Antibacterial effect and biocompatibility of silver nanoparticle-coated bone allograft substitutes
This study aimed to coat bone allografts with silver nanoparticles and assess their antibacterial activity and biocompatibility compared to uncoated bone allografts. In this study, the bone allografts were coated with varying concentrations of silver nanoparticles (5 mg/l, 10 mg/l, and 50 mg/l) through a simple adsorption technique. Subsequently, the coated samples underwent characterization using SEM, FTIR, EDS, and XRD. The Minimal Inhibitory Concentration (MIC) of the silver nanoparticles was determined against Staphylococcus aureus and Streptococcus mutans. Bacterial growth inhibition was evaluated by measuring turbidi...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Sanna Hadi Othman Omar Source Type: research
Leukotriene B4: A Potential Mediator and Biomarker for Cardiac Allograft Vasculopathy
Cardiac allograft vasculopathy (CAV) remains the leading cause of long-term graft failure and mortality after heart transplantation. Effective preventive and treatment options are not available to-date, largely because underlying mechanisms remain poorly understood. We studied the potential role of leukotriene B4 (LTB4), an inflammatory lipid mediator, in development of CAV. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 23, 2024 Category: Transplant Surgery Authors: Dong Wang, Grigol Tediashvili, Daniel Kim, Xiaomeng Hu, Helen Luikart, Thomas Renne, Amy Tian, Kari C. Nadeau, Joachim Velden, Sonja Schrepfer, Kiran K. Khush Source Type: research
Autogenous structural bone graft reconstruction of ≥ 10-mm-deep uncontained medial proximal tibial defects in primary total knee arthroplasty
ConclusionsAutogenous bone graft reconstruction is a safe and effective method of addressing uncontained medial proximal tibial defects in primary TKA.Level of evidenceLevel IV. (Source: Journal of Orthopaedics and Traumatology)
Source: Journal of Orthopaedics and Traumatology - April 23, 2024 Category: Orthopaedics Source Type: research
Comparison of the clinical efficacy of bone grafting and bone grafting combined with guided tissue regeneration in periodontal regenerative therapy: a meta-analysis
CONCLUSION: Both simple bone grafting and bone grafting combined with membrane materials have good clinical efficacy in periodontal regenerative therapy, and no significant difference in clinical efficacy is indicated between the two, with the exception of GR.PMID:38646940 | DOI:10.2340/aos.v83.40255 (Source: Acta Odontologica Scandinavica)
Source: Acta Odontologica Scandinavica - April 22, 2024 Category: Dentistry Authors: Fengqi Zhang Guolin Liu Source Type: research
Spectrum of chronic lung allograft dysfunction pathology in human lung transplantation
Long-term survival after lung transplantation (LTx) remains limited by Chronic Lung Allograft Dysfunction (CLAD), which includes two main phenotypes: bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS), with possible overlap. We aimed to detail and quantify pathological features of these CLAD sub-types. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 22, 2024 Category: Transplant Surgery Authors: Benjamin Renaud-Picard, Gregory Berra, David Hwang, Ella Huszti, Ei Miyamoto, Gerald J Berry, Prodipto Pal, Stephen Juvet, Shaf Keshavjee, Tereza Martinu Tags: Original Clinical Science Source Type: research
Trends, Outcomes, and Evaluation of the Older Living Kidney Donor
AbstractPurpose of ReviewWe aim to review trends, donor and recipient outcomes, and considerations in the evaluation of older living kidney donors (LD).Recent FindingsOlder donors comprise a small but growing proportion of LDs. Aging is associated with nephrosclerosis, nephron loss, and a physiologic decline in kidney function. Importantly, living donor outcomes are favorable, with older LDs having similar mortality to age-matched healthy older non-donors, a lower lifetime risk of ESKD than younger LDs, and preserved quality of life. Allograft survival of LDKT from older LDs is also acceptable, and recipient survival is be...
Source: Current Transplantation Reports - April 19, 2024 Category: Transplant Surgery Source Type: research
The Role of Ultrasound in the Diagnosis and Treatment of Meniscal Injuries
AbstractPurpose of ReviewThis review evaluates the current understanding of the role of ultrasound in the diagnosis and treatment of meniscal disorders.Recent FindingsUltrasound (US) demonstrates similar sensitivity and specificity when compared to magnetic resonance imaging in the evaluation of meniscal injuries when compared to arthroscopy. Meniscal extrusion (ME) under US can be a reliable metric to evaluate for meniscal root tears in knees with and without osteoarthritis (OA). Sonographic ME is associated with development of OA in knees without OA. US following allograft meniscal transplant may be useful in predicting ...
