The Role of Multiple Birth and Birth Complications in the Association Between Assisted Reproductive Technology Conception and Autism Diagnosis
Am J Epidemiol. 2024 Apr 15:kwae049. doi: 10.1093/aje/kwae049. Online ahead of print.ABSTRACTIn recent decades, the use of assisted reproductive technology (ART) has increased rapidly. To assess the relationship between ART and autism diagnosis, we linked California birth records from 2000 through 2016 with contemporaneous records from the National ART Surveillance System (NASS) and autism caseload records from California's Department of Developmental Services from 2000 through November 2019. All 95,149 birth records that were successfully linked to a NASS record, indicating an ART birth, were matched 1:1 using propensity ...
Source: Am J Epidemiol - April 17, 2024 Category: Epidemiology Authors: Alix S Winter Anthony K Yartel Christine Fountain Keely Cheslack-Postava Yujia Zhang Laura A Schieve Dmitry M Kissin Peter Bearman Source Type: research
Dodecyl creatine ester therapy: from promise to reality
Cell Mol Life Sci. 2024 Apr 17;81(1):186. doi: 10.1007/s00018-024-05218-y.ABSTRACTPathogenic variants in SLC6A8, the gene which encodes creatine transporter SLC6A8, prevent creatine uptake in the brain and result in a variable degree of intellectual disability, behavioral disorders (e.g., autism spectrum disorder), epilepsy, and severe speech and language delay. There are no treatments to improve neurodevelopmental outcomes for creatine transporter deficiency (CTD). In this spotlight, we summarize recent advances in innovative molecules to treat CTD, with a focus on dodecyl creatine ester, the most promising drug candidate...
Source: Cellular and Molecular Life Sciences : CMLS - April 17, 2024 Category: Cytology Authors: Alo ïse Mabondzo Jiddeke van de Kamp Saadet Mercimek-Andrews Source Type: research
Profile of paediatric occupational therapy practice in Eastern Mediterranean countries
CONCLUSION: Paediatric occupational therapists are usually exposed to specific age groups and conditions. However, a lack of knowledge practice in some areas and challenges in others exist.SIGNIFICANCE: Within the EM region, knowledge regarding therapists' practices is lacking. Actions should be taken to improve current practice and meet the current needs of clients, and utilise evidence-based practices.PMID:38631391 | DOI:10.1080/11038128.2024.2342536 (Source: Scandinavian Journal of Occupational Therapy)
Source: Scandinavian Journal of Occupational Therapy - April 17, 2024 Category: Occupational Health Authors: Zainab A Jasem Source Type: research
Conduction velocity, G-ratio, and extracellular water as microstructural characteristics of autism spectrum disorder
This study is the first to reveal that ASD involves MRI-measurablein vivo differences of myelin and axonal development with implications for neuronal and behavioral function. We also introduce a novel formulation for calculating aggregate conduction velocity, that is highly sensitive to these changes. We conclude that ASD may be characterized by otherwise intact structural connectivity but that functional connectivity may be attenuated by network properties affecting neural transmission speed. This effect may explain the putative reliance on local connectivity in contrast to more distal connectivity observed in ASD. (Source: PLoS One)
Source: PLoS One - April 17, 2024 Category: Biomedical Science Authors: Benjamin T. Newman Source Type: research
Sex Differences in Autism Heritability and Likelihood
Autism is a neurodevelopmental condition that includes difficulties with communication, social interaction, and adjusting to unexpected change, alongside differences in narrow interests, unusually repetitive behavior, and sensory hypersensitivity. Some differences are strengths, such as excellent attention to detail. After years of multidisciplinary research, autism diagnosis still relies on behavioral assessments and no reliable biomarker has been consistently associated with the condition. Autistic people are very heterogeneous in their range of behaviors, cognitive skills, co-occurring conditions, and levels of disabili...
Source: JAMA Psychiatry - April 17, 2024 Category: Psychiatry Source Type: research
Examining Sex Differences in Autism Heritability
This cohort study analyzes sex-specific differences in heritability of autism spectrum disorder among individuals in Sweden. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - April 17, 2024 Category: Psychiatry Source Type: research
Amygdalar neurotransmission alterations in the BTBR mice model of idiopathic autism
Translational Psychiatry, Published online: 17 April 2024; doi:10.1038/s41398-024-02905-zAmygdalar neurotransmission alterations in the BTBR mice model of idiopathic autism (Source: Translational Psychiatry)
Source: Translational Psychiatry - April 17, 2024 Category: Psychiatry Authors: Maria Bove Maria Adelaide Palmieri Martina Santoro Lisa Pia Agosti Silvana Gaetani Adele Romano Stefania Dimonte Giuseppe Costantino Vladyslav Sikora Paolo Tucci Stefania Schiavone Maria Grazia Morgese Luigia Trabace Source Type: research
The Brain Gene Registry: a data snapshot
AbstractMonogenic disorders account for a large proportion of population-attributable risk for neurodevelopmental disabilities. However, the data necessary to infer a causal relationship between a given genetic variant and a particular neurodevelopmental disorder is often lacking. Recognizing this scientific roadblock, 13 Intellectual and Developmental Disabilities Research Centers (IDDRCs) formed a consortium to create the Brain Gene Registry (BGR), a repository pairing clinical genetic data with phenotypic data from participants with variants in putative brain genes. Phenotypic profiles are assembled from the electronic ...
