Intravascular Imaging Volumetric Analysis of Early Cardiac Allograft Vasculopathy: Head-to-Head Comparison of Serial Paired Intravascular Ultrasound and Optical Coherence Tomography
This study examined the relationship between IVUS and OCT-based volumetric analysis of CAV early post HT. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: R. Bajaj, , V. Dzavik, D. So, N. Aleksova, C. Overgaard, R.S. Beanlands, G.A. Wells, J. Bernick, L. Mielniczuk, E. Stadnick, C. McGuinty, H. Ross, A. Chong Source Type: research
CAV by PET/MBF Has Robust Negative Predictive Value for Development of Moderate to Severe CAV
Purpose: Cardiac allograft vasculopathy (CAV) affects the majority of heart transplant (HT) recipients by 10 years post-HT and is a leading cause of mortality. Standard CAV screening is via invasive coronary angiography (ICA). Recently, it has been shown that PET with myocardial blood flow (PET/MBF) has excellent diagnostic validity for CAV, but the prognostic value is unknown. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: N. Prasad, E.S. Harris, J. Fried, V.K. Topkara, J. Raikhelkar, E.M. DeFilippis, F. Latif, M. Yuzefpolskaya, P.C. Colombo, G. Sayer, N. Uriel, A.J. Einstein, Source Type: research
CAV Grading by PET Provides Improved Risk Stratification Compared to CA
Purpose: Cardiac allograft vasculopathy (CAV) is marked by impaired blood flow in epicardial vessels and/or coronary microvasculature and is the leading cause of late mortality for heart transplant (HT) recipients. Commonly, CAV screening occurs via coronary angiography (CA) for assessment of epicardial disease. Recent studies have shown excellent diagnostic utility of PET with myocardial blood flow reserve (MBFR) for both macro- and microvascular CAV. We sought to assess prognostic differences on CAV assessed by PET and CA. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: N. Prasad, E.S. Harris, J. Fried, V.K. Topkara, J. Raikhelkar, E.M. DeFilippis, F. Latif, M. Yuzefpolskaya, P.C. Colombo, G. Sayer, N. Uriel, A.J. Einstein, Source Type: research
High-Grade Eosinophils on Diagnostic Transbronchial Biopsy are Associated with Chronic Lung Allograft Dysfunction After Lung Transplantation
This study aimed to validate the prognostic role of systematic quantification of eosinophils (Eos) in diagnostic transbronchial biopsy (TBBx) for risk of chronic lung allograft dysfunction (CLAD). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , V. Sivasubramaniam, M. Qiu, W. Barrett, S. Wong, L. Thwe, K. Tonga, T. Martinu, P. MacDonald, M. Plit Source Type: research
FEV1 Monitoring of Allograft Function: Virtual or Reality?
Purpose: Chronic Lung Allograft Dysfunction (CLAD) remains the leading cause of graft loss after lung transplantation (LTx). FEV1 has been used as a surrogate to classify CLAD, with %changes in individual FEV1 baselines being used to define CLAD. Reasoning behind individual baselines is historical, to facilitate comparisons between single-lung and heart-lung transplant recipients. Given shifts towards bilateral LTx as well as candidate demographics, the utility of % baseline and its impact on decision-making is unknown. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , S. Dumschat, S. Kruszona, N. de Manna, J. Salman, T. Welte, A. Ruhparwar, F. Ius Source Type: research
