Clinico-epidemiological characteristics of early- versus late-onset cytomegalovirus disease among renal transplant recipients: A two-decade experience
CONCLUSIONS: Early CMV disease presents more frequently as CMV syndrome while late CMV disease usually manifests itself as tissue invasive disease. Graft loss is more common in patients with late onset of CMV disease.PMID:38565378 | DOI:10.1016/j.trim.2024.102040 (Source: Transplant Immunology)
Source: Transplant Immunology - April 2, 2024 Category: Transplant Surgery Authors: Shuvam Roy Anupma Kaul Dharmendra Singh Bhadhuria Narayan Prasad Atul Garg Rungmei S K Marak Manas Ranjan Patel Manas Ranjan Behera Ravi Shankar Kushwaha Monika Yachha Source Type: research
Outcomes of Ulnar Shortening Osteotomy with an Intramedullary Bone Graft for Idiopathic Ulnar Impaction Syndrome
CONCLUSIONS: USO with an intramedullary bone graft for idiopathic UIS has favorable radiological and clinical outcomes. The advantage of this technique is the significant shortening of bone union time.PMID:38562625 | PMC:PMC10973609 | DOI:10.4055/cios23266 (Source: Clinics in Orthopedic Surgery)
Source: Clinics in Orthopedic Surgery - April 2, 2024 Category: Orthopaedics Authors: Kyung Wook Kim Ji Hyeung Kim Hyung Ryul Lim Kee Jeong Bae Yo Han Lee Young Kwang Shin Goo Hyun Baek Source Type: research
Clinico-epidemiological characteristics of early- versus late-onset cytomegalovirus disease among renal transplant recipients: A two-decade experience
CONCLUSIONS: Early CMV disease presents more frequently as CMV syndrome while late CMV disease usually manifests itself as tissue invasive disease. Graft loss is more common in patients with late onset of CMV disease.PMID:38565378 | DOI:10.1016/j.trim.2024.102040 (Source: Transplant Immunology)
Source: Transplant Immunology - April 2, 2024 Category: Transplant Surgery Authors: Shuvam Roy Anupma Kaul Dharmendra Singh Bhadhuria Narayan Prasad Atul Garg Rungmei S K Marak Manas Ranjan Patel Manas Ranjan Behera Ravi Shankar Kushwaha Monika Yachha Source Type: research
Outcomes of Ulnar Shortening Osteotomy with an Intramedullary Bone Graft for Idiopathic Ulnar Impaction Syndrome
CONCLUSIONS: USO with an intramedullary bone graft for idiopathic UIS has favorable radiological and clinical outcomes. The advantage of this technique is the significant shortening of bone union time.PMID:38562625 | PMC:PMC10973609 | DOI:10.4055/cios23266 (Source: Clinics in Orthopedic Surgery)
Source: Clinics in Orthopedic Surgery - April 2, 2024 Category: Orthopaedics Authors: Kyung Wook Kim Ji Hyeung Kim Hyung Ryul Lim Kee Jeong Bae Yo Han Lee Young Kwang Shin Goo Hyun Baek Source Type: research
Daratumumab for Antibody Mediated Rejection in Lung Transplant
Introduction: Antibody-mediated rejection (AMR) in lung transplantation is associated with chronic lung allograft dysfunction and decreased survival. Current treatment modalities for AMR include corticosteroids, plasmapheresis, intravenous immunoglobulin (IVIG), B-cell depleting agents and proteasome inhibitors, all with variable clinical responses. Daratumumab is a monoclonal antibody that targets CD-38 on plasma cells resulting in complement-dependent cytotoxicity, antibody-dependent phagocytosis, and apoptosis. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , D. Brezhnev, L. Zaffiri, R. Rampolla Source Type: research
The Enigma of Elevated Donor-Derived Cell-Free DNA with Negative Endomyocardial Biopsy
Purpose: The emergent use of donor-derived cell-free DNA (dd-cfDNA) as a biomarker forearly assessment of allograft injury has rapidly become part of rejection surveillance following hearttransplantation (HT). However, the significance of elevated dd-cfDNA is still nebulous without clinical orhistological evidence of rejection.The aim of the study is to describe the characteristics of patients with elevated dd-cfDNA ( ≥0.12%) inpatients with negative biopsy. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , M. Liotta, S. Marek-Iannucci, G. Gibson, S. Masri, J. Rame, E. Storozynsky, H. Eisen, R. Alvarez, I. Rajapreyar, Y. Brailovsky Source Type: research
Is Chronic Lung Allograft Dysfunction More Common After Lung Transplantation for Pulmonary Complications of Hematopoietic Stem Cell Transplantation?
