GSE234046 Single-cell RNA-sequencing of stromal vascular cells (SVCs) from the epididymal fat of obese mice.
Contributors : Theresa V Rohm ; Jerrold M OlefskySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe obesity epidemic continues to worsen worldwide, driving metabolic and chronic inflammatory diseases. Thiazolidinediones (TZDs), such as rosiglitazone (Rosi), are PPARy ligands that promote anti-inflammatory changes in adipose tissue macrophages (ATMs) and cause insulin sensitization. We performed single-cell RNA-seuqnecing (scRNA-seq) to analyze the diversity and the phenotype of ATM subpopulations under Rosi and ATM-Exosome treatment. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - February 27, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
PPAR γ Agonist Rosiglitazone and Antagonist GW9662: Antihypertensive Effects on Chronic Intermittent Hypoxia-Induced Hypertension in Rats
AbstractThe increased incidence of hypertension associated with obstructive sleep apnea (OSA) presents significant physical, psychological, and economic challenges. Peroxisome proliferator-activated receptor gamma (PPAR γ) plays a role in both OSA and hypertension, yet the therapeutic potential of PPARγ agonists and antagonists for OSA-related hypertension remains unexplored. Therefore, we constructed a chronic intermittent hypoxia (CIH)-induced hypertension rat model that mimics the pathogenesis of OSA-related h ypertension in humans. The model involved administering PPARγ agonist rosiglitazone (RSG), PPARγ antagonist...
Source: Journal of Cardiovascular Translational Research - February 27, 2024 Category: Cardiology Source Type: research
Toxicometabolomics-based cardiotoxicity evaluation of Thiazolidinedione exposure in human-derived cardiomyocytes
ConclusionThese findings demonstrate the utility of toxicometabolomics in elaborating on mechanisms of drug toxicity and identifying potential biomarkers, thus encouraging its application in the toxicological sciences. (245 words) (Source: Metabolomics)
Source: Metabolomics - February 23, 2024 Category: Biology Source Type: research
Vimentin protein is a factor for decreasing breast cancer cell proliferation co-culture with human bone marrow-derived mesenchymal stem cells pre-treated with thiazolidinedione solutions
CONCLUSIONS: The present study identified a novel intracellular protein that may represent the promising target in pre-treated BMSCs to decrease the proliferation of breast cancer MCF-7 cells for human health and wellness.PMID:38381204 | DOI:10.1007/s11033-024-09269-z (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - February 21, 2024 Category: Molecular Biology Authors: Lim Shern Kwok Shim Siang Yian Layla Qasim Ismael Yvonne Tee Get Bee Gam Lay Harn Khoo Boon Yin Source Type: research
Vimentin protein is a factor for decreasing breast cancer cell proliferation co-culture with human bone marrow-derived mesenchymal stem cells pre-treated with thiazolidinedione solutions
CONCLUSIONS: The present study identified a novel intracellular protein that may represent the promising target in pre-treated BMSCs to decrease the proliferation of breast cancer MCF-7 cells for human health and wellness.PMID:38381204 | DOI:10.1007/s11033-024-09269-z (Source: Mol Biol Cell)
Source: Mol Biol Cell - February 21, 2024 Category: Molecular Biology Authors: Lim Shern Kwok Shim Siang Yian Layla Qasim Ismael Yvonne Tee Get Bee Gam Lay Harn Khoo Boon Yin Source Type: research
Vimentin protein is a factor for decreasing breast cancer cell proliferation co-culture with human bone marrow-derived mesenchymal stem cells pre-treated with thiazolidinedione solutions
CONCLUSIONS: The present study identified a novel intracellular protein that may represent the promising target in pre-treated BMSCs to decrease the proliferation of breast cancer MCF-7 cells for human health and wellness.PMID:38381204 | DOI:10.1007/s11033-024-09269-z (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - February 21, 2024 Category: Molecular Biology Authors: Lim Shern Kwok Shim Siang Yian Layla Qasim Ismael Yvonne Tee Get Bee Gam Lay Harn Khoo Boon Yin Source Type: research
Vimentin protein is a factor for decreasing breast cancer cell proliferation co-culture with human bone marrow-derived mesenchymal stem cells pre-treated with thiazolidinedione solutions
CONCLUSIONS: The present study identified a novel intracellular protein that may represent the promising target in pre-treated BMSCs to decrease the proliferation of breast cancer MCF-7 cells for human health and wellness.PMID:38381204 | DOI:10.1007/s11033-024-09269-z (Source: Mol Biol Cell)
Source: Mol Biol Cell - February 21, 2024 Category: Molecular Biology Authors: Lim Shern Kwok Shim Siang Yian Layla Qasim Ismael Yvonne Tee Get Bee Gam Lay Harn Khoo Boon Yin Source Type: research
Identification of TACSTD2 as novel therapeutic targets for cisplatin-induced acute kidney injury by multi-omics data integration
In this study, after initially processed individual omics datasets, we integrated multi-omics data to construct a ferroptosis network in the kidney, resulting in the identification of the key driverTACSTD2. In vitro and in vivo results showed thatTACSTD2 was notably upregulated in cisplatin-treated kidneys and BUMPT cells. Overexpression ofTACSTD2 accelerated ferroptosis, while its gene disruption decelerated ferroptosis, likely mediated by its potential downstream targetsHMGB1, IRF6, andLCN2. Drug prediction and molecular docking were further used to propose that drugs targetingTACSTD2 may have therapeutic potential in CP...
