Factors correlating with recovery of quadriceps strength after double-bundle anterior cruciate ligament reconstruction with hamstring tendon autografts
ConclusionsPostoperative quadriceps strength index at 6  months after double-bundle ACL reconstruction with hamstring tendon autografts was affected by preoperative quadriceps strength index. Adequate preoperative quadriceps strength may need to be considered in order to facilitate better recovery of quadriceps strength after ACL reconstruction and to s upport an earlier return to sports activities. (Source: European Journal of Orthopaedic Surgery and Traumatology)
Source: European Journal of Orthopaedic Surgery and Traumatology - October 14, 2019 Category: Orthopaedics Source Type: research

Functional and anatomical outcomes of single-stage arthroscopic bimeniscal replacement
ConclusionBimeniscal replacement by an allograft and/or substitute provides good short-term functional and anatomical outcomes. Nevertheless, this procedure is warranted only in highly selected patients.Level of evidenceIV, retrospective study. (Source: Orthopaedics and Traumatology: Surgery and Research)
Source: Orthopaedics and Traumatology: Surgery and Research - October 13, 2019 Category: Orthopaedics Source Type: research

Arthroscopic Revision with Autologous Iliac Crest Bone Graft for Failed Anatomic Glenoid Reconstruction Using Distal Tibia Allograft
Publication date: Available online 11 October 2019Source: Arthroscopy TechniquesAuthor(s): Rakesh John, Catherine M. Coady, Ivan WongAbstractRecurrent instability after anterior shoulder stabilization surgery is not an uncommon complication, with variable rates of recurrences associated with different surgical procedures. The Latarjet procedure continues to be the gold standard in the management of anterior instability with significant glenoid bone loss, although a recent trend toward arthroscopic anatomic glenoid reconstruction (AAGR) with distal tibial allograft has been noted, with excellent short-term results and minim...
Source: Arthroscopy Techniques - October 12, 2019 Category: Surgery Source Type: research

Stem Cell–Infused Anterior Cruciate Ligament Reconstruction
Publication date: Available online 11 October 2019Source: Arthroscopy TechniquesAuthor(s): Gun Min Youn, Angelica Marie Remigio Van Gogh, Alyssa Alvarez, Sophia Sarang Shin Yin, Moyukh O. Chakrabarti, Patrick J. McGahan, James L. ChenAbstractAnterior cruciate ligament (ACL) tears are unfortunate but common injuries in the athletic population. The standard of care for ACL tears is a surgical intervention to reconstruct the ACL to restore knee functionality as well as quality of life. In recent years, bone marrow aspirate concentrate (BMAC) has seen increasing use in various orthopaedic settings. This increase can be attribu...
Source: Arthroscopy Techniques - October 12, 2019 Category: Surgery Source Type: research

Hepatic flow is an intraoperative predictor of early allograft dysfunction in whole-graft deceased donor liver transplantation: An observational cohort study.
CONCLUSION: Intraoperative measurement of blood flow after reperfusion appears to be a predictor of EAD; Moreover, HAF should be considered a predictor of 30-d patient mortality. PMID: 31598193 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - October 12, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Is There a Cutoff in Favor of Penetrating Keratoplasty Rather than Endothelial Keratoplasty for Long-Standing Endothelial Decompensation?
Authors: Jeng BH Abstract Endothelial keratoplasty (EK) has evolved to become the standard of care over traditional penetrating keratoplasty (PK) for treating isolated corneal endothelial disease. EK provides numerous advantages including faster, more reliable visual rehabilitation, along with a lower allograft rejection rate. There are some situations, however, in which EK may not necessarily be the best option, and PK should at least be considered. In such situations, a careful weighing and balancing needs to be done in conjunction with the patient. PMID: 31600815 [PubMed - as supplied by publisher] (Source: ...
Source: Klinische Monatsblatter fur Augenheilkunde - October 11, 2019 Category: Opthalmology Tags: Klin Monbl Augenheilkd Source Type: research

Early radiographic failure of reverse total shoulder arthroplasty with structural bone graft for glenoid bone loss
Structural glenoid bone grafting in reverse total shoulder arthroplasty (RSA) has previously been reported to have good functional outcomes and low complication rates. We have observed different complication rates and hypothesized that baseplate fixation and severity of deformity may be predictors of early failure. (Source: Journal of Shoulder and Elbow Surgery)
Source: Journal of Shoulder and Elbow Surgery - October 11, 2019 Category: Orthopaedics Authors: Jason C. Ho, Ocean Thakar, Wayne W. Chan, Thema Nicholson, Gerald R. Williams, Surena Namdari Source Type: research

