Clearance of Senescent Cells as a Way to Expand the Donor Organ Supply
Researchers here provide a proof of principle to suggest that the presence of senescent cells in older organs contributes meaningfully to transplant rejection, via mechanisms that spur greater immune activity. This is of course only one of the ways in which senescent cell accumulation with age contributes to degenerative aging, the dysfunction of cells and tissues throughout the body. It may be possible to apply senolytic treatments that clear senescent cells to donor organs prior to transplantation (preferably), or to the patient immediately following transplantation (with the risk that it will suppress regeneration for a...
Source: Fight Aging! - September 3, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Ross procedure – Cardiology MCQ – Answer
Ross procedure – Cardiology MCQ – Answer Ross procedure is – Correct answer: 1. Pulmonary autograft for aortic stenosis Ross procedure (pulmonary autograft for aortic position) was used for aortic valve disease initially in children and later in adults. The pulmonary valve along with part of the main pulmonary artery is taken and made into a neo-aortic root. Either a cryopreserved homograft or xenograft is placed in the pulmonary position. Sometimes a polytetrafluoroethylene (PTFE) conduit is used in the pulmonary position. The advantage of the autograft in children is that it would grow in size as the ch...
Source: Cardiophile MD - August 11, 2020 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs

Ross procedure – Cardiology MCQ
Ross procedure – Cardiology MCQ Ross procedure is: Pulmonary autograft for aortic stenosis Valved conduit for infundibular pulmonary stenosis Total cavopulmonary anastomosis Double switch operation Click here for the correct answer The post Ross procedure – Cardiology MCQ appeared first on All About Cardiovascular System and Disorders. (Source: Cardiophile MD)
Source: Cardiophile MD - August 9, 2020 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs

Left ventricular assist device (LVAD)
Left ventricular assist device is used to support the failing left ventricle when it is refractory to guideline directed medical therapy. It can be either a bridge to cardiac transplantation or a destination therapy. In general, cardiac transplantation offers better long term surival compared to LVAD according data available from devices except the most recent. As per the The Registry of the International Society for Heart and Lung Transplantation: Thirty-fourth Adult Heart Transplantation Report-2017 [1], there were 126,753 pediatric and adult heart transplants between 1982 and June 2015. Median survival was 10.7 years i...
Source: Cardiophile MD - April 16, 2020 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiac Surgery LVAD Source Type: blogs

A Sticky Solution to a Hard Problem : Interview with Dr. Luiz Alavarez, CEO of Theradaptive
The development of biomaterials for orthopedic applications is a crowded space with several large and small companies designing innovative materials. One approach is the use of these materials to deliver therapeutic proteins that enhance healing. Theradaptive has developed a novel method to modify the proteins themselves so that they coat the surface of implants like paint, making them more readily available for cells of the body to interact with. We recently had the opportunity to chat with the CEO of Theradaptive, Dr. Luiz Alvarez, about the company’s technology which can be used for several applications with a var...
Source: Medgadget - April 7, 2020 Category: Medical Devices Authors: Rukmani Sridharan Tags: Exclusive Medicine Nanomedicine Orthopedic Surgery Source Type: blogs

A Sticky Solution to a Hard Problem : Interview with Dr. Luis Alvarez, CEO of Theradaptive
The development of biomaterials for orthopedic applications is a crowded space with several large and small companies designing innovative materials. One approach is the use of these materials to deliver therapeutic proteins that enhance healing. Theradaptive has developed a novel method to modify the proteins themselves so that they coat the surface of implants like paint, making them more readily available for cells of the body to interact with. We recently had the opportunity to chat with the CEO of Theradaptive, Dr. Luis Alvarez, about the company’s technology which can be used for several applications with a var...
Source: Medgadget - April 7, 2020 Category: Medical Devices Authors: Rukmani Sridharan Tags: Exclusive Medicine Nanomedicine Orthopedic Surgery Source Type: blogs

