Psychoneuroimmunology in multiple myeloma and autologous hematopoietic stem cell transplant: Opportunities for research among patients and caregivers
Brain Behav Immun. 2024 Apr 19:S0889-1591(24)00366-0. doi: 10.1016/j.bbi.2024.04.019. Online ahead of print.ABSTRACTMultiple myeloma (MM) is an incurable cancer and is the leading indication for autologous hematopoietic stem cell transplantation (HSCT). To be eligible for HSCT, a patient must have a caregiver, as caregivers play a central role in HSCT preparation and recovery. MM patients remain on treatment indefinitely, and thus patients and their caregivers face long-term challenges including the intensity of HSCT and perpetual therapy after transplant. Importantly, both patients and their caregivers show heightened dep...
Source: Brain, Behavior, and Immunity - April 21, 2024 Category: Neurology Authors: Lisa M Christian Janice K Kiecolt-Glaser Steve W Cole Christin E Burd Annelise A Madison Stephanie J Wilson Ashley E Rosko Source Type: research
Cardio-protective effects of statins in patients undergoing anthracycline-based chemotherapy: An updated meta-analysis of randomized controlled trials
CONCLUSION: In this meta-analysis of RCTs, statins were significantly associated with a lower incidence of anthracycline-induced CTRCD and attenuated changes in the left ventricular end-systolic volume. Thus, our findings suggest that statins should be considered as a cardio-protection strategy for patients with planned anthracycline-based chemotherapy.PMID:38643042 | DOI:10.1016/j.ejim.2024.04.007 (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - April 20, 2024 Category: Internal Medicine Authors: Nicole Felix Paula C Nogueira Isadora M Silva Thomaz Alexandre Costa Carlos Alberto Campello Carlos Stecca Renato D Lopes Source Type: research
The nucleolus: Coordinating stress response and genomic stability
Biochim Biophys Acta Gene Regul Mech. 2024 Apr 18:195029. doi: 10.1016/j.bbagrm.2024.195029. Online ahead of print.ABSTRACTThe perception that the nucleoli are merely the organelles where ribosome biogenesis occurs is challenged. Only around 30 % of nucleolar proteins are solely involved in producing ribosomes. Instead, the nucleolus plays a critical role in controlling protein trafficking during stress and, according to its dynamic nature, undergoes continuous protein exchange with nucleoplasm under various cellular stressors. Hence, the concept of nucleolar stress has evolved as cellular insults that disrupt the structur...
Source: Biochimica et Biophysica Acta - April 20, 2024 Category: Biochemistry Authors: Katiuska Gonz ález-Arzola Source Type: research
Breast cancer therapy: from the perspective of glucose metabolism and glycosylation
Mol Biol Rep. 2024 Apr 20;51(1):546. doi: 10.1007/s11033-024-09466-w.ABSTRACTBreast cancer is a leading cause of mortality and the most prevalent form of malignant tumor among women worldwide. Breast cancer cells exhibit an elevated glycolysis and altered glucose metabolism. Moreover, these cells display abnormal glycosylation patterns, influencing invasion, proliferation, metastasis, and drug resistance. Consequently, targeting glycolysis and mitigating abnormal glycosylation represent key therapeutic strategies for breast cancer. This review underscores the importance of protein glycosylation and glucose metabolism alter...
Source: Molecular Biology Reports - April 20, 2024 Category: Molecular Biology Authors: Jiaqi Zhao Haiting Sun Che Wang Dejing Shang Source Type: research
Overexpression of WT1 in all molecular subtypes of breast cancer and its impact on survival: exploring oncogenic and tumor suppressor roles of distinct WT1 isoforms
CONCLUSIONS: Interestingly, this overexpression was observed in all molecular subtypes of invasive breast cancer, underscoring the significance of WT1 as a potential target in all these subtypes. The observed WT1 down-expression in a few cases of invasive breast cancer, associated with better survival outcomes, may correspond to the down-regulation of a particular WT1-KTS (-) isoform: the WT1 A isoform (EX5-/KTS-). The co-expression of this WT1 oncogenic isoform with a regulated WT1- tumor suppressor isoform, such as the major WT1 F isoform (EX5-/KTS +), could also explain such survival outcomes. Due to its capacity to ado...
