Hypermethylation of PPARG-encoding gene promoter mediates fine particulate matter-induced pulmonary fibrosis by regulating the HMGB1/NLRP3 axis

In conclusion, the HMGB1/NLRP3 signaling pathway was activated in pulmonary fibrosis triggered by PM2.5 through the hypermethylation of the PPARG-encoding gene promoter.PMID:38330871 | DOI:10.1016/j.ecoenv.2024.116068

Source: Ecotoxicology and Environmental Safety - February 8, 2024 Category: Environmental Health Authors: Siyu Yang Yaochuan Sun Yajun Luo Yingyi Liu Mengyu Jiang Jiayou Li Qibing Zhang Jun Bai Source Type: research