Fight Aging! Newsletter, October 21st 2019
In this study, AT1-AAs were detected in the sera of patients with peripheral arterial disease (PAD) and the positive rate was 44.44% vs. 17.46% in non-PAD volunteers. In addition, analysis showed that AT1-AAs level was positively correlated with PAD. To reveal the causal relationship between AT1-AAs and vascular aging, an AT1-AAs-positive rat model was established by active immunization. The carotid pulse wave velocity was higher, and the aortic endothelium-dependent vasodilatation was attenuated significantly in the immunized rats. Morphological staining showed thickening of the aortic wall. Histological examination showe...
Source: Fight Aging! - October 20, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Autoimmunity Against AT1 Receptor Spurs Endothelial Cellular Senescence and Vascular Aging
In this study, AT1-AAs were detected in the sera of patients with peripheral arterial disease (PAD) and the positive rate was 44.44% vs. 17.46% in non-PAD volunteers. In addition, analysis showed that AT1-AAs level was positively correlated with PAD. To reveal the causal relationship between AT1-AAs and vascular aging, an AT1-AAs-positive rat model was established by active immunization. The carotid pulse wave velocity was higher, and the aortic endothelium-dependent vasodilatation was attenuated significantly in the immunized rats. Morphological staining showed thickening of the aortic wall. Histological examination showe...
Source: Fight Aging! - October 17, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Injectable Bone Scaffolding Made of Plant Cellulose
The majority of bone implants, cements, and grafts are hard objects that don’t always work well in filling the space they’re supposed to inhabit. Soft objects can gently expand and relocate their mass evenly over a volume, and they tent to be less dense so as to leave room for cells to make home inside of. Researchers at the University of British Columbia and McMaster University in Canada have just reportred on a plant cellulose-based bone scaffolds that can be injected into areas of damage. The material allows native tissue cells to invade into its interior and to propagate. Eventually, because it is biodegrad...
Source: Medgadget - March 20, 2019 Category: Medical Devices Authors: Editors Tags: Materials Nanomedicine Source Type: blogs

Bioreactors Inside Body Grow New Bones for Transplantation
This study demonstrated that we could create viable bone grafts from artificial bone substitute materials. Study in Proceedings of the National Academy of Sciences: Biomaterials-aided mandibular reconstruction using in vivo bioreactors… Via: Rice… (Source: Medgadget)
Source: Medgadget - March 19, 2019 Category: Medical Devices Authors: Editors Tags: ENT Genetics Materials Neurosurgery Source Type: blogs

Alternative Orthopedic Fixation Company Ossio Developing Absorbable Fixation Devices
Ossio, a medical device company with offices in Caesarea, Israel and Woburn, Massachusetts, recently announced a $22 million Series A venture investment round led by LA-based OCV Partners. This brings the company’s total venture funding to $35 million. This technology received FDA 510(k) clearance in January 2019. Ossio has developed the OSSIOfiber Intelligent Bone Regeneration Technology, which provides a biocompatible framework for bone regeneration after traumatic fractures or orthopedic surgery. The platform is a bioabsorbable polymer resin (PLDLA) combined with natural mineral fibers, constructed in a sturd...
Source: Medgadget - March 15, 2019 Category: Medical Devices Authors: Kurt Yaeger Tags: Materials Orthopedic Surgery Source Type: blogs

Mid-Semester Check-Ins Keep Your A & P Course on Track | Episode 38
00:45 | Sperm Speed02:48 | Sponsored by HAPS03:32 | Hematopoiesis in the Gut07:04 | Sponsored by AAA07:22 | Swallow Legos Much?10:41 | New Sponsor: MS-HAPI Program15:23 |Featured: Mid-Semester Check-Ins Keep Your A&P Course on TrackIf you cannot see or activate the audio playerclick here.Questions& Feedback:1-833-LION-DEN (1-833-546-6336)FollowThe A&P Professor onTwitter,Facebook,Blogger,Nuzzel,Tumblr, orInstagram! Vulnerability sounds like truth and feels like courage. Truth and courage aren't always comfortable, but they're never weakness. (Bren é Brown) 1 | Sperm Speed2 minutesWe know t...
Source: The A and P Professor - February 25, 2019 Category: Physiology Authors: Kevin Patton Source Type: blogs

Bioengineered Bone Grafts for Large Bone Defects
Researchers at the New York Stem Cell Foundation have developed a technique to produce bioengineered bone grafts for large bone defects, which are currently difficult to treat using conventional techniques. To deal with bone defects, clinicians currently use either synthetic materials or bone grafts from the patient or a donor. However, these grafts can trigger an immune response, and do not always integrate with the surrounding bone. “Bone defects obtained in disease or injury are a growing issue, and having effective treatment options in place for personalized relief, no matter the severity of a patient’s con...
Source: Medgadget - July 18, 2018 Category: Medical Devices Authors: Conn Hastings Tags: Genetics Materials Orthopedic Surgery Source Type: blogs

