Diterpenoids inhibit ox-LDL-induced foam cell formation in RAW264.7 cells by promoting ABCA1 mediated cholesterol efflux
Conclusion: Our research indicates that diterpenoids effectively inhibit ox-LDL-induced macrophage foam cell formation by promoting cholesterol efflux from macrophages via the PPARγ-LXRα-ABCA1 pathway. Further investigation of diterpenoids as potential drugs for the treatment of atherosclerosis is warranted.PMID:36713845 | PMC:PMC9877220 | DOI:10.3389/fphar.2023.1066758 (Source: Atherosclerosis)
Source: Atherosclerosis - January 30, 2023 Category: Cardiology Authors: Cheng Zhang Xuewen Wu Pengmin Shi Hongyu Ma Fei Fang Qianlang Feng Shuang Zhao Ruipu Zhang Jinyuan Huang Xinting Xu Weilie Xiao Guang Cao Xu Ji Source Type: research

GSE206990 Simplifying adipogenic differentiation – a step towards a food compatible media
Contributors : Rada Mitic ; Federica Cantoni ; Christoph S B örlin ; Mark J Post ; Laura JackischSeries Type : Expression profiling by high throughput sequencingOrganism : Bos taurusCultivated meat is a promising technology with the potential to mitigate the ethical and environmental problems associated with traditional meat. Fat plays a key role in meat flavour and texture, however little academic research has focused on fat production resulting in a paucity of adequate adipogenesis protocols for most livestock-derived cells. The development of a suitable protocol is essential to pave the way for cultivated fat as an ...
Source: GEO: Gene Expression Omnibus - January 18, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Bos taurus Source Type: research

Astragaloside IV ameliorates insulin induced insulin resistance in HepG2 cells through reactive oxygen species mediated c-Jun N-terminal kinase pathway
CONCLUSIONS: Our results indicated that AS-IV improve liver IR through the JNK pathway and ROS, which meant a new molecular target for the treatment of diabetes. The AS-IV also helped to prevent and improved the insulin resistance of rats.PMID:36639996 | DOI:10.19852/j.cnki.jtcm.2023.01.007 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - January 14, 2023 Category: Complementary Medicine Authors: Y E Xiaomei Xing Xiaowei Yuan Kangrui Wang Dongming W U Dudu Chen Zhi Y U Zhiqiang Source Type: research

Astragaloside IV ameliorates insulin induced insulin resistance in HepG2 cells through reactive oxygen species mediated c-Jun N-terminal kinase pathway
CONCLUSIONS: Our results indicated that AS-IV improve liver IR through the JNK pathway and ROS, which meant a new molecular target for the treatment of diabetes. The AS-IV also helped to prevent and improved the insulin resistance of rats.PMID:36639996 | DOI:10.19852/j.cnki.jtcm.2023.01.007 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - January 14, 2023 Category: Complementary Medicine Authors: Y E Xiaomei Xing Xiaowei Yuan Kangrui Wang Dongming W U Dudu Chen Zhi Y U Zhiqiang Source Type: research

Astragaloside IV ameliorates insulin induced insulin resistance in HepG2 cells through reactive oxygen species mediated c-Jun N-terminal kinase pathway
CONCLUSIONS: Our results indicated that AS-IV improve liver IR through the JNK pathway and ROS, which meant a new molecular target for the treatment of diabetes. The AS-IV also helped to prevent and improved the insulin resistance of rats.PMID:36639996 | DOI:10.19852/j.cnki.jtcm.2023.01.007 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - January 14, 2023 Category: Complementary Medicine Authors: Y E Xiaomei Xing Xiaowei Yuan Kangrui Wang Dongming W U Dudu Chen Zhi Y U Zhiqiang Source Type: research

Astragaloside IV ameliorates insulin induced insulin resistance in HepG2 cells through reactive oxygen species mediated c-Jun N-terminal kinase pathway
CONCLUSIONS: Our results indicated that AS-IV improve liver IR through the JNK pathway and ROS, which meant a new molecular target for the treatment of diabetes. The AS-IV also helped to prevent and improved the insulin resistance of rats.PMID:36639996 | DOI:10.19852/j.cnki.jtcm.2023.01.007 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - January 14, 2023 Category: Complementary Medicine Authors: Y E Xiaomei Xing Xiaowei Yuan Kangrui Wang Dongming W U Dudu Chen Zhi Y U Zhiqiang Source Type: research

Astragaloside IV ameliorates insulin induced insulin resistance in HepG2 cells through reactive oxygen species mediated c-Jun N-terminal kinase pathway
CONCLUSIONS: Our results indicated that AS-IV improve liver IR through the JNK pathway and ROS, which meant a new molecular target for the treatment of diabetes. The AS-IV also helped to prevent and improved the insulin resistance of rats.PMID:36639996 | DOI:10.19852/j.cnki.jtcm.2023.01.007 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - January 14, 2023 Category: Complementary Medicine Authors: Y E Xiaomei Xing Xiaowei Yuan Kangrui Wang Dongming W U Dudu Chen Zhi Y U Zhiqiang Source Type: research

