Natural polysaccharides and their derivatives targeting the tumor microenvironment: A review
This article reviews recent strategies for targeting the tumor microenvironment with polysaccharides and briefly discusses the structure-activity relationships of anti-tumor polysaccharides. It also summarises the main chemical modification methods of polysaccharides and discusses the impact of chemical modifications on the anti-tumor activity of polysaccharides. The review aims to lay a theoretical foundation for the development of anti-tumor polysaccharides and their derivatives.PMID:38677708 | DOI:10.1016/j.ijbiomac.2024.131789 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 27, 2024 Category: Biochemistry Authors: Wenli Wang Bin Zhao Zhongtao Zhang Takashi Kikuchi Wei Li Pensak Jantrawut Feng Feng FuLei Liu Jie Zhang Source Type: research
Prospects of focal adhesion kinase inhibitors as a cancer therapy in preclinical and early phase study
Expert Opin Investig Drugs. 2024 Apr 27. doi: 10.1080/13543784.2024.2348068. Online ahead of print.ABSTRACTINTRODUCTION: FAK, a nonreceptor cytoplasmic tyrosine kinase, plays a crucial role in tumor metastasis, drug resistance, tumor stem cell maintenance, and regulation of the tumor microenvironment. FAK has emerged as a promising target for tumor therapy based on both preclinical and clinical data.AREAS COVERED: This paper aims to summarize the molecular mechanisms underlying FAK's involvement in tumorigenesis and progression. Encouraging results have emerged from ongoing clinical trials of FAK inhibitors. Additionally, ...
Source: Expert Opinion on Investigational Drugs - April 27, 2024 Category: Drugs & Pharmacology Authors: Jiaming Gao Jingwen Cheng Wanyu Xie Ping Zhang Xuebin Liu Zaiqi Wang Baoyuan Zhang Source Type: research
An extensive overview of the role of lncRNAs generated from immune cells in the etiology of cancer
Int Immunopharmacol. 2024 Apr 26;133:112063. doi: 10.1016/j.intimp.2024.112063. Online ahead of print.ABSTRACTLong non-coding RNAs (lncRNAs) are involved in the control of critical tumor-suppressor and oncogenic pathways in cancer. These types of non-coding RNAs could affect both immune and cancer cells. The thorough analysis of lncRNAs derived from immune cells and the incorporation of new findings significantly advance our understanding of the complex role of lncRNAs in the context of cancer. This work highlights the promise of lncRNAs for translational therapeutic approaches while also establishing a solid foundation fo...
Source: International Immunopharmacology - April 27, 2024 Category: Allergy & Immunology Authors: Hong Luo Hailiang Jing Wei Chen Source Type: research
The Influence of Inset and Shaping of Abdominal-Based Free Flap Breast Reconstruction on Patient-Reported Aesthetic Outcome Scores-A Systematic Review
Conclusions: Emphasis on the aesthetic outcome in terms of breast shape and symmetry, providing an individualized approach of flap inset, considering the contralateral breast's shape and volume, results in higher satisfaction scores.PMID:38673668 | PMC:PMC11051228 | DOI:10.3390/jcm13082395 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 27, 2024 Category: Cancer & Oncology Authors: Isabel Zucal Laura De Pellegrin Corrado Parodi Yves Harder Riccardo Schweizer Source Type: research
The Influence of Inset and Shaping of Abdominal-Based Free Flap Breast Reconstruction on Patient-Reported Aesthetic Outcome Scores-A Systematic Review
Conclusions: Emphasis on the aesthetic outcome in terms of breast shape and symmetry, providing an individualized approach of flap inset, considering the contralateral breast's shape and volume, results in higher satisfaction scores.PMID:38673668 | PMC:PMC11051228 | DOI:10.3390/jcm13082395 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 27, 2024 Category: Cancer & Oncology Authors: Isabel Zucal Laura De Pellegrin Corrado Parodi Yves Harder Riccardo Schweizer Source Type: research
Natural polysaccharides and their derivatives targeting the tumor microenvironment: A review