Fight Aging! Newsletter, June 4th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - June 3, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Exploring the Utility of Decellularized Muscle Grafts in Animal Models
In this open access paper, researchers explore the utility of decellularized muscle grafts to repair severe injury. Decellularization is the process by which a donor tissue is cleared of cells, leaving behind the extracellular matrix. This intricate structure includes capillary networks and chemical cues to guide cells, line items that the research community has yet to reliably recreate when building tissue from scratch. Over the past decade, researchers have demonstrated the ability to repopulate decellularized tissue with patient-derived cells, a capacity that in principle allows for the production of patient-matched don...
Source: Fight Aging! - May 29, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Gold standard for cardiac allograft rejection – Cardiology MCQ – Answer
 >>>Available Here with Free Look Inside Option Correct Answer: 3. Endomyocardial Biopsy Original methods to detect cardiac allograft rejection were signs of heart failure and ECG abnormalities. But these were quite insensitive. Endomyocardial biopsies are taken from the right ventricular aspect of the interventricular septum using bioptomes introduced through right internal jugular vein. Back to question (Source: Cardiophile MD)
Source: Cardiophile MD - January 4, 2018 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs

Gold standard for cardiac allograft rejection – Cardiology MCQ
Gold standard for detection of cardiac allograft rejection: HLA Antibody estimation Signs of heart failure Endomyocardial biopsy ECG Echocardiography Please post your answer as a comment below. Correct answer will be published on: Jan 4, 2018 @ 21:20 (Source: Cardiophile MD)
Source: Cardiophile MD - January 2, 2018 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs

When the Nurse Becomes the Patient
While nurses have a great deal of experience treating and caring for patients, unforeseen circumstances will occasionally cause the tables to turn, giving the nurse the chance to be a patient. This became my personal reality just last week. Friday, Bloody FridayOn a recent Friday afternoon, I was doing my usual workout at a local gym where I can be found pretty much every other day most weeks of the year. Cardio, weightlifting, various machines, balance exercises, and resistance training all figure in my personalized routine. Early in my workout, I was using thick rubber tubes for resistance training. These bunge...
Source: Digital Doorway - July 17, 2017 Category: Nursing Tags: nurse nurses nursing Source Type: blogs

Fight Aging! Newsletter, June 26th 2017
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - June 25, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Altering Relative Macrophage Population Numbers to Enhance Nerve Regeneration
This study suggests that biasing the infiltrating inflammatory/immune cellular milieu after injury toward a proregenerative population creates a permissive environment for repair. This approach is a shift from the current modes of clinical and laboratory methods for nerve repair, which potentially opens an alternative paradigm to stimulate endogenous peripheral nerve repair. Link: https://doi.org/10.1073/pnas.1705757114 (Source: Fight Aging!)
Source: Fight Aging! - June 22, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

A Combination Cell and Gene Therapy Repairs Severe Bone Fractures
The progress in various approaches to gene therapy over the past decade has succeeded in reducing cost and increasing reliability. This has reached the point at which researchers can afford, from the point of view of both time and funding, to begin to combine gene therapies with other areas of medicine under development. In particular, reliable gene therapies targeting the controlling switches and dials of cell growth and regeneration should be a way to greatly improve the effectiveness of cell therapies and other, similar forms of regenerative medicine. The research reported below is a good example of the type, in which s...
Source: Fight Aging! - June 20, 2017 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Ross procedure in adults
Ross procedure (pulmonary autograft for aortic position) was used for aortic valve disease initially in children and later in adults. The pulmonary valve along with part of the main pulmonary artery is taken and made into a neo-aortic root. Either a cryopreserved homograft or xenograft is placed in the pulmonary position. Sometimes a polytetrafluoroethylene (PTFE) conduit is used in the pulmonary position. The advantage of the autograft in children is that it would grow in size as the child grows, unlike a prosthetic valve. A recent study has reported 90.7% ten year survival after Ross procedure in adults [1]. Di...
Source: Cardiophile MD - August 17, 2016 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiac Surgery Cardiology Source Type: blogs