Use of intravoxel incoherent motion imaging to monitor a rat kidney chronic allograft damage model
Chronic allograft damage (CAD) is the leading cause of long-term graft dysfunction. A noninvasive method that can diagnose CAD early and monitor its development is needed. (Source: BMC Nephrology)
Source: BMC Nephrology - October 10, 2019 Category: Urology & Nephrology Authors: Qiang Zhang, Zexing Yu, Song Zeng, Lu Liang, Yue Xu, Zijian Zhang, Hao Tang, Wenjiao Jiao, Wenrui Xue, Wei Wang, Xiaodong Zhang, Tao Jiang and Xiaopeng Hu Tags: Research article Source Type: research

Arthroscopic Posterior Glenohumeral Capsular Augmentation With Gracilis Tendon Allograft
Publication date: Available online 7 October 2019Source: Arthroscopy TechniquesAuthor(s): Michael D. Maloney, Joseph C. Schaffer, Raymond J. KenneyAbstractRecurrent shoulder instability complicated by capsular insufficiency due to underlying soft-tissue disorders or multiple prior failed surgical procedures poses a challenging surgical problem. Traditional capsulolabral soft-tissue reconstruction techniques are less effective in this setting, and bony procedures sacrifice normal anatomic relations. The described arthroscopic technique aims to prevent instability while maintaining range of motion through creation of a soft-...
Source: Arthroscopy Techniques - October 10, 2019 Category: Surgery Source Type: research

Eplet mismatch analysis and allograft outcome across racially diverse groups in a pediatric transplant cohort: a single-center analysis
AbstractHLA eplet mismatch load has been suggested as an improvement to HLA antigen mismatch determination for organ selection. Given that eplet mismatches are determined based on amino acid sequence difference among HLA alleles, and that the frequency of HLA alleles varies between racial groups, we investigated the correlation between eplet mismatch load and allograft outcomes in 110 pediatric kidney transplant recipients who received their first organ from a donor of the same race (SRT) versus a donor of a different race (DRT). Adjusted modified Poisson regression was used to assess the interaction between eplet mismatch...
Source: Pediatric Nephrology - October 10, 2019 Category: Urology & Nephrology Source Type: research

Recent developments in biomaterials for long-bone segmental defect reconstruction: A narrative overview
Publication date: Available online 8 October 2019Source: Journal of Orthopaedic TranslationAuthor(s): Meng Zhang, Jukka P. Matinlinna, James K.H. Tsoi, Wenlong Liu, Xu Cui, William W. Lu, Haobo PanAbstractReconstruction of long-bone segmental defects (LBSDs) has been one of the biggest challenges in orthopaedics. Biomaterials for the reconstruction are required to be strong, osteoinductive, osteoconductive, and allowing for fast angiogenesis, without causing any immune rejection or disease transmission. There are four main types of biomaterials including autograft, allograft, artificial material, and tissue-engineered bone...
Source: Journal of Orthopaedic Translation - October 9, 2019 Category: Orthopaedics Source Type: research

[Pott's puffy tumour: innovative technique in calvarial reconstruction].
CONCLUSION: Modified distraction osteogenesis is a novel technique in the primary reconstruction of calvarial bone. PMID: 31587674 [PubMed - as supplied by publisher] (Source: Journal of Laryngology and Otology)
Source: Journal of Laryngology and Otology - October 9, 2019 Category: ENT & OMF Tags: J Laryngol Otol Source Type: research

Expanding the Lung Donor Pool and Improving Outcomes
Limited donor lung availability and prolonged wait times remain substantial barriers to lung transplant. According to the Scientific Registry of Transplant Recipients, 11% of patients were removed from the wait-list in 2017 because of death or clinical deterioration and 40% of patients waited longer than 1 year before transplant. Ex vivo lung perfusion (EVLP) provides the opportunity to expand the donor pool, but despite encouraging early posttransplant outcomes, the long-term effect of EVLP remains unclear. In this issue of JAMA Surgery, Divithotawela et al present 10-year outcomes of the Toronto Lung Transplant Group &rs...
Source: JAMA Surgery - October 9, 2019 Category: Sports Medicine Source Type: research