This article reviews recent strategies for targeting the tumor microenvironment with polysaccharides and briefly discusses the structure-activity relationships of anti-tumor polysaccharides. It also summarises the main chemical modification methods of polysaccharides and discusses the impact of chemical modifications on the anti-tumor activity of polysaccharides. The review aims to lay a theoretical foundation for the development of anti-tumor polysaccharides and their derivatives.PMID:38677708 | DOI:10.1016/j.ijbiomac.2024.131789 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 27, 2024 Category: Biochemistry Authors: Wenli Wang Bin Zhao Zhongtao Zhang Takashi Kikuchi Wei Li Pensak Jantrawut Feng Feng FuLei Liu Jie Zhang Source Type: research
Prospects of focal adhesion kinase inhibitors as a cancer therapy in preclinical and early phase study
Expert Opin Investig Drugs. 2024 Apr 27. doi: 10.1080/13543784.2024.2348068. Online ahead of print.ABSTRACTINTRODUCTION: FAK, a nonreceptor cytoplasmic tyrosine kinase, plays a crucial role in tumor metastasis, drug resistance, tumor stem cell maintenance, and regulation of the tumor microenvironment. FAK has emerged as a promising target for tumor therapy based on both preclinical and clinical data.AREAS COVERED: This paper aims to summarize the molecular mechanisms underlying FAK's involvement in tumorigenesis and progression. Encouraging results have emerged from ongoing clinical trials of FAK inhibitors. Additionally, ...
Source: Expert Opinion on Investigational Drugs - April 27, 2024 Category: Drugs & Pharmacology Authors: Jiaming Gao Jingwen Cheng Wanyu Xie Ping Zhang Xuebin Liu Zaiqi Wang Baoyuan Zhang Source Type: research
Enhancing X ‐Ray Sensitization with Multifunctional Nanoparticles
This study investigates the potential of NPs, particularly those comprised of high atomic number elements, as radiosensitizers. This aims to optimize localized radiation doses within tumors, thereby maximizing therapeutic efficacy while preserving surrounding tissues. The multifaceted applications of NPs in radiotherapy encompass collaborative interactions with chemotherapeutic, immunotherapeutic, and targeted pharmaceuticals, along with contributions to photodynamic/photothermal therapy, imaging enhancement, and the integration of artificial intelligence technology. Despite promising preclinical outcomes, the paper acknow...
Source: Small - April 27, 2024 Category: Nanotechnology Authors: Jiayi Liu,
JunYong Wu,
Taili Chen,
Bin Yang,
XiangPing Liu,
Jing Xi,
Ziyang Zhang,
Yawen Gao,
ZhiHong Li Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1709: Immune System Disorder and Cancer-Associated Cachexia
omi
Cancer-associated cachexia (CAC) is a debilitating condition marked by muscle and fat loss, that is unresponsive to nutritional support and contributes significantly to morbidity and mortality in patients with cancer. Immune dysfunction, driven by cytokine imbalance, contributes to CAC progression. This review explores the potential relationship between CAC and anti-cancer immune response in pre-clinical and clinical studies. Pre-clinical studies showcase the involvement of cytokines like IL-1β, IL-6, IL-8, IFN-γ, TNF-α, and TGF-β, in CAC. IL-6 and TNF-&...
Source: Cancers - April 27, 2024 Category: Cancer & Oncology Authors: Lingbing Zhang Philip D. Bonomi Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1705: Survivin as a Therapeutic Target for the Treatment of Human Cancer
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Survivin was initially identified as a member of the inhibitor apoptosis (IAP) protein family and has been shown to play a critical role in the regulation of apoptosis. More recent studies showed that survivin is a component of the chromosome passenger complex and acts as an essential mediator of mitotic progression. Other potential functions of survivin, such as mitochondrial function and autophagy, have also been proposed. Survivin has emerged as an attractive target for cancer therapy because its overexpression has been found in most human cancers and is frequently associated with chemotherapy resistance, recurr...