Source: Human Genetics - February 18, 2024 Category: Genetics & Stem Cells Source Type: research
Hypermethylation of PPARG-encoding gene promoter mediates fine particulate matter-induced pulmonary fibrosis by regulating the HMGB1/NLRP3 axis
In conclusion, the HMGB1/NLRP3 signaling pathway was activated in pulmonary fibrosis triggered by PM2.5 through the hypermethylation of the PPARG-encoding gene promoter.PMID:38330871 | DOI:10.1016/j.ecoenv.2024.116068 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - February 8, 2024 Category: Environmental Health Authors: Siyu Yang Yaochuan Sun Yajun Luo Yingyi Liu Mengyu Jiang Jiayou Li Qibing Zhang Jun Bai Source Type: research
A pan-PPAR agonist E17241 ameliorates hyperglycemia and diabetic dyslipidemia in KKAy mice via up-regulating ABCA1 in islet, liver, and white adipose tissue
CONCLUSIONS: Our results demonstrate that E17241 regulates glucolipid metabolism in KKAy diabetic mice while having cardiorenal benefits without inducing weight gain. It is a promising drug candidate for the treatment of T2DM.PMID:38308968 | DOI:10.1016/j.biopha.2024.116220 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 3, 2024 Category: Drugs & Pharmacology Authors: Ren Sheng Yining Li Yexiang Wu Chang Liu Weizhi Wang Xiaowan Han Yinghong Li Lijuan Lei Xinhai Jiang Yuyan Zhang Yuhao Zhang Shunwang Li Bin Hong Chao Liu Yanni Xu Shuyi Si Source Type: research
Thiazolidinedione enhances the efficacy of immunotherapy in murine melanoma
Am J Physiol Endocrinol Metab. 2024 Jan 31. doi: 10.1152/ajpendo.00346.2023. Online ahead of print.ABSTRACTSeveral clinical studies observed a surprising beneficial effect of obesity to increase immunotherapy responsiveness in melanoma patients, highlighting an as-yet insufficiently understood relationship between metabolism and immunogenicity. Here we demonstrate that the thiazolidinedione (TZD) rosiglitazone, a drug used to treat diabetes by sequestering fatty acids in the metabolically inert subcutaneous adipose tissue, improved sensitivity to anti-Programmed Cell Death Protein 1 (PD-1) treatment in YUMMER1.7 tumor-bear...
Source: American Journal of Physiology. Endocrinology and Metabolism - January 31, 2024 Category: Physiology Authors: Xinyi Zhang Yuan Gao Keyun Tang Zongyu Li Alexandra A Halberstam Liqun Zhou Rachel J Perry Source Type: research
Thiazolidinedione enhances the efficacy of immunotherapy in murine melanoma
Am J Physiol Endocrinol Metab. 2024 Jan 31. doi: 10.1152/ajpendo.00346.2023. Online ahead of print.ABSTRACTSeveral clinical studies observed a surprising beneficial effect of obesity to increase immunotherapy responsiveness in melanoma patients, highlighting an as-yet insufficiently understood relationship between metabolism and immunogenicity. Here we demonstrate that the thiazolidinedione (TZD) rosiglitazone, a drug used to treat diabetes by sequestering fatty acids in the metabolically inert subcutaneous adipose tissue, improved sensitivity to anti-Programmed Cell Death Protein 1 (PD-1) treatment in YUMMER1.7 tumor-bear...
Source: Am J Physiol Endocri... - January 31, 2024 Category: Endocrinology Authors: Xinyi Zhang Yuan Gao Keyun Tang Zongyu Li Alexandra A Halberstam Liqun Zhou Rachel J Perry Source Type: research
