Fight Aging! Newsletter, June 12th 2023
In this study, we investigated the effect of NXP032 on neurovascular stabilization through the changes of PECAM-1, PDGFR-β, ZO-1, laminin, and glial cells involved in maintaining the integrity of the blood-brain barrier (BBB) in aged mice. NXP032 was orally administered daily for 8 weeks. Compared to young mice and NXP032-treated mice, 20-month-old mice displayed cognitive impairments in Y-maze and passive avoidance tests. NXP032 treatment contributed to reducing the BBB damage by attenuating the fragmentation of microvessels and reducing PDGFR-β, ZO-1, and laminin expression, thereby mitigating astrocytes and microglia ...
Source: Fight Aging! - June 11, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Senescent Cells Appear Involved in Graft-Versus-Host Disease
Now that increasing attention is given to senescent cells in the biology of aging, their involvement in a wide range of conditions has been uncovered. The transient creation of senescent cells is a part of wound healing, a process that is harmed by the growing burden of lingering senescent cells that occurs with advancing age, and the inability of the aged immune system to remove these cells in a timely fashion. Given the role in wound healing, is perhaps not surprising to find senescent cells involved in graft-versus-host disease following surgical transplantation of tissue. Senolytic therapies may prove to be useful here...
Source: Fight Aging! - June 9, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Automated Computer Assistant for Kidney Transplant Rejection Diagnostics: Interview with Study Authors
A recent study in Nature Medicine, entitled “An automated histological classification system for precision diagnostics of kidney allografts,” has showcased the efforts of a group of researchers who have developed an automated system that can diagnose kidney transplant rejection.
A variety of disparate factors can affect the chances that a transplant will be rejected. At present, clinicians have to manually consider these complex data when making decisions about transplant patients, which can lead to a high level of misdiagnosis and patient morbidity.
This new system incorporates an algorithm that can synthesize t...
Source: Medgadget - May 23, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Surgery Urology INSERM kidney transplant univ_paris_cite Source Type: blogs
Fight Aging! Newsletter, December 5th 2022
In conclusion, the PAAIs examined (i.e. mTOR loss of function, Ghrhr loss of function, intermittent fasting-based version of dietary restriction) often influenced age-sensitive traits in a direct way and not by slowing age-dependent change. Previous studies often failed to include young animals subjected to PAAI to account for age-independent PAAI effects. However, any study not accounting for such age-independent intervention effects will be prone to overestimate the extent to which an intervention delays the effects of aging on the phenotypes studied. This can result in a considerable bias of our view on how modifiable a...
Source: Fight Aging! - December 4, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing the State of Gene Editing to Make Cells Compatible Between Donor and Recipient
A sizable level of funding in academia and industry is devoted to the goal of enabling cell transplants between different individuals, with large and well funded pharma companies such as Astellas, Sana, and others involved. This would allow for the creation of cost-effective cell therapies of all sorts, in which the donor cells used in every patient originate from the same few well-vetted and well-controlled cell lines.
Logistics is everything in the realm of cell therapies, and the reason why autologous cell therapies, such as CAR-T treatments for cancer, are so expensive is that every treatment site must have the ...
Source: Fight Aging! - November 29, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, June 7th 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - June 6, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Senescent Cells as a Mechanism for Worse Outcomes in Transplantation of Older Organs
Senescent cells accumulate with age in tissues throughout the body. They secrete a mix of signals that provokes chronic inflammation, disruption of tissue maintenance, and changes in cell behavior that lead to pathology. Targeted clearance of senescent cells has been shown to produce rejuvenation in mice, a reversal of many different age-related conditions, particularly those strongly linked to the chronic inflammation of aging. In this context, researchers here discuss the presence of greater numbers of senescent cells in older tissues as an important mechanism determining outcomes for patients following organ transplanta...
Source: Fight Aging! - May 31, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Placental Allografts for Diabetic Foot Ulcers: Interview with Tim Wright, CEO of MiMedx
MiMedx, a medtech company based in Georgia, has developed EpiFix, an off-the-shelf allograft system for the treatment of diabetic foot ulcers. The grafts are made using donated human placental tissues that are obtained from consenting mothers during caesarean section procedures. The tissues then undergo a proprietary processing procedure to clean them and eventually produce a dehydrated graft that can be stored at room temperature long term.
Diabetic foot ulcers are relatively common in patients with diabetes, presenting in as many as 15% of such patients. These wounds are stubborn and typically resistant to treatment, ...