Linking innate immunity and chronic antibody-mediated allograft rejection.
Abstract PURPOSE OF THE REVIEW: To summarize recent findings linking donor-specific antibodies with innate immunity resulting in chronic allograft rejection. RECENT FINDINGS: Studies in recent years highlight the problem of donor-specific antibodies (DSA) in both acute and chronic allograft rejection. Since chronic rejection is the leading cause of graft failure, this review centers on the contribution of three areas of innate immunity of particular recent focus: complement, NK cells, and macrophages. Recent advances indicate the diverse roles that complement components play both in directly initiating allogr...
Source: Current Opinion in Organ Transplantation - October 9, 2019 Category: Transplant Surgery Authors: Gill RG, Lin CM Tags: Curr Opin Organ Transplant Source Type: research

Losartan improves alveolar bone dynamics in normotensive rats but not in hypertensive rats
Conclusion: Losartan can improve bone mineralization parameters under normal physiological conditions, but the same anabolic effect does not occur under hypertension. (Source: Journal of Applied Oral Science)
Source: Journal of Applied Oral Science - October 8, 2019 Category: Dentistry Source Type: research

Monofilament cerclage wiring fixation with locking plates for distal femoral fracture: Is it appropriate ?
Conclusions: Open reduction and locking plate fixation with additional cerclage wiring is a useful method for the reduction of complicated distal femoral fractures, without increased complications such as nonunion. Level of Evidence: Level III, retrospective cohort design, treatment study. (Source: Indian Journal of Orthopaedics)
Source: Indian Journal of Orthopaedics - October 7, 2019 Category: Orthopaedics Authors: Sung Hyun Lee Young Chae Choi Suc Hyun Kweon Source Type: research

Failure to return to preinjury activity level after hamstring anterior cruciate ligament reconstruction: Factors involved and considerations in goal setting
Conclusion: Psychological factors are important (and may require targeted input), but return-to-sport is multifactorial. Ongoing symptoms may prompt further surgery, but this is frequently unsuccessful in achieving return. Patient-specific goals should be sought and revisited throughout the rehabilitation program. Acknowledging psychological barriers, in those aiming to return to the same level, may help achieve this goal. In other patients, success may be return to a desired lower level. Understanding the patient's expectations is important in goal setting. (Source: Indian Journal of Orthopaedics)
Source: Indian Journal of Orthopaedics - October 7, 2019 Category: Orthopaedics Authors: Jonathan D Kosy Jonathan RP Phillips Adaeze Edordu Rahul Pankhania Peter J Schranz Vipul Mandalia Source Type: research

Short term results of a new comprehensive protocol for the management of congenital pseudarthrosis of the Tibia
Conclusion: Our study demonstrates that the new comprehensive protocol is extremely effective for achieving sound union in Congenital Pseudarthrosis of Tibia. (Source: Indian Journal of Orthopaedics)
Source: Indian Journal of Orthopaedics - October 7, 2019 Category: Orthopaedics Authors: Sandeep Vijaykumar Vaidya Alaric Aroojis Rujuta Mehta Mandar Vikas Agashe Arjun Dhawale Ankita Vijay Bansal Kailash Sarathy Source Type: research

Three dimensionally printed surgical guides for removing fixation screws from onlay bone grafts in flapless implant surgeries
Publication date: Available online 4 October 2019Source: The Journal of Prosthetic DentistryAuthor(s): Otavio Henrique Pinhata-Baptista, Roger Nascimento Gonçalves, Ivan Onone Gialain, Marcelo Gusmão Paraíso Cavalcanti, Ricardo Yudi Tateno, Arthur Rodriguez Gonzalez CortesAbstractThe present technique report describes a digital workflow for flapless implant surgery after onlay block bone graft healing in the esthetic area. Virtual removal of block fixation screws and optimal single-tooth implant position and digital crown waxing were planned from cone beam computed tomography (CBCT) and intraoral scans...
Source: The Journal of Prosthetic Dentistry - October 6, 2019 Category: Dentistry Source Type: research