Source: Molecular Biology Reports - April 20, 2024 Category: Molecular Biology Authors: Hind Ben Haj Othmen Houcemeddine Othman Oussema Khamessi Ilhem Bettaieb Sonia Gara Maher Kharrat Source Type: research
Quantitative Assessment of Drug Efficacy and Emergence of Resistance in Patients with Metastatic Renal Cell Carcinoma Using a Longitudinal Exposure-Tumor Growth Inhibition Model: Apitolisib (Dual PI3K/mTORC1/2 Inhibitor) Versus Everolimus (mTORC1 Inhibitor)
J Clin Pharmacol. 2024 Apr 19. doi: 10.1002/jcph.2444. Online ahead of print.ABSTRACTCancer remains a significant global health challenge, and despite remarkable advancements in therapeutic strategies, poor tolerability of drugs (causing dose reduction/interruptions) and/or the emergence of drug resistance are major obstacles to successful treatment outcomes. Metastatic renal cell carcinoma (mRCC) accounts for 2% of global cancer diagnoses and deaths. Despite the initial success of targeted therapies in mRCC, challenges remain to overcome drug resistance that limits the long-term efficacy of these treatments. Our analysis ...
Source: The Journal of Clinical Pharmacology - April 19, 2024 Category: Drugs & Pharmacology Authors: Anita Moein Jin Y Jin Matthew R Wright Harvey Wong Source Type: research
Hierarchical self-recognition and response in CSC and non-CSC micro-niches for cancer therapy
Biomaterials. 2024 Apr 15;308:122581. doi: 10.1016/j.biomaterials.2024.122581. Online ahead of print.ABSTRACTCancer stem cells (CSCs) characterized by self-renewal, invasiveness, tumorigenicity and resistance to treatment are regarded as the thorniest issues in refractory tumors. We develop a targeted and hierarchical controlled release nano-therapeutic platform (SEED-NPs) that self-identifies and responds to CSC and non-CSC micro-niches of tumors. In non-CSC micro-niche, reactive oxygen species (ROS) trigger the burst release of the chemotherapeutic drug and photosensitizer to kill tumor cells and reduce tumor volume by c...
Source: Biomaterials - April 19, 2024 Category: Materials Science Authors: Yiliang Yang Yiwei Peng Yitian Du Meng Lin Jiajia Li Datong Gao Zhenzhen Yang Wei Wang Yanxia Zhou Xinru Li Taiqiang Yan Xianrong Qi Source Type: research
Prospects and challenges of CAR-T in the treatment of ovarian cancer
Int Immunopharmacol. 2024 Apr 18;133:112112. doi: 10.1016/j.intimp.2024.112112. Online ahead of print.ABSTRACTOvarian cancer ranks as the seventh most prevalent cancer among women and is considered the most lethal gynecological malignancy on a global scale. The absence of reliable screening techniques, coupled with the insidious onset of nonspecific symptoms, often results in a delayed diagnosis, typically at an advanced stage characterized by peritoneal involvement. Management of advanced tumors typically involves a combination of chemotherapy and cytoreductive surgery. However, the therapeutic arsenal for ovarian cancer ...
Source: International Immunopharmacology - April 19, 2024 Category: Allergy & Immunology Authors: Biqing Chen Jiaqi Liu Source Type: research
High expression of SLC27A2 predicts unfavorable prognosis and promotes inhibitory immune infiltration in acute lymphoblastic leukemia
In conclusion, SLC27A2 plays a vital role in the development of ALL.PMID:38640787 | DOI:10.1016/j.tranon.2024.101952 (Source: Translational Oncology)
Source: Translational Oncology - April 19, 2024 Category: Cancer & Oncology Authors: Lihua Lu Jiazheng Li Yongzhi Zheng Luting Luo Yan Huang Jianda Hu Yanxin Chen Source Type: research
Doxorubicin-based ENO1 targeted drug delivery strategy enhances therapeutic efficacy against colorectal cancer
Biochem Pharmacol. 2024 Apr 17;224:116220. doi: 10.1016/j.bcp.2024.116220. Online ahead of print.ABSTRACTAlpha-enolase (ENO1), a multifunctional protein with carcinogenic properties, has emerged as a promising cancer biomarker because of its differential expression in cancer and normal cells. On the basis of this characteristic, we designed a cell-targeting peptide that specifically targets ENO1 and connected it with the drug doxorubicin (DOX) by aldehyde-amine condensation. A surface plasmon resonance (SPR) assay showed that the affinity for ENO1 was stronger (KD = 2.5 µM) for the resulting cell-targeting drug, DOX-P, th...
Source: Biochemical Pharmacology - April 19, 2024 Category: Drugs & Pharmacology Authors: Jun Liu Xiaoyu Hu Guanghao Yu Qingrong Wang Liwei Gu Jianying Shen Qinghe Zhao Hao Sun Shi Wang Zhongyuan Guo Yu Zhao Hai Ma Source Type: research
Quantitative Assessment of Drug Efficacy and Emergence of Resistance in Patients with Metastatic Renal Cell Carcinoma Using a Longitudinal Exposure-Tumor Growth Inhibition Model: Apitolisib (Dual PI3K/mTORC1/2 Inhibitor) Versus Everolimus (mTORC1 Inhibitor)
J Clin Pharmacol. 2024 Apr 19. doi: 10.1002/jcph.2444. Online ahead of print.ABSTRACTCancer remains a significant global health challenge, and despite remarkable advancements in therapeutic strategies, poor tolerability of drugs (causing dose reduction/interruptions) and/or the emergence of drug resistance are major obstacles to successful treatment outcomes. Metastatic renal cell carcinoma (mRCC) accounts for 2% of global cancer diagnoses and deaths. Despite the initial success of targeted therapies in mRCC, challenges remain to overcome drug resistance that limits the long-term efficacy of these treatments. Our analysis ...