The objective of this study was to investigate whether CLAD occurs more frequently after lung transplantation for LONIPCs of HSCT. The impact of the donor source was also examined, comparing living-donor lobar lung transplantation (LDLLT) with deceased-donor lung transplantation (DDLT). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , S. Tanaka, H. Hiramatsu, J. Kanda, M. Takahashi, Y. Yutaka, A. Ohsumi, D. Nakajima Source Type: research
Bile Acids Aspiration Induces Fibrosis and Disrupts Surfactant Homeostasis in Human Lungs
Purpose: Lung transplantation remains the only treatment for end stage lung disease. However, survival remains limited by chronic lung allograft dysfunction (CLAD) characterized by progressive distal airway fibrosis. Multiple risk factors have been associated with CLAD, including gastroesophageal reflux aspiration. Previous studies have established Bile Acids (BA), detected in the airways, as marker of reflux aspiration and predictors of CLAD. The action of BA on human broncho-alveolar cell and tissue components is poorly explored, although its understanding could contribute to define mechanisms for CLAD. (Source: The Jour...
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , S. Russum, E. Floris, M. Della Zoppa, B. Kim, S. Ryeom, L. Benvenuto, F. D'Ovidio Source Type: research
Clinical Utility of Molecular Microscope Diagnostic System (MMDx) in Heart Transplant Recipients: Moving Towards a New Paradigm
Purpose: Histological assessment has traditionally been considered the gold standard for diagnosis of cardiac allograft rejection. The MMDx utilizing biopsy-based gene expression profiling, has emerged as a complementary tool. We aimed to evaluate the clinical impact of MMDx in patients with suspected rejection. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , C.M. Moeller, G. Rubinstein, S. Rahman, J. Baranowska, C. Lee, D. Oren, Y. Mehlman, S. Slomovich, J. Lindekens, B. Fuselier, R. Salazar, C.A. Hennecken, E.M. DeFilippis, K. Theodoropoulos, V. Topkara, M. Yuzefpolskaya, P. Colombo, D. Lotan, D. Bae, E. L Source Type: research
Impact of Race Mismatch in Allograft Rejection After Heart Transplantation. Molecular Microscope (MMDx) Results
Purpose: The influence of donor/recipient race matching on rejection after heart transplantation (HT) is not well understood. Our goal is to examine the effect of race matching on rejection after HT utilizing biopsy-based gene expression profiling. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , C.M. Moeller, J. Baranowska, D. Oren, G. Rubinstein, S. Rahman, C. Lee, Y. Mehlman, S. Slomovich, D. Lotan, E.M. DeFilippis, D. Bae, A. Rahman, R. Shah, K. Oh, J. Fried, K. Clerkin, K. Theodoropoulos, G.T. Sayer, N. Uriel, F. Latif Source Type: research
Outcomes of Heart Transplant Recipients with Highly Elevated Donor-Derived Cell-Free DNA Values: A Single Center Experience
We describe characteristics and outcomes in a large cohort of HT recipients with highly elevated dd-cfDNA (HEdd-cfDNA), defined as> 1%, a population not previously well-described. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , B. Foreman, V. Franco, G. Haas, A. Hasan, V. Patel, A. Vallakati, B. Lampert Source Type: research
Impact of MTOR Inhibitors on Heart Allograft Rejection Using Tissue-Based Gene-Expression Profiling. Molecular Microscope (MMDx) Results
Purpose: mTOR inhibitors have been traditionally used as second line immunosupressants, but their use has been hindered by a higher risk of rejection. We aimed to evaluate the association between mTOR use and rejection outcomes utilizing the MMDx, and further provide a description of the associated gene-expression transcripts. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , C.M. Moeller, G. Rubinstein, D. Oren, S. Rahman, J. Baranowska, C. Lee, S. Slomovich, D. Lotan, J. Fried, E.M. DeFilippis, J. Raikhelkar, K. Theodoropoulos, F. Latif, M. Yuzefpolskaya, K. Clerkin, G.T. Sayer, N. Uriel, D. Majure Source Type: research
Free-Breathing Cardiac Magnetic Resonance CMR Oedema Assessment in Acute Cardiac Rejection
Purpose: Cardiac MRI is an emerging non-invasive assessment technique in acute allograft rejection. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , N. Quaife, N. Miaris, C. Borguezan Daros, S. Hadjiphilippou, O. Dar, F. Riesgo Gil, A. Morley-Smith, R. Bannerjee, M. Usman, O. Mukhtar, J. Dunning, K. Chow, P. Kellman, C. Buccarelli-Ducci, J. Wong Source Type: research
