Impact of Race Mismatch in Allograft Rejection After Heart Transplantation. Molecular Microscope (MMDx) Results
Purpose: The influence of donor/recipient race matching on rejection after heart transplantation (HT) is not well understood. Our goal is to examine the effect of race matching on rejection after HT utilizing biopsy-based gene expression profiling. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , C.M. Moeller, J. Baranowska, D. Oren, G. Rubinstein, S. Rahman, C. Lee, Y. Mehlman, S. Slomovich, D. Lotan, E.M. DeFilippis, D. Bae, A. Rahman, R. Shah, K. Oh, J. Fried, K. Clerkin, K. Theodoropoulos, G.T. Sayer, N. Uriel, F. Latif Source Type: research
Long-Term Outcomes of Invasive Aspergillosis and Aspergillus Colonization in Lung Transplant Recipient - A Nationwide Cohort Study
Purpose: No consensus on invasive aspergillosis (IA) prevention in lung transplantat recipients (LTXr) exists. Further knowledge is needed on how IA and Aspergillus colonization affect the long term outcomes chronic lung allograft dysfunction (CLAD) and mortality. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , H. Lawaetz Schultz, S.T. Shahri, M.C. Arendrup, M. Helleberg, M. Perch Source Type: research
Impact of COVID-19 Infection on the Development of Chronic Lung Allograft Dysfunction (CLAD) After Lung Transplantation
This study aims to evaluate the impact of COVID-19 infection on time-to-CLAD and survival in a large single-center study. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , A. Benazzo, M. Aversa, Q. Li, S. Wang, E. Huszti, R. Ghany, J.T. Solera, D. Kumar, S. Keshavjee, T. Martinu, S. Juvet Source Type: research
Quantifying Total Cell-Free DNA an a Heart Transplant Patient with Acute Cellular Rejection
Introduction: Donor-derived cell-free DNA (dd-cfDNA) is a relatively new biomarker for the detection of heart allograft injury and rejection. Clinically available assays typically report dd-cfDNA as a percentage (dd-cfDNA%) of total cfDNA, which comprises both donor and recipient cfDNA. Factors other than rejection can influence total cfDNA levels, including recipient BMI, exercise and infection. As such, changes in a recipient ’s total cfDNA levels can distort dd-cfDNA% results, potentially suppressing the detection of rejection. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: A. Alge, M. Rodich, K. Nyikos, A. Porter, , K. Morris, A. Ravichandran Source Type: research
Favorable Response to Daratumumab in the Treatment of Antibody Mediated Rejection in Pediatric Heart Transplant
Introduction: Antibody-mediated rejection (AMR) due to donor specific anti-HLA antibodies (DSA) poses a significant threat to allograft survival in solid organ transplantation (txp). This is primarily due to limited effectiveness of current therapies, such as Rituximab, that fail to target long-lived B- and plasma- cells residing in the bone marrow, responsible for DSA production against human leukocyte antigens (HLA). Recent studies in kidney and heart txp have introduced Daratumumab (Dara) as a potential therapeutic to combat AMR. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , D.M. Peng, A. McCormick, H. Lim, G. Simmons, S. Stoll, A. Huebschman, N. Sinicropi, B. Giacobbe, M. Zamberlan, K. Shumacher, M. Cusick Source Type: research
CABG for Coronary Allograft Vasculopathy - Still a Viable Option?
