High expression of SLC27A2 predicts unfavorable prognosis and promotes inhibitory immune infiltration in acute lymphoblastic leukemia
In conclusion, SLC27A2 plays a vital role in the development of ALL.PMID:38640787 | DOI:10.1016/j.tranon.2024.101952 (Source: Translational Oncology)
Source: Translational Oncology - April 19, 2024 Category: Cancer & Oncology Authors: Lihua Lu Jiazheng Li Yongzhi Zheng Luting Luo Yan Huang Jianda Hu Yanxin Chen Source Type: research
Doxorubicin-based ENO1 targeted drug delivery strategy enhances therapeutic efficacy against colorectal cancer
Biochem Pharmacol. 2024 Apr 17;224:116220. doi: 10.1016/j.bcp.2024.116220. Online ahead of print.ABSTRACTAlpha-enolase (ENO1), a multifunctional protein with carcinogenic properties, has emerged as a promising cancer biomarker because of its differential expression in cancer and normal cells. On the basis of this characteristic, we designed a cell-targeting peptide that specifically targets ENO1 and connected it with the drug doxorubicin (DOX) by aldehyde-amine condensation. A surface plasmon resonance (SPR) assay showed that the affinity for ENO1 was stronger (KD = 2.5 µM) for the resulting cell-targeting drug, DOX-P, th...
Source: Biochemical Pharmacology - April 19, 2024 Category: Drugs & Pharmacology Authors: Jun Liu Xiaoyu Hu Guanghao Yu Qingrong Wang Liwei Gu Jianying Shen Qinghe Zhao Hao Sun Shi Wang Zhongyuan Guo Yu Zhao Hai Ma Source Type: research
Quantitative Assessment of Drug Efficacy and Emergence of Resistance in Patients with Metastatic Renal Cell Carcinoma Using a Longitudinal Exposure-Tumor Growth Inhibition Model: Apitolisib (Dual PI3K/mTORC1/2 Inhibitor) Versus Everolimus (mTORC1 Inhibitor)
J Clin Pharmacol. 2024 Apr 19. doi: 10.1002/jcph.2444. Online ahead of print.ABSTRACTCancer remains a significant global health challenge, and despite remarkable advancements in therapeutic strategies, poor tolerability of drugs (causing dose reduction/interruptions) and/or the emergence of drug resistance are major obstacles to successful treatment outcomes. Metastatic renal cell carcinoma (mRCC) accounts for 2% of global cancer diagnoses and deaths. Despite the initial success of targeted therapies in mRCC, challenges remain to overcome drug resistance that limits the long-term efficacy of these treatments. Our analysis ...
Source: The Journal of Clinical Pharmacology - April 19, 2024 Category: Drugs & Pharmacology Authors: Anita Moein Jin Y Jin Matthew R Wright Harvey Wong Source Type: research
A Platinum-Aluminum Bimetallic Salen Complex for Pro-senescence Cancer Therapy
Chembiochem. 2024 Apr 19:e202400105. doi: 10.1002/cbic.202400105. Online ahead of print.ABSTRACTCell senescence is defined as irreversible cell cycle arrest, which can be triggered by telomere shortening or by various types of genotoxic stress. Induction of senescence is emerging as a new strategy for the treatment of cancer, especially when sequentially combined with a second senolytic drug capable of killing the resulting senescent cells, however severely suffering from the undesired off-target side effects from the senolytic drugs. Here, we prepare a bimetalic platinum-aluminum salen complex (Alumiplatin) for cancer the...
Source: Chembiochem - April 19, 2024 Category: Biochemistry Authors: Juan Tang Yahui Yang Hao-Yan Yin Bin Ma Mengliang Zhu Zi-Shu Yang Xin-Xin Peng Feifei Jia Yao Zhao Fuyi Wang Tianfeng Chen Jun-Long Zhang Source Type: research
< em > Therapy-na ïve malignancy causes cardiovascular disease: A state-of-the-art cardio-oncology perspective < /em >
Am J Physiol Heart Circ Physiol. 2024 Apr 19. doi: 10.1152/ajpheart.00795.2023. Online ahead of print.ABSTRACTCardiovascular disease (CVD) and cancer are the leading causes of mortality worldwide. Although generally thought of as distinct diseases, the intersectional overlap between CVD and cancer is increasingly evident in both causal and mechanistic relationships. The field of cardio-oncology is largely focused on cardiotoxic effects of cancer therapies (e.g., chemotherapy, radiation). Further, the cumulative effects of cardiotoxic therapy exposure and the prevalence of CVD risk factors in cancer patients leads to long-t...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 19, 2024 Category: Physiology Authors: Leslie M Ogilvie Bridget Coyle-Asbil Keith R Brunt Jim Petrik Jeremy A Simpson Source Type: research
Hierarchical self-recognition and response in CSC and non-CSC micro-niches for cancer therapy
Biomaterials. 2024 Apr 15;308:122581. doi: 10.1016/j.biomaterials.2024.122581. Online ahead of print.ABSTRACTCancer stem cells (CSCs) characterized by self-renewal, invasiveness, tumorigenicity and resistance to treatment are regarded as the thorniest issues in refractory tumors. We develop a targeted and hierarchical controlled release nano-therapeutic platform (SEED-NPs) that self-identifies and responds to CSC and non-CSC micro-niches of tumors. In non-CSC micro-niche, reactive oxygen species (ROS) trigger the burst release of the chemotherapeutic drug and photosensitizer to kill tumor cells and reduce tumor volume by c...