A combination regimen of low-dose bortezomib and rapamycin prolonged the graft survival in a murine allogeneic islet transplantation model.
In this study, we showed that the short-term combination treatment of low-dose bortezomib and rapamycin significantly prolonged the survival of islet allografts. Short-term treatment of low-dose (0.05 mg/kg or 0.1 mg/kg) bortezomib reduced the MHC class II expression in dendritic cells (DCs) of alloantigen-sensitized mice, and prolonged the islet allograft survival for up to 50 days in diabetic mice. Notably, when bortezomib was combined with rapamycin, it induced islet-specific immunological tolerance which allowed the acceptance of a second graft without additional immunosuppression. This regimen dramatical...
Source: Immunology Letters - October 5, 2019 Category: Allergy & Immunology Authors: Hong SH, Kim K, Shin JS, Chung H, Park CG Tags: Immunol Lett Source Type: research

Mini-Simple Limbal Epithelial Transplantation Versus Conjunctival Autograft Fixation With Fibrin Glue After Pterygium Excision: A Randomized Controlled Trial
Purpose: To compare the outcomes between mini-simple limbal epithelial transplantation (mini-SLET) and conjunctival autograft (CAG) fixation with fibrin glue after excision of pterygium. Methods: Ninety-two eyes with primary nasal pterygium were prospectively randomized into a CAG control arm and a mini-SLET study arm. Follow-up examinations were set at the first and third day, at weeks 1, 2, and 4, and at the third and sixth month after surgery. The primary outcome measure was the recurrence rate at 1, 3, and 6 months after surgery, whereas the secondary outcome measures were the intraoperative time, postoperative sy...
Source: Cornea - October 4, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Modified Sutureless and Glue-Free Method Versus Conventional Sutures for Conjunctival Autograft Fixation in Primary Pterygium Surgery: A Randomized Controlled Trial
Purpose: To compare the advantages and disadvantages of a modified sutureless and glue-free method with those of conventional sutures for conjunctival autograft fixation in pterygium surgery. Methods: A prospective randomized controlled study was performed on 73 eyes with primary nasal pterygium. After pterygium excision, the bare sclera was covered with a limbal conjunctival autograft, which was fixed using a modified sutureless and glue-free method in group 1 (39 eyes) and sutures in group 2 (34 eyes). The main outcome measures were operative time, autograft stability, postoperative discomfort, autograft thickness, ...
Source: Cornea - October 4, 2019 Category: Opthalmology Tags: Clinical Science Source Type: research

Commercially available bone graft substitutes: the impact of origin and processing on graft functionality.
Authors: Bow A, Anderson DE, Dhar M Abstract Development of effective and cost-efficient bone tissue engineering grafts has been the key area of research for regenerative medicine, yet an ideal grafting material has remained elusive due in large part to the highly dynamic nature of bone. A wide array of materials, both natural and synthetic, have been implemented as potential candidates for commercially available products, yet the gold standard for grafting material still remains autogenous bone. We review currently commercially available bone graft materials and relevant graft characteristics that impact the effec...
Source: Drug Metabolism Reviews - October 4, 2019 Category: Drugs & Pharmacology Tags: Drug Metab Rev Source Type: research

The Role of Complement in Organ Transplantation
The current immunosuppressive protocols used in transplant recipients have improved short-term outcomes, but long-term allograft failure remains an important clinical problem. Greater understanding of the immunologic mechanisms that cause allograft failure are needed, as well as new treatment strategies for protecting transplanted organs. The complement cascade is an important part of the innate immune system. Studies have shown that complement activation contributes to allograft injury in several clinical settings, including ischemia/reperfusion injury and antibody mediated rejection. Furthermore, the complement system pl...
Source: Frontiers in Immunology - October 4, 2019 Category: Allergy & Immunology Source Type: research

Indications of Intestinal Transplantation
“The intestinal transplantation is reserved for patients with life-threatening complications of permanent intestinal failure or underlying gastrointestinal disease. The choice of the allograft for a particular patient depends on several factors and the presence of concurrent organ failure, and ava ilability of the donor organs, and specialized care. Combined liver and intestinal transplant allows for patients who have parenteral nutrition–associated liver disease a possibility of improved quality of life and nutrition as well as survival. Intestinal transplantation has made giant strides ov er the past few deca...
Source: Gastroenterology Clinics of North America - October 4, 2019 Category: Gastroenterology Authors: Arshad B. Kahn, Kiara A. Tulla, Ivo G. Tzvetanov Source Type: research

Multifocal and hormone-dependent epithelioid hemangioendothelioma with osteolysis of the second cervical vertebral body: report of an unprecedented surgical approach by using autologous bone graft
. (Source: British Journal of Neurosurgery)
Source: British Journal of Neurosurgery - October 4, 2019 Category: Neurosurgery Authors: Hanno M. Witte Armin Riecke Thomas Mayer Carsten Hackenbroch Konrad Steinestel Niklas Gebauer Dirk Puckhaber Ren é Mathieu Uwe Max Mauer Chris Schulz Source Type: research

