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Organotin mixtures reveal interactions that modulate adipogenic differentiation in 3T3-L1 preadipocytes
In conclusion, DBT and TPT interfere with TBT's adipogenic differentiation possibly via PPARγ signaling. These findings highlight the antagonistic effects among organotins and the need to understand the effects and mechanism of action of complex organotin mixtures on adipogenic outcomes.PMID:37142754 | DOI:10.1007/s00204-023-03512-5 (Source: Archives of Toxicology)
Source: Archives of Toxicology - May 4, 2023 Category: Toxicology Authors: Elvis Ticiani Yong Pu Madison White Victoria Adomshick Almudena Veiga-Lopez Source Type: research

Retraction Note: Rosiglitazone Inhibits Activation of Hepatic Stellate Cells via Up-Regulating Micro-RNA-124-3p to Alleviate Hepatic Fibrosis
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 27, 2023 Category: Gastroenterology Source Type: research

Spheroids derived from the stromal vascular fraction of adipose tissue self-organize in complex adipose organoids and secrete leptin
CONCLUSION: Newborn mice adipose SVF can be efficiently differentiated into leptin-secreting AS. Prolonged stimulation with insulin and rosiglitazone allows the formation of structurally complex adipose organoids able to respond to adrenergic lipolytic stimulation.PMID:37024989 | DOI:10.1186/s13287-023-03262-2 (Source: Cell Research)
Source: Cell Research - April 6, 2023 Category: Cytology Authors: Ferm ín Robledo Lila Gonz ález-Hodar Pablo Tapia Ana-Mar ía Figueroa Fernando Ezquer V íctor Cortés Source Type: research

Involvement of peroxisome proliferator ‐activated receptor gamma (PPARγ) and autophagic pathways in the mechanism of action of the tris(2,3‐dibromopropyl) isocyanurate (TDBP‐TAZTO or TBC) flame retardant in the lung adenocarcinoma (A549) cells in vitro
AbstractTris(2,3-dibromopropyl) isocyanurate (TDBP-TAZTO or TBC) belongs to the class of novel brominated flame retardants. TBC is relatively easily released from products both during production and use; hence, it has been detected in various environmental samples. It has also been reported that TBC causes toxic effects in different cell types and now its mechanism of action is connected with oxidative stress. However, the molecular mechanism of the TBC action is mostly unknown. The aim of this study was to determine the involvement of the PPAR γ receptor and certain autophagic proteins (mTOR and p62) in the mechanism of ...
Source: Journal of Applied Toxicology - March 31, 2023 Category: Toxicology Authors: Konrad A. Szychowski, Bartosz Sk óra Tags: RESEARCH ARTICLE Source Type: research

Retraction Note: Rosiglitazone Inhibits Activation of Hepatic Stellate Cells via Up-Regulating Micro-RNA-124-3p to Alleviate Hepatic Fibrosis
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - March 29, 2023 Category: Gastroenterology Source Type: research

Involvement of peroxisome proliferator ‐activated receptor gamma (PPARγ) and autophagic pathways in the mechanism of action of the tris(2,3‐dibromopropyl) isocyanurate (TDBP‐TAZTO or TBC) flame retardant in the lung adenocarcinoma (A549) cells in vitro.
AbstractTris(2,3-dibromopropyl) isocyanurate (TDBP-TAZTO or TBC) belongs to the class of novel brominated flame retardants. TBC is relatively easily released from products both during production and use; hence, it has been detected in various environmental samples. It has also been reported that TBC causes toxic effects in different cell types and now its mechanism of action is connected with oxidative stress. However, the molecular mechanism of the TBC action is mostly unknown. The aim of this study was to determine the involvement of the PPAR γ receptor and certain autophagic proteins (mTOR and p62) in the mechanism of ...
Source: Journal of Applied Toxicology - March 27, 2023 Category: Toxicology Authors: Konrad A. Szychowski, Bartosz Sk óra Tags: RESEARCH ARTICLE Source Type: research

In silico identification of natural compounds from virgin coconut oil as potential ligand peroxisome proliferator-activated receptor-gamma as preventive food leads against colitis: Is it really work?
J Adv Pharm Technol Res. 2023 Jan-Mar;14(1):39-45. doi: 10.4103/japtr.japtr_505_22. Epub 2023 Jan 20.ABSTRACTUlcerative colitis (UC) is an inflammation of the large intestine characterized by diarrhea with blood. UC has a more extensive manifestation in children. Current therapy has not given satisfactory results. This is the basis for the need for preventive therapy to reduce the morbidity and mortality of UC in children. Virgin coconut oil (VCO) is a viable dietary supplement option due to its ability to act as a peroxisome proliferator-activated receptor (PPAR) ligand, inhibiting the release of pro-inflammatory cytokine...
Source: Adv Data - March 23, 2023 Category: Epidemiology Authors: Ni Made Rika Trismayanti None Kusworini Handayani Dian Source Type: research

A partial peroxisome proliferator-activated receptor gamma agonist isolated from the roots of Euphorbia sikkimensis 
Nat Prod Res. 2023 Feb 25:1-5. doi: 10.1080/14786419.2023.2183201. Online ahead of print.ABSTRACTChemical constituents of the Euphorbia sikkimensis roots was investigated and twelve known compounds were isolated, including three ent-atisane diterpenes: ent-(13S)-hydroxyatis-16-ene-3,14-dione (1), ent-(5β,8α,9β,10α,11α,12α)-11-hydroxyatis-16-ene-3,14-dione (2), ent-atisane-3-oxo-16α,17-diol (3); two kaurene diterpenes: ent-kaurane-3-oxo-16α,17-diol (4), ent-kaurane-3-oxo-16β,17-diol (5); one lathyane diterpene of latilagascene B (6); two flavonoids: quercetin (7), luteolin (8); one lignin d-pinoresinol (9); one cou...
Source: Natural Product Research - February 25, 2023 Category: Biochemistry Authors: Liping He Daili Yuchen Shangzhi Zhang Yangyang Hui Namei Wei Yangqing He Source Type: research

Thiazolidinediones lower the risk of pneumonia in patients with type 2 diabetes
DiscussionThis cohort study demonstrated that TZD use was associated with significantly lower risks of hospitalization for pneumonia, invasive mechanical ventilation, and death due to pneumonia in patients with T2D. Higher cumulative duration and dose of pioglitazone were associated with a further lower risk of outcomes. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - February 17, 2023 Category: Microbiology Source Type: research

miR-223 Plays A Key Role in Obesogen-Enhanced Adipogenesis in Mesenchymal Stem Cells and in Transgenerational Obesity
Endocrinology. 2023 Feb 6:bqad027. doi: 10.1210/endocr/bqad027. Online ahead of print.ABSTRACTExposure of pregnant F0 mouse dams to the obesogen tributyltin (TBT) predisposes unexposed male descendants to obesity and diverts mesenchymal stem cells (MSCs) toward the adipocytic lineage. TBT promotes adipogenic commitment and differentiation of MSCs, in vitro. To identify TBT-induced factors predisposing MSCs toward the adipocytic fate, we exposed mouse MSCs to TBT, the PPARγ-selective agonist rosiglitazone or the RXR-selective agonist LG-100268. Then we determined their transcriptomal profiles to determine candidate microRN...
Source: Endocrinology - February 6, 2023 Category: Endocrinology Authors: Richard C Chang Erika M Joloya Zhuorui Li Bassem M Shoucri Toshi Shioda Bruce Blumberg Source Type: research