The FDA Shield - The Medtronic Infuse Case and the Latest Tango of Preemption Versus Liability
The U.S. Supreme Court will shortly decide whether it will hear a case that will have a significant impact on the life sciences and medical device industry, specifically on the issue of whether approval by the Food and Drug Administration (FDA) of medical devices for "single limited use" shields and otherwise immunizes manufacturers from product liability suits results from non-FDA approved uses What is the Medtronic Infuse Case About? In 2010, Patricia Caplinger underwent spinal surgery in which as part of the procedure, a "Medtronic bioengineered bone graft device … was inserted through the back...
Source: Policy and Medicine - April 26, 2016 Category: American Health Authors: Thomas Sullivan - Policy & Medicine Writing Staff Source Type: blogs

Fight Aging! Newsletter, April 4th 2016
This study shows for the first time that increasing arterial stiffness is detrimental to the brain, and that increasing stiffness and brain injury begin in early middle life, before we commonly think of prevalent diseases such as atherosclerosis, coronary artery disease or stroke having an impact." The study also noted that elevated arterial stiffness is the earliest manifestation of systolic hypertension. The large study involved approximately 1,900 diverse participants in the Framingham Heart Study, who underwent brain magnetic resonance imaging (MRI), as well as arterial tonometry. The tests measured the force o...
Source: Fight Aging! - April 3, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Towards Bioprinted Sections of Jawbone and Gum Tissue
Many groups are working to advance the state of the art in bioprinting, seeking to engineer simpler tissue structures using a printed scaffold and cells cultured from a patient tissue sample. This example is focused on dental reconstruction: The team are using the latest 3D bioprinting to produce new, totally 'bespoke,' tissue engineered bone and gum that can be implanted into a patient's jawbone. The approach begins with a scan of the affected jaw, prior to the design of a replacement part using computer-assisted design. A specialised bioprinter, which is set at the correct physiological temperature (in order to avoid de...
Source: Fight Aging! - March 31, 2016 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

A Matter of Ethics and Policy in the Era of Regenerative Transplantation in the United States
by Macey L. Henderson and Brianna L Doby Why do we need to care about the ethical development of health policies that impact research, donation, and transplantation in the United States? The story of Zion Harvey is a good place to start. Zion lost all of his limbs to amputation from sepsis at the age of two. The infection that ravished his body and took his limbs also caused renal failure, resulting in a successful kidney transplant when he was 4 years old.… (Source: blog.bioethics.net)
Source: blog.bioethics.net - August 17, 2015 Category: Medical Ethics Authors: Macey Henderson Tags: Featured Posts Organ Transplant & Donation Pediatrics regenerative transplantation Vascularized Composite Allograft Source Type: blogs

Thymus Organoids Restore Immune Function in Mice
Researchers here demonstrate restoration of immune function in mice via transplant of tissue engineered thymus-like organoids, one of a number of lines of research that aims to restore thymic function to boost the aging immune system. A sizable part of the age-related decline of the adaptive immune system arises from a problem of supply: there are no longer enough naive T cells to mount an effective response to new threats. Some potential approaches to solving this problem involve dealing with issues that reduce the naive T cell population, while others focus on increasing the supply of new T cells. The thymus plays a vit...
Source: Fight Aging! - July 10, 2015 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Aortic Stenosis
Aortic stenosis can be congenital or acquired. Congenital aortic stenosis is often secondary to degenerative changes in a bicuspid aortic valve. Calcific aortic stenosis of the elderly is related to dyslipidemia and atherosclerosis. Rheumatic fever is an important cause for aortic stenosis in the developing countries. Rheumatic aortic valve disease is often a combination of stenosis and regurgitation. Severe aortic stenosis causes left ventricular hypertrophy and angina pectoris as a result of coronary supply demand mismatch. When a person with severe aortic stenosis exercises, syncope can occur due to the fixity of cardia...
Source: Cardiophile MD - April 23, 2015 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: General Cardiology Source Type: blogs

Aortic Regurgitation
Aortic regurgitation can occur due to damage to the aortic valve as well as due to dilatation of the aortic root so that aortic valve leaflets fail to coapt. The later condition occurs in annulo-aortic ectasia, often associated with Marfan syndrome. Aortic regurgitation due valvular damage can occur in rheumatic fever. A bicuspid aortic valve can also become regurgitant as age advances.  In the yester years, tertiary syphilis was an important cause of aortic root dilatation and aortic regurgitation. Aortic regurgitation is quantified in terms of regurgitant fraction,which is the fraction of left ventricular output tha...
Source: Cardiophile MD - April 22, 2015 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Echocardiogram Library Source Type: blogs

