Dendritic cells and macrophages in cancer therapy: Dr. Jekyll and Mr. Hyde
Immunology Interest Group
Dr. Karolina Palucka is an internationally recognized clinical oncologist and cancer immunologist. She joined The Jackson Laboratory for Genomic Medicine (JAX) as professor and associate director of cancer immunology in 2014. Prior to joining JAX, Karolina was the Michael A.E. Ramsay Chair for Cancer Immunology Research and director of the Ralph M. Steinman Center for Cancer Vaccines at the Baylor Institute for Immunology Research in Dallas, where she was principal investigator of a large research award from the Human Immunology Project Consortium. She is also professor of oncological sciences an...
Source: Videocast - All Events - May 21, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video
Redox Biology 2014 - Cancer Therapy, Redox Enzymology
Presented by: Jim Mitchell, Ph.D., NIH; L. Ridnour, Ph.D., NIHCategory: Redox BiologyAired date: 10/21/2014 (Source: Videocast - All Events)
Source: Videocast - All Events - October 27, 2014 Category: Journals (General) Tags: Past Events Source Type: video
Normalizing the Tumor Microenvironment to Enhance Cancer Treatment
Wednesday Afternoon Lecture Series
For more than three decades, Dr. Jain's laboratory research has focused on one challenge: improving the delivery and efficacy of anti-cancer therapies. Working on the hypothesis that the abnormal tumor microenvironment fuels tumor progression and treatment resistance, the Jain laboratory has developed an array of novel imaging technologies and animal models as well as mathematical models to unravel the complex biology of tumors. They demonstrated that the blood and lymphatic vasculature, fibroblasts, immune cells, and the extracellular matrix associated with tumors are abnormal and togeth...
Source: Videocast - All Events - October 21, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video
Redox Biology 2014 - NADPH Oxidase, Redox Imaging
Redox Biology
Recent advances in the biochemistry of redox-active species and radicals are beginning to be translated into improvements in prevention and treatment of cancer. Traditionally, reactive species such as superoxide, hydrogen peroxide and nitric oxide (NO) are associated with toxicity; however, NO is useful in the treatment of angina and cardiovascular disease. Also, NO is involved in cancer tumor angiogenesis and apoptosis of cancer cells. This course is an overview presenting how redox-active species and radicals are generated; their effects on the cellular and physiological level, how they alter carcinogene...
Source: Videocast - All Events - August 21, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video
Redox Biology 2014 - Cancer Therapy, Redox Enzymology
Redox Biology
Recent advances in the biochemistry of redox-active species and radicals are beginning to be translated into improvements in prevention and treatment of cancer. Traditionally, reactive species such as superoxide, hydrogen peroxide and nitric oxide (NO) are associated with toxicity; however, NO is useful in the treatment of angina and cardiovascular disease. Also, NO is involved in cancer tumor angiogenesis and apoptosis of cancer cells. This course is an overview presenting how redox-active species and radicals are generated; their effects on the cellular and physiological level, how they alter carcinogene...
Source: Videocast - All Events - August 21, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video
Redox Biology 2014 - Inflammation, Epidemiology
Redox Biology
Recent advances in the biochemistry of redox-active species and radicals are beginning to be translated into improvements in prevention and treatment of cancer. Traditionally, reactive species such as superoxide, hydrogen peroxide and nitric oxide (NO) are associated with toxicity; however, NO is useful in the treatment of angina and cardiovascular disease. Also, NO is involved in cancer tumor angiogenesis and apoptosis of cancer cells. This course is an overview presenting how redox-active species and radicals are generated; their effects on the cellular and physiological level, how they alter carcinogene...
Source: Videocast - All Events - August 21, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video
Redox Biology 2014 - Signal Transduction, Redox Physiology
Redox Biology
Recent advances in the biochemistry of redox-active species and radicals are beginning to be translated into improvements in prevention and treatment of cancer. Traditionally, reactive species such as superoxide, hydrogen peroxide and nitric oxide (NO) are associated with toxicity; however, NO is useful in the treatment of angina and cardiovascular disease. Also, NO is involved in cancer tumor angiogenesis and apoptosis of cancer cells. This course is an overview presenting how redox-active species and radicals are generated; their effects on the cellular and physiological level, how they alter carcinogene...
Source: Videocast - All Events - August 21, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video
Redox Biology 2014 - Redox Biology, Angiogenesis
Redox Biology
Recent advances in the biochemistry of redox-active species and radicals are beginning to be translated into improvements in prevention and treatment of cancer. Traditionally, reactive species such as superoxide, hydrogen peroxide and nitric oxide (NO) are associated with toxicity; however, NO is useful in the treatment of angina and cardiovascular disease. Also, NO is involved in cancer tumor angiogenesis and apoptosis of cancer cells. This course is an overview presenting how redox-active species and radicals are generated; their effects on the cellular and physiological level, how they alter carcinogene...
Source: Videocast - All Events - August 21, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video
Redox Biology 2014 - Introduction, Redox Chemistry
Redox Biology
Recent advances in the biochemistry of redox-active species and radicals are beginning to be translated into improvements in prevention and treatment of cancer. Traditionally, reactive species such as superoxide, hydrogen peroxide and nitric oxide (NO) are associated with toxicity; however, NO is useful in the treatment of angina and cardiovascular disease. Also, NO is involved in cancer tumor angiogenesis and apoptosis of cancer cells. This course is an overview presenting how redox-active species and radicals are generated; their effects on the cellular and physiological level, how they alter carcinogene...
Source: Videocast - All Events - August 21, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video
Roles for Transcriptional Super-Enhancers in Cell Identity and Disease
NHGRI DIR Genome Seminar
The Young laboratory studies super-enhancers (also known as stretch enhancers), which are large clusters of transcriptional enhancers that drive high-level expression of key cell identity genes. For many diseases, trait-associated sequence variation is especially enriched in the super-enhancers of disease-relevant cell types. Furthermore, the Young lab has found that cancer cells acquire super-enhancers at oncogenes and other genes important to tumor pathogenesis. In tumor cells, super-enhancer-driven oncogene expression can be exceptionally vulnerable to drugs that target transcriptional cofactor...
Source: Videocast - All Events - November 18, 2013 Category: Journals (General) Tags: Upcoming Events Source Type: video