Source: The Journal of Clinical Pharmacology - April 19, 2024 Category: Drugs & Pharmacology Authors: Anita Moein Jin Y Jin Matthew R Wright Harvey Wong Source Type: research
A Platinum-Aluminum Bimetallic Salen Complex for Pro-senescence Cancer Therapy
Chembiochem. 2024 Apr 19:e202400105. doi: 10.1002/cbic.202400105. Online ahead of print.ABSTRACTCell senescence is defined as irreversible cell cycle arrest, which can be triggered by telomere shortening or by various types of genotoxic stress. Induction of senescence is emerging as a new strategy for the treatment of cancer, especially when sequentially combined with a second senolytic drug capable of killing the resulting senescent cells, however severely suffering from the undesired off-target side effects from the senolytic drugs. Here, we prepare a bimetalic platinum-aluminum salen complex (Alumiplatin) for cancer the...
Source: Chembiochem - April 19, 2024 Category: Biochemistry Authors: Juan Tang Yahui Yang Hao-Yan Yin Bin Ma Mengliang Zhu Zi-Shu Yang Xin-Xin Peng Feifei Jia Yao Zhao Fuyi Wang Tianfeng Chen Jun-Long Zhang Source Type: research
< em > Therapy-na ïve malignancy causes cardiovascular disease: A state-of-the-art cardio-oncology perspective < /em >
Am J Physiol Heart Circ Physiol. 2024 Apr 19. doi: 10.1152/ajpheart.00795.2023. Online ahead of print.ABSTRACTCardiovascular disease (CVD) and cancer are the leading causes of mortality worldwide. Although generally thought of as distinct diseases, the intersectional overlap between CVD and cancer is increasingly evident in both causal and mechanistic relationships. The field of cardio-oncology is largely focused on cardiotoxic effects of cancer therapies (e.g., chemotherapy, radiation). Further, the cumulative effects of cardiotoxic therapy exposure and the prevalence of CVD risk factors in cancer patients leads to long-t...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 19, 2024 Category: Physiology Authors: Leslie M Ogilvie Bridget Coyle-Asbil Keith R Brunt Jim Petrik Jeremy A Simpson Source Type: research
Hierarchical self-recognition and response in CSC and non-CSC micro-niches for cancer therapy
Biomaterials. 2024 Apr 15;308:122581. doi: 10.1016/j.biomaterials.2024.122581. Online ahead of print.ABSTRACTCancer stem cells (CSCs) characterized by self-renewal, invasiveness, tumorigenicity and resistance to treatment are regarded as the thorniest issues in refractory tumors. We develop a targeted and hierarchical controlled release nano-therapeutic platform (SEED-NPs) that self-identifies and responds to CSC and non-CSC micro-niches of tumors. In non-CSC micro-niche, reactive oxygen species (ROS) trigger the burst release of the chemotherapeutic drug and photosensitizer to kill tumor cells and reduce tumor volume by c...
Source: Biomaterials - April 19, 2024 Category: Materials Science Authors: Yiliang Yang Yiwei Peng Yitian Du Meng Lin Jiajia Li Datong Gao Zhenzhen Yang Wei Wang Yanxia Zhou Xinru Li Taiqiang Yan Xianrong Qi Source Type: research
< em > Therapy-na ïve malignancy causes cardiovascular disease: A state-of-the-art cardio-oncology perspective < /em >
Am J Physiol Heart Circ Physiol. 2024 Apr 19. doi: 10.1152/ajpheart.00795.2023. Online ahead of print.ABSTRACTCardiovascular disease (CVD) and cancer are the leading causes of mortality worldwide. Although generally thought of as distinct diseases, the intersectional overlap between CVD and cancer is increasingly evident in both causal and mechanistic relationships. The field of cardio-oncology is largely focused on cardiotoxic effects of cancer therapies (e.g., chemotherapy, radiation). Further, the cumulative effects of cardiotoxic therapy exposure and the prevalence of CVD risk factors in cancer patients leads to long-t...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 19, 2024 Category: Physiology Authors: Leslie M Ogilvie Bridget Coyle-Asbil Keith R Brunt Jim Petrik Jeremy A Simpson Source Type: research