MOPS Bone and Cartilage Preservation System (VIDEO)
Bone and cartilage grafts harvested from donor tissue don’t survive for very long, with estimates that around 80% of tissue donated for joint repair is going to waste. Researchers at University of Missouri School of Medicine have now developed a new way to preserve such tissue for much longer than previously possible, doubling its lifetime and hopefully leading to a major reduction in the need for such tissue. Currently, donor tissue is preserved in refrigerators, floating within a special solution that keeps it viable for about a month. The Missouri Osteochondral Allograft Preservation System (MOPS) uses a...
Source: Medgadget - January 29, 2015 Category: Technology Consultants Authors: Editors Tags: in the news... Source Type: blogs

A Scaffolding Approach to Anterior Cruciate Ligament Repair
The use of scaffolding in regenerative medicine is becoming more sophisticated, with researchers developing a wider range of approaches that offer a variety of different structural characteristics. This allows for attempts to repair load bearing or supporting tissues such as ligaments and tendons: Not only is the anterior cruciate ligament (ACL) inelastic and prone to popping, it is incapable of healing itself, causing surgeons to rely on autografts for reconstruction. Most common is the bone-patellar tendon-bone (BPTB) graft, in which the surgeon removes part of the patellar tendon to replace the damaged ACL. "BPTB ...
Source: Fight Aging! - December 31, 2014 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

RICO: Offering Co-Pay Coupons Does Not Constitute A Racketeering “Enterprise,” Rules Federal Court
Pharmaceutical manufacturer co-payment coupons have come under a lot of scrutiny recently. HHS-OIG recently warned these coupons may violate the anti-kickback statute if they encourage the purchase of Medicare Part D drugs. Manufacturers seem to be safe, however, from co-pay challenges under RICO—the federal Racketeer Influenced and Corrupt Organizations Act which was originally enacted to combat organized crime. Last week, a Federal Court judge dismissed an insurance company’s claim that they overpaid for drugs in which Abbott Laboratories and Abbvie allegedly committed mail and wire fraud by offering co-...
Source: Policy and Medicine - October 14, 2014 Category: American Health Authors: Thomas Sullivan Source Type: blogs

Delayed cardiac complications of radiotherapy
Radiation damages the vascular endothelium leading to accelerated coronary atherosclerosis. Due to improvement in radiotherapy techniques, radiation associated cardiac damage is lesser with modern techniques. Most cases occur in those who have undergone mediastinal radiation in a younger age for diseases like Hodgkins disease for which longer survival gives a chance for long term cardiac issue to manifest. Radiotherapy for breast cancer is another important cause of cardiac complications of radiotherapy. Radiation induced cardiac damage is enhanced with concomitant use of adriamycin based chemotherapy. Important delayed c...
Source: Cardiophile MD - August 12, 2014 Category: Cardiology Authors: Prof. Dr. Johnson Francis MD, DM, FACC, FRCP Edin, FRCP London Tags: General Cardiology Source Type: blogs

Case of the Week 297
A patient was noted to have rapidly increasing serum creatinine 4 months after receiving a renal allograft. A renal biopsy was performed, which revealed small oval/elongate objects within the renale tubules.  (CLICK ON IMAGES TO ENLARGE).  A variety of stains and additional studies were performed:H&E, 200x H&E, 400x H&E, 1000x (note how tiny the structures inside the renal tubule cells are) The structures were partially acid fast (Ziehl Neelsen, 1000x) A Ryan's trichrome performed on tissue nicely highlighted the objects (1000x) A urine specimen stained with Ryan's trichrome a...
Source: Creepy Dreadful Wonderful Parasites - March 24, 2014 Category: Pathologists Source Type: blogs

Medtronic Sued by 1,000 Infuse Patients
by John FauberMedtronic said about 1,000 people have sued the company over its bone morphogenetic protein-2 (BMP-2) product, Infuse, and that many more lawsuits may be coming.In addition, several states now are looking into sales and marketing practices involving Infuse, which is used in spine surgery.In a statement, company spokesperson Cindy Resman said the cases are in early procedural stages, and none have resulted in a finding of liability against Medtronic.Some court rulings have led to dismissals and others have limited claims."Medtronic stands behind Infuse bone graft and will vigorously defend it in...
Source: PharmaGossip - March 5, 2014 Category: Pharma Commentators Authors: insider Source Type: blogs

