H2AX: A key player in DNA damage response and a promising target for cancer therapy
Biomed Pharmacother. 2024 Apr 29;175:116663. doi: 10.1016/j.biopha.2024.116663. Online ahead of print.ABSTRACTCancer is caused by a complex interaction of factors that interrupt the normal growth and division of cells. At the center of this process is the intricate relationship between DNA damage and the cellular mechanisms responsible for maintaining genomic stability. When DNA damage is not repaired, it can cause genetic mutations that contribute to the initiation and progression of cancer. On the other hand, the DNA damage response system, which involves the phosphorylation of the histone variant H2AX (γH2AX), is cruci...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 30, 2024 Category: Drugs & Pharmacology Authors: Kirti S Prabhu Shilpa Kuttikrishnan Nuha Ahamad Ummu Habeeba Zahwa Mariyam Muhammad Suleman Ajaz A Bhat Shahab Uddin Source Type: research
Design, synthesis, and evaluation of novel quindoline derivatives with fork-shaped side chains as RNA G-quadruplex stabilizers for repressing oncogene NRAS translation
Eur J Med Chem. 2024 Apr 16;271:116406. doi: 10.1016/j.ejmech.2024.116406. Online ahead of print.ABSTRACTNRAS mutation is the second most common oncogenic factor in cutaneous melanoma. Inhibiting NRAS translation by stabilizing the G-quadruplex (G4) structure with small molecules seems to be a potential strategy for cancer therapy due to the NRAS protein's lack of a druggable pocket. To enhance the effects of previously reported G4 stabilizers quindoline derivatives, we designed and synthesized a novel series of quindoline derivatives with fork-shaped side chains by introducing (alkylamino)alkoxy side chains. Panels of exp...
Source: European Journal of Medicinal Chemistry - April 30, 2024 Category: Chemistry Authors: Jia-Wei Sun Jing Zou Ying Zheng Hao Yuan Yuan-Ze-Yu Xie Xiao-Na Wang Tian-Miao Ou Source Type: research
Exploring the Antitumor Efficacy of PEGylated Liposomes Loaded with Licorice Extract for Cancer Therapy
CONCLUSION: These results have been corroborated by apoptosis assays, which have demonstrated GA PEG-Lip and Lic PEG-Lip to induce stronger apoptotic effects compared to free GA and Lic on both PC-3 and AGS cells. This study has underscored the potential of encapsulating GA and Lic in PEG-Lip as a promising strategy to augment their anticancer efficacy against prostate and gastric cancers.PMID:38685810 | DOI:10.2174/0115680096292153240416115744 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - April 30, 2024 Category: Cancer & Oncology Authors: Zeinab Azizi Haghighat Aliakbar Safekordi Mehdi Ardjmand Azim Akbarzadeh Source Type: research
Pharmacological inhibition of HPK1 synergizes with PD-L1 blockade to provoke antitumor immunity against tumors with low antigenicity
Biochem Biophys Res Commun. 2024 Apr 24;715:149995. doi: 10.1016/j.bbrc.2024.149995. Online ahead of print.ABSTRACTImmune checkpoint inhibitors have significantly transformed the landscape of cancer therapy. Nevertheless, while these inhibitors are highly effective for certain patient groups, many do not benefit due to primary or acquired resistance. Specifically, these treatments often lack sufficient therapeutic efficacy against cancers with low antigenicity. Thus, the development of an effective strategy to overcome cancers with low antigenicity is imperative for advancing next-generation cancer immunotherapy. Here, we ...
Source: Biochemical and Biophysical Research communications - April 30, 2024 Category: Biochemistry Authors: Genzui Setsu Megumi Goto Kentaro Ito Tomoe Taira Masaya Miyamoto Tomohiro Watanabe Saito Higuchi Source Type: research
Multi-omics analysis reveals the association between specific solute carrier proteins gene expression patterns and the immune suppressive microenvironment in glioma
J Cell Mol Med. 2024 May;28(9):e18339. doi: 10.1111/jcmm.18339.ABSTRACTGlioma is the most prevalent malignant brain tumour. Currently, reshaping its tumour microenvironment has emerged as an appealing strategy to enhance therapeutic efficacy. As the largest group of transmembrane transport proteins, solute carrier proteins (SLCs) are responsible for the transmembrane transport of various metabolites and ions. They play a crucial role in regulating the metabolism and functions of malignant cells and immune cells within the tumour microenvironment, making them a promising target in cancer therapy. Through multidimensional da...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Wenjie Wu Cheng Jiang Wende Zhu Xiaobing Jiang Source Type: research
The emerging role of deubiquitylating enzyme USP21 as a potential therapeutic target in cancer
Bioorg Chem. 2024 Apr 25;147:107400. doi: 10.1016/j.bioorg.2024.107400. Online ahead of print.ABSTRACTAlthough certain members of the Ubiquitin-specific peptidases (USPs) have been recognized as promising therapeutic targets for various diseases, research progress regarding USP21 has been relatively sluggish in its early stages. USP21 is a crucial member of the USPs subfamily, involved in diverse cellular processes such as apoptosis, DNA repair, and signal transduction. Research findings from the past decade demonstrate that USP21 mediates the deubiquitination of multiple well-known target proteins associated with critical...
Source: Bioorganic Chemistry - April 30, 2024 Category: Chemistry Authors: Zhen-Yuan Shi Chang-Yun Li Ru-Yi Chen Jin-Jin Shi Yan-Jun Liu Jian-Fei Lu Guan-Jun Yang Jiong Chen Source Type: research
Targeting focal adhesion kinase (FAK) for cancer therapy: FAK inhibitors, FAK-based dual-target inhibitors and PROTAC degraders
Biochem Pharmacol. 2024 Apr 27;224:116246. doi: 10.1016/j.bcp.2024.116246. Online ahead of print.ABSTRACTFocal adhesion kinase (FAK), a non-receptor tyrosine kinase, plays an essential role in regulating cell proliferation, migration and invasion through both kinase-dependent enzymatic function and kinase-independent scaffolding function. The overexpression and activation of FAK is commonly observed in various cancers and some drug-resistant settings. Therefore, targeted disruption of FAK has been identified as an attractive strategy for cancer treatment. To date, numerous structurally diverse inhibitors targeting distinct...
