5 Year Outcomes Following Ex Vivo Lung Perfusion Using a Centralized Lung Evaluation System at a Dedicated Facility
Purpose: Ex vivo lung perfusion (EVLP) can increase the number of transplantable allografts by allowing for evaluation of lungs not initially considered for transplantation. Feasibility of remote EVLP with a centralized lung evaluation system (CLES) at a dedicated facility was previously demonstrated (NCT02234128) and despite a higher rate of primary graft dysfunction grade 3 at 72 hours (PGD3-72h) in the CLES cohort, survival out to 3 years was similar to controls. These data will present 5-year outcomes with CLES-EVLP. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , J. D'Cunha, P. Sanchez, Z. Kon, R. Pierson, C. Keller, D. Erasmus, M. Hartwig, D. Dilling, A. Brown, W. Lynch, M.R. Sketch, D. Cella, M. Roberts, K. McCurry Source Type: research
Epicardial and Microvascular CAV are Associated with Restrictive Physiology After Heart Transplantation
Purpose: Cardiac allograft vasculopathy (CAV) is a major cause of graft failure following heart transplantation (HT). One criterion for ISHLT CAV3 is restrictive physiology (RP), and recently, modified RP (RA>8 mmHg, PCWP>15 mmHg, CI (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , N. Prasad, J.A. Fried, V.K. Topkara, J. Raikhelkar, E.M. DeFilippis, F. Latif, M. Yuzefpolskaya, P.C. Colombo, G. Sayer, N. Uriel, K. Clerkin Source Type: research
Long Term Outcome of First-Year C1q Positive Donor Specific Antibodies After Heart Transplantation
Purpose: Detection of donor specific antibodies (DSA) after heart transplantation (HTx) has been associated with poor outcome in the long term. DSA have been associated with decreased survival, increased incidence of cardiac allograft vasculopathy (CAV), increase in cardiac dysfunction, and increase in non-fatal major adverse cardiac events (NF-MACE). DSA are heterogeneous and amount of antibody-binding can be detected by the Luminex assay. Functional studies indicate whether the DSA can cause killing by the ability to bind complement. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , J. Patel, M. Kittleson, M. Welton, N. Bhatnagar, A. Kanungo, M. Lee, Z. Wakefield, M. Hamilton, A. Hage, L. Czer, P. Catarino, J. Kobashigawa Source Type: research
Efficacy and Safety if JAK2 Inhibitor Plus Extracorporeal Photopheresis in Chronic Lung Allograft Dysfunction: A Single Centre Experience
Purpose: Post lung transplantation survival is limited by the development of chronic lung allograft dysfunction(CLAD),for which only few effective therapies exists and no standardized management. There are studies showing proven benefits of JAK2 inhibitor plus ECP in post bone marrow transplantation GVHD patients.We analysed JAK2 inhibitor plus ECP therapy in clinically diagnosed CLAD. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , V. Rahulan, M. Lalani, O. Tisekar, S. Priyaranjan, P. Dutta, A. Mohandas, M. B N, M. M, M. Sameer, S. Attawar Source Type: research
Corticosteroid Dose Impacts Early Outcomes in Lung Allograft Recipients: A Dual-Center Study
Purpose: Early post-transplant corticosteroid (CS) dosing varies between programs, yet the impact on outcomes is unknown. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , T.C. Lewis, L. Angel, S. Chang, D.B. Erasmus, M. Bacchetta, A.J. Trindade Source Type: research
Non-HLA Antibodies Are Associated with Chronic Lung Allograft Dysfunction in Lung Transplant Recipients
This study aimed to elucidate the role of non-HLA Abs on the development of chronic lung allograft dysfunction (CLAD) and overall survival in LTRs. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: K. Vyskocilov á, M. Röder, K. Vychytilová, A. Glosová, A. Zajacova, , A. Dutkova, L. Fila, R. Lischke, A. Slavčev, J. Havlin Source Type: research
Impact of COVID-19 Infection on the Development of Chronic Lung Allograft Dysfunction (CLAD) After Lung Transplantation
This study aims to evaluate the impact of COVID-19 infection on time-to-CLAD and survival in a large single-center study. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , A. Benazzo, M. Aversa, Q. Li, S. Wang, E. Huszti, R. Ghany, J.T. Solera, D. Kumar, S. Keshavjee, T. Martinu, S. Juvet Source Type: research
Long-Term Outcomes of Invasive Aspergillosis and Aspergillus Colonization in Lung Transplant Recipient - A Nationwide Cohort Study
Purpose: No consensus on invasive aspergillosis (IA) prevention in lung transplantat recipients (LTXr) exists. Further knowledge is needed on how IA and Aspergillus colonization affect the long term outcomes chronic lung allograft dysfunction (CLAD) and mortality. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , H. Lawaetz Schultz, S.T. Shahri, M.C. Arendrup, M. Helleberg, M. Perch Source Type: research
Role of Traditional Cardiac Biomarkers in Donation After Circulatory Death Heart Transplantation
