Hypermethylation of PPARG-encoding gene promoter mediates fine particulate matter-induced pulmonary fibrosis by regulating the HMGB1/NLRP3 axis
In conclusion, the HMGB1/NLRP3 signaling pathway was activated in pulmonary fibrosis triggered by PM2.5 through the hypermethylation of the PPARG-encoding gene promoter.PMID:38330871 | DOI:10.1016/j.ecoenv.2024.116068 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - February 8, 2024 Category: Environmental Health Authors: Siyu Yang Yaochuan Sun Yajun Luo Yingyi Liu Mengyu Jiang Jiayou Li Qibing Zhang Jun Bai Source Type: research
A pan-PPAR agonist E17241 ameliorates hyperglycemia and diabetic dyslipidemia in KKAy mice via up-regulating ABCA1 in islet, liver, and white adipose tissue
CONCLUSIONS: Our results demonstrate that E17241 regulates glucolipid metabolism in KKAy diabetic mice while having cardiorenal benefits without inducing weight gain. It is a promising drug candidate for the treatment of T2DM.PMID:38308968 | DOI:10.1016/j.biopha.2024.116220 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 3, 2024 Category: Drugs & Pharmacology Authors: Ren Sheng Yining Li Yexiang Wu Chang Liu Weizhi Wang Xiaowan Han Yinghong Li Lijuan Lei Xinhai Jiang Yuyan Zhang Yuhao Zhang Shunwang Li Bin Hong Chao Liu Yanni Xu Shuyi Si Source Type: research
Thiazolidinedione enhances the efficacy of immunotherapy in murine melanoma
Am J Physiol Endocrinol Metab. 2024 Jan 31. doi: 10.1152/ajpendo.00346.2023. Online ahead of print.ABSTRACTSeveral clinical studies observed a surprising beneficial effect of obesity to increase immunotherapy responsiveness in melanoma patients, highlighting an as-yet insufficiently understood relationship between metabolism and immunogenicity. Here we demonstrate that the thiazolidinedione (TZD) rosiglitazone, a drug used to treat diabetes by sequestering fatty acids in the metabolically inert subcutaneous adipose tissue, improved sensitivity to anti-Programmed Cell Death Protein 1 (PD-1) treatment in YUMMER1.7 tumor-bear...
Source: American Journal of Physiology. Endocrinology and Metabolism - January 31, 2024 Category: Physiology Authors: Xinyi Zhang Yuan Gao Keyun Tang Zongyu Li Alexandra A Halberstam Liqun Zhou Rachel J Perry Source Type: research
Thiazolidinedione enhances the efficacy of immunotherapy in murine melanoma
Am J Physiol Endocrinol Metab. 2024 Jan 31. doi: 10.1152/ajpendo.00346.2023. Online ahead of print.ABSTRACTSeveral clinical studies observed a surprising beneficial effect of obesity to increase immunotherapy responsiveness in melanoma patients, highlighting an as-yet insufficiently understood relationship between metabolism and immunogenicity. Here we demonstrate that the thiazolidinedione (TZD) rosiglitazone, a drug used to treat diabetes by sequestering fatty acids in the metabolically inert subcutaneous adipose tissue, improved sensitivity to anti-Programmed Cell Death Protein 1 (PD-1) treatment in YUMMER1.7 tumor-bear...
