CCR Grand Rounds: Learning the Molecular Logic of Cancer
CCR Grand Rounds “ Learning the Molecular Logic of Cancer ” Eliezer Van Allen, M.D.Associate Professor, Medicine, Harvard Medical SchoolChief, Division of Population Sciences, Dana-Farber Cancer InstituteFriday, April 26, 202412:00 – 1:00 p.m.Lipsett AmphitheaterDr. Eliezer (Eli) Van Allen is an Associate Professor of Medicine at Harvard Medical School, Chief of the Division of Population Sciences at the Dana-Farber Cancer Institute, an Institute Member at the Broad Institute of MIT and Harvard, and a Member Researcher in The Parker Institute for Cancer Immunotherapy at the Dana-Farber Cancer Institute. As both ...
Source: Videocast - All Events - April 16, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH Director's Seminar Series: Harnessing Mechanistic Insights into microRNA Function for Cancer Therapy
As a class of small non-coding RNAs, microRNAs (miRNAs) function as master gene regulators. My laboratory studies how miRNAs themselves are regulated and their applications in cancer treatment. Despite the success of using miRNAs including their isoforms (isomiRs) as disease biomarkers, development of miRNA-based cancer treatments was somewhat lagging behind mainly due to the difficulty in identifying tumor-driver miRNA variations. In this talk, I will discuss our endeavor in addressing this challenge by investigating the mechanisms of miRNA biogenesis and function. I will demonstrate how the addition of sequences at their...
Source: Videocast - All Events - April 1, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar - IL-27: King of Cytokines
Cytokines are not inherently pro- or anti-inflammatory and the Hunter laboratory is interested in how these factors govern the development of immunity to infection but can also be involved in the prevention of immune hyperactivity. The presentation will cover the immunobiology of the cytokine IL-27, its ability to limit infection-induced pathological T cell and monocyte responses and how this pathway can be targeted as a cancer therapy. The knowledge of the biology of IL-27 can also be used to inform strategies to enhance mRNA vaccination.Air date: 4/3/2024 4:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - March 18, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar: Harnessing Innate Immunity and Inflammasome Activation in Vaccines and Cancer Therapy
The IIG Seminar Series consists of invited speakers speaking on topics of great interest to the immunology community at the NIH and FDA. Each year, intramural and extramural speakers are chosen and invited by the IIG Steering Committee.Air date: 2/7/2024 4:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 18, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
2023 AAAS Martin and Rose Wachtel Cancer Research Award and Lecture
Special CCR Grand Rounds 2023 AAAS Martin and Rose Wachtel Cancer Research Award and Lecture “ Harnessing Microenvironmental Dependencies for Cancer Therapy – The Role of the Nervous System in Cancer Growth ” Humsa Venkatesh, Ph.D.Assistant Professor of Neurology Brigham and Women's Hospital Harvard Medical SchoolFriday, July 28, 202312:00 – 1:15 p.m.Lipsett AmphitheaterAlso available to view via NIH Videocast.To register for the lecture, please visit https://go.cancer.gov/BsJHlb0 The Wachtel Cancer Research Award is presented to early-career scientists who have made outstanding contributions to the field of cancer...
Source: Videocast - All Events - July 7, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Engineered biomaterials for lymph node drug delivery and disease modeling enable next-generation approaches in cancer immunotherapy
The advent of the cancer immunotherapy era has created wide-reaching new opportunities for drug delivery and biomaterial technologies to impact cancer therapy. Major barriers to the safer and more effective treatment of cancer using immunotherapy include achieving sufficient drug doses in target tissues at appropriate time scales as well as enabling drug synergies by co-delivery of combination therapies. More effective modeling of immunotherapy effects in disease-relevant preclinical models also represents a critical hurdle to the effective translation of newly developed therapies, that could likewise enable the developmen...
Source: Videocast - All Events - March 2, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH Director ’ s Seminar: The Power and Potential of the Microenvironment in Cancer Metastasis
NIH Director ’ s Seminar
The tumor microenvironment – cellular and molecular changes in non-cancer cells and tissues – drive cancer progression. The pre-metastatic niche is the microenvironment important for metastatic initiation that is established at distant sites in response to primary tumor factors during cancer progression. We first characterized this microenvironment, which involves changes in both stromal and immune populations, in the pre-metastatic lungs of tumor-bearing mice. We have identified unique changes in these pre-metastatic sites by flow cytometry and RNA sequencing approaches, defining a gene sign...