We describe 3 patients that underwent heart transplantation (HT), developed CAV and were referred for CABG. All patients were operated by experienced cardiac surgeons in a large tertiary center. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , Y. Wasserstrum, L. Sternik, A. Morgan, J. Lavee, Y. Peled Source Type: research
Discordant Donor-Derived Cell-Free DNA and Endomyocardial Biopsy Scores
Introduction: dd-cfDNA is a non-invasive, quantitative marker of allograft injury in heart transplant (HT). While thresholds exist for quiescent grafts, there are patients who have higher dd-cfDNA scores and a lack of histological evidence of rejection. Clinical management of these patients remains a challenge but there is increasing evidence for worse long-term outcomes. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , A.B. Cochrane, A. Thatcher, K. Bussa, M. Maydosz, S. Ma, C. Falke, K. Schillinger, C. Murphey, A. Rollins, J. Kennedy Source Type: research
Weight-Adjusted Rabbit Antithymocyte Globulin Induction and Outcomes in Heart Transplantation
Purpose: Optimal Rabbit anti-thymocyte globulin (RATG) dose for heart transplantation (HTx) induction is unknown. Like many centers, we use a fixed RATG dose for all our primary HTx. The hypothesis was that a weight-based (mg/kg) dose offers the best protection in terms of allograft rejection, death or infection. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , M. Tremblay-Gravel, P. Noly, J. Boulet, S. de Denus, A. Fortier, M. Carrier, Y. Lamarche, G. Giraldeau, M. Liszkowski, M. Parent, A. Ducharme Source Type: research
Corticosteroid Dose Impacts Early Outcomes in Lung Allograft Recipients: A Dual-Center Study
Purpose: Early post-transplant corticosteroid (CS) dosing varies between programs, yet the impact on outcomes is unknown. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , T.C. Lewis, L. Angel, S. Chang, D.B. Erasmus, M. Bacchetta, A.J. Trindade Source Type: research
Efficacy and Safety if JAK2 Inhibitor Plus Extracorporeal Photopheresis in Chronic Lung Allograft Dysfunction: A Single Centre Experience
Purpose: Post lung transplantation survival is limited by the development of chronic lung allograft dysfunction(CLAD),for which only few effective therapies exists and no standardized management. There are studies showing proven benefits of JAK2 inhibitor plus ECP in post bone marrow transplantation GVHD patients.We analysed JAK2 inhibitor plus ECP therapy in clinically diagnosed CLAD. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , V. Rahulan, M. Lalani, O. Tisekar, S. Priyaranjan, P. Dutta, A. Mohandas, M. B N, M. M, M. Sameer, S. Attawar Source Type: research
The 4-Year Outcome of the ScanCLAD Study
Purpose: The ScanCLAD trial showed a significant lower incidence of chronic lung allograft dysfunction (CLAD) three years after lung transplantation (LTx) in recipients treated with tacrolimus compared to cyclosporine. We now determine CLAD and survival outcomes at four years follow-up. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , T. Kromann Lund, P. Raivio, I. Leuckfeld, J. Svahn, E.C. Holmberg, J. Magnusson Source Type: research
Radiographic Assessment of Lung Edema (RALE) Score on Day 3 After Lung Transplantation is Associated with Poor Clinical Outcomes
Purpose: Primary graft dysfunction (PGD), as defined by hypoxemia and presence of allograft edema, is associated with increased mortality in lung transplant recipients. We tested whether radiographic quantification of pulmonary edema using RALE scoring is associated with PGD severity, hospital length of stay, and death. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , T. Koyama, M. Oyster, L. Kalman, J. Diamond, J. Christie, L. Ware Source Type: research
The Kinetics of Donor-Derived Cell-Free DNA During Treatment of Allograft Rejection in a Highly Sensitized Heart Transplant Recipient
Introduction: Donor-derived cell-free DNA (dd-cfDNA) has been identified as a noninvasive biomarker for allograft injury in orthotopic heart transplantation (OHT) where changes in its percentage may suggest acute rejection. Its utility in following response to treatment is unclear. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: C. Aseervatham, D. Iyer, Source Type: research
Percutaneous Coronary Intervention in Pediatric Transplant Recipients- Delaying the Inevitable
Purpose: Coronary allograft vasculopathy (CAV) is the leading cause of allograft failure in pediatric patients. Atherosclerotic coronary disease is usually focal and is managed with lifestyles modifications, medications and percutaneous interventions; however, CAV is more diffuse. Limited data is available regarding use of percutaneous interventions (PCI) for CAV. We sought to retrospectively review patients who were transplanted as pediatric patients and who underwent PCI for CAV and evaluate their outcomes. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: M.S. Purlee, , D. Lopez-Colon, M. Bleiweis, J. Jacobs, G. Peek, F. Fricker, B. Pietra, H. Vyas, J. Fudge, D. Gupta Source Type: research
Non-HLA Antibodies Are Associated with Chronic Lung Allograft Dysfunction in Lung Transplant Recipients
This study aimed to elucidate the role of non-HLA Abs on the development of chronic lung allograft dysfunction (CLAD) and overall survival in LTRs. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: K. Vyskocilov á, M. Röder, K. Vychytilová, A. Glosová, A. Zajacova, , A. Dutkova, L. Fila, R. Lischke, A. Slavčev, J. Havlin Source Type: research