Source: Biomaterials - April 19, 2024 Category: Materials Science Authors: Yiliang Yang Yiwei Peng Yitian Du Meng Lin Jiajia Li Datong Gao Zhenzhen Yang Wei Wang Yanxia Zhou Xinru Li Taiqiang Yan Xianrong Qi Source Type: research
< em > Therapy-na ïve malignancy causes cardiovascular disease: A state-of-the-art cardio-oncology perspective < /em >
Am J Physiol Heart Circ Physiol. 2024 Apr 19. doi: 10.1152/ajpheart.00795.2023. Online ahead of print.ABSTRACTCardiovascular disease (CVD) and cancer are the leading causes of mortality worldwide. Although generally thought of as distinct diseases, the intersectional overlap between CVD and cancer is increasingly evident in both causal and mechanistic relationships. The field of cardio-oncology is largely focused on cardiotoxic effects of cancer therapies (e.g., chemotherapy, radiation). Further, the cumulative effects of cardiotoxic therapy exposure and the prevalence of CVD risk factors in cancer patients leads to long-t...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 19, 2024 Category: Physiology Authors: Leslie M Ogilvie Bridget Coyle-Asbil Keith R Brunt Jim Petrik Jeremy A Simpson Source Type: research
Hierarchical self-recognition and response in CSC and non-CSC micro-niches for cancer therapy
Biomaterials. 2024 Apr 15;308:122581. doi: 10.1016/j.biomaterials.2024.122581. Online ahead of print.ABSTRACTCancer stem cells (CSCs) characterized by self-renewal, invasiveness, tumorigenicity and resistance to treatment are regarded as the thorniest issues in refractory tumors. We develop a targeted and hierarchical controlled release nano-therapeutic platform (SEED-NPs) that self-identifies and responds to CSC and non-CSC micro-niches of tumors. In non-CSC micro-niche, reactive oxygen species (ROS) trigger the burst release of the chemotherapeutic drug and photosensitizer to kill tumor cells and reduce tumor volume by c...
Source: Biomaterials - April 19, 2024 Category: Materials Science Authors: Yiliang Yang Yiwei Peng Yitian Du Meng Lin Jiajia Li Datong Gao Zhenzhen Yang Wei Wang Yanxia Zhou Xinru Li Taiqiang Yan Xianrong Qi Source Type: research
< em > Therapy-na ïve malignancy causes cardiovascular disease: A state-of-the-art cardio-oncology perspective < /em >
Am J Physiol Heart Circ Physiol. 2024 Apr 19. doi: 10.1152/ajpheart.00795.2023. Online ahead of print.ABSTRACTCardiovascular disease (CVD) and cancer are the leading causes of mortality worldwide. Although generally thought of as distinct diseases, the intersectional overlap between CVD and cancer is increasingly evident in both causal and mechanistic relationships. The field of cardio-oncology is largely focused on cardiotoxic effects of cancer therapies (e.g., chemotherapy, radiation). Further, the cumulative effects of cardiotoxic therapy exposure and the prevalence of CVD risk factors in cancer patients leads to long-t...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 19, 2024 Category: Physiology Authors: Leslie M Ogilvie Bridget Coyle-Asbil Keith R Brunt Jim Petrik Jeremy A Simpson Source Type: research
Cancers, Vol. 16, Pages 1569: CD44: A New Prognostic Marker in Colorectal Cancer?
Pusceddu
Massimo Castagnola
Mario Scartozzi
Gavino Faa
Cluster of differentiation 44 (CD44) is a non-kinase cell surface glycoprotein. It is overexpressed in several cell types, including cancer stem cells (CSCs). Cells overexpressing CD44 exhibit several CSC traits, such as self-renewal, epithelial&ndash;mesenchymal transition (EMT) capability, and resistance to chemo- and radiotherapy. The role of CD44 in maintaining stemness and the CSC function in tumor progression is accomplished by binding to its main ligand, hyaluronan (HA). The HA-CD44 complex activates several signaling pathways that lead to cel...
