Development of a novel immune infiltration-related diagnostic model for Alzheimer ’s disease using bioinformatic strategies
ConclusionFor the first time, we identified 10 immune infiltration-related biomarkers in AD, which may be helpful for the diagnosis of AD and provide guidance in the treatment of AD. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - July 20, 2023 Category: Allergy & Immunology Source Type: research
Mechanical stress induced EndoMT in endothelial cells through PPAR γ downregulation
In this study, elastic silicone chambers were used to simulate the effects of mechanical stretch on ECs under portal hypertension. We found that mechanical stretch decreased PPARγ expression in ECs by blocking the PI3K/AKT/CREB signaling pathway or increasing NEDD4-mediated ubiquitination and degradation of PPARγ. Moreover, PPARγ downregulation triggered Endothelial-to-mesenchymal transition (EndoMT) in ECs under stretch by promoting Smad3 phosphorylation. The PPARγ agonist rosiglitazone mitigated stretch-induced EndoMT in vitro and alleviated EndoMT of the portal vein endothelium in cirrhotic rats.PMID:37468053 | DOI:...
Source: Cellular Signalling - July 19, 2023 Category: Cytology Authors: Gang Dong Xiaoquan Huang Ye Xu Rongxin Chen Shiyao Chen Source Type: research
Mechanical stress induced EndoMT in endothelial cells through PPAR γ downregulation
In this study, elastic silicone chambers were used to simulate the effects of mechanical stretch on ECs under portal hypertension. We found that mechanical stretch decreased PPARγ expression in ECs by blocking the PI3K/AKT/CREB signaling pathway or increasing NEDD4-mediated ubiquitination and degradation of PPARγ. Moreover, PPARγ downregulation triggered Endothelial-to-mesenchymal transition (EndoMT) in ECs under stretch by promoting Smad3 phosphorylation. The PPARγ agonist rosiglitazone mitigated stretch-induced EndoMT in vitro and alleviated EndoMT of the portal vein endothelium in cirrhotic rats.PMID:37468053 | DOI:...
Source: Cellular Signalling - July 19, 2023 Category: Cytology Authors: Gang Dong Xiaoquan Huang Ye Xu Rongxin Chen Shiyao Chen Source Type: research
Rosiglitazone attenuates amyloid beta and glial fibrillary acidic protein in the hippocampus and neuroinflammation associated learning and memory impairments in rats
CONCLUSION: The findings showed Rosi attenuated Aβ, GFAP, and oxidative stress in the hippocampus and neuroinflammation-associated learning and memory impairments in rats.PMID:37343837 | DOI:10.1016/j.bbr.2023.114549 (Source: Brain Research)
Source: Brain Research - June 21, 2023 Category: Neurology Authors: Farimah Beheshti Mahmoud Hosseini Hossein Bakhtiari-Dovvombaygi Hossein Salmani Somaieh Ahmadabady Narges Marefati Yousef Baghcheghi Source Type: research
Rosiglitazone attenuates amyloid beta and glial fibrillary acidic protein in the hippocampus and neuroinflammation associated learning and memory impairments in rats
CONCLUSION: The findings showed Rosi attenuated Aβ, GFAP, and oxidative stress in the hippocampus and neuroinflammation-associated learning and memory impairments in rats.PMID:37343837 | DOI:10.1016/j.bbr.2023.114549 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - June 21, 2023 Category: Neurology Authors: Farimah Beheshti Mahmoud Hosseini Hossein Bakhtiari-Dovvombaygi Hossein Salmani Somaieh Ahmadabady Narges Marefati Yousef Baghcheghi Source Type: research
Rosiglitazone attenuates amyloid beta and glial fibrillary acidic protein in the hippocampus and neuroinflammation associated learning and memory impairments in rats
CONCLUSION: The findings showed Rosi attenuated Aβ, GFAP, and oxidative stress in the hippocampus and neuroinflammation-associated learning and memory impairments in rats.PMID:37343837 | DOI:10.1016/j.bbr.2023.114549 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - June 21, 2023 Category: Neurology Authors: Farimah Beheshti Mahmoud Hosseini Hossein Bakhtiari-Dovvombaygi Hossein Salmani Somaieh Ahmadabady Narges Marefati Yousef Baghcheghi Source Type: research
No causal effects between rosiglitazone and cardiovascular disease or risk factors: a Mendelian randomization study
CONCLUSIONS: The findings from this MR study indicate no causal relationship between rosiglitazone and CVDs or risk factors. Hence, previous observational studies may have been biased.PMID:37318502 | DOI:10.26355/eurrev_202306_32647 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - June 15, 2023 Category: Drugs & Pharmacology Authors: X-M Li Z-J Wu Z-L Xu A Li M-Q Liu C-G Song K Wu Source Type: research
No causal effects between rosiglitazone and cardiovascular disease or risk factors: a Mendelian randomization study
CONCLUSIONS: The findings from this MR study indicate no causal relationship between rosiglitazone and CVDs or risk factors. Hence, previous observational studies may have been biased.PMID:37318502 | DOI:10.26355/eurrev_202306_32647 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - June 15, 2023 Category: Drugs & Pharmacology Authors: X-M Li Z-J Wu Z-L Xu A Li M-Q Liu C-G Song K Wu Source Type: research
No causal effects between rosiglitazone and cardiovascular disease or risk factors: a Mendelian randomization study
CONCLUSIONS: The findings from this MR study indicate no causal relationship between rosiglitazone and CVDs or risk factors. Hence, previous observational studies may have been biased.PMID:37318502 | DOI:10.26355/eurrev_202306_32647 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - June 15, 2023 Category: Drugs & Pharmacology Authors: X-M Li Z-J Wu Z-L Xu A Li M-Q Liu C-G Song K Wu Source Type: research
1,8-Cineole ameliorates diabetic retinopathy by inhibiting retinal pigment epithelium ferroptosis via PPAR- γ/TXNIP pathways
Biomed Pharmacother. 2023 Jun 2;164:114978. doi: 10.1016/j.biopha.2023.114978. Online ahead of print.ABSTRACT1,8-Cineole, the main component of volatile oil in aromatic plants, has diverse pharmacological properties, including antioxidant, anti-inflammatory, and anti-cancer properties. Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus (DM). Here, we investigated the protective effect of 1,8-cineole on DR and found that 1,8-cineole treatment could alter the expression of several genes in both high glucose (HG)-induced ARPE-19 cells and retinal tissues of DM mice, as well as inhibit ferrop...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 4, 2023 Category: Drugs & Pharmacology Authors: Zhangnian Liu Shiquan Gan Lingyun Fu Yini Xu Shengquan Wang Guangqiong Zhang Di Pan Ling Tao Xiangchun Shen Source Type: research