Source: Biochemical Pharmacology - April 30, 2024 Category: Drugs & Pharmacology Authors: Ming Yang Hua Xiang Guoshun Luo Source Type: research
Exploring the Antitumor Efficacy of PEGylated Liposomes Loaded with Licorice Extract for Cancer Therapy
CONCLUSION: These results have been corroborated by apoptosis assays, which have demonstrated GA PEG-Lip and Lic PEG-Lip to induce stronger apoptotic effects compared to free GA and Lic on both PC-3 and AGS cells. This study has underscored the potential of encapsulating GA and Lic in PEG-Lip as a promising strategy to augment their anticancer efficacy against prostate and gastric cancers.PMID:38685810 | DOI:10.2174/0115680096292153240416115744 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - April 30, 2024 Category: Cancer & Oncology Authors: Zeinab Azizi Haghighat Aliakbar Safekordi Mehdi Ardjmand Azim Akbarzadeh Source Type: research
Exploring the Antitumor Efficacy of PEGylated Liposomes Loaded with Licorice Extract for Cancer Therapy
CONCLUSION: These results have been corroborated by apoptosis assays, which have demonstrated GA PEG-Lip and Lic PEG-Lip to induce stronger apoptotic effects compared to free GA and Lic on both PC-3 and AGS cells. This study has underscored the potential of encapsulating GA and Lic in PEG-Lip as a promising strategy to augment their anticancer efficacy against prostate and gastric cancers.PMID:38685810 | DOI:10.2174/0115680096292153240416115744 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - April 30, 2024 Category: Cancer & Oncology Authors: Zeinab Azizi Haghighat Aliakbar Safekordi Mehdi Ardjmand Azim Akbarzadeh Source Type: research
Exploring the Antitumor Efficacy of PEGylated Liposomes Loaded with Licorice Extract for Cancer Therapy
CONCLUSION: These results have been corroborated by apoptosis assays, which have demonstrated GA PEG-Lip and Lic PEG-Lip to induce stronger apoptotic effects compared to free GA and Lic on both PC-3 and AGS cells. This study has underscored the potential of encapsulating GA and Lic in PEG-Lip as a promising strategy to augment their anticancer efficacy against prostate and gastric cancers.PMID:38685810 | DOI:10.2174/0115680096292153240416115744 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - April 30, 2024 Category: Cancer & Oncology Authors: Zeinab Azizi Haghighat Aliakbar Safekordi Mehdi Ardjmand Azim Akbarzadeh Source Type: research
GSE262596 EIF6 conditions drug-tolerant persister-like transdifferentiation in small cell lung carcinoma (eIF6_KD)
This study sheds light on eIF6's potential therapeutic interventions to mitigate treatment resistance in SCLC. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 30, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE262593 EIF6 conditions drug-tolerant persister-like transdifferentiation in small cell lung carcinoma (SCLC cell lines)
This study sheds light on eIF6's potential therapeutic interventions to mitigate treatment resistance in SCLC. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 30, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE260759 Targeting a Lineage-Specific PI3K ɣ/AKT Signaling Module in Acute Myeloid Leukemia Using a Heterobifunctional Degrader Molecule
Contributors : Lois Kelly ; Alexandre Puissant ; Camille LobrySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDose-limiting toxicity poses a major limitation to the clinical utility of targeted cancer therapies, often arising from target engagement in non-malignant tissues. This obstacle can be minimized by targeting cancer dependencies driven by proteins with tissue- and/or tumor-restricted expression. Here, we show that in acute myeloid leukemia (AML), suppression of the myeloid-restricted PIK3CG/p110 𝛾-PIK3R5/p101 axis blocks AKT signaling, compromises cell fitness, and sensi...
Source: GEO: Gene Expression Omnibus - April 30, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Cancers, Vol. 16, Pages 1751: Challenges and Opportunities in Breast Cancer Care in Low-Resourced Countries, Jordan as An Example
our
Jordan is a relatively small country with a rapidly growing population and a challenged economy. Breast cancer is the most diagnosed cancer among women worldwide and also in Jordan. Though the age-standardized rate (ASR) of breast cancer incidence is still lower than that in Western societies, the number of newly diagnosed cases continues to increase, involving younger women, and new cases are usually detected at more advanced stages. Improvements in breast cancer care across the health care continuum, including early detection, prevention, treatment, and survivorship and palliative care, have become very visible, ...
Source: Cancers - April 30, 2024 Category: Cancer & Oncology Authors: Hikmat Abdel-Razeq Asem Mansour Tags: Review Source Type: research
The Influence of Exercise on Cancer Risk, the Tumor Microenvironment and the Treatment of Cancer
AbstractThere are several modifiable factors that can be targeted to prevent and manage the occurrence and progression of cancer, and maintaining adequate exercise is a crucial one. Regular physical exercise has been shown to be a beneficial strategy in preventing cancer, potentially amplifying the effectiveness of established cancer therapies, alleviating certain cancer-related symptoms, and possibly mitigating side effects resulting from treatment. Nevertheless, the exact mechanisms by which exercise affects tumors, especially its impact on the tumor microenvironment (TME), remain uncertain. This review aims to present a...
Source: Sports Medicine - April 30, 2024 Category: Sports Medicine Source Type: research
