An Artemisia scoparia extract attenuates glucocorticoid-induced lipolysis in adipocytes
CONCLUSIONS: SCO attenuates GC-induced lipolysis independently of GR activity. Future studies are needed to elucidate underlying mechanisms.PMID:37254272 | DOI:10.1002/oby.23775 (Source: Obesity)
Source: Obesity - May 31, 2023 Category: Eating Disorders & Weight Management Authors: Innocence Harvey Jacqueline M Stephens Source Type: research
An Artemisia scoparia extract attenuates glucocorticoid-induced lipolysis in adipocytes
CONCLUSIONS: SCO attenuates GC-induced lipolysis independently of GR activity. Future studies are needed to elucidate underlying mechanisms.PMID:37254272 | DOI:10.1002/oby.23775 (Source: Obesity)
Source: Obesity - May 31, 2023 Category: Eating Disorders & Weight Management Authors: Innocence Harvey Jacqueline M Stephens Source Type: research
An Artemisia scoparia extract attenuates glucocorticoid-induced lipolysis in adipocytes
CONCLUSIONS: SCO attenuates GC-induced lipolysis independently of GR activity. Future studies are needed to elucidate underlying mechanisms.PMID:37254272 | DOI:10.1002/oby.23775 (Source: Obesity)
Source: Obesity - May 31, 2023 Category: Eating Disorders & Weight Management Authors: Innocence Harvey Jacqueline M Stephens Source Type: research
An Artemisia scoparia extract attenuates glucocorticoid-induced lipolysis in adipocytes
CONCLUSIONS: SCO attenuates GC-induced lipolysis independently of GR activity. Future studies are needed to elucidate underlying mechanisms.PMID:37254272 | DOI:10.1002/oby.23775 (Source: Obesity)
Source: Obesity - May 31, 2023 Category: Eating Disorders & Weight Management Authors: Innocence Harvey Jacqueline M Stephens Source Type: research
Co-Delivery of Therapeutics and Bioactive Gas Using a Novel Liposomal Platform for Enhanced Treatment of Acute Arterial Injury
In this study, liposomes loaded with nitric oxide (NO) and rosiglitazone, a peroxisome proliferator-activated receptor agonist, were prepared using hydration, sonication, freeze-thawing, and pressurization. The efficacy of this delivery system was evaluated in a rabbit model of acute arterial injury induced by balloon injury to the common carotid artery. Intra-arterial administration of rosiglitazone/NO co-encapsulated liposomes (R/NO-ELIP) immediately following injury resulted in reduced intimal thickening after 14 days. The anti-inflammatory and anti-proliferative effects of the co-delivery system were investigated. Thes...
Source: Atherosclerosis - May 27, 2023 Category: Cardiology Authors: Shao-Ling Huang Melanie R Moody Xing Yin David D McPherson Hyunggun Kim Source Type: research
Co-Delivery of Therapeutics and Bioactive Gas Using a Novel Liposomal Platform for Enhanced Treatment of Acute Arterial Injury
In this study, liposomes loaded with nitric oxide (NO) and rosiglitazone, a peroxisome proliferator-activated receptor agonist, were prepared using hydration, sonication, freeze-thawing, and pressurization. The efficacy of this delivery system was evaluated in a rabbit model of acute arterial injury induced by balloon injury to the common carotid artery. Intra-arterial administration of rosiglitazone/NO co-encapsulated liposomes (R/NO-ELIP) immediately following injury resulted in reduced intimal thickening after 14 days. The anti-inflammatory and anti-proliferative effects of the co-delivery system were investigated. Thes...
Source: Atherosclerosis - May 27, 2023 Category: Cardiology Authors: Shao-Ling Huang Melanie R Moody Xing Yin David D McPherson Hyunggun Kim Source Type: research
Recent developments in antimalarial drug discovery
Bioorg Med Chem. 2023 May 20;88-89:117339. doi: 10.1016/j.bmc.2023.117339. Online ahead of print.ABSTRACTAlthough malaria remains a big burden to many countries that it threatens their socio-economic stability, particularly in the countries where malaria is endemic, there have been great efforts to eradicate this disease with both successes and failures. For example, there has been a great improvement in malaria prevention and treatment methods with a net reduction in infection and mortality rates. However, the disease remains a global threat in terms of the number of people affected because it is one of the infectious dis...
