The Role of Ultrasound in the Diagnosis and Treatment of Meniscal Injuries
AbstractPurpose of ReviewThis review evaluates the current understanding of the role of ultrasound in the diagnosis and treatment of meniscal disorders.Recent FindingsUltrasound (US) demonstrates similar sensitivity and specificity when compared to magnetic resonance imaging in the evaluation of meniscal injuries when compared to arthroscopy. Meniscal extrusion (ME) under US can be a reliable metric to evaluate for meniscal root tears in knees with and without osteoarthritis (OA). Sonographic ME is associated with development of OA in knees without OA. US following allograft meniscal transplant may be useful in predicting ...
Source: Current Reviews in Musculoskeletal Medicine - April 19, 2024 Category: Orthopaedics Source Type: research
Trends, Outcomes, and Evaluation of the Older Living Kidney Donor
AbstractPurpose of ReviewWe aim to review trends, donor and recipient outcomes, and considerations in the evaluation of older living kidney donors (LD).Recent FindingsOlder donors comprise a small but growing proportion of LDs. Aging is associated with nephrosclerosis, nephron loss, and a physiologic decline in kidney function. Importantly, living donor outcomes are favorable, with older LDs having similar mortality to age-matched healthy older non-donors, a lower lifetime risk of ESKD than younger LDs, and preserved quality of life. Allograft survival of LDKT from older LDs is also acceptable, and recipient survival is be...
Source: Current Transplantation Reports - April 19, 2024 Category: Transplant Surgery Source Type: research
Polytherapy versus monotherapy in the treatment of tibial non-unions: a retrospective study
ConclusionsPolytherapy is more effective than monotherapy for severe tibial non-unions, offering a higher success ratio. The NUSS score supports decision-making in treating tibial non-unions.Level of evidenceLevel III. (Source: Journal of Orthopaedics and Traumatology)
Source: Journal of Orthopaedics and Traumatology - April 18, 2024 Category: Orthopaedics Source Type: research
Lateralising reverse shoulder arthroplasty using bony increased offset (BIO-RSA) or increasing glenoid component diameter: comparison of clinical, radiographic and patient reported outcomes in a matched cohort
ConclusionsUsing a larger glenosphere is a feasible alternative to BIO-RSA for lateralising RSA, providing comparable ROM, patient-reported and radiographic results, while potentially decreasing costs, operative time and complication rates.Level of evidence III. (Source: Journal of Orthopaedics and Traumatology)
Source: Journal of Orthopaedics and Traumatology - April 18, 2024 Category: Orthopaedics Source Type: research
GSE254388 CDK12 Loss Promotes Prostate Cancer Development While Exposing Vulnerabilities to Paralog-Based Synthetic Lethality [RNA-Seq]
Contributors : Jean C Tien ; Yuping Zhang ; Yu Chang ; Yunhui Cheng ; Rahul Mannan ; Palak Shan ; Xiaoming Wang ; Sanjana Eyunni ; Caleb Cheng ; Brian Magnuson ; Lanbo Xiao ; Marcin Cieslik ; Abhijit Parolia ; Yi Bao ; Shuqin Li ; Alice Xu ; Fengyun Su ; Xuhong Cao ; Yi-Mi Wu ; Dan Robinson ; George Wang ; Ke Ding ; Arul M ChinnaiyanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBiallelic loss of cyclin-dependent kinase 12 (CDK12) defines a unique molecular subtype of metastatic castration resistant prostate cancer (mCRPC). It remains unclear, however, whether C...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE254387 CDK12 Loss Promotes Prostate Cancer Development While Exposing Vulnerabilities to Paralog-Based Synthetic Lethality [scRNA-Seq]
Contributors : Jean C Tien ; Yuping Zhang ; Yu Chang ; Yunhui Cheng ; Rahul Mannan ; Palak Shan ; Xiaoming Wang ; Sanjana Eyunni ; Caleb Cheng ; Brian Magnuson ; Lanbo Xiao ; Marcin Cieslik ; Abhijit Parolia ; Yi Bao ; Shuqin Li ; Alice Xu ; Fengyun Su ; Xuhong Cao ; Yi-Mi Wu ; Dan Robinson ; George Wang ; Ke Ding ; Arul M ChinnaiyanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBiallelic loss of cyclin-dependent kinase 12 (CDK12) defines a unique molecular subtype of metastatic castration resistant prostate cancer (mCRPC). It remains unclear, however, whether C...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Additional suture augmentation to anterior cruciate ligament reconstruction with hamstring autografts bring no benefits to clinical results, graft maturation and graft-bone interface healing