Influence of Pregnancy on Long Term Durability of Allografts in Right Ventricular Outflow Tract
We present the first study using mixed and joint modeling. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - October 4, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Jamie LR. Romeo, Grigorios Papageorgiou, Johanna JM. Takkenberg, Jolien W. Roos-Hesselink, Wouter J. van Leeuwen, Jerome MJ. Cornette, Dimitris Rizopoulos, Ad JJC. Bogers, M Mostafa Mokhles Source Type: research

Single Nucleotide Polymorphisms of Ubiquitin-Related Genes were Associated with Allograft Fibrosis of Renal Transplant Fibrosis.
CONCLUSIONS We are the first to reveal that mutations of rs644731 in the PIAS2 gene were significantly correlated with the progression of IF/TA in kidney transplant recipients. PMID: 31582715 [PubMed - in process] (Source: Annals of Transplantation)
Source: Annals of Transplantation - October 4, 2019 Category: Transplant Surgery Authors: Gui Z, Li W, Fei S, Guo M, Chen H, Sun L, Han Z, Tao J, Ju X, Yang H, Wei JF, Tan R, Gu M Tags: Ann Transplant Source Type: research

Innate immunity in ischemia-reperfusion injury and graft rejection.
Abstract PURPOSE OF REVIEW: Although organ transplantation has become the standard life-saving strategy for patients with end-stage organ failure and those with malignancies, effective and safe therapeutic strategies to combat allograft loss remain to be established. With the emerging evidence suggesting the critical role of innate immunity in the mechanism of allograft injury, we summarize the latest understanding of macrophage-neutrophil cross-communication and discuss therapeutic prospects of their targeting in transplant recipients. RECENT FINDINGS: Macrophages and neutrophils contribute to the pathogenes...
Source: Current Opinion in Organ Transplantation - October 4, 2019 Category: Transplant Surgery Authors: Nakamura K, Kageyama S, Kupiec-Weglinski JW Tags: Curr Opin Organ Transplant Source Type: research

Impact of extracellular vesicles on innate immunity.
Abstract PURPOSE OF REVIEW: Extracellular vesicles released by prokaryote or eukaryote cells are emerging as mechanisms of cell-to-cell communication, by either physically interacting with the surface of target cells or transferring proteins/peptides, lipids, carbohydrates, and nuclei acids to acceptor cells. Accumulating evidence indicates that extracellular vesicles, among other functions, regulate innate and adaptive immune responses. We revisit here the effects that extracellular vesicles of various origins have on innate immunity. RECENT FINDINGS: Extracellular vesicles comprise a heterogeneous group of ...
Source: Current Opinion in Organ Transplantation - October 4, 2019 Category: Transplant Surgery Authors: Chen Z, Larregina AT, Morelli AE Tags: Curr Opin Organ Transplant Source Type: research

The Adipo-Fascial ALT Flap in Lower Extremities Reconstruction Gustillo IIIC-B Fractures. An Osteogenic Inducer?
Conclusion: Despite the goods results, further studies applied on a large number of patients are needed to confirm authors theory, however, we can consider the fascial ALT flap as a valid help for bone healing in 3B-C open tibial fractures. PMID: 31576766 [PubMed - as supplied by publisher] (Source: Journal of Investigative Surgery)
Source: Journal of Investigative Surgery - October 3, 2019 Category: Surgery Tags: J Invest Surg Source Type: research

Magnetic resonance imaging of the quadriceps tendon autograft in anterior cruciate ligament reconstruction
AbstractBackgroundQuadriceps tendon (QT) autograft is emerging as a popular technique for primary anterior cruciate ligament (ACL) reconstruction. Studies have shown that it has comparable outcomes to bone-patellar tendon-bone (BPTB) and hamstring tendon (HT) autografts while mitigating post-operative complications associated with these grafts.PurposeTo provide a literature summary of the important pre- and post-operative magnetic resonance imaging (MRI) findings of the quadriceps tendon and pertinent postoperative complications associated with the QT harvest. Radiologists should be familiar with MR findings after autologo...
Source: Skeletal Radiology - October 3, 2019 Category: Radiology Source Type: research