Astragaloside IV ameliorates insulin induced insulin resistance in HepG2 cells through reactive oxygen species mediated c-Jun N-terminal kinase pathway
CONCLUSIONS: Our results indicated that AS-IV improve liver IR through the JNK pathway and ROS, which meant a new molecular target for the treatment of diabetes. The AS-IV also helped to prevent and improved the insulin resistance of rats.PMID:36639996 | DOI:10.19852/j.cnki.jtcm.2023.01.007 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - January 14, 2023 Category: Complementary Medicine Authors: Y E Xiaomei Xing Xiaowei Yuan Kangrui Wang Dongming W U Dudu Chen Zhi Y U Zhiqiang Source Type: research

Astragaloside IV ameliorates insulin induced insulin resistance in HepG2 cells through reactive oxygen species mediated c-Jun N-terminal kinase pathway
CONCLUSIONS: Our results indicated that AS-IV improve liver IR through the JNK pathway and ROS, which meant a new molecular target for the treatment of diabetes. The AS-IV also helped to prevent and improved the insulin resistance of rats.PMID:36639996 | DOI:10.19852/j.cnki.jtcm.2023.01.007 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - January 14, 2023 Category: Complementary Medicine Authors: Y E Xiaomei Xing Xiaowei Yuan Kangrui Wang Dongming W U Dudu Chen Zhi Y U Zhiqiang Source Type: research

Astragaloside IV ameliorates insulin induced insulin resistance in HepG2 cells through reactive oxygen species mediated c-Jun N-terminal kinase pathway
CONCLUSIONS: Our results indicated that AS-IV improve liver IR through the JNK pathway and ROS, which meant a new molecular target for the treatment of diabetes. The AS-IV also helped to prevent and improved the insulin resistance of rats.PMID:36639996 | DOI:10.19852/j.cnki.jtcm.2023.01.007 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - January 14, 2023 Category: Complementary Medicine Authors: Y E Xiaomei Xing Xiaowei Yuan Kangrui Wang Dongming W U Dudu Chen Zhi Y U Zhiqiang Source Type: research

Astragaloside IV ameliorates insulin induced insulin resistance in HepG2 cells through reactive oxygen species mediated c-Jun N-terminal kinase pathway
CONCLUSIONS: Our results indicated that AS-IV improve liver IR through the JNK pathway and ROS, which meant a new molecular target for the treatment of diabetes. The AS-IV also helped to prevent and improved the insulin resistance of rats.PMID:36639996 | DOI:10.19852/j.cnki.jtcm.2023.01.007 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - January 14, 2023 Category: Complementary Medicine Authors: Y E Xiaomei Xing Xiaowei Yuan Kangrui Wang Dongming W U Dudu Chen Zhi Y U Zhiqiang Source Type: research

Astragaloside IV ameliorates insulin induced insulin resistance in HepG2 cells through reactive oxygen species mediated c-Jun N-terminal kinase pathway
CONCLUSIONS: Our results indicated that AS-IV improve liver IR through the JNK pathway and ROS, which meant a new molecular target for the treatment of diabetes. The AS-IV also helped to prevent and improved the insulin resistance of rats.PMID:36639996 | DOI:10.19852/j.cnki.jtcm.2023.01.007 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - January 14, 2023 Category: Complementary Medicine Authors: Y E Xiaomei Xing Xiaowei Yuan Kangrui Wang Dongming W U Dudu Chen Zhi Y U Zhiqiang Source Type: research

Astragaloside IV ameliorates insulin induced insulin resistance in HepG2 cells through reactive oxygen species mediated c-Jun N-terminal kinase pathway
CONCLUSIONS: Our results indicated that AS-IV improve liver IR through the JNK pathway and ROS, which meant a new molecular target for the treatment of diabetes. The AS-IV also helped to prevent and improved the insulin resistance of rats.PMID:36639996 | DOI:10.19852/j.cnki.jtcm.2023.01.007 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - January 14, 2023 Category: Complementary Medicine Authors: Y E Xiaomei Xing Xiaowei Yuan Kangrui Wang Dongming W U Dudu Chen Zhi Y U Zhiqiang Source Type: research

Astragaloside IV ameliorates insulin induced insulin resistance in HepG2 cells through reactive oxygen species mediated c-Jun N-terminal kinase pathway
CONCLUSIONS: Our results indicated that AS-IV improve liver IR through the JNK pathway and ROS, which meant a new molecular target for the treatment of diabetes. The AS-IV also helped to prevent and improved the insulin resistance of rats.PMID:36639996 | DOI:10.19852/j.cnki.jtcm.2023.01.007 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - January 14, 2023 Category: Complementary Medicine Authors: Y E Xiaomei Xing Xiaowei Yuan Kangrui Wang Dongming W U Dudu Chen Zhi Y U Zhiqiang Source Type: research

Luteolin protects against adipogenic and lipogenic potency induced by human relevant mixtures of persistent organic pollutants (POPs) in the 3T3-L1 model
In conclusion, this in vitro study shows that dietary polyphenols such as luteolin may protect against POP induced adipo- and lipogenic effects.PMID:36639049 | DOI:10.1016/j.fct.2023.113608 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - January 13, 2023 Category: Food Science Authors: Y Xie H F Berntsen K E Zimmer E Ropstad S Verhaegen L Connolly Source Type: research