Therapeutic exploitation of ferroptosis
Biochem Soc Trans. 2024 Apr 17:BST20230550. doi: 10.1042/BST20230550. Online ahead of print.ABSTRACTPathological breakdown of membrane lipids through excessive lipid peroxidation (LPO) was first described in the mid-20th century and is now recognized as a form of regulated cell death, dubbed ferroptosis. Accumulating evidence unveils how metabolic regulation restrains peroxidation of phospholipids within cellular membranes, thereby impeding ferroptosis execution. Unleashing these metabolic breaks is currently therapeutically explored to sensitize cancers to ferroptosis inducing anti-cancer therapies. Reversely, these natur...
Source: Biochemical Society Transactions - April 17, 2024 Category: Biochemistry Authors: Magali Walravens Ine Koeken Tom Vanden Berghe Source Type: research
Unlocking the Potential of Induced Pluripotent Stem Cells in Revolutionizing Cancer Therapy
This article highlights the potential of iPSC- based NK cells and dendritic cells for immunotherapy and delves into the role of iPSC-based mesenchymal cells in targeted therapy. The potential of iPSC-derived organoids as a vital tool for disease modeling and drug discovery has been showcased, and the importance of iPSC-based cancer vaccines is also emphasized. The ongoing clinical trials of iPSC-based cancer treatment have also been highlighted. Though much work remains to be done to implicate these iPSC-based therapeutic options from research labs to clinics and hospitals, ongoing studies and clinical/translational follow...
Source: Current Stem Cell Research and Therapy - April 17, 2024 Category: Stem Cells Authors: Amrita Mondal Ankita Talukdar Rizwanul Haque Source Type: research
Combination therapy involving HSP90 inhibitors for combating cancer: an overview of clinical and preclinical progress
Arch Pharm Res. 2024 Apr 17. doi: 10.1007/s12272-024-01494-1. Online ahead of print.ABSTRACTThe molecular chaperone heat shock protein 90 (HSP90) regulates multiple crucial signalling pathways in cancer by driving the maturation of key signalling components, thereby playing a crucial role in tumorigenesis and drug resistance in cancer. Inhibition of HSP90 results in metastable conformational collapse of its client proteins and their proteasomal degradation. Considerable efforts have been devoted to the development of small-molecule inhibitors targeting HSP90, and more than 20 inhibitors have been evaluated in clinical tria...
Source: Archives of Pharmacal Research - April 17, 2024 Category: Drugs & Pharmacology Authors: Yajun Liu Chenyao Li Hongwei Liu Shutao Tan Source Type: research
Therapeutic exploitation of ferroptosis
Biochem Soc Trans. 2024 Apr 24;52(2):693-706. doi: 10.1042/BST20230550.ABSTRACTPathological breakdown of membrane lipids through excessive lipid peroxidation (LPO) was first described in the mid-20th century and is now recognized as a form of regulated cell death, dubbed ferroptosis. Accumulating evidence unveils how metabolic regulation restrains peroxidation of phospholipids within cellular membranes, thereby impeding ferroptosis execution. Unleashing these metabolic breaks is currently therapeutically explored to sensitize cancers to ferroptosis inducing anti-cancer therapies. Reversely, these natural ferroptotic defens...
Source: Biochemical Society Transactions - April 17, 2024 Category: Biochemistry Authors: Magali Walravens Ine Koeken Tom Vanden Berghe Source Type: research
Unlocking the Potential of Induced Pluripotent Stem Cells in Revolutionizing Cancer Therapy
This article highlights the potential of iPSC- based NK cells and dendritic cells for immunotherapy and delves into the role of iPSC-based mesenchymal cells in targeted therapy. The potential of iPSC-derived organoids as a vital tool for disease modeling and drug discovery has been showcased, and the importance of iPSC-based cancer vaccines is also emphasized. The ongoing clinical trials of iPSC-based cancer treatment have also been highlighted. Though much work remains to be done to implicate these iPSC-based therapeutic options from research labs to clinics and hospitals, ongoing studies and clinical/translational follow...