Graft interposition for preventing Frey's syndrome in patients undergoing parotidectomy.
CONCLUSIONS: The evidence for the effectiveness of graft interposition in preventing Frey's syndrome is of low or very low certainty. The use of acellular dermal matrix may be associated with an increase in the wound infection rate, and little or no difference in the incidence of seromas or sialoceles. Further studies are needed to draw reliable conclusions. PMID: 31578708 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - October 3, 2019 Category: General Medicine Authors: Ye L, Cao Y, Yang W, Wu F, Lin J, Li L, Li C Tags: Cochrane Database Syst Rev Source Type: research

The outcome of TGF β antagonism in metastatic breast cancer models in vivo reflects a complex balance between tumor-suppressive and pro-progression activities of TGFβ.
CONCLUSIONS: Contrary to dogma, tumor suppressive responses to TGF-β are retained in some advanced metastatic tumors. Safe deployment of TGF-β antagonists in the clinic will require good predictive biomarkers. PMID: 31582516 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - October 3, 2019 Category: Cancer & Oncology Authors: Yang Y, Yang H, Tang B, Wu AML, Flanders KC, Moshkovich N, Weinberg DS, Welsh MA, Weng J, Ochoa HJ, Hu TY, Herrmann MA, Chen J, Edmondson EF, Simpson RM, Liu F, Liu H, Lee M, Wakefield LM Tags: Clin Cancer Res Source Type: research

Microwave Ablation of Renal Cell Carcinoma of the Transplanted Kidney: Two Cases
AbstractThermal ablative techniques have been increasingly recognized as a valuable alternative to graftectomy and nephron-sparing surgery for the treatment of small neoplasms arising in the transplanted kidney. However, long-term efficacy and safety data are still lacking. In particular, current experience with microwave ablation is limited to a very recent single-centre series of three cases. We herein report two microwave ablations of renal cell carcinoma of the kidney allograft. The procedures were successfully performed under ultrasound guidance with complete tumour necrosis, no peri-operative complications, and prese...
Source: CardioVascular and Interventional Radiology - October 2, 2019 Category: Radiology Source Type: research

Retrospective Cohort-Based Comparison of Intraoperative Liposomal Bupivacaine Versus Bupivacaine for Donor Site Iliac Crest Analgesia during Alveolar Bone Grafting
Bone grafting of alveolar clefts is routinely performed with cancellous bone harvested from the iliac crest. Graft site morbidity is frequently seen, with early post-operative pain being one of the most common complaints. Liposomal bupivacaine has been demonstrated to provide improvement in post-operative pain for patients undergoing bunionectomy or hemorrhoidectomy, which may translate to patients requiring iliac crest bone graft harvest. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - October 2, 2019 Category: Cosmetic Surgery Authors: Ronak A. Patel, Eric M. Jablonka, Kristine C. Rustad, Brian C. Pridgen, Sarah S. Sorice-Virk, Mimi R. Borrelli, Rohit K. Khosla, H. Peter Lorenz, Arash Momeni, Derrick C. Wan Source Type: research

Optimized Timing of Post-Transplantation Cyclophosphamide in MHC-Haploidentical Murine Hematopoietic Cell Transplantation
The use of post-transplantation cyclophosphamide (PTCy) has overcome historical barriers to hematopoietic cell transplantation (HCT) by safely facilitating human leukocyte antigen (HLA)-haploidentical HCT and by reducing rates of severe acute and particularly chronic graft-versus-host disease (GVHD). [1] The clinical implementation of PTCy was based on studies in major histocompatibility complex (MHC)-matched skin allografting models, which suggested that a high 200 mg/kg dose of PTCy on day +2 or +3 after donor splenocyte infusion was effective in prolonging survival of a subsequently placed skin allograft; lower doses or...
Source: Biology of Blood and Marrow Transplantation - October 2, 2019 Category: Hematology Authors: Lucas P. Wachsmuth, Michael T. Patterson, Michael A. Eckhaus, David J. Venzon, Christopher G. Kanakry Source Type: research

Applications of Bone Morphogenetic Protein-2: Alternative Therapies in Craniofacial Reconstruction
Large defects of the craniofacial skeleton can be exceedingly difficult to reconstruct since autologous bone grafts are limited by donor site morbidity and alloplastic implants have low biocompatibility. Bone morphogenetic proteins (BMPs) in craniofacial reconstruction have been used with mixed outcomes and complication concerns; however, results for specific indications have been promising. In alveolar clefts, cranial vault defects, mandibular defects, and rare Tessier craniofacial clefts, BMP-2 impregnated in collagen matrix was looked at as an alternative therapy for challenging cases. In cases where structural support...
Source: Journal of Craniofacial Surgery - October 1, 2019 Category: Surgery Tags: Original Articles Source Type: research