Source: Bioorganic and Medicinal Chemistry - May 26, 2023 Category: Chemistry Authors: Th éoneste Umumararungu Jean Bosco Nkuranga Gratien Habarurema Jean Baptiste Nyandwi Marie Jeanne Mukazayire Janvier Mukiza Raymond Muganga Innocent Hahirwa Matabishi Mpenda Alain Nyirimigabo Katembezi Emmanuel Oladayo Olawode Egide Kayitare Pierre Clave Source Type: research
Recent developments in antimalarial drug discovery
Bioorg Med Chem. 2023 May 20;88-89:117339. doi: 10.1016/j.bmc.2023.117339. Online ahead of print.ABSTRACTAlthough malaria remains a big burden to many countries that it threatens their socio-economic stability, particularly in the countries where malaria is endemic, there have been great efforts to eradicate this disease with both successes and failures. For example, there has been a great improvement in malaria prevention and treatment methods with a net reduction in infection and mortality rates. However, the disease remains a global threat in terms of the number of people affected because it is one of the infectious dis...
Source: Bioorganic and Medicinal Chemistry - May 26, 2023 Category: Chemistry Authors: Th éoneste Umumararungu Jean Bosco Nkuranga Gratien Habarurema Jean Baptiste Nyandwi Marie Jeanne Mukazayire Janvier Mukiza Raymond Muganga Innocent Hahirwa Matabishi Mpenda Alain Nyirimigabo Katembezi Emmanuel Oladayo Olawode Egide Kayitare Pierre Clave Source Type: research
Recent developments in antimalarial drug discovery
Bioorg Med Chem. 2023 May 20;88-89:117339. doi: 10.1016/j.bmc.2023.117339. Online ahead of print.ABSTRACTAlthough malaria remains a big burden to many countries that it threatens their socio-economic stability, particularly in the countries where malaria is endemic, there have been great efforts to eradicate this disease with both successes and failures. For example, there has been a great improvement in malaria prevention and treatment methods with a net reduction in infection and mortality rates. However, the disease remains a global threat in terms of the number of people affected because it is one of the infectious dis...
Source: Bioorganic and Medicinal Chemistry - May 26, 2023 Category: Chemistry Authors: Th éoneste Umumararungu Jean Bosco Nkuranga Gratien Habarurema Jean Baptiste Nyandwi Marie Jeanne Mukazayire Janvier Mukiza Raymond Muganga Innocent Hahirwa Matabishi Mpenda Alain Nyirimigabo Katembezi Emmanuel Oladayo Olawode Egide Kayitare Pierre Clave Source Type: research
Effect of Rosiglitazone, the Peroxisome Proliferator-Activated Receptor (PPAR)- γ Agonist, on Apoptosis, Inflammatory Cytokines and Oxidative Stress in pentylenetetrazole-Induced Seizures in Kindled Mice
Neurochem Res. 2023 May 19. doi: 10.1007/s11064-023-03951-7. Online ahead of print.ABSTRACTA growing body of evidence has shown that seizure can trigger inflammatory cascades through increasing the expression of several inflammatory cytokines. It has been proved that peroxisome proliferator-activated receptor-γ agonists have immunomodulatory, anti-inflammatory, and neuroprotective effects beyond the putative hypoglycemic effects. Thus, we investigated the inhibitory effect of rosiglitazone on the development of pentylenetetrazol (PTZ)-induced kindling via affecting the inflammatory pathway. Male C57BL/6 mice were randomly...
Source: Neurochemical Research - May 19, 2023 Category: Neuroscience Authors: Jinliang Li Suping Chen Feilong Wang Jingyu Zhang Mohammad Ali Zeyghami Faramarz Koohsar Ali Asghar Ayatollahi Abolfazl Amini Source Type: research
Effect of Rosiglitazone, the Peroxisome Proliferator-Activated Receptor (PPAR)- γ Agonist, on Apoptosis, Inflammatory Cytokines and Oxidative Stress in pentylenetetrazole-Induced Seizures in Kindled Mice
Neurochem Res. 2023 May 19. doi: 10.1007/s11064-023-03951-7. Online ahead of print.ABSTRACTA growing body of evidence has shown that seizure can trigger inflammatory cascades through increasing the expression of several inflammatory cytokines. It has been proved that peroxisome proliferator-activated receptor-γ agonists have immunomodulatory, anti-inflammatory, and neuroprotective effects beyond the putative hypoglycemic effects. Thus, we investigated the inhibitory effect of rosiglitazone on the development of pentylenetetrazol (PTZ)-induced kindling via affecting the inflammatory pathway. Male C57BL/6 mice were randomly...