Source: Current Stem Cell Research and Therapy - April 17, 2024 Category: Stem Cells Authors: Amrita Mondal Ankita Talukdar Rizwanul Haque Source Type: research
Combination therapy involving HSP90 inhibitors for combating cancer: an overview of clinical and preclinical progress
Arch Pharm Res. 2024 Apr 17. doi: 10.1007/s12272-024-01494-1. Online ahead of print.ABSTRACTThe molecular chaperone heat shock protein 90 (HSP90) regulates multiple crucial signalling pathways in cancer by driving the maturation of key signalling components, thereby playing a crucial role in tumorigenesis and drug resistance in cancer. Inhibition of HSP90 results in metastable conformational collapse of its client proteins and their proteasomal degradation. Considerable efforts have been devoted to the development of small-molecule inhibitors targeting HSP90, and more than 20 inhibitors have been evaluated in clinical tria...
Source: Archives of Pharmacal Research - April 17, 2024 Category: Drugs & Pharmacology Authors: Yajun Liu Chenyao Li Hongwei Liu Shutao Tan Source Type: research
GSE262864 Targeting an immunoregulatory dendritic cell-CCL22 program alleviates radioresistance
Conclusions: We identify a previously unappreciated cDC mechanism mediating Treg tumor infiltration after RT. Our findings suggest blocking the cDC1-CCL22-Treg axis augments RT efficacy. αEGFR-IFNα added to RT provided robust antitumor responses better than systemic free interferon administration, and may overcome clinical limitations to interferon therapy. Our findings highlight the complex behavior of cDC after RT and provide novel therapeutic strategies for overcoming RT-driven immunosuppression to improve RT efficacy. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE236373 p53 rapidly restructures 3D chromatin organization to trigger a transcriptional response [PCHiC]
Contributors : Fran çois Serra ; Andrea Nieto-Aliseda ; Llorenç Rovirosa ; Mónica Cabrera-Pasadas ; Lucía Fanlo ; Aleksey Lazarenkov ; Blanca Urmeneta ; Andrei L Okorokov ; Peter Fraser ; Jose L Sardina ; Alfonso Valencia ; Biola M JavierreSeries Type : OtherOrganism : Homo sapiensActivation of the p53 tumor suppressor triggers a transcriptional program to control cellular response to stress. However, the molecular mechanisms by which p53 controls gene transcription are not completely understood. Here, using a multi-omics integration framework, we uncover the critical role of spatio-temporal genome architectur...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
GSE236372 p53 rapidly restructures 3D chromatin organization to trigger a transcriptional response [ChIP-seq]
Contributors : Fran çois Serra ; Andrea Nieto-Aliseda ; Llorenç Rovirosa ; Mónica Cabrera-Pasadas ; Lucía Fanlo ; Aleksey Lazarenkov ; Blanca Urmeneta ; Andrei L Okorokov ; Peter Fraser ; Jose L Sardina ; Alfonso Valencia ; Biola M JavierreSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensActivation of the p53 tumor suppressor triggers a transcriptional program to control cellular response to stress. However, the molecular mechanisms by which p53 controls gene transcription are not completely understood. Here, using a multi-omics integration framework, we unco...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
GSE235946 p53 rapidly restructures 3D chromatin organization to trigger a transcriptional response [RNA-seq]
Contributors : Fran çois Serra ; Andrea Nieto-Aliseda ; Llorenç Rovirosa ; Mónica Cabrera-Pasadas ; Lucía Fanlo ; Aleksey Lazarenkov ; Blanca Urmeneta ; Andrei L Okorokov ; Peter Fraser ; Jose L Sardina ; Alfonso Valencia ; Biola M JavierreSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensActivation of the p53 tumor suppressor triggers a transcriptional program to control cellular response to stress. However, the molecular mechanisms by which p53 controls gene transcription are not completely understood. Here, using a multi-omics integration framework, we uncover the critic...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE235944 p53 rapidly restructures 3D chromatin organization to trigger a transcriptional response [HiC]