Rigid External Le Fort I Distraction Followed by Secondary Bone Grafting for Maxillary Advancements in Patients With Cleft Lip and Palate
This study describes surgical outcomes of a 2-stage technique utilizing distraction osteogenesis combined with bone grafting and rigid fixation, which may optimize skeletal stability by reducing relapse. Methods: A retrospective review of CLP patients with severe maxillary hypoplasia evaluated by a single surgeon from 2003 to 2014 was performed. Twenty-one subjects were identified that underwent maxillary advancement via a 2-stage technique: (1) Le Fort I external rigid distraction using a HALO device, followed by (2) autologous iliac crest bone graft application and plate-fixation. Post-operative cephalograms were take...
Source: Journal of Craniofacial Surgery - October 1, 2019 Category: Surgery Tags: Original Articles Source Type: research

Evaluation of the Effects of Low-Level Laser Therapy on Diabetic Bone Healing
The aim of the present study was to evaluate the effects of low-level laser therapy (LLLT) and biphasic alloplastic bone graft material on diabetic bone healing. Induction of diabetes was performed in 14 male Sprague-Dawley rats by intraperitoneal injection of a 50 mg/kg dose of streptozotocin. Two bilaterally symmetrical non-critical-sized bone defects were created in the parietal bones in each rat. Right defects were filled with biphasic alloplastic bone graft. Rats were randomly divided into 2 groups, with 1 group receiving 10 sessions of LLLT (GaAlAs, 78.5 J/cm2, 100mW, 0.028 cm2 beam). The LLLT was started immed...
Source: Journal of Craniofacial Surgery - October 1, 2019 Category: Surgery Tags: Original Articles Source Type: research

Spontaneous Osteogenesis of a Traumatic Mandibular Defect in the Pediatric Population
Spontaneous osteogenesis of traumatic mandibular defects in the pediatric population remains a relatively rare phenomenon with only 2 patients reported in the literature. In the adult population, a low threshold exists for bone graft placement in the presence of small mandibular gaps, with no role for spontaneous osteogenesis in significant mandibular defects. The approach to traumatic mandibular defects in the pediatric population is not clearly described in the literature and the risks and benefits associated with donor site morbidity of bone graft harvest must be tempered by the possibility for potential spontaneous ost...
Source: Journal of Craniofacial Surgery - October 1, 2019 Category: Surgery Tags: Original Articles Source Type: research

Cranioplasty With Autogenous Frozen and Autoclaved Bone: Management and Treatment Outcomes
Cranioplasty is a widely employed procedure for restoration of calvarial form and shape. The use of autogenous bone flap offers biological reconstruction with minimal donor site morbidity. One of the options to re-use bone autograft is low temperature preservation followed by autoclaving during cranioplasty. A retrospective evaluation of 12 patients with a mean age of 32.58 ± 10.04 years who underwent frozen autogenous autoclaved bone cranioplasty was done. Cranial bone flaps were removed during the initial craniectomy and stored at 4°C for 20 minutes followed by preservation at −40°C in the deep...
Source: Journal of Craniofacial Surgery - October 1, 2019 Category: Surgery Tags: Original Articles Source Type: research

Reconstruction of a Large Posttraumatic Mandibular Defect Using Bone Tissue Engineering With Fresh-Frozen Humeral Allograft Seeded With Autologous Bone Marrow Aspirate and Vascularized With a Radial Forearm Flap
Discussion: The authors chose to use iliac bone marrow aspirate to seed the allograft scaffold since hematopoietic stem cells and mesenchymal stem cell are able to differentiate into osteoblasts, ease of harvest of the iliac crest and its low rate of morbidity. Contemporary biomaterials used for BTE are bioceramic but bone is still the better scaffold to engineer bone and only allografting avoids donor site morbidity. Vascularization is one of the main challenges of BTE; insertion of autologous vascular bundles from pedicle or free flaps is 1 solution. The authors chose the radial forearm flap since the pedicle is long a...
Source: Journal of Craniofacial Surgery - October 1, 2019 Category: Surgery Tags: Original Articles Source Type: research