Purpose: Cardiac allografts recovered after circulatory death (DCD) presumably sustain a myocardial injury during the obligatory warm ischemia phase that is currently difficult to characterize. The purpose of this study is to investigate whether traditional cardiac biomarkers in DCD donation are representative of reversible or irreversible myocardial damage. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , S. Lundgren, R. Garvin, L. Fristoe, B. Lowes, A. Castleberry, J. Um Source Type: research
Cardiac Donation After Circulatory Death Utilizing Normothermic Regional Perfusion: The Three-Year Vanderbilt Experience
Purpose: The aim of this study was to evaluate the outcomes and evolution of thoraco-abdominal normothermic regional perfusion (NRP) to recover and evaluate donation after circulatory death (DCD) cardiac allografts. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , A. DeBose-Scarlett, P. Mark, S. Bommareddi, T. Absi, H. Siddiqi, K. Amancherla, D. Brinkley, J. Lindenfeld, J. Menachem, H. Ooi, D. Pedrotty, L. Punnoose, A. Rali, S. Sacks, M. Wigger, S. Zalawadiya, S. DeVries, C. Keck, S. Scholl, A. Lepore, M. Warhoov Source Type: research
Human Lung Spheroid Cell Exosomes Protect Against Lung Ischemia-Reperfusion Injury in a Prolonged Warm Ischemia Porcine DCD Model
Purpose: Despite advances in donor lung management and preservation, most donor lung grafts are still unsuitable for transplantation due to concerns for ischemia-reperfusion injury (IRI) and primary graft dysfunction. Human lung spheroid cell exosomes (LSC-Exo) have been shown to promote lung repair in pulmonary fibrosis. Here, we sought to investigate the potential of LSC-Exo to repair injured lung allografts in a DCD porcine model. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , D.L. Segamanasinghe, S.T. Aldin, S. Altarabsheh, G. Knop, F. Al-Azzam, F.A. Reynolds, A. Richman, C. Colby, H.L. Zeman, J. Mallea, Y. Jing, K. Cheng, S. Saddoughi Source Type: research
Correlation of Donor-Derived Cell-Free DNA to Rejection Events in Pediatric Heart Transplant Recipients
Purpose: Acute cellular (ACR) and antibody-mediated (AMR) rejection are risk factors for allograft loss in heart transplant (HT) recipients. Endomyocardial biopsy (EMB), although considered gold standard for rejection surveillance, is invasive and has high interobserver variability. Non-invasive donor-derived cell free DNA (dd-cfDNA) sampling has high negative predictive value for rejection in adults and is increasingly used in pediatrics. This single center study aimed to test the performance of dd-cfDNA in detecting acute rejection in pediatric HT recipients. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: S.A. Bravo, L.D. Akabas, A.D. Simonelli, W.A. Zuckerman, M.E. Richmond, Source Type: research
How Well Does the Molecular Microscope Diagnostic System (MMDx) Correlate with Traditional Pathologic Biopsy Interpretation in a Pediatric Heart Transplant Population?
Purpose: Histologic evaluation of endomyocardial biopsies (EMB) is the gold-standard for diagnosis of rejection post heart transplant (HT), but the methodology is subject to interobserver variability and sampling error. The molecular microscope diagnostic system (MMDx) analyzes RNA transcripts from EMB tissue to differentiate quiescent allograft tissue from that with rejection/injury. While MMDx results have been described in adult HT cohorts, less is known about its utility in pediatric patients which differ regarding indications for HT, degree of anti-HLA sensitization, and post HT immunosuppression. (Source: The Journal...
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , T.P. Singh, G. Nava, M. Clark, R. Kobayashi, P. Esteso, C. Carreon, A. Al-Ibraheemi, L.A. Sleeper, K.P. Daly Source Type: research
Impact of Primary Graft Failure: Analysis of the PHTS Database
Purpose: Primary graft failure (PGF) is a leading cause of early morbidity and mortality after heart transplant (HTx). It manifests as allograft dysfunction in the absence of other causes. While the impact of PGF on early mortality in pediatrics has been described, it is unclear if PGF also influences long-term survival and post-HTx complications. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , T. Pidborochynski, J. Kirklin, R. Cantor, H. Zhao, A. Sheybani, J. Lamour, L.G. Hahn, L. Collins, J. Laks, D.H. Freed Source Type: research
Predictors of Intraoperative Donor Lung Turndown After Initial Acceptance
Purpose: Turndown of donor lungs at the time of potential recovery wastes transplant team, hospital, and system resources. We investigated predictors of intraoperative turndown (ITD) of donor lung allografts that were initially accepted. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , A.L. Zhou, J.M. Ruck, A. Kalra, A.J. Casillan, J.S. Ha, C.A. Merlo, E.L. Bush Source Type: research