Source: Am J Physiol Endocri... - January 31, 2024 Category: Endocrinology Authors: Xinyi Zhang Yuan Gao Keyun Tang Zongyu Li Alexandra A Halberstam Liqun Zhou Rachel J Perry Source Type: research
Intra-amniotic Sildenafil and Rosiglitazone Late in Gestation Ameliorate the Pulmonary Hypertension Phenotype in Congenital Diaphragmatic Hernia
Pulmonary hypertension remains difficult to manage in congenital diaphragmatic hernia (CDH). Prenatal therapy may ameliorate postnatal pulmonary hypertension. We hypothesized that intra-amniotic (IA) injection of either sildenafil, a phosphodiesterase 5 inhibitor, or rosiglitazone, a PPAR- γ agonist, or both late in gestation would decrease the detrimental pulmonary vascular remodeling seen in CDH and improve peripheral pulmonary blood flow. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - January 22, 2024 Category: Surgery Authors: Shiho Yoshida, Olivia Eichelberger, Michael Ulis, Alexander M. Kreger, George K. Gittes, Joseph T. Church Source Type: research
Multiple gene-drug prediction tool reveals Rosiglitazone based treatment pathway for non-segmental vitiligo
In this study, we performed a comprehensive analysis of two vitiligo microarray datasets from the GEO database using bioinformatics tools to identify 297 up-regulated mRNAs and 186 down-regulated mRNAs, revealing important roles for pathways related to melanin synthesis, tyrosine metabolism, and inflammatory factors, such as “PPAR signaling pathway”, “tyrosine metabolism”, “nonalcoholic fatty liver disease (NAFLD) pathway”, “melanogenesis”, and “IL-17 signaling pathway”. Combining the Search Tool for Interacting Chemicals (STITCH) database 5.0 and the drug-gene interaction database 3.0 (DGIdb), we id en...
Source: Inflammation - December 30, 2023 Category: Allergy & Immunology Source Type: research
Dose-response technique combined with stable isotope tracing for drug metabolite profiling by using high-resolution mass spectrometry
Conclusion: The results reveal that the proposed approach can effectively and comprehensively identify ROS metabolites. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 13, 2023 Category: Drugs & Pharmacology Source Type: research
Inhibition of cisplatin-induced Acsl4-mediated ferroptosis alleviated ovarian injury
In this study, we demonstrated that cisplatin treatment caused the accumulation of iron ions which induced ferroptosis in ovarian tissue. And our results show that ferrostatin-1 was able to suppress the ovarian injury and granulosa cell death caused by cisplatin (Cis) in vivo and in vitro. At the same time, we observed significant changes in the expression levels of Acyl-CoA synthetase long-chain family member 4 (Acsl4) and glutathione peroxidase 4 (GPX4). Similarly, Rosiglitazone, an inhibitor of Acsl4, administration alleviated the ovary damage of the mice undergoing chemotherapy. Further mechanistic investigation showed...
Source: Chemico-Biological Interactions - December 6, 2023 Category: Molecular Biology Authors: Siyuan Wang Xuqing Li Jun Li Aiping Wang Fangfang Li Huiqing Hu Tengfei Long Xueting Pei Hongyan Li Fei Zhong Fengyu Zhu Source Type: research
Inhibition of cisplatin-induced Acsl4-mediated ferroptosis alleviated ovarian injury
In this study, we demonstrated that cisplatin treatment caused the accumulation of iron ions which induced ferroptosis in ovarian tissue. And our results show that ferrostatin-1 was able to suppress the ovarian injury and granulosa cell death caused by cisplatin (Cis) in vivo and in vitro. At the same time, we observed significant changes in the expression levels of Acyl-CoA synthetase long-chain family member 4 (Acsl4) and glutathione peroxidase 4 (GPX4). Similarly, Rosiglitazone, an inhibitor of Acsl4, administration alleviated the ovary damage of the mice undergoing chemotherapy. Further mechanistic investigation showed...
Source: Chemico-Biological Interactions - December 6, 2023 Category: Molecular Biology Authors: Siyuan Wang Xuqing Li Jun Li Aiping Wang Fangfang Li Huiqing Hu Tengfei Long Xueting Pei Hongyan Li Fei Zhong Fengyu Zhu Source Type: research
Inhibition of cisplatin-induced Acsl4-mediated ferroptosis alleviated ovarian injury
In this study, we demonstrated that cisplatin treatment caused the accumulation of iron ions which induced ferroptosis in ovarian tissue. And our results show that ferrostatin-1 was able to suppress the ovarian injury and granulosa cell death caused by cisplatin (Cis) in vivo and in vitro. At the same time, we observed significant changes in the expression levels of Acyl-CoA synthetase long-chain family member 4 (Acsl4) and glutathione peroxidase 4 (GPX4). Similarly, Rosiglitazone, an inhibitor of Acsl4, administration alleviated the ovary damage of the mice undergoing chemotherapy. Further mechanistic investigation showed...
