Janssen Presents Initial Results from the Phase 2 RAGNAR Study of BALVERSA ® (erdafitinib) in Patients with Advanced Solid Tumors with FGFR Alterations
CHICAGO, ILLINOIS, June 7, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced initial results from the pivotal Phase 2 RAGNAR study evaluating the investigational use of BALVERSA® (erdafitinib), a fibroblast growth factor receptor (FGFR) kinase inhibitor, in patients with advanced solid tumors with prespecified FGFR alterations. At a planned interim analysis (IA), responses were observed across a variety of FGFR-driven solid tumors for patients who had exhausted standard treatment options prior to being treated with BALVERSA®. These results will be featured in an oral presentation (...
Source: Johnson and Johnson - June 7, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news
Cutaneous metastasis of renal cell carcinoma: Fine needle aspiration provides rapid diagnosis
The diagnosis of cutaneous metastasis of renal cell carcinoma is challenging in a young person in absence of a prior history of cancer. In such situation, fine needle aspiration alone as a minimally invasive procedure can provide rapid, accurate and cost effective diagnosis, even in case of unknown primary.01/23/2019 (Source: Kidney Cancer Association)
Source: Kidney Cancer Association - January 23, 2019 Category: Urology & Nephrology Source Type: news
Liquid biopsies find distinct genomic profiles in most patients with carcinoma of unknown primary
(American Association for Cancer Research) Next-generation sequencing of circulating tumor DNA identified distinct genomic profiles with potentially targetable alterations in 99.7 percent of patients with carcinoma of unknown primary who have detectable alterations. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 15, 2017 Category: Cancer & Oncology Source Type: news
Oropharyngeal Cancer, Extracapsular Spread, and HPV p16 StatusOropharyngeal Cancer, Extracapsular Spread, and HPV p16 Status
Spread beyond the lymph nodes of oropharyngeal cancer and carcinoma of unknown primary site (CUP) is associated with greater recurrence and poorer survival in patients with human papillomavirus (HPV) p16-negative tumors, but not in those with p16-positive tumors. Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - May 31, 2016 Category: Pathology Tags: Hematology-Oncology News Source Type: news
Unknown Primary Head/Neck SCC More CommonUnknown Primary Head/Neck SCC More Common
The last decade has seen an increase in the frequency of unknown primary squamous cell carcinoma (UPSCC) of the head and neck, and human papillomavirus (HPV) is behind most of these cases, new research suggests. Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - January 20, 2016 Category: Pathology Tags: Hematology-Oncology News Source Type: news
Wearing a bra 'doesn't raise breast cancer risk'
Conclusion This study suggests that past bra-wearing characteristics are not associated with breast cancer risk in postmenopausal women. The study does have some limitations: There was only limited matching of the cases and controls, which could mean that other differences between the groups may be contributing to results. The potential confounders assessed were reported to not have a large impact on the results, which suggests that the lack of matching may not be having a large effect, but these results were not shown to allow assessment of this by the reader. Controls were not selected for the women with invasi...
Source: NHS News Feed - September 8, 2014 Category: Consumer Health News Tags: Cancer Lifestyle/exercise Source Type: news