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Pina Ziranu Andrea Pretta Valentina Aimola Flaviana Cau Stefano Mariani Alessandra Pia D ’Agata Claudia Codipietro Daiana Rizzo Veronica Dell ’Utri Giorgia Sanna Giusy Moledda Andrea Cadoni Eleonora Lai Marco Puzzoni Valeria Pusceddu Massimo Castagnol Tags: Review Source Type: research
Intratumoural delivery of TRAIL mRNA induces colon cancer cell apoptosis
Biomed Pharmacother. 2024 Apr 17;174:116603. doi: 10.1016/j.biopha.2024.116603. Online ahead of print.ABSTRACTNovel strategies in intratumoral injection and emerging immunotherapies have heralded a new era of precise cancer treatments. The affinity of SARS-CoV-2 to ACE2 receptors, a feature which facilitates virulent human infection, is leveraged in this research. Colon cancer cells, with their high ACE2 expression, provide a potentially strategic target for using this SARS-CoV-2 feature. While the highly expression of ACE2 is observed in several cancer types, the idea of using the viral spike protein for targeting colon c...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 18, 2024 Category: Drugs & Pharmacology Authors: Tingxuan Gu Mengqiao Wang Xiaorong Fu Xueli Tian Juanjuan Bi Ning Lu Chen Chen Shijia Yan Ang Li Luyun Wang Xiang Li Kangdong Liu Zigang Dong Source Type: research
Intratumoural delivery of TRAIL mRNA induces colon cancer cell apoptosis
Biomed Pharmacother. 2024 Apr 17;174:116603. doi: 10.1016/j.biopha.2024.116603. Online ahead of print.ABSTRACTNovel strategies in intratumoral injection and emerging immunotherapies have heralded a new era of precise cancer treatments. The affinity of SARS-CoV-2 to ACE2 receptors, a feature which facilitates virulent human infection, is leveraged in this research. Colon cancer cells, with their high ACE2 expression, provide a potentially strategic target for using this SARS-CoV-2 feature. While the highly expression of ACE2 is observed in several cancer types, the idea of using the viral spike protein for targeting colon c...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 18, 2024 Category: Drugs & Pharmacology Authors: Tingxuan Gu Mengqiao Wang Xiaorong Fu Xueli Tian Juanjuan Bi Ning Lu Chen Chen Shijia Yan Ang Li Luyun Wang Xiang Li Kangdong Liu Zigang Dong Source Type: research
Advancements in fertility preservation strategies for pediatric male cancer patients: a review of cryopreservation and transplantation of immature testicular tissue
Reprod Biol Endocrinol. 2024 Apr 18;22(1):47. doi: 10.1186/s12958-024-01219-5.ABSTRACTRecently, there has been increasing emphasis on the gonadotoxic effects of cancer therapy in prepubertal boys. As advances in oncology treatments continue to enhance survival rates for prepubertal boys, the need for preserving their functional testicular tissue for future reproduction becomes increasingly vital. Therefore, we explore cutting-edge strategies in fertility preservation, focusing on the cryopreservation and transplantation of immature testicular tissue as a promising avenue. The evolution of cryopreservation techniques, from ...
Source: Reproductive Biology - April 18, 2024 Category: Reproduction Medicine Authors: Zih-Yi Sung Yong-Qi Liao Jung-Hsiu Hou Hong-Hsien Lai Sung-Ming Weng Hai-Wei Jao Buo-Jia Lu Chi-Huang Chen Source Type: research
Neil 1 deficiency facilitates chemoresistance through upregulation of RAD18 expression in ovarian cancer stem cells
This study delves into the regulatory role of NEIL1, a DNA glycosylase, in chemoresistance in ovarian CSCs. We first observed a decreased expression of NEIL1 in ovarian CSCs, suggesting its potential involvement in CSC regulation. Using pan-cancer analysis, we confirmed the diminished NEIL1 expression in ovarian tumors compared to normal tissues. Furthermore, NEIL1 downregulation correlated with an increase in stemness markers and enrichment of CSCs, highlighting its role in modulating CSC phenotype. Further mechanistic investigation revealed an inverse correlation between NEIL1 and RAD18 expression in ovarian CSCs. NEIL1 ...
Source: Biochemical and Biophysical Research communications - April 18, 2024 Category: Biochemistry Authors: Devendra Shukla Tanima Mandal Amit Kumar Srivastava Source Type: research
Molecules, Vol. 29, Pages 1845: Self-Assembled Matrine-PROTAC Encapsulating Zinc(II) Phthalocyanine with GSH-Depletion-Enhanced ROS Generation for Cancer Therapy
Lisheng Wang
The integration of a multidimensional treatment dominated by active ingredients of traditional Chinese medicine (TCM), including enhanced chemotherapy and synergistically amplification of oxidative damage, into a nanoplatform would be of great significance for furthering accurate and effective cancer treatment with the active ingredients of TCM. Herein, in this study, we designed and synthesized four matrine-proteolysis-targeting chimeras (PROTACs) (depending on different lengths of the chains named LST-1, LST-2, LST-3, and LST-4) based on PROTAC technology to overcome the limitations of matrine. LST-4,...
Source: Molecules - April 18, 2024 Category: Chemistry Authors: Sitong Lai Bing Wang Kunhui Sun Fan Li Qian Liu Xie-An Yu Lihe Jiang Lisheng Wang Tags: Article Source Type: research