Pain In The Back? Exercise May Help You Learn Not To Feel It : Shots - Health News : NPR
More than 1 in 4 adult Americans say they've recently suffered a bout of low-back pain. It's one of the most common reasons people go to the doctor. And more and more people are being treated for it. America spends more than $80 billion a year on back pain treatments. But many specialists say less treatment is usually more effective. In fact, there's evidence that many standard treatments for back pain — surgery, spinal injections and painkillers — are often ineffective and can even worsen and prolong the problem. Dr. Jerome Groopman agrees with that premise. He suffered back pain for almost 20 y...
Source: Psychology of Pain - January 15, 2014 Category: Psychiatrists and Psychologists Source Type: blogs

Delayed cardiac complications of radiotherapy
: a) Accelerated coronary artery disease b) Restrictive cardiomyopathy c) Constrictive pericarditis (Radiation is one of the conditions which can cause both constriction and restriction; the other condition being cardiac allograft rejection) d) Cardiac conduction abnormalities e) Valvular dysfunction – left sided valves are more commonly affected by fibrosis. But regurgitant lesions are more common than stenotic lesions. (Source: Cardiophile MD)
Source: Cardiophile MD - December 27, 2013 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

Aurora Spine Gains US Approval for ZIP MIS Interspinous Fusion System
Aurora Spine Corporation, a company based in Carlsbad, CA that focuses on spinal implant technologies, has received FDA 510(k) clearance for the minimally invasive ZIP MIS Interspinous Fusion System. The ZIP system provides surgeons an alternative to the prevalent pedicle screw technologies to perform spinal fixation. The device is intended for treatment of degenerative disc disease, spondylolisthesis, spinal tumors,and trauma, and is used to provide stabilization during  non-cervical spine (T1-S1 lumbar) fusion procedures. The device is designed to be attached to plate fixation for supplemental fu...
Source: Medgadget - December 10, 2013 Category: Technology Consultants Authors: Gaurav Krishnamurthy Tags: Orthopedic Surgery Source Type: blogs

BonAlive Biomaterials Gets CE Mark for BonAlive Putty
BonAlive Biomaterials Ltd (Turku, Finland) has been awarded CE Mark approval for its BonAlive Putty, a bone graft substitute indicated for treatment of bony voids and gaps. The putty builds on their current osteostimulative S53P4 bioactive glass granules, and combines it with a synthetic binder which dissolves soon after implantation. The bioactive granules develop a silica-gel layer, which promotes calcium phosphate deposition and allows for bonding between the native bone and the granules. With the surface transformed into one that is chemically and structurally similar to the mineral phase of natural bone, osteoblast ac...
Source: Medgadget - November 25, 2013 Category: Technology Consultants Authors: Nishey Wanchoo Tags: Orthopedic Surgery Source Type: blogs

NLT Spine Receives FDA Approval for Second Generation PROW FUSION and eSPIN Spinal Devices
NLT Spine (Kfar Saba, Israel), a maker of minimally invasive spinal technologies, has received FDA approval for the second generation  of the PROW FUSION implant and eSPIN discectomy tool. The two devices help to perform  lumbar interbody fusion via a small posterior incision in a reliable, safe and minimally invasive procedure. The second generation products make use of fewer instruments, better irrigation, improved material and optimized design. The PROW FUSION interbody fusion implant, which is used for Transforaminal Lumbar Interbody Fusion (TLIF) procedures, consists of a segmented non-linear ...
Source: Medgadget - November 12, 2013 Category: Technology Consultants Authors: Gaurav Krishnamurthy Tags: Orthopedic Surgery Source Type: blogs

New books received this week
Principles and practice of single implant and restoration / Mahmoud Torabinejad. St. Louis: Elsevier, 2013. Covering treatment planning to restoration, this book is specifically designed to train Endodontists and General Dentists for a single tooth implant and restorations. It describes surgical principles, implant placement, implant site preparation, bone grafts and bone substitute materials, tooth extraction, guided bone regeneration, immediate implant placement, surgical defects, and single-tooth esthetic considerations. Haematology: an illustrated colour text. / Martin R. Howard. 4th ed., Edinburgh: Churchi...
Source: DentistryLibrary@Sydney - October 29, 2013 Category: Dentists Tags: New books Source Type: blogs

