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Effects of Moringa Oleifera Leaf Extract Plus Rosiglitazone on Serum Leptin and Glucose and Lipid Metabolism in Type 2 Diabetic Rats
CONCLUSION: MOLE plus RSG can effectively reduce blood glucose and blood lipids in T2DM rats.PMID:37678870 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - September 7, 2023 Category: Complementary Medicine Authors: Can Zhao Jian-Zhong Zhu Cui-Rong Song Hui-Jie Ruan Jian-Hui Liu Yuan-Yuan Liu Yue-Lin Sui Source Type: research

Rosiglitazone inhibits acyl-CoA synthetase long-chain family number 4 and improves secondary brain injury in a rat model of surgical brain injury
This study aimed to investigate the role of ACSL4 in SBI via the ferroptosis pathway. Ninety male Sprague-Dawley rats were examined using a model of SBI. Subsequently, the inhibitory effect of rosiglitazone on ACSL4 was assessed via western blot, real-time polymerase chain reaction (PCR), immunofluorescence, fluoro-jade C staining, Perl's staining, ROS assay, and neurological scoring. The results showed that compared with the Sham group, the protein levels of ACSL4 and transferrin were significantly increased after SBI. Administration of rosiglitazone significantly reduced neuronal necrosis, iron deposition, brain water co...
Source: Clinical and Experimental Pharmacology and Physiology - September 7, 2023 Category: Drugs & Pharmacology Authors: Jinchao Shen Min Qian Muyao Wu Jiafeng Tang Yating Gong Jie Li Jinfen Ji Baoqi Dang Source Type: research

Cancers, Vol. 15, Pages 4276: Thiazolidinedione Use Is Associated with a Borderline Lower Risk of Multiple Myeloma and a Significantly Lower Risk of Death in Patients with Type 2 Diabetes Mellitus in Taiwan
Conclusions: In Taiwanese patients with type 2 diabetes mellitus, TZD use is associated with a borderline lower risk of MM, which is more remarkable in patients aged &ge; 65 years. Because of the low incidence of MM, the use of TZD for the prevention of MM may not be cost-effective. Patients who have been treated with TZD may have a survival advantage. Future research is required to confirm the findings. (Source: Cancers)
Source: Cancers - August 26, 2023 Category: Cancer & Oncology Authors: Chin-Hsiao Tseng Tags: Article Source Type: research

Peroxisome Proliferator Activated Receptor- γ Agonistic Compounds from the Jellyfish-Derived Fungus Cladosporium oxysporum
Chem Biodivers. 2023 Aug 16:e202300851. doi: 10.1002/cbdv.202300851. Online ahead of print.ABSTRACTIn our search for peroxisome proliferator-activated receptor (PPAR) agonists, five undescribed compounds, namely two acyclic diterpenes (1 and 2; cladopsol A and cladopsol B), two sesquiterpenes (3 and 4; cladopsol C and cladopsol D), and one C21-ecdysteroid (5; cladopsol E), and 15 known compounds were isolated from the jellyfish-derived fungus-Cladosporium oxysporum. The structures of the undescribed compounds were defined using UV, NMR, HRESIMS, and electronic circular dichroism (ECD) spectroscopy and a modified Mosher's m...
Source: Chemistry and Biodiversity - August 16, 2023 Category: Biochemistry Authors: Dan-Dan Li Xiaowei Luo Wang Ying Eun La Kim Jongki Hong Joon-Hee Lee Jee H Jung Source Type: research

Retracted: Rosiglitazone Alleviates Contrast-Induced Acute Kidney Injury in Rats via the PPAR < em > γ < /em > /NLRP3 Signaling Pathway
Dis Markers. 2023 Jul 26;2023:9826918. doi: 10.1155/2023/9826918. eCollection 2023.ABSTRACT[This retracts the article DOI: 10.1155/2022/4158692.].PMID:37538083 | PMC:PMC10396759 | DOI:10.1155/2023/9826918 (Source: Disease Markers)
Source: Disease Markers - August 4, 2023 Category: Laboratory Medicine Authors: Disease Markers Source Type: research