FEV1 Monitoring of Allograft Function: Virtual or Reality?

Purpose: Chronic Lung Allograft Dysfunction (CLAD) remains the leading cause of graft loss after lung transplantation (LTx). FEV1 has been used as a surrogate to classify CLAD, with %changes in individual FEV1 baselines being used to define CLAD. Reasoning behind individual baselines is historical, to facilitate comparisons between single-lung and heart-lung transplant recipients. Given shifts towards bilateral LTx as well as candidate demographics, the utility of % baseline and its impact on decision-making is unknown.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research