Carcinoma of Unknown Primary Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The Role of Trans Oral Robotic Surgery in the Carcinoma of Unknown Primary: A New Evidence in the Horizon?
AbstractThe detection of the primary site in Carcinoma of Unknown Primary (CUP) is a challenging task which can significantly alter the course of management and also prognosis. Various modalities have been assessed with varying sensitivity and specificity. Imaging and cytological diagnosis have formed a key part of the diagnostic algorithm of CUP. Trans Oral Robotic Surgery offers the advantage of being both diagnostic as well as therapeutic with promising sensitivity and specificity and can form an integral part in the management of CUP. A prospective study was carried out at a tertiary care centre over a period of one ye...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - January 8, 2024 Category: ENT & OMF Source Type: research

Impact of the Identification of Nonhuman Genetic Signatures in the Diagnosis and Management of Carcinoma of Unknown Primary
This report presents the case of a 62-year-old woman who was diagnosed in 1999 with stage I cervical carcinoma treated by surgical resection. In 2021, she presented to the emergency department with a complaint of predominantly right-sided lower back pain. A CT scan of the lumbosacral region revealed a bone lesion in the L5 vertebra and retroperitoneal lymphadenopathies suggestive of malignancy. Histology of the L5 vertebra biopsy showed a poorly differentiated carcinoma with an inconclusive immunophenotypic profile. Treatment for carcinoma of unknown primary was started with a combination of carboplatin and paclitaxel ever...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - December 27, 2023 Category: Cancer & Oncology Authors: Arantzazu Barqu ín García Sara Palacios-Zambrano Felipe Lozano Alarc ón Beatriz Paumard-Hern ández Miguel Quiralte Pulido Paloma Navarro Laura Rodr íguez Isabel Salas Villar Jes ús García-Donas Source Type: research

Step Serial Sectioning in Head and Neck Squamous Cell Carcinoma of Unknown Primary
This cohort study examines the outcomes of step serial sectioning vs conventional histopathology when analyzing diagnostic tissue specimens from tongue base mucosectomy and tonsillectomy performed for head and neck squamous cell carcinoma of unknown primary. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - December 21, 2023 Category: ENT & OMF Source Type: research

Intrahepatic cholangiocarcinoma initially diagnosed as adenocarcinoma of unknown primary with hepatoduodenal ligament lymph node metastases: A case report
Oncol Lett. 2023 Nov 8;27(1):7. doi: 10.3892/ol.2023.14140. eCollection 2024 Jan.ABSTRACTIntrahepatic cholangiocarcinoma (iCCA) with regional lymph node metastases, which lacks a well-delineated liver mass, may be misdiagnosed as a carcinoma of unknown primary (CUP) origin. The present study reports the case of a 69-year-old man initially diagnosed with CUP, who was incidentally found to have abdominal lymphadenopathy during ultrasonography (US). The clinical course from the time of lymphadenectomy and CUP diagnosis to iCCA detection after long-term follow-up is reported. A patient with a history of hypertensive renal dise...
Source: Oncology Letters - November 29, 2023 Category: Cancer & Oncology Authors: Sangik Noh Ahrong Ham Je Ryung Gil Miji Lee Taekyu Lim Source Type: research

The practical utility of AI-assisted molecular profiling in the diagnosis and management of cancer of unknown primary: an updated review
In conclusion, AI- and ML-driven approaches are revolutionizing CUP management by enhancing diagnostic accuracy. Precision oncology utilizing enhanced molecular profiling facilitates the identification of targeted therapies that transcend the need to identify the tissue of origin, ultimately improving patient outcomes. (Source: Virchows Archiv)
Source: Virchows Archiv - November 24, 2023 Category: Pathology Source Type: research

Head and Neck Squamous Cell Carcinoma of Unknown Primary: A Diagnostic Work-Up
This article seeks to consolidate contemporary strategies used to identify the primary tumor site of an unknown primary head and neck squamous cell carcinoma and offer recommendations based on current literature review.PMID:37995312 | DOI:10.1093/oncolo/oyad311 (Source: The Oncologist)
Source: The Oncologist - November 23, 2023 Category: Cancer & Oncology Authors: Meenakkshy Manoharan Noah S Kalman Guilherme Rabinowits Source Type: research

Merkel cell carcinoma recurrence risk estimation is improved by integrating factors beyond cancer stage: a multivariable model and web-based calculator
Merkel cell carcinoma (MCC) recurs in 40% of patients. In addition to stage, factors known to affect recurrence risk include: sex, immunosuppression, unknown primary status, age, site of primary tumor, and time since diagnosis. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - November 18, 2023 Category: Dermatology Authors: Aubriana M. McEvoy, Daniel S. Hippe, Kristina Lachance, Song Park, Kelsey Cahill, Mary Redman, Ted Gooley, Michael W. Kattan, Paul Nghiem Source Type: research

Cancer of unknown primary histologically, genetically and spatially diagnosed as left ovary ‑derived cancer: A case report
Oncol Lett. 2023 Oct 19;26(6):522. doi: 10.3892/ol.2023.14109. eCollection 2023 Dec.ABSTRACTCancer of unknown primary (CUP) is a heterogeneous syndrome of metastatic cancer in which the primary site cannot be determined even after a standard and comprehensive search. The present report describes a case in which the spatial distribution of the lymph node metastases contributed to the identification of the primary site. While the standard workup did not identify the primary tumor, genomic profiling analysis was useful in therapeutic management. A 68-year-old woman presented with a cancerous pleural effusion (adenocarcinoma)....
Source: Oncology Letters - November 6, 2023 Category: Cancer & Oncology Authors: Harunori Honjoh Ayumi Taguchi Hirofumi Rokutan Ayako Mori Takahiro Ando Akira Nishijima Satoko Eguchi Yuichiro Miyamoto Kenbun Sone Mayuyo Uchino-Mori Yutaka Osuga Source Type: research