Strategy of Mandibular Central Arch Reconstruction After Firearm Injury
Gunshot wounds can cause extensive destruction of soft tissue and bone, and the maxillofacial region is often affected. The reconstructive treatment is complex due to the difficulty to reestablish the central arch mandibular contour and volume. Moreover, the goal is to avoid postoperative infections and obtain bone graft neovascularization. Therefore, this report shows a clinical case of a patient presenting mandibular deformity with a mandibular central arch discontinuity caused by a firearm injury. The strategy to the reconstructive treatment as performed with a condensed and stabilized particulate autogenous bone graft ...
Source: Journal of Craniofacial Surgery - October 1, 2019 Category: Surgery Tags: Brief Clinical Studies Source Type: research

Use of Bone Morphogenetic Protein in Pediatric Cranioplasty With Pre- and Postoperative Radiation Therapy
Conclusion: The use of BMP has the potential to aid in bone generation for high-risk calvarial defects. It can be safe and efficacious to use in the pediatric population; however, future studies should be done to determine the safest and most effective dosing of BMP. (Source: Journal of Craniofacial Surgery)
Source: Journal of Craniofacial Surgery - October 1, 2019 Category: Surgery Tags: Brief Clinical Studies Source Type: research

Membranous Nephropathy Posttransplantation: An Update of the Pathophysiology and Management
Membranous nephropathy (MN) is a common cause of nephrotic syndrome after transplantation and is associated with an increased risk of allograft loss. MN may occur either as a recurrent or as a de novo disease. As in native kidneys, the pathophysiology of the MN recurrence is in most cases associated with antiphospholipid A2 receptor antibodies. However, the posttransplant course has some distinct features when compared with primary MN, including a lower chance of spontaneous remission and a greater requirement for adjuvant immunosuppressive therapy to induce complete remission. Although the efficacy of rituximab in primary...
Source: Transplantation - October 1, 2019 Category: Transplant Surgery Tags: Reviews Source Type: research

The Effects of an IL-21 Receptor Antagonist on the Alloimmune Response in a Humanized Mouse Skin Transplant Model
Conclusions. These findings demonstrate that blockade of IL-21 signaling can delay allograft rejection in a humanized skin transplantation model. (Source: Transplantation)
Source: Transplantation - October 1, 2019 Category: Transplant Surgery Tags: Original Basic Science–General Source Type: research

Differential Regulation of T-cell Immunity and Tolerance by Stromal Laminin Expressed in the Lymph Node
Conclusions. Laminins α4 and α5 are coinhibitory and costimulatory ligands for human and mouse CD4 T cells, respectively. Laminins and their receptors modulate immune responses by acting as one of the molecular switches for immunity or suppression. (Source: Transplantation)
Source: Transplantation - October 1, 2019 Category: Transplant Surgery Tags: Original Basic Science–General Source Type: research

Long-term Effects of Hypothermic Ex Situ Perfusion on Skeletal Muscle Metabolism, Structure, and Force Generation After Transplantation
In this study, we investigated the long-term effects of the HESP on skeletal muscle metabolism, structure, and force generation and compared it with the current standard of preservation. Methods. Forty male Lewis rats (250 ± 25 g) were divided into 5 groups, including naive control, sciatic nerve transection or repair, immediate transplantation, SCS, and HESP. For the SCS group, limbs were preserved at 4°C for 6 hours. In the HESP group, limbs were continuously perfused with oxygenated histidine-tryptophan-ketoglutarate (HTK) solution at 10–15°C for 6 hours. Hemodynamic and biochemical parame...
Source: Transplantation - October 1, 2019 Category: Transplant Surgery Tags: Original Basic Science–General Source Type: research

GSE112927 Pretransplant transcriptomic signature in peripheral blood predicts acute rejection and renal allograft loss
Contributors : Weijia Zhang ; Zhengzi Yi ; Paolo Cravedi ; Barbara MurphySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEarly development of acute rejection after kidney transplantation is associated with diminished long-term graft survival. Predicting early acute rejection (EAR) at the time of transplant is important to risk-stratify patients and titrate immunosuppression accordingly. We performed whole-blood RNA sequencing at the time of transplant in 235 kidney transplant recipients enrolled in a prospective-cohort study [one discovery set (N=81), two validation sets (N=74 and N=8...
Source: GEO: Gene Expression Omnibus - October 1, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research