Contributors : Fran çois Serra ; Andrea Nieto-Aliseda ; Llorenç Rovirosa ; Mónica Cabrera-Pasadas ; Lucía Fanlo ; Aleksey Lazarenkov ; Blanca Urmeneta ; Andrei L Okorokov ; Peter Fraser ; Jose L Sardina ; Alfonso Valencia ; Biola M JavierreSeries Type : OtherOrganism : Homo sapiensActivation of the p53 tumor suppressor triggers a transcriptional program to control cellular response to stress. However, the molecular mechanisms by which p53 controls gene transcription are not completely understood. Here, using a multi-omics integration framework, we uncover the critical role of spatio-temporal genome architectur...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
Cancers, Vol. 16, Pages 1531: The Role of Ion Channels and Chemokines in Cancer Growth and Metastasis: A Proposed Mode of Action using Peptides in Cancer Therapy
i
Metastasis (Met) largely contributes to the major cause of cancer deaths throughout the world, rather than the growth of the tumor mass itself. The present report brings together several of the pertinent contributors to cancer growth and metastatic processes from an activity standpoint. Such biological activities include the following: (1) cell adherence and detachment; (2) cell-to-cell contact; (3) contact inhibition; (4) the cell interfacing with the extracellular matrix (ECM); (5) tumor cell-to-stroma communication networks; (6) chemotaxis; and (7) cell membrane potential. Moreover, additional biochemical factors ...
Source: Cancers - April 17, 2024 Category: Cancer & Oncology Authors: Gerald J. Mizejewski Tags: Review Source Type: research
Cuproptosis: Advances in Stimulus-Responsive Nanomaterials for Cancer Therapy
Adv Healthc Mater. 2024 Apr 15:e2400652. doi: 10.1002/adhm.202400652. Online ahead of print.ABSTRACTCuproptosis, a recently identified non-apoptotic programmed cell death modality, attracts considerable attention in the realm of cancer therapeutics owing to its unique cellular demise mechanisms. Since its initial report in 2022, strategies inducing or amplifying cuproptosis for cancer treatment emerge. The engineering of nano-systems to elicit cuproptosis effectively circumvents constraints associated with conventional small-molecule pharmaceutical interventions, presenting novel prospects for oncological therapy. Stimulus...
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Jiacheng Lu Yuqing Miao Yuhao Li Source Type: research
Eosinophil Plasticity and Diversity: Proceedings of the 2023 International Eosinophil Society Symposium
J Leukoc Biol. 2024 Apr 16:qiae089. doi: 10.1093/jleuko/qiae089. Online ahead of print.ABSTRACTThis issue highlights and details the programme and scientific presentations at the International Eosinophil Society's 12th biennial Symposium, which was held in Hamilton, Ontario, Canada in July 2023. The meeting included sessions on regulation of eosinophil development; cell death, stress, and autophagy in eosinophils; local immunity interactions of eosinophils with multiple cell types; eosinophils in host defense; eosinophils and mast cells in gastrointestinal disorders; reciprocal interactions between eosinophils and the micr...
Source: Journal of Leukocyte Biology - April 16, 2024 Category: Hematology Authors: Judah A Denburg Paul M O'Byrne Gail M Gauvreau Source Type: research
Early Detection, Precision Treatment, Recurrence Monitoring: Liquid Biopsy Transforms Colorectal Cancer Therapy
This study investigates the world of liquid biopsy, a rapidly growing field. We want to understand how it can help us better recognize the molecular aspects of cancer, improve and diagnostics, tailor treatments to individual patients, and keep track of the disease over the long-term. We explored specific components of liquid biopsy, like extracellular vesicles and cell-free DNA, and how they are used to detect CRC. This review sheds light on the current state of knowledge and the many ways a liquid biopsy can be used in treating colorectal cancer. It can transform patient care, disease management, and clinical outcomes by ...
Source: Current Cancer Drug Targets - April 16, 2024 Category: Cancer & Oncology Authors: Harshvardhan Raval Sankha Bhattacharya Source Type: research