From the perspective of graft protection and early rehabilitation during the maturation and remodeling phases of graft healing, suture augmentation (SA) for anterior cruciate ligament reconstruction (ACLR) has... (Source: BMC Musculoskeletal Disorders)
Source: BMC Musculoskeletal Disorders - April 17, 2024 Category: Orthopaedics Authors: Qingyang Meng, Ruilan Dai, Cheng Wang, Weili Shi, Yanfang Jiang, Ningjing Liu, Rui Li, Yingfang Ao, Xi Gong and Yong Ma Tags: Research Source Type: research
Collagen Bridging of Massive Rotator Cuff Tears Using Fascia Lata Autograft Could Provide a Lasting Solution
Shoulder rotator cuff tears are ideally primarily repaired, but large and massive, chronic, and/or retracted tears result in challenges. In response, innovative solutions include superior capsular reconstruction, tendon transfers, subacromial balloon spacer, tuberoplasty, partial repair, and marginal convergence. Recently, an innovation is to use collagen tissue to bridge repair of compromised tendon. Recent research using fascia lata autografts for supraspinatus tendon reconstruction in a rat model shows positive outcomes with structural similarity to normal muscle-tendon interface, decreased fatty infiltration, and incre...
Source: Arthroscopy - Journal of Arthroscopic and Related Surgery - April 17, 2024 Category: Surgery Authors: In-Ho Jeon, Erica Kholinne Tags: Editorial Commentary Source Type: research
Epithelial cell states associated with kidney and allograft injury
Nature Reviews Nephrology, Published online: 17 April 2024; doi:10.1038/s41581-024-00834-0This Review describes parallels in the injury mechanisms that underlie acute kidney injury, chronic kidney disease and allograft injury, and explains how our understanding of the molecular changes that occur in epithelia in the context of kidney disease may contribute to the therapeutic targeting of specific epithelial cell phenotypes for the treatment of transplantation complications. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 17, 2024 Category: Urology & Nephrology Authors: Christian Hinze Svjetlana Lovric Philip F. Halloran Jonathan Barasch Kai M. Schmidt-Ott Source Type: research
COVID-19 and renal allograft rejection: insight from controlled and non-controlled studies
CONCLUSION: In conclusion, the limited number of published controlled studies revealed no statistically significant association between COVID-19 infection and biopsy-proven rejection among KTRs. However, the broader analysis of non-controlled studies showed a variable rejection incidence with a pooled rejection rate of 11.8%. There is insufficient high-quality data to explore the association of COVID-19 infection and rejection.PMID:38627208 | DOI:10.1080/0886022X.2024.2336126 (Source: Renal Failure)
Source: Renal Failure - April 16, 2024 Category: Urology & Nephrology Authors: Ahmed Daoud Karim Soliman Maria Aurora Posadas Salas Genta Uehara Sakshi Vaishnav Wisit Cheungpasitporn Michael J Casey Source Type: research
Viruses, Vol. 16, Pages 619: Mesenchymal Stem Cell-Derived Exosomes Attenuate Murine Cytomegalovirus-Infected Pneumonia via NF- & kappa;B/NLRP3 Signaling Pathway
Viruses, Vol. 16, Pages 619: Mesenchymal Stem Cell-Derived Exosomes Attenuate Murine Cytomegalovirus-Infected Pneumonia via NF-κB/NLRP3 Signaling Pathway
Viruses doi: 10.3390/v16040619
Authors:
Fei Chen
Zhida Chen
Hui-Ting Wu
Xin-Xiang Chen
Peiqi Zhan
Zheng-Yi Wei
Zizhang Ouyang
Xueyan Jiang
Ao Shen
Min-Hua Luo
Qifa Liu
Yue-Peng Zhou
Aiping Qin
Reactivation and infection with cytomegalovirus (CMV) are frequently observed in recipients of solid organ transplants, bone marrow transplants, and individuals with HIV infection. This presents an increasing risk of allograft rejection, opp...