InterFuse L Modular Implant from Vertebral Technologies Receives FDA 510(k) Clearance
Lateral lumbar interbody fusion is a minimally invasive procedure to remove spinal discs damaged by degenerative disc disease, and replace them with bone graft implants. By entering through the patient’s side, the major back muscles and nerves are spared. Vertebral Technologies, Inc. (VTI) has received 510(k) clearance from the FDA for the InterFuse Lateral (Interfuse L), which uses a proprietary rail and slot technology to deliver the graft implants. The implants themselves are modularized, allowing physicians to replace larger discs with the implant through smaller incisions, further reducing muscle and nerve damag...
Source: Medgadget - September 27, 2013 Category: Technology Consultants Authors: Nishey Wanchoo Tags: Orthopedic Surgery Source Type: blogs

Interesting Things in MeSH 2014
This one is for the medlibs and me, some interesting changes in MeSH for 2014: The concept (and term for) TEN has been absorbed into Stevens-Johnson Syndrome – makes some sense given the “spectrum of disease” aspect. Drug Toxicity has been replaced by Drug-Related Side Effects and Adverse Reactions, which is much more tedious to type from memory. Fetal Alcohol Syndrome has been replaced by Fetal Alcohol Spectrum Disorders. Arachnidism has been changed to the much easier to remember Spider Bites. Tick Bites is new, too. Hearing Impaired Persons has been changed to the more person-first Persons with Heari...
Source: Women's Health News - September 22, 2013 Category: Medical Librarians Authors: Rachel Tags: Uncategorized language medical librarians MeSH Source Type: blogs

Interesting Things in MeSH 2014
This one is for the medlibs and me, some interesting changes in MeSH for 2014: The concept (and term for) TEN has been absorbed into Stevens-Johnson Syndrome – makes some sense given the “spectrum of disease” aspect. Drug Toxicity has been replaced by Drug-Related Side Effects and Adverse Reactions, which is much more tedious to type from memory. Fetal Alcohol Syndrome has been replaced by Fetal Alcohol Spectrum Disorders. Arachnidism has been changed to the much easier to remember Spider Bites. Tick Bites is new, too. Hearing Impaired Persons has been changed to the more person-first Persons with Heari...
Source: Women's Health News - September 22, 2013 Category: Consumer Health News Authors: Rachel Tags: Uncategorized language medical librarians MeSH Source Type: blogs

Spinal Tap: Medtronic And The Virtues Of Releasing Trial Data
As the result of an unusual effort designed to bolster transparency in clinical trials, two independent analyses have found that a Medtronic product used as a bone graft substitute in spinal fusion surgeries offers little benefit over conventional procedures and may be linked to an increased risk of cancer as well as the possibility of sterility in men. Beyond the findings, the significance of these analyses is that they were funded by Medtronic (MDT), which was widely criticized after reports disclosed that doctors with financial ties to the device maker were aware of serious problems with the Infuse spinal fusion product...
Source: Pharmalot - June 18, 2013 Category: Pharma Commentators Authors: esilverman Source Type: blogs

New e-books
Antibiotics and antiseptics in periodontal therapy / Dumitrescu, Alexandrina L. Heidelberg ; New York: Springer, 2011. Periodontal diseases are the major cause of tooth mortality in many industrialized countries and most developing nations. The significance of microorganisms in the development of virtually all types of periodontal disease is indisputable. This book is an encyclopedic collection of data from scientific papers and textbooks that form a sound basis for a thorough understanding of the antibiotics and antiseptics used in periodontal therapy. Treatment of periodontal disease / Frank A. Scannapieco.(ed)...
Source: DentistryLibrary@Sydney - March 15, 2013 Category: Dentists Tags: New books E-books Source Type: blogs

New Journal Subscription: Clinical Implant Dentistry & Related Research
Bibby Library is pleased to provide you with full-text access to the journal Clinical Implant Dentistry & Related Research.   The journal publishes original research and reviews on osseointegrated implants, bone biology, bone grafts and bone substitutes. To access the journal enter the title here.  If you are offsite you will be prompted for your URMC [...] (Source: Bibby Library News and Tips)
Source: Bibby Library News and Tips - January 7, 2013 Category: Dentists Authors: emamo Tags: Bibby Library Dental Journals Source Type: blogs