Source: Cancers - April 27, 2024 Category: Cancer & Oncology Authors: Qiang Wang Mark I. Greene Tags: Review Source Type: research
A Review of Practice-Changing Therapies in Oncology in the Era of Personalized Medicine
Curr Oncol. 2024 Apr 2;31(4):1913-1919. doi: 10.3390/curroncol31040143.ABSTRACTIn the past decade, a lot of insight was gathered into the composition of the host and tumor factors that promote oncogenesis and treatment resistance. This in turn has led to the ingenious design of multiple new classes of drugs, which have now become the new standards of care in cancer therapy. These include novel antibody-drug conjugates, chimeric antigen receptor T cell therapies (CAR-T), and bispecific T cell engagers (BitTE). Certain host factors, such as the microbiome composition, are also emerging not only as biomarkers for the response...
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Mariana Pilon Capella Khashayar Esfahani Source Type: research
Optimized Synthesis of Poly(Lactic Acid) Nanoparticles for the Encapsulation of Flutamide
This study evaluated the influence of several experimental parameters for accurate control of the PLA NPs' size distribution and aggregation. Tip sonication (as the stirring method), a PLA concentration of 10 mg/mL, a PVA concentration of 2.5 mg/mL, and low-molecular-weight PLA (Mw = 5000) were established as the best experimental conditions to obtain monodisperse PLA NPs. After gelification process optimization, flutamide (FLU) was used as a model drug to evaluate the encapsulation capability of the PLA NPs. The results showed an encapsulation efficiency of 44% for this cytostatic compound. Furthermore, preliminary cell v...
Source: Cancer Control - April 26, 2024 Category: Cancer & Oncology Authors: Duarte Almeida Mariana Dias Beatriz Teixeira Carolina Fraz ão M ónica Almeida Gil Gon çalves Miguel Oliveira Ricardo J B Pinto Source Type: research
Meta-analysis of nano-phytosomes: unleashing the potential of plant-derived compounds for advancing cancer therapy
In conclusion, nano-phytosomes offer promising prospects for revolutionising drug delivery methodologies and advancing the development of innovative therapeutic solutions in the domain of cancer therapy.PMID:38666545 | DOI:10.1080/14786419.2024.2344182 (Source: Natural Product Research)
Source: Natural Product Research - April 26, 2024 Category: Biochemistry Authors: Ali Al-Samydai Hamdi Nsairat Maha N Abu Hajleh Bayan Aburas Amal Akour Tha'er Husam Ata Tabarek H Mahmood Tabarak Riyadh Al-Sammarraie Rawan Atta Rahaf Ali Qasim Khalid Alazzawi Ahmed Aburjai Simone Carradori Source Type: research
Multi-Omics Integration for Liver Cancer Using Regression Analysis
This report elucidates how the integration of comprehensive data on methylation, gene expression, and copy number variations can effectively facilitate the unsupervised clustering of cancer samples. We have identified regressors that can effectively classify tumor and normal samples with an optimal integration of RNA sequencing, DNA methylation, and copy number variation while also achieving significant p-values. Further, these regressors were trained using linear and logistic regression with k-means clustering. For comparison, we employed autoencoder- and stacking-based omics integration and computed silhouette scores to ...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Aditya Raj Ruben C Petreaca Golrokh Mirzaei Source Type: research
A ferroptosis amplifier based on triple-enhanced lipid peroxides accumulation strategy for effective pancreatic cancer therapy
Biomaterials. 2024 Apr 21;309:122574. doi: 10.1016/j.biomaterials.2024.122574. Online ahead of print.ABSTRACTAs an iron dependent regulatory cell death process driven by excessive lipid peroxides (LPO), ferroptosis is recognized as a powerful weapon for pancreatic cancer (PC) therapy. However, the tumor microenvironment (TME) with hypoxia and elevated glutathione (GSH) expression not only inhibits LPO production, but also induces glutathione peroxidase 4 (GPX4) mediated LPO clearance, which greatly compromise the therapeutic outcomes of ferroptosis. To address these issues, herein, a novel triple-enhanced ferroptosis ampli...
Source: Biomaterials - April 26, 2024 Category: Materials Science Authors: Mengyao Chen Xiaohan Tong Yanting Sun Chunyan Dong Chen Li Chunhui Wang Minyi Zhang Yixuan Wen Pinting Ye Ruihao Li Jie Wan Shujing Liang Shuo Shi Source Type: research