Source: Viruses - April 16, 2024 Category: Virology Authors: Fei Chen Zhida Chen Hui-Ting Wu Xin-Xiang Chen Peiqi Zhan Zheng-Yi Wei Zizhang Ouyang Xueyan Jiang Ao Shen Min-Hua Luo Qifa Liu Yue-Peng Zhou Aiping Qin Tags: Article Source Type: research
Design, cohort profile and comparison of the KTD-Innov study: a prospective multidimensional biomarker validation study in kidney allograft rejection
AbstractThere is an unmet need for robust and clinically validated biomarkers of kidney allograft rejection. Here we present the KTD-Innov study (ClinicalTrials.gov, NCT03582436), an unselected deeply phenotyped cohort of kidney transplant recipients with a holistic approach to validate the clinical utility of precision diagnostic biomarkers. In 2018–2019, we prospectively enrolled consecutive adult patients who received a kidney allogr aft at seven French centers and followed them for a year. We performed multimodal phenotyping at follow-up visits, by collecting clinical, biological, immunological, and histological p...
Source: European Journal of Epidemiology - April 16, 2024 Category: Epidemiology Source Type: research
In vitro evaluation of bone cell response to novel 3D-printable nanocomposite biomaterials for bone reconstruction
J Biomed Mater Res A. 2024 Apr 15. doi: 10.1002/jbm.a.37719. Online ahead of print.ABSTRACTCritically-sized segmental bone defects represent significant challenges requiring grafts for reconstruction. 3D-printed synthetic bone grafts are viable alternatives to structural allografts if engineered to provide appropriate mechanical performance and osteoblast/osteoclast cell responses. Novel 3D-printable nanocomposites containing acrylated epoxidized soybean oil (AESO) or methacrylated AESO (mAESO), polyethylene glycol diacrylate, and nanohydroxyapatite (nHA) were produced using masked stereolithography. The effects of volume ...
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Zahra Haghpanah Dibakar Mondal Nikan Momenbeitollahi Sadaf Mohsenkhani Kiyoumars Zarshenas Yutong Jin Michael Watson Thomas Willett Maud Gorbet Source Type: research
In vitro evaluation of bone cell response to novel 3D-printable nanocomposite biomaterials for bone reconstruction
J Biomed Mater Res A. 2024 Apr 15. doi: 10.1002/jbm.a.37719. Online ahead of print.ABSTRACTCritically-sized segmental bone defects represent significant challenges requiring grafts for reconstruction. 3D-printed synthetic bone grafts are viable alternatives to structural allografts if engineered to provide appropriate mechanical performance and osteoblast/osteoclast cell responses. Novel 3D-printable nanocomposites containing acrylated epoxidized soybean oil (AESO) or methacrylated AESO (mAESO), polyethylene glycol diacrylate, and nanohydroxyapatite (nHA) were produced using masked stereolithography. The effects of volume ...
Source: Biomed Res - April 15, 2024 Category: Research Authors: Zahra Haghpanah Dibakar Mondal Nikan Momenbeitollahi Sadaf Mohsenkhani Kiyoumars Zarshenas Yutong Jin Michael Watson Thomas Willett Maud Gorbet Source Type: research