Source: Journal of Neurodevelopmental Disorders - April 17, 2024 Category: Neurology Source Type: research
Enhancing IEP Goal Development for Preschoolers with Autism: A Preliminary Study on ChatGPT Integration
CONCLUSION: The potential of ChatGPT as an effective tool for supporting special education teachers in developing high-quality IEP goals suggests promising implications for improving outcomes for preschool children with autism. Its integration may offer valuable assistance in tailoring individualized goals to meet the diverse needs of students in special education settings.PMID:38625490 | DOI:10.1007/s10803-024-06343-0 (Source: Journal of Autism and Developmental Disorders)
Source: Journal of Autism and Developmental Disorders - April 16, 2024 Category: Psychiatry Authors: Salih Rakap Serife Balikci Source Type: research
Correlates of Impairment and Growth in Families of Young Autistic Children
J Autism Dev Disord. 2024 Apr 16. doi: 10.1007/s10803-024-06339-w. Online ahead of print.ABSTRACTThe purpose of this project was to investigate potential correlates of family life impairment in families of young autistic children. This project incorporated measures of specific child and parent challenges in addition to a commonly used unidimensional measure of autism characteristics. In this way, we could assess whether such challenges explain variance in family life impairment, and whether their inclusion diminish associations between autism characteristics and family life impairment. Cross-sectional data were collected f...
Source: Journal of Autism and Developmental Disorders - April 16, 2024 Category: Psychiatry Authors: Kristen T MacKenzie Mario J Crown Jessie B Northrup Elizabeth Rutenberg Amy G Hartman Carla A Mazefsky Source Type: research
DHCR7 links cholesterol synthesis with neuronal development and axonal integrity
Biochem Biophys Res Commun. 2024 Apr 12;712-713:149932. doi: 10.1016/j.bbrc.2024.149932. Online ahead of print.ABSTRACTThe DHCR7 enzyme converts 7-DHC into cholesterol. Mutations in DHCR7 can block cholesterol production, leading to abnormal accumulation of 7-DHC and causing Smith-Lemli-Opitz syndrome (SLOS). SLOS is an autosomal recessive disorder characterized by multiple malformations, including microcephaly, intellectual disability, behavior reminiscent of autism, sleep disturbances, and attention-deficit/hyperactivity disorder (ADHD)-like hyperactivity. Although 7-DHC affects neuronal differentiation in ex vivo experi...
Source: Biochemical and Biophysical Research communications - April 16, 2024 Category: Biochemistry Authors: Shuya Miyazaki Nobuyuki Shimizu Hiroaki Miyahara Hitoshi Teranishi Ryohei Umeda Shinji Yano Tatsuo Shimada Hiroshi Shiraishi Kosaku Komiya Akira Katoh Akihiko Yoshimura Reiko Hanada Toshikatsu Hanada Source Type: research
Autistic traits and anthropomorphism: the case of vehicle fascia perception
Cogn Process. 2024 Apr 16. doi: 10.1007/s10339-024-01187-z. Online ahead of print.ABSTRACTIndividuals high in autistic traits can have difficulties with social interactions which may stem from difficulties with mentalizing abilities, yet findings from research investigating anthropomorphism of non-human objects in high trait individuals are inconsistent. Measuring emotions and attributes of front-facing vehicles, individuals scoring high versus low on the AQ-10 were compared for ratings of angry-happy, hostile-friendly, masculine-feminine, and submissive-dominant, as a function of vehicle size (large versus small). Our res...
Source: Cognitive Processing - April 16, 2024 Category: Neuroscience Authors: Leilani Forby Farid Pazhoohi Alan Kingstone Source Type: research
DHCR7 links cholesterol synthesis with neuronal development and axonal integrity
Biochem Biophys Res Commun. 2024 Apr 12;712-713:149932. doi: 10.1016/j.bbrc.2024.149932. Online ahead of print.ABSTRACTThe DHCR7 enzyme converts 7-DHC into cholesterol. Mutations in DHCR7 can block cholesterol production, leading to abnormal accumulation of 7-DHC and causing Smith-Lemli-Opitz syndrome (SLOS). SLOS is an autosomal recessive disorder characterized by multiple malformations, including microcephaly, intellectual disability, behavior reminiscent of autism, sleep disturbances, and attention-deficit/hyperactivity disorder (ADHD)-like hyperactivity. Although 7-DHC affects neuronal differentiation in ex vivo experi...
Source: Cell Research - April 16, 2024 Category: Cytology Authors: Shuya Miyazaki Nobuyuki Shimizu Hiroaki Miyahara Hitoshi Teranishi Ryohei Umeda Shinji Yano Tatsuo Shimada Hiroshi Shiraishi Kosaku Komiya Akira Katoh Akihiko Yoshimura Reiko Hanada Toshikatsu Hanada Source Type: research
Enhancing IEP Goal Development for Preschoolers with Autism: A Preliminary Study on ChatGPT Integration
CONCLUSION: The potential of ChatGPT as an effective tool for supporting special education teachers in developing high-quality IEP goals suggests promising implications for improving outcomes for preschool children with autism. Its integration may offer valuable assistance in tailoring individualized goals to meet the diverse needs of students in special education settings.PMID:38625490 | DOI:10.1007/s10803-024-06343-0 (Source: Journal of Autism and Developmental Disorders)
Source: Journal of Autism and Developmental Disorders - April 16, 2024 Category: Psychiatry Authors: Salih Rakap Serife Balikci Source Type: research
