Heart Allograft Recovery Using Temperature-Controlled Cold Storage is Associated with Decreased Myocardial Injury
Purpose: Observational cohort studies suggest a lower incidence of severe primary graft dysfunction (PGD) following temperature-controlled preservation. Whether this novel cold storage platform attenuates ischemia-reperfusion myocardial injury, as quantified by cardiac enzymes, remains unknown. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , H. Beaini, J.S. Murala, C. Heid, A. Weston, A. Gorrai, S. Garg, M. Farr, M. Peltz Source Type: research
Decoding T Cell Clonal Dynamics in Acute Lung Rejection
Purpose: T cell-mediated acute cellular rejection (ACR) is a common complication in lung transplant (LTx) recipients within the first post-transplant year, affecting 30-50% of patients and is often associated with later development of chronic lung allograft dysfunction (CLAD). Traditional genomics studies, utilizing bulk RNA-Seq, lack the cellular granularity required to completely understand ACR. Our research leverages single-cell RNA +TCR sequencing (scRNAseq/TCRseq) to investigate the clonal repertoire and gene expression changes in expanded T cells during ACR, highlighting the crucial role of single-cell TCR sequencing...
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: A. Potter, K. Wikenheiser-Brokamp, D. Hildeman, N. Sharma, M. Gu, K. Patel, M. Qureshi, M.M. Khan, C. Wallace, A. Ziady, Source Type: research
Does Ex Vivo Lung Perfusion Mitigate the Detrimental Effects of Primary Graft Dysfunction? A Propensity Matched Analysis of the United Network for Organ Sharing Database
Purpose: Previous studies and anecdotal reports have proposed that recipients who develop primary graft dysfunction grade 3 (PGD3) following lung transplantation from allografts that underwent ex vivo lung perfusion (EVLP) have improved outcomes, as compared to those who did not undergo EVLP. We sought to determine if this held true in a national database. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , E.Y. Cui, D. Satija, M.C. Henn, C.T. Walk, K. Choi, V. Ramsammy, N.A. Mokadam, A.M. Ganapathi, B.A. Whitson Source Type: research
Impact of Total Allograft Ischemic Time on Heart-Lung Transplantation Outcomes in the United States
The objective of this study was to elucidate the association between total allograft ischemic time and HLTx outcomes. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , H. He, Y. Woo, Y. Shudo Source Type: research
Baseline Lung Allograft Dysfunction: Clinical Characteristics, Outcomes, and Contributing Factors
This study investigates the contributing factors and outcomes of baseline lung allograft dysfunction (BLAD) in a high-volume lung transplant center. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , M. Salan-Gomez, M. Sanders, R. Fernandez, P. Garcha, A. Mattar, A. Elsenousi, A. Shafii, G. Loor Source Type: research
High-Grade Eosinophils on Diagnostic Transbronchial Biopsy are Associated with Chronic Lung Allograft Dysfunction After Lung Transplantation
This study aimed to validate the prognostic role of systematic quantification of eosinophils (Eos) in diagnostic transbronchial biopsy (TBBx) for risk of chronic lung allograft dysfunction (CLAD). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , V. Sivasubramaniam, M. Qiu, W. Barrett, S. Wong, L. Thwe, K. Tonga, T. Martinu, P. MacDonald, M. Plit Source Type: research
Incidence and Outcomes of BKV in Simultaneous Heart-Kidney Transplant Recipients: A Multi-Center Review
Purpose: BK polyomavirus viremia (BKV) is most commonly seen following kidney transplantation (KT), and can lead to kidney allograft dysfunction. Around 3% of KT recipients develop BKV within 1 yr following transplant, with ~29% of those KT recipients progressing to graft loss. The mainstay intervention for BKV is the reduction of maintenance immunosuppression (MIS). There are few reports of BKV following simultaneous heart-kidney (SHK) transplant. The aim of this project was to evaluate the incidence of BKV following SHK transplant to identify opportunities for improvement in our immunosuppression protocols. (Source: The ...
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: M.M. Eiting, L. Woolley, , K. Zukauckas, T. Larson, B. Sirandas, A. Chan, L. Smith, C. Truax Source Type: research
FEV1 Monitoring of Allograft Function: Virtual or Reality?