Source: Neurochemical Research - May 19, 2023 Category: Neuroscience Authors: Jinliang Li Suping Chen Feilong Wang Jingyu Zhang Mohammad Ali Zeyghami Faramarz Koohsar Ali Asghar Ayatollahi Abolfazl Amini Source Type: research
Cancers, Vol. 15, Pages 2737: Bone Marrow Adipocytes Contribute to Tumor Microenvironment-Driven Chemoresistance via Sequestration of Doxorubicin
In this study, we developed 2D and 3D in vitro models of bone marrow adipocytes to examine the mechanisms underlying adipocyte-induced chemoresistance. We first established a protocol for the rapid and robust differentiation of human bone marrow stromal cells (hBMSCs) into mature adipocytes in 2D tissue culture plastic using rosiglitazone (10 μM), a PPARγ agonist. Next, we created a 3D adipocyte culture model by inducing aggregation of hBMSCs and adipogenesis to create adipocyte spheroids in porous hydrogel scaffolds that mimic bone marrow sinusoids. Simulated chemotherapy treatment with doxorubici...
Source: Cancers - May 12, 2023 Category: Cancer & Oncology Authors: Jun-Goo Kwak Jungwoo Lee Tags: Article Source Type: research
Effect of PPAR γ on oxidative stress in diabetes-related dry eye
Exp Eye Res. 2023 May 9:109498. doi: 10.1016/j.exer.2023.109498. Online ahead of print.ABSTRACTOxidative stress is closely associated with diabetes and can cause free radical accumulation and eventually lead to ocular surface tissue damage. The purpose of this study was to investigate peroxisome proliferator-activated receptor-γ (PPARγ) expression in the lacrimal gland (LG), meibomian gland, and cornea of diabetes-related dry eye mice and whether the PPARγ agonist rosiglitazone can alleviate the oxidative stress of the ocular surface, thereby improving the condition of diabetes-related dry eye. Quantitative RT-PCR (Q-PC...
Source: Experimental Eye Research - May 11, 2023 Category: Opthalmology Authors: Jing Wang Shuangping Chen Xiuxiu Zhao Qian Guo Ruibo Yang Chen Zhang Yue Huang Lechong Ma Shaozhen Zhao Source Type: research
Effect of PPAR γ on oxidative stress in diabetes-related dry eye
Exp Eye Res. 2023 May 9:109498. doi: 10.1016/j.exer.2023.109498. Online ahead of print.ABSTRACTOxidative stress is closely associated with diabetes and can cause free radical accumulation and eventually lead to ocular surface tissue damage. The purpose of this study was to investigate peroxisome proliferator-activated receptor-γ (PPARγ) expression in the lacrimal gland (LG), meibomian gland, and cornea of diabetes-related dry eye mice and whether the PPARγ agonist rosiglitazone can alleviate the oxidative stress of the ocular surface, thereby improving the condition of diabetes-related dry eye. Quantitative RT-PCR (Q-PC...
Source: Cell Research - May 11, 2023 Category: Cytology Authors: Jing Wang Shuangping Chen Xiuxiu Zhao Qian Guo Ruibo Yang Chen Zhang Yue Huang Lechong Ma Shaozhen Zhao Source Type: research
Effect of PPAR γ on oxidative stress in diabetes-related dry eye
Exp Eye Res. 2023 May 9:109498. doi: 10.1016/j.exer.2023.109498. Online ahead of print.ABSTRACTOxidative stress is closely associated with diabetes and can cause free radical accumulation and eventually lead to ocular surface tissue damage. The purpose of this study was to investigate peroxisome proliferator-activated receptor-γ (PPARγ) expression in the lacrimal gland (LG), meibomian gland, and cornea of diabetes-related dry eye mice and whether the PPARγ agonist rosiglitazone can alleviate the oxidative stress of the ocular surface, thereby improving the condition of diabetes-related dry eye. Quantitative RT-PCR (Q-PC...
Source: Experimental Eye Research - May 11, 2023 Category: Opthalmology Authors: Jing Wang Shuangping Chen Xiuxiu Zhao Qian Guo Ruibo Yang Chen Zhang Yue Huang Lechong Ma Shaozhen Zhao Source Type: research
