Peroxisome Proliferator Activated Receptor- γ Agonistic Compounds from the Jellyfish-Derived Fungus Cladosporium oxysporum

Chem Biodivers. 2023 Aug 16:e202300851. doi: 10.1002/cbdv.202300851. Online ahead of print.ABSTRACTIn our search for peroxisome proliferator-activated receptor (PPAR) agonists, five undescribed compounds, namely two acyclic diterpenes (1 and 2; cladopsol A and cladopsol B), two sesquiterpenes (3 and 4; cladopsol C and cladopsol D), and one C21-ecdysteroid (5; cladopsol E), and 15 known compounds were isolated from the jellyfish-derived fungus-Cladosporium oxysporum. The structures of the undescribed compounds were defined using UV, NMR, HRESIMS, and electronic circular dichroism (ECD) spectroscopy and a modified Mosher's method. Luciferase reporter assay and docking analysis suggested that cladopsol B may function as a PPAR-g partial agonist with a potential antidiabetic lead which may evade the side effects of full agonists. Moreover, cladopsol B stimulated glucose uptake in HepG2 cells with an efficacy comparable to that of rosiglitazone, but with less side effect induced by lipid accumulation in 3T3-L1 cells. Therefore, cladopsol B could serve as a molecular skeleton in a study of advanced antidiabetic lead with less side effect.PMID:37584103 | DOI:10.1002/cbdv.202300851
Source: Chemistry and Biodiversity - Category: Biochemistry Authors: Source Type: research