknown despite an IHC analysis, thereby necessitating the use of more diagnostic procedures or gene expression studies for reaching a definitive diagnosis. (Source: Applied Immunohistochemistry and Molecular Morphology)
Source: Applied Immunohistochemistry and Molecular Morphology - October 1, 2022 Category: Chemistry Tags: Research Articles Source Type: research

Cancers, Vol. 14, Pages 4777: Nodal Merkel Cell Carcinoma with Unknown Primary Site and No Distant Metastasis: A Single-Center Series
o Prestianni Guido Bonomo Luigi Funicelli Emilio Bertani Paola Queirolo Davide Ravizza Manila Rubino Giulio Tosti Elisabetta Pennacchioli Merkel cell carcinoma (MCC) is a very rare and aggressive neuroendocrine carcinoma originating from Merkel cells, typically with a skin nodule; however, it exceptionally presents with only a basin lymph node localization, with neither a cutaneous primary site nor distant metastases. From 1996 to 2020, among patients with histologically confirmed MCC managed at a neuroendocrine neoplasm-referral center, we selected those with an exclusive nodal basin, no distant metast...
Source: Cancers - September 29, 2022 Category: Cancer & Oncology Authors: Nicola Fazio Patrick Maisonneuve Francesca Spada Lorenzo Gervaso Chiara Alessandra Cella Marta Pozzari Dario Zerini Eleonora Pisa Caterina Fumagalli Massimo Barberis Alice Laffi Chiara Maria Grana C. Gianmarco Orsolini Pierpaolo Prestianni Guido Bonomo Lu Tags: Article Source Type: research

An Immunohistochemical Expression of CK5/6, CK7, and CK20 on Cell Blocks in Metastatic Cervical Lymphadenopathy
CONCLUSION: Our study showed that the combined use of the cell block technique and FNAC was more useful and sensitive in diagnosing the metastatic cervical lymph nodes and the accuracy can be further improved by the use of IHC on the cell blocks. The combined use of CK5/6, CK7, and CK20 in metastatic cervical lymphadenopathy is helpful in diagnosing squamous cell carcinoma and adenocarcinoma with known/unknown primary sites.PMID:36131858 | PMC:PMC9484508 | DOI:10.4103/ijabmr.ijabmr_813_21 (Source: Cell Research)
Source: Cell Research - September 22, 2022 Category: Cytology Authors: Amanpreet Kaur Jaspreet Singh Rajiv Devgan Utkarshni Utreja Source Type: research

Confirmation of lung adenocarcinoma as the primary cancer with detection of EML4-ALK rearrangement using next-generation sequencing: a case study
This study suggested that NGS be recommended to detect ALK rearrangement in the patients with carcinoma of unknown primary site, and that resistance to targeted therapy with ALK inhibitors should be considered for personalized precision medicine.PMID:36099717 | DOI:10.1016/j.prp.2022.154105 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - September 13, 2022 Category: Pathology Authors: Yijun Mo Lina Lin Jianhua Zhang Yan Zhong Tao Zhang Chenghua Zhong Jun Yan Jun Kuang Quanwei Guo Jianfeng Tan Dongfang Li Mengxi Wu Source Type: research