Cancers, Vol. 16, Pages 1686: Digital Pathology for Better Clinical Practice
Conclusion: The ongoing progress in DP holds the potential to revolutionize pathology practices, emphasizing the need to incorporate powerful AI technologies, including IS, into clinical settings to enhance personalized cancer therapy. (Source: Cancers)
Source: Cancers - April 26, 2024 Category: Cancer & Oncology Authors: Assia Hijazi Carlo Bifulco Pamela Baldin J érôme Galon Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1674: Deciphering the Role of BCAR3 in Cancer Progression: Gene Regulation, Signal Transduction, and Therapeutic Implications
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This review comprehensively explores the gene BCAR3, detailing its regulation at the gene, mRNA, and protein structure levels, and delineating its multifunctional roles in cellular signaling within cancer contexts. The discussion covers BCAR3’s involvement in integrin signaling and its impact on cancer cell migration, its capability to induce anti-estrogen resistance, and its significant functions in cell cycle regulation. Further highlighted is BCAR3’s modulation of immune responses within the tumor microenvironment, a novel area of interest that holds potential for innovative cancer ther...
Source: Cancers - April 26, 2024 Category: Cancer & Oncology Authors: Dong Oh Moon Tags: Review Source Type: research
Cancer and arterial thrombosis: therapeutic options
Res Pract Thromb Haemost. 2024 Mar 27;8(3):102393. doi: 10.1016/j.rpth.2024.102393. eCollection 2024 Mar.ABSTRACTA State of the Art lecture titled "Cancer and Arterial Thrombosis: Therapeutic Options" was presented at the International Society on Thrombosis and Haemostasis Congress in 2023. This State of the Art review delves into the complex relationship between cancer and arterial thromboembolism (ATE), encompassing acute coronary syndrome, ischemic strokes, and peripheral arterial disease. The burden of cancer-associated ATE is not well defined, but studies indicate elevated risks, particularly in the 6 months after a c...
Source: Thrombosis and Haemostasis - April 25, 2024 Category: Hematology Authors: May Anne Cheong Avi Leader Source Type: research
Factors affecting heterogeneity in breast cancer microenvironment: A narrative mini review
Int Rev Cell Mol Biol. 2024;385:211-226. doi: 10.1016/bs.ircmb.2024.01.002. Epub 2024 Feb 15.ABSTRACTBreast cancer (BC) heterogeneity is a key trait of BC tumors with crucial implications on tumorigenesis, diagnosis, and therapeutic modalities. It is influenced by tumor intrinsic features and by the tumor microenvironment (TME) composition of different intra-tumoral regions, which in turn affect cancer progression within patients. In this mini review, we will highlight the mechanisms that generate cancer heterogeneity in BC and how they affect the responses to cancer therapies.PMID:38663960 | DOI:10.1016/bs.ircmb.2024.01.0...
Source: Mol Biol Cell - April 25, 2024 Category: Molecular Biology Authors: Anirban Ganguly Sumit Mukherjee Kaushiki Chatterjee Sheila Spada Source Type: research
Factors affecting heterogeneity in breast cancer microenvironment: A narrative mini review
Int Rev Cell Mol Biol. 2024;385:211-226. doi: 10.1016/bs.ircmb.2024.01.002. Epub 2024 Feb 15.ABSTRACTBreast cancer (BC) heterogeneity is a key trait of BC tumors with crucial implications on tumorigenesis, diagnosis, and therapeutic modalities. It is influenced by tumor intrinsic features and by the tumor microenvironment (TME) composition of different intra-tumoral regions, which in turn affect cancer progression within patients. In this mini review, we will highlight the mechanisms that generate cancer heterogeneity in BC and how they affect the responses to cancer therapies.PMID:38663960 | DOI:10.1016/bs.ircmb.2024.01.0...