Source: Chemico-Biological Interactions - December 6, 2023 Category: Molecular Biology Authors: Siyuan Wang Xuqing Li Jun Li Aiping Wang Fangfang Li Huiqing Hu Tengfei Long Xueting Pei Hongyan Li Fei Zhong Fengyu Zhu Source Type: research
Inhibition of cisplatin-induced Acsl4-mediated ferroptosis alleviated ovarian injury
In this study, we demonstrated that cisplatin treatment caused the accumulation of iron ions which induced ferroptosis in ovarian tissue. And our results show that ferrostatin-1 was able to suppress the ovarian injury and granulosa cell death caused by cisplatin (Cis) in vivo and in vitro. At the same time, we observed significant changes in the expression levels of Acyl-CoA synthetase long-chain family member 4 (Acsl4) and glutathione peroxidase 4 (GPX4). Similarly, Rosiglitazone, an inhibitor of Acsl4, administration alleviated the ovary damage of the mice undergoing chemotherapy. Further mechanistic investigation showed...
Source: Chemico-Biological Interactions - December 6, 2023 Category: Molecular Biology Authors: Siyuan Wang Xuqing Li Jun Li Aiping Wang Fangfang Li Huiqing Hu Tengfei Long Xueting Pei Hongyan Li Fei Zhong Fengyu Zhu Source Type: research
Inhibition of cisplatin-induced Acsl4-mediated ferroptosis alleviated ovarian injury
In this study, we demonstrated that cisplatin treatment caused the accumulation of iron ions which induced ferroptosis in ovarian tissue. And our results show that ferrostatin-1 was able to suppress the ovarian injury and granulosa cell death caused by cisplatin (Cis) in vivo and in vitro. At the same time, we observed significant changes in the expression levels of Acyl-CoA synthetase long-chain family member 4 (Acsl4) and glutathione peroxidase 4 (GPX4). Similarly, Rosiglitazone, an inhibitor of Acsl4, administration alleviated the ovary damage of the mice undergoing chemotherapy. Further mechanistic investigation showed...
Source: Chemico-Biological Interactions - December 6, 2023 Category: Molecular Biology Authors: Siyuan Wang Xuqing Li Jun Li Aiping Wang Fangfang Li Huiqing Hu Tengfei Long Xueting Pei Hongyan Li Fei Zhong Fengyu Zhu Source Type: research
Environmental chemicals change extracellular lipidome of mature human white adipocytes
This study points to early signs of metabolic disruption and likely systemic effects of mature adipocyte exposure to environmental chemicals, as well as to the need to include lipidomic endpoints in the assessment of adverse effects of MDCs.PMID:38048832 | DOI:10.1016/j.chemosphere.2023.140852 (Source: Chemosphere)
Source: Chemosphere - December 4, 2023 Category: Chemistry Authors: Paula Burkhardt Susana Alejandra Palma-Duran AstrudR R Tuck Kalle Norgren Xinyi Li Violetta Nikiforova Julian L Griffin Vesna Munic Kos Source Type: research
Environmental chemicals change extracellular lipidome of mature human white adipocytes
This study points to early signs of metabolic disruption and likely systemic effects of mature adipocyte exposure to environmental chemicals, as well as to the need to include lipidomic endpoints in the assessment of adverse effects of MDCs.PMID:38048832 | DOI:10.1016/j.chemosphere.2023.140852 (Source: Chemosphere)
Source: Chemosphere - December 4, 2023 Category: Chemistry Authors: Paula Burkhardt Susana Alejandra Palma-Duran AstrudR R Tuck Kalle Norgren Xinyi Li Violetta Nikiforova Julian L Griffin Vesna Munic Kos Source Type: research
