Impact of MTOR Inhibitors on Heart Allograft Rejection Using Tissue-Based Gene-Expression Profiling. Molecular Microscope (MMDx) Results

Purpose: mTOR inhibitors have been traditionally used as second line immunosupressants, but their use has been hindered by a higher risk of rejection. We aimed to evaluate the association between mTOR use and rejection outcomes utilizing the MMDx, and further provide a description of the associated gene-expression transcripts.

Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , C.M. Moeller, G. Rubinstein, D. Oren, S. Rahman, J. Baranowska, C. Lee, S. Slomovich, D. Lotan, J. Fried, E.M. DeFilippis, J. Raikhelkar, K. Theodoropoulos, F. Latif, M. Yuzefpolskaya, K. Clerkin, G.T. Sayer, N. Uriel, D. Majure Source Type: research