Source: International Review of Cell and Molecular Biology - April 25, 2024 Category: Cytology Authors: Anirban Ganguly Sumit Mukherjee Kaushiki Chatterjee Sheila Spada Source Type: research
Cancers, Vol. 16, Pages 1646: Protective Effects of Melatonin against Carcinogen-Induced Oxidative Damage in the Thyroid
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Melatonin, primarily synthesized in the pineal gland, plays a crucial role in regulating circadian rhythms and possesses significant antioxidative properties. By neutralizing free radicals and reducing oxidative stress, melatonin emerges as a promising agent for the prevention and therapy of many different disorders, including cancer. This paper reviews the relationship between the thyroid gland and melatonin, presenting experimental evidence on the protective effects of this indoleamine against oxidative damage to macromolecules in thyroid tissue caused by documented carcinogens (as classified by the International A...
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Jan St ępniak Ma łgorzata Karbownik-Lewińska Tags: Review Source Type: research
Genes, Vol. 15, Pages 543: Downregulation of Histone H3.3 Induces p53-Dependent Cellular Senescence in Human Diploid Fibroblasts
etoshi Tahara
Cellular senescence is an irreversible growth arrest that acts as a barrier to cancer initiation and progression. Histone alteration is one of the major events during replicative senescence. However, little is known about the function of H3.3 in cellular senescence. Here we found that the downregulation of H3.3 induced growth suppression with senescence-like phenotypes such as senescence-associated heterochromatin foci (SAHF) and β-galactosidase (SA-β-gal) activity. Furthermore, H3.3 depletion induced senescence-like phenotypes with the p53/p21-depedent pathway. In addition, we i...
Source: Genes - April 25, 2024 Category: Genetics & Stem Cells Authors: Yuki Yamamoto Ryou-u Takahashi Masaki Kinehara Kimiyoshi Yano Tatsuya Kuramoto Akira Shimamoto Hidetoshi Tahara Tags: Article Source Type: research
The role of interventional radiology and molecular imaging for near infrared photoimmunotherapy
AbstractNear infrared photoimmunotherapy (NIR-PIT) is a recently approved cancer therapy for recurrent head and neck cancer. It involves the intravenous administration of an antibody-photoabsorber (IRDye700DX: IR700) conjugate (APC) to target cancer cells, followed 24 h later by exposure to near infrared light to activate cell-specific cytotoxicity. NIR-PIT selectively targets cancer cells for destruction and activates a strong anticancer host immunity. The fluorescent signal emitted by IR700 enables the visualization of the APC in vivo using fluorescence imagi ng. Similarly, the activation of IR700 during therapy can be...
Source: Japanese Journal of Radiology - April 25, 2024 Category: Radiology Source Type: research
Assembly of Glycopeptides in Living Cells Resembling Viral Infection for Cargo Delivery
Angew Chem Int Ed Engl. 2024 Apr 24:e202404703. doi: 10.1002/anie.202404703. Online ahead of print.ABSTRACTSelf-assembly in living cells represents one versatile strategy for drug delivery; however, it suffers from the limited precision and efficiency. Inspired by viral traits, we here report a cascade targeting-hydrolysis-transformation (THT) assembly of glycosylated peptides in living cells holistically resembling viral infection for efficient cargo delivery and combined tumor therapy. We design a glycosylated peptide via incorporating a β-galactose-serine residue into bola-amphiphilic sequences. Co-assembling of the gl...
Source: Angewandte Chemie - April 24, 2024 Category: Chemistry Authors: Feng Tian Ruo-Chen Guo Chunxia Wu Xin Liu Zeyu Zhang Yamei Wang Hao Wang Gongyu Li Zhilin Yu Source Type: research
The evolvement of breast cancer therapies: What we have done and where all these head off
Saudi Med J. 2024 Apr;45(4):331-340. doi: 10.15537/smj.2024.45.4.20230492.ABSTRACTAlthough, from a therapeutic standpoint, breast cancer (BC) is considerably well-characterized, it still leaves puzzling spots. The Her-2+/PR+/ER+ BC can benefit from the mainstays of anticancer therapy and immunotherapy and overall have a better prognosis. Triple-negative BC, due to the concomitant absence of Her-2/PR/ER receptors, is more challenging and necessitates different strategies. It has been learned that the mainstay anti-BC therapies were initially designed to demolish as many cancer cells as they possibly could. However, the numb...
