Carcinoma of Unknown Primary Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Transoral Robotic Surgery and Radiation Volume Deintensification in Unknown Primary Squamous Cell Carcinoma of the Neck: The Phase 2 FIND Nonrandomized Controlled Trial
CONCLUSIONS AND RELEVANCE: These findings indicate that TORS for p16-positive CUP allows RT volume deintensification with excellent outcomes and support future investigation in randomized clinical trials.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03281499.PMID:38602692 | DOI:10.1001/jamaoto.2024.0423 (Source: Cancer Control)
Source: Cancer Control - April 11, 2024 Category: Cancer & Oncology Authors: John R de Almeida Rosemary Martino Ali Hosni David P Goldstein Scott V Bratman Douglas B Chepeha John N Waldron Ilan Weinreb Bayardo Perez-Ordonez Eugene Yu Ur Metser Aaron R Hansen Wei Xu Susie Jie Su John Kim Source Type: research

TORS and Radiation Volume in Unknown Primary Squamous Cell Carcinoma of the Neck
This phase 2 trial assesses whether transoral robotic surgery and tailored radiotherapy are associated with favorable outcomes among patients with unknown primary squamous cell carcinoma. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - April 11, 2024 Category: ENT & OMF Source Type: research

Human papillomavirus circulating tumor DNA: a diagnostic tool in squamous cell carcinoma of unknown primary —a pilot study
DiscussionctHPVDNA demonstrated good diagnostic accuracy for both known and unknown primaries. Incorporation of ctHPVDNA into the diagnostic algorithm for SCCUP may reduce the need for multiple procedures to establish HPV status. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - April 2, 2024 Category: Cancer & Oncology Source Type: research

Decoding the Enigma: Harnessing HPV Testing for the Precision Care in Carcinoma Unknown Primary with Secondary Metastasis to the Neck in North Indian Population Undergoing TORS for Primary Identification
AbstractTo assess the exact role of high-risk HPV testing in patients of carcinoma unknown primary with secondary metastasis to the neck who underwent TORS and neck dissection for identification of the primary site.A prospective study was carried out at a tertiary care centre over one year. Patients with unilateral neck swelling, which was cytologically proven squamous cell carcinoma neck metastasis, were included in the study. After clinicopathological evaluation, they underwent TORS-assisted ipsilateral radical tonsillectomy, tongue base mucosal wedge biopsy for primary site identification, and ipsilateral neck dissectio...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - March 28, 2024 Category: ENT & OMF Source Type: research

Retrospective analysis of clinical characteristics and outcomes of patients with carcinoma of unknown primary from three tertiary centers in Australia
ConclusionsIn this real-world cohort, CUP presentations were heterogenous. Overall survival and rates of systemic treatment were poor. Poor performance status and unfavorable risk were associated with worse survival. For most patients, site-specific therapy did not improve survival outcome. Improved and timely access to diagnostic tests and therapeutics for this group of patients is urgently required. (Source: Cancer Medicine)
Source: Cancer Medicine - March 25, 2024 Category: Cancer & Oncology Authors: Emma L. Boys, Bo Gao, Peter Grimison, Sarah Sutherland, Karen L. MacKenzie, Roger R. Reddel, Jia Liu Tags: RESEARCH ARTICLE Source Type: research

GSE256413 DNA methylation profiles of lymph node tissue of head and neck cancer of unknown primary
Conclusions. On DNA methylation level, hnCUP is comparable to primary tumor tissue cancer types that commonly metastasize to cervical lymph nodes. Our SVM-based classifier can accurately predict these cancers’ tissues of origin and could significantly re duce the invasiveness of hnCUP diagnostics and enable a more precise therapy after clinical validation. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 4, 2024 Category: Genetics & Stem Cells Tags: Methylation profiling by genome tiling array Homo sapiens Source Type: research

Head and Neck Cancer of Unknown Primary: A Multicenter Retrospective Cohort study in Northern Thailand, an Endemic Nasopharyngeal Cancer Area
CONCLUSION: Our survival outcomes were comparable to previous studies with a low rate of PTE. The matched pair analysis of EBER-positive and -negative groups revealed similar oncological outcomes and no primary tumor emergence when total mucosal irradiation was administered.PMID:38415558 | DOI:10.31557/APJCP.2024.25.2.699 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2024 Category: Cancer & Oncology Authors: Pichit Sittitrai Donyarat Ruenmarkkaew Imjai Chitapanarux Pooriwat Muangwong Kanchana Kangsadarnwiroon Ratcharin Benjawongsatien Chonticha Srivanitchapoom Supawit Donchalermpak Tussawan Asakij Source Type: research