Source: Videocast - All Events - February 9, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH Director ’ s Seminar Series: The Power and Potential of the Microenvironment in Cancer Metastasis
Although genetic including epigenetic alterations are the driving events in cancer, the tumor microenvironment, the cellular and molecular changes in non-cancer cells and tissues are altered during cancer progression. The microenvironment is involved in multiple aspect of cancer progression. Tumor metastasis is a critical step in the progression of solid tumors that is associated with patient mortality, and the metastatic microenvironment is a key regulator of this process. The pre-metastatic niche is the microenvironment important for metastatic initiation that is established at distant sites in response to primary tumor ...
Source: Videocast - All Events - February 7, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Neural-immune Interactions in Cognitive Impairment Following Cancer Therapy or COVID
Michelle Monje is a leading neuroscientist and neuro-oncologist who is advancing our understanding of postnatal brain development and translating her findings into promising therapies for pediatric brain tumors. She has made seminal contributions to elucidating the phenomena of " chemobrain, " a debilitating side effect of chemotherapy which include symptoms such as memory lapses, slowed thinking, and mental fog. Her COVID-themed seminar will be focused on her recent studies into the similarities between the chemobrain phenomena and the short- and long-term neurological effects of COVID. See https://med.stanford.edu/profil...
Source: Videocast - All Events - September 26, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
CC Grand Rounds: Clinicopathologic Grand Rounds: Clinical Cases from the NIH Clinical Center A Clinical Case Highlighting Mucosal Bleeding Risk Exacerbated by TGF beta Inhibition for Cancer Therapy
For more information go tohttps://cc.nih.gov/about/news/grcurrent.htmlAir date: 5/26/2021 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - April 29, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Immune checkpoint blockade in cancer therapy: historical perspective, new opportunities, and prospects for cures
NIH Director ’ s Wednesday Afternoon Lecture SeriesAir date: 3/11/2020 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 28, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
Cancer, Autoimmunity and Immunology 2020 (Day 1)
This event brings together clinicians from multiple disciplines and basic research scientists to discuss the latest findings on how autoimmunity impacts the latest approaches in immunotherapy to treat cancer. Clinical trials will be highlighted and the development of unexpected autoimmunity will be discussed in the context of the approaches that are being currently utilized for cancer therapy.Air date: 3/23/2020 8:00:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - February 24, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
Cancer, Autoimmunity and Immunology 2020 (Day 2)
This event brings together clinicians from multiple disciplines and basic research scientists to discuss the latest findings on how autoimmunity impacts the latest approaches in immunotherapy to treat cancer. Clinical trials will be highlighted and the development of unexpected autoimmunity will be discussed in the context of the approaches that are being currently utilized for cancer therapy.Air date: 3/24/2020 8:00:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - February 24, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
Poly-Aneuploid Cancer Cells: Actuators of Cancer Resistance
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Dr. Pienta is a Professor of Urology, Oncology, Pharmacology and Molecular Sciences and Chemical and Biomolecular Engineering as well an American Cancer Society Clinical Research Professor. Between 1995 and 2013, Dr. Pienta served as the Director of the Prostate Specialized Program of Research Excellence (SPORE) at the University of Michigan and has served as co-PI of the Johns Hopkins Prostate SPORE from 2013-2018. He has a proven, peer-reviewed track record in organizing and administering a translational research program that successfully incorporates bench research...
Source: Videocast - All Events - January 6, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
Anna F. Farago, MD, PhD - The TRK to Tumor-Agnostic Care in Solid Tumors: A Pathology-Focused Guide to the Clinical Role of TRK Fusions in Personalizing Cancer Therapy
The TRK to Tumor-Agnostic Care in Solid Tumors: A Pathology-Focused Guide to the Clinical Role of TRK Fusions in Personalizing Cancer Therapy (Source: Peerview CME/CE Video Podcast - Internal Medicine International)
Source: Peerview CME/CE Video Podcast - Internal Medicine International - March 6, 2019 Category: Internal Medicine Authors: PVI, PeerView Institute for Medical Education Tags: Science, Medicine Source Type: video