Purpose: Chronic Lung Allograft Dysfunction (CLAD) remains the leading cause of graft loss after lung transplantation (LTx). FEV1 has been used as a surrogate to classify CLAD, with %changes in individual FEV1 baselines being used to define CLAD. Reasoning behind individual baselines is historical, to facilitate comparisons between single-lung and heart-lung transplant recipients. Given shifts towards bilateral LTx as well as candidate demographics, the utility of % baseline and its impact on decision-making is unknown. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , S. Dumschat, S. Kruszona, N. de Manna, J. Salman, T. Welte, A. Ruhparwar, F. Ius Source Type: research
Association of Donor Derived Cell-Free DNA Fractions with Acute Rejection and Pulmonary Infections in Lung Transplant Recipients
Purpose: Acute cellular rejection (ACR) and pulmonary infections (PI) predispose to the development of chronic lung allograft dysfunction, the leading cause of late morbidity following lung transplantation. While bronchoscopy is the gold standard for diagnosis of ACR or PI, its invasive nature can cause complications and certain patients are ineligible. Therefore, alternative methods to diagnose and follow response to treatment after ACR or PI are needed. Donor derived cell free DNA (dd-cfDNA) is an established biomarker to detect graft injury, but there is limited data on differences of dd-cfDNA levels during ACR or PI, a...
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: S. Pasupneti, H. Mudgett, E. Mann, S. Jacobs, J. Mooney, Source Type: research
Utilization of Pseudomonas Eradication Protocols Amongst Lung Transplant Centers
Purpose: Chronic airway colonization with Pseudomonas is associated with the development of chronic lung allograft dysfunction (CLAD) in lung transplant recipients (LTRs). Eradication efforts with inhaled and/or systemic antibiotics are common in the cystic fibrosis population. The aim of our survey is to understand current Pseudomonas eradication practices within the lung transplant population. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , K. Saharia, E. Heil, J. Baddley, R. Reed, M. Eberlein, K. Prakash Source Type: research
Asymptomatic Viral Carriage in Lung Transplant Recipients and Donors on Day of Transplant
Purpose: The aim of this pilot study is to estimate prevalence of asymptomatic community respiratory viral (CRV) carriage in lung transplant (LuTx) recipients and donors at the time of transplant, and to determine if asymptomatic carriage of CRVs increases the risk of post-transplant infection, allograft rejection or mortality. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , L. Cavey, V. Patel, M. Eberlein, R. Reed, A. Charya, A. Krupnick, J. Rabin, J. Baddley, G. Bittle, H. Porterfield, K. Saharia Source Type: research
Grade 3 Primary Graft Dysfunction After Ex-Vivo Lung Perfusion is Associated with Better Short-Term Outcomes Compared to Direct Transplantation
Purpose: Grade 3 PGD has been described as a major risk factor for morbidity after lung transplantation. The aim of this study is to investigate the clinical impact of grade 3 PGD in patients who received allografts after EVLP compared with patients who received direct transplants. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , J. Peel, M. Aversa, S. Keshavjee, M. Cypel Source Type: research
Sex Differences in Allograft Rejection After Heart Transplantation (HT). Molecular Microscope (MMDx) Results
Purpose: The association between sex and rejection outcomes following HT remains controversial. We aim to investigate the impact of sex differences on rejection assessed by MMDx. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , A. Fernandez Valledor, S. Rahman, D. Oren, D. Lotan, G. Rubinstein, Y. Mehlman, J. Raikhelkar, M. Yuzefpolskaya, E.M. DeFilippis, J. Fried, K. Clerkin, N. Uriel, G.T. Sayer Source Type: research
Ex-Vivo Lung Perfusion: National Trends and Post-Transplant Outcomes
We examined trends in EVLP use and recipient outcomes in the United States. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , S. Schaefer, A.M. Williams, D.D. Odell, K.H. Lagisetty Source Type: research
NKG2D - A Potential Target for Alloreactive CD8 T Cells
Purpose: Long term survival after lung transplantation is greatly limited by the high incidence of chronic lung allograft dysfunction (CLAD), however mechanisms are incompletely characterized and effective therapy is limited. NKG2D is a cell surface protein associated with lymphocyte cytoxicity that may be involved in CLAD pathogenesis. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: K. Moghbeli, , A. Craig, J. Sembrat, M. Bueno, O. Eickelberg, M. Snyder Source Type: research