Source: Medgadget - February 18, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Medicine Surgery Vascular Surgery Source Type: blogs
Fight Aging! Newsletter, September 7th 2020
In conclusion, using a large cohort with rich health and DNA methylation data, we provide the first comparison of six major epigenetic measures of biological ageing with respect to their associations with leading causes of mortality and disease burden. DNAm GrimAge outperformed the other measures in its associations with disease data and associated clinical traits. This may suggest that predicting mortality, rather than age or homeostatic characteristics, may be more informative for common disease prediction. Thus, proteomic-based methods (as utilised by DNAm GrimAge) using large, physiologically diverse protein sets for p...
Source: Fight Aging! - September 6, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Clearance of Senescent Cells as a Way to Expand the Donor Organ Supply
Researchers here provide a proof of principle to suggest that the presence of senescent cells in older organs contributes meaningfully to transplant rejection, via mechanisms that spur greater immune activity. This is of course only one of the ways in which senescent cell accumulation with age contributes to degenerative aging, the dysfunction of cells and tissues throughout the body. It may be possible to apply senolytic treatments that clear senescent cells to donor organs prior to transplantation (preferably), or to the patient immediately following transplantation (with the risk that it will suppress regeneration for a...
Source: Fight Aging! - September 3, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Ross procedure – Cardiology MCQ – Answer
Ross procedure – Cardiology MCQ – Answer
Ross procedure is – Correct answer: 1. Pulmonary autograft for aortic stenosis
Ross procedure (pulmonary autograft for aortic position) was used for aortic valve disease initially in children and later in adults. The pulmonary valve along with part of the main pulmonary artery is taken and made into a neo-aortic root. Either a cryopreserved homograft or xenograft is placed in the pulmonary position. Sometimes a polytetrafluoroethylene (PTFE) conduit is used in the pulmonary position. The advantage of the autograft in children is that it would grow in size as the ch...
Source: Cardiophile MD - August 11, 2020 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
Ross procedure – Cardiology MCQ
Ross procedure – Cardiology MCQ
Ross procedure is:
Pulmonary autograft for aortic stenosis
Valved conduit for infundibular pulmonary stenosis
Total cavopulmonary anastomosis
Double switch operation
Click here for the correct answer
The post Ross procedure – Cardiology MCQ appeared first on All About Cardiovascular System and Disorders. (Source: Cardiophile MD)
Source: Cardiophile MD - August 9, 2020 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
Left ventricular assist device (LVAD)
Left ventricular assist device is used to support the failing left ventricle when it is refractory to guideline directed medical therapy. It can be either a bridge to cardiac transplantation or a destination therapy. In general, cardiac transplantation offers better long term surival compared to LVAD according data available from devices except the most recent.
As per the The Registry of the International Society for Heart and Lung Transplantation: Thirty-fourth Adult Heart Transplantation Report-2017 [1], there were 126,753 pediatric and adult heart transplants between 1982 and June 2015. Median survival was 10.7 years i...
Source: Cardiophile MD - April 16, 2020 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiac Surgery LVAD Source Type: blogs
A Sticky Solution to a Hard Problem : Interview with Dr. Luiz Alavarez, CEO of Theradaptive
The development of biomaterials for orthopedic applications is a crowded space with several large and small companies designing innovative materials. One approach is the use of these materials to deliver therapeutic proteins that enhance healing. Theradaptive has developed a novel method to modify the proteins themselves so that they coat the surface of implants like paint, making them more readily available for cells of the body to interact with. We recently had the opportunity to chat with the CEO of Theradaptive, Dr. Luiz Alvarez, about the company’s technology which can be used for several applications with a var...
Source: Medgadget - April 6, 2020 Category: Medical Devices Authors: Rukmani Sridharan Tags: Exclusive Medicine Nanomedicine Orthopedic Surgery Source Type: blogs
A Sticky Solution to a Hard Problem : Interview with Dr. Luis Alvarez, CEO of Theradaptive
The development of biomaterials for orthopedic applications is a crowded space with several large and small companies designing innovative materials. One approach is the use of these materials to deliver therapeutic proteins that enhance healing. Theradaptive has developed a novel method to modify the proteins themselves so that they coat the surface of implants like paint, making them more readily available for cells of the body to interact with. We recently had the opportunity to chat with the CEO of Theradaptive, Dr. Luis Alvarez, about the company’s technology which can be used for several applications with a var...
Source: Medgadget - April 6, 2020 Category: Medical Devices Authors: Rukmani Sridharan Tags: Exclusive Medicine Nanomedicine Orthopedic Surgery Source Type: blogs