Source: Saudi Medical Journal - April 24, 2024 Category: Middle East Health Authors: Ika Nurlaila Sabar Pambudi Source Type: research
Identification of naphthalimide-derivatives as novel PBD-targeted polo-like kinase 1 inhibitors with efficacy in drug-resistant lung cancer cells
Eur J Med Chem. 2024 Apr 20;271:116416. doi: 10.1016/j.ejmech.2024.116416. Online ahead of print.ABSTRACTTargeting polo-box domain (PBD) small molecule for polo-like kinase 1 (PLK1) inhibition is a viable alternative to target kinase domain (KD), which could avoid pan-selectivity and dose-limiting toxicity of ATP-competitive inhibitors. However, their efficacy in these settings is still low and inaccessible to clinical requirement. Herein, we utilized a structure-based high-throughput virtual screen to find novel chemical scaffold capable of inhibiting PLK1 via targeting PBD and identified an initial hit molecule compound ...
Source: European Journal of Medicinal Chemistry - April 24, 2024 Category: Chemistry Authors: Pingping Li Yongkun Li Xuesong Ma Liangping Li Shulan Zeng Yan Peng Hong Liang Guohai Zhang Source Type: research
Assembly of Glycopeptides in Living Cells Resembling Viral Infection for Cargo Delivery
Angew Chem Int Ed Engl. 2024 Apr 24:e202404703. doi: 10.1002/anie.202404703. Online ahead of print.ABSTRACTSelf-assembly in living cells represents one versatile strategy for drug delivery; however, it suffers from the limited precision and efficiency. Inspired by viral traits, we here report a cascade targeting-hydrolysis-transformation (THT) assembly of glycosylated peptides in living cells holistically resembling viral infection for efficient cargo delivery and combined tumor therapy. We design a glycosylated peptide via incorporating a β-galactose-serine residue into bola-amphiphilic sequences. Co-assembling of the gl...
Source: Angewandte Chemie - April 24, 2024 Category: Chemistry Authors: Feng Tian Ruo-Chen Guo Chunxia Wu Xin Liu Zeyu Zhang Yamei Wang Hao Wang Gongyu Li Zhilin Yu Source Type: research
Identification of drug responsible glycogene signature in liver carcinoma from meta-analysis using RNA-seq data
In this study, we search public databases for Sequence Read Archive data on drug-treated liver cancer cells, with the aim to comprehensively analyze the drug responses of glycogenes via bioinformatic meta-analysis. The study comprised 86 datasets, encompassing eight distinct liver cancer cell lines and 13 different drugs. Differentially expressed genes were quantified, and 399 glycogenes were identified. The glycogenes signature was then analyzed using bioinformatics methodologies. In the Protein-protein interaction network analysis, we identified drug-responsive glycogenes such as Beta-1,4-Galactosyltransferase 1, GDP-Man...
Source: Glycoconjugate Journal - April 24, 2024 Category: Biochemistry Source Type: research
Therapeutic bacteria and viruses to combat cancer: double-edged sword in cancer therapy: new insights for future
Cancer, ranked as the second leading cause of mortality worldwide, leads to the death of approximately seven million people annually, establishing itself as one of the most significant health challenges global... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - April 24, 2024 Category: Molecular Biology Authors: Aref Yarahmadi, Mitra Zare, Masoomeh Aghayari, Hamed Afkhami and Gholam Ali Jafari Tags: Review Source Type: research
Codelivery of CPT and siPHB1 with GSH/ROS Dual-Responsive Hybrid Nanoparticles Based on a [12]aneN(3)-Derived Lipid for Synergistic Lung Cancer Therapy
ACS Appl Bio Mater. 2024 Apr 23. doi: 10.1021/acsabm.4c00206. Online ahead of print.ABSTRACTThe combination of small-interfering RNA (siRNA)-mediated gene silencing and chemotherapeutic agents for lung cancer treatment has attracted widespread attention in terms of a greater therapeutic effect, minimization of systemic toxicity, and inhibition of multiple drug resistance (MDR). In this work, three amphiphiles, CBN1-CBN3, were first designed and synthesized as a camptothecin (CPT) conjugate and gene condensation agents by the combination of CPT prodrugs and di(triazole-[12]aneN3) through the ROS-responsive phenylborate este...
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Ya-Xuan Liang Xue-Yi Sun De-Zhong Xu Yi-Nan Gao Quan Tang Zhong-Lin Lu Yang Liu Source Type: research