Source: Current Reviews in Musculoskeletal Medicine - April 19, 2024 Category: Orthopaedics Source Type: research
A Comparative Study of Volar Locking-Plate Fixation with Corticocancellous and Pure Cancellous Bone Grafts for Scaphoid Nonunion with Dorsal Intercalated Segmental Instability Secondary to Scaphoid Humpback Deformity
Treatment for scaphoid nonunion with associated dorsal intercalated segmental instability (DISI) secondary to scaphoid humpback deformity aims to restore carpal alignment and achieve fracture union. To attain these goals, standard procedures of surgical treatment for scaphoid nonunion with deformity involves adequate reduction of the scaphoid deformity, internal fixation, and bone grafting [1 –3]. Various bone grafting techniques have been described, using two types of bone graft: cortcicocancellous bone graft or pure cancellous bone graft [3,4]. (Source: Injury)
Source: Injury - April 19, 2024 Category: Orthopaedics Authors: Joung Woo Shin, Dong Whan Kim, Dong Hee Kwak, Jong Woong Park, Jung Il Lee Source Type: research
Polytherapy versus monotherapy in the treatment of tibial non-unions: a retrospective study
ConclusionsPolytherapy is more effective than monotherapy for severe tibial non-unions, offering a higher success ratio. The NUSS score supports decision-making in treating tibial non-unions.Level of evidenceLevel III. (Source: Journal of Orthopaedics and Traumatology)
Source: Journal of Orthopaedics and Traumatology - April 18, 2024 Category: Orthopaedics Source Type: research
Lateralising reverse shoulder arthroplasty using bony increased offset (BIO-RSA) or increasing glenoid component diameter: comparison of clinical, radiographic and patient reported outcomes in a matched cohort
ConclusionsUsing a larger glenosphere is a feasible alternative to BIO-RSA for lateralising RSA, providing comparable ROM, patient-reported and radiographic results, while potentially decreasing costs, operative time and complication rates.Level of evidence III. (Source: Journal of Orthopaedics and Traumatology)
Source: Journal of Orthopaedics and Traumatology - April 18, 2024 Category: Orthopaedics Source Type: research
GSE254388 CDK12 Loss Promotes Prostate Cancer Development While Exposing Vulnerabilities to Paralog-Based Synthetic Lethality [RNA-Seq]
Contributors : Jean C Tien ; Yuping Zhang ; Yu Chang ; Yunhui Cheng ; Rahul Mannan ; Palak Shan ; Xiaoming Wang ; Sanjana Eyunni ; Caleb Cheng ; Brian Magnuson ; Lanbo Xiao ; Marcin Cieslik ; Abhijit Parolia ; Yi Bao ; Shuqin Li ; Alice Xu ; Fengyun Su ; Xuhong Cao ; Yi-Mi Wu ; Dan Robinson ; George Wang ; Ke Ding ; Arul M ChinnaiyanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBiallelic loss of cyclin-dependent kinase 12 (CDK12) defines a unique molecular subtype of metastatic castration resistant prostate cancer (mCRPC). It remains unclear, however, whether C...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE254387 CDK12 Loss Promotes Prostate Cancer Development While Exposing Vulnerabilities to Paralog-Based Synthetic Lethality [scRNA-Seq]
Contributors : Jean C Tien ; Yuping Zhang ; Yu Chang ; Yunhui Cheng ; Rahul Mannan ; Palak Shan ; Xiaoming Wang ; Sanjana Eyunni ; Caleb Cheng ; Brian Magnuson ; Lanbo Xiao ; Marcin Cieslik ; Abhijit Parolia ; Yi Bao ; Shuqin Li ; Alice Xu ; Fengyun Su ; Xuhong Cao ; Yi-Mi Wu ; Dan Robinson ; George Wang ; Ke Ding ; Arul M ChinnaiyanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBiallelic loss of cyclin-dependent kinase 12 (CDK12) defines a unique molecular subtype of metastatic castration resistant prostate cancer (mCRPC). It remains unclear, however, whether C...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Epithelial cell states associated with kidney and allograft injury
Nature Reviews Nephrology, Published online: 17 April 2024; doi:10.1038/s41581-024-00834-0This Review describes parallels in the injury mechanisms that underlie acute kidney injury, chronic kidney disease and allograft injury, and explains how our understanding of the molecular changes that occur in epithelia in the context of kidney disease may contribute to the therapeutic targeting of specific epithelial cell phenotypes for the treatment of transplantation complications. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 17, 2024 Category: Urology & Nephrology Authors: Christian Hinze Svjetlana Lovric Philip F. Halloran Jonathan Barasch Kai M. Schmidt-Ott Source Type: research
Collagen Bridging of Massive Rotator Cuff Tears Using Fascia Lata Autograft Could Provide a Lasting Solution
Shoulder rotator cuff tears are ideally primarily repaired, but large and massive, chronic, and/or retracted tears result in challenges. In response, innovative solutions include superior capsular reconstruction, tendon transfers, subacromial balloon spacer, tuberoplasty, partial repair, and marginal convergence. Recently, an innovation is to use collagen tissue to bridge repair of compromised tendon. Recent research using fascia lata autografts for supraspinatus tendon reconstruction in a rat model shows positive outcomes with structural similarity to normal muscle-tendon interface, decreased fatty infiltration, and incre...
Source: Arthroscopy - Journal of Arthroscopic and Related Surgery - April 17, 2024 Category: Surgery Authors: In-Ho Jeon, Erica Kholinne Tags: Editorial Commentary Source Type: research
Additional suture augmentation to anterior cruciate ligament reconstruction with hamstring autografts bring no benefits to clinical results, graft maturation and graft-bone interface healing
From the perspective of graft protection and early rehabilitation during the maturation and remodeling phases of graft healing, suture augmentation (SA) for anterior cruciate ligament reconstruction (ACLR) has... (Source: BMC Musculoskeletal Disorders)
Source: BMC Musculoskeletal Disorders - April 17, 2024 Category: Orthopaedics Authors: Qingyang Meng, Ruilan Dai, Cheng Wang, Weili Shi, Yanfang Jiang, Ningjing Liu, Rui Li, Yingfang Ao, Xi Gong and Yong Ma Tags: Research Source Type: research
