Prenatal exposure to valproic acid reduces synaptic δ-catenin levels and disrupts ultrasonic vocalization in neonates
Neuropharmacology. 2024 Apr 22:109963. doi: 10.1016/j.neuropharm.2024.109963. Online ahead of print.ABSTRACTValproic acid (VPA) is an effective and commonly prescribed drug for epilepsy and bipolar disorder. However, children born from mothers treated with VPA during pregnancy exhibit an increased incidence of autism spectrum disorder (ASD). Although VPA may impair brain development at the cellular level, the mechanism of VPA-induced ASD has not been completely addressed. A previous study has found that VPA treatment strongly reduces δ-catenin mRNA levels in cultured human neurons. δ-catenin is important for the control ...
Source: Neuropharmacology - April 24, 2024 Category: Drugs & Pharmacology Authors: Seung Hyun Roh Hadassah Mendez-Vazquez Matheus F Sathler Michael J Doolittle Anastasiya Zaytseva Hannah Brown Morgan Sainsbury Seonil Kim Source Type: research
Cognitive and social adaptation in autism spectrum disorder: A prospective cohort study
CONCLUSION: Logic mathematics and memory promote better social insertion in children with autism spectrum disorder. General cognitive ability promotes communication.PMID:38655981 | DOI:10.1590/1516-3180.2023.0184.R1.16022024 (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - April 24, 2024 Category: General Medicine Authors: M árcia Regina Fumagalli Marteleto Jacy Perissinoto Source Type: research
Oxytocin, GABA, and dopamine interplay in autism
Endocr Regul. 2024 Apr 24;58(1):105-114. doi: 10.2478/enr-2024-0012. Print 2024 Jan 1.ABSTRACTOxytocin plays an important role in brain development and is associated with various neurotransmitter systems in the brain. Abnormalities in the production, secretion, and distribution of oxytocin in the brain, at least during some stages of the development, are critical for the pathogenesis of neuropsychiatric diseases, particularly in the autism spectrum disorder. The etiology of autism includes changes in local sensory and dopaminergic areas of the brain, which are also supplied by the hypothalamic sources of oxytocin. It is ve...
Source: Endocrine Regulations - April 24, 2024 Category: Endocrinology Authors: Tomas Havranek Zuzana Bacova Jan Bakos Source Type: research
Association of Breastfeeding Duration with Neurodevelopmental Outcomes in an Enriched Familial Likelihood Cohort for Autism Spectrum Disorder
This study aimed to compare the breastfeeding (BF) duration of the younger siblings of children with ASD in an enriched-likelihood cohort for autism spectrum disorder (ASD), and to determine whether longer BF duration was associated with differences in neurodevelopmental outcomes in this cohort. Information on BF practices was collected via surveys in the MARBLES (Markers of Autism Risk in Babies-Learning Early Signs) study. Developmental evaluations, including the Mullen Scales of Early Learning and the Autism Diagnostic Observation Schedule, were conducted by expert clinicians. Participants' neurodevelopmental outcome wa...
Source: Child Psychiatry and Human Development - April 24, 2024 Category: Child Development Authors: Ruchi Punatar Kathleen Angkustsiri Laura R Kair Daniel J Tancredi Danielle J Harvey Rebecca J Schmidt Source Type: research
Awareness of Autism Spectrum Disorder Among Population of Kazakhstan
CONCLUSION: Low awareness on ASD symptoms and treatment methods was identified in both areas. There is a need to develop activities to increase the public awareness on ASD, including knowledge on early symptoms of ASD and facilities that address the needs of people on the ASD and their families.PMID:38656465 | DOI:10.1007/s10803-024-06350-1 (Source: Journal of Autism and Developmental Disorders)
Source: Journal of Autism and Developmental Disorders - April 24, 2024 Category: Psychiatry Authors: Sandugash Kurmanalina Aizhan Samambayeva Nazgul Akhtayeva Laura Kozhageldiyeva Lyazzat Kosherbayeva Source Type: research
Prenatal exposure to valproic acid reduces synaptic δ-catenin levels and disrupts ultrasonic vocalization in neonates
Neuropharmacology. 2024 Apr 23;253:109963. doi: 10.1016/j.neuropharm.2024.109963. Online ahead of print.ABSTRACTValproic acid (VPA) is an effective and commonly prescribed drug for epilepsy and bipolar disorder. However, children born from mothers treated with VPA during pregnancy exhibit an increased incidence of autism spectrum disorder (ASD). Although VPA may impair brain development at the cellular level, the mechanism of VPA-induced ASD has not been completely addressed. A previous study has found that VPA treatment strongly reduces δ-catenin mRNA levels in cultured human neurons. δ-catenin is important for the cont...
Source: Neuropharmacology - April 24, 2024 Category: Drugs & Pharmacology Authors: Seung Hyun Roh Hadassah Mendez-Vazquez Matheus F Sathler Michael J Doolittle Anastasiya Zaytseva Hannah Brown Morgan Sainsbury Seonil Kim Source Type: research
Cognitive and social adaptation in autism spectrum disorder: A prospective cohort study
CONCLUSION: Logic mathematics and memory promote better social insertion in children with autism spectrum disorder. General cognitive ability promotes communication.PMID:38655981 | DOI:10.1590/1516-3180.2023.0184.R1.16022024 (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - April 24, 2024 Category: General Medicine Authors: M árcia Regina Fumagalli Marteleto Jacy Perissinoto Source Type: research
Oxytocin, GABA, and dopamine interplay in autism
Endocr Regul. 2024 Apr 24;58(1):105-114. doi: 10.2478/enr-2024-0012. Print 2024 Jan 1.ABSTRACTOxytocin plays an important role in brain development and is associated with various neurotransmitter systems in the brain. Abnormalities in the production, secretion, and distribution of oxytocin in the brain, at least during some stages of the development, are critical for the pathogenesis of neuropsychiatric diseases, particularly in the autism spectrum disorder. The etiology of autism includes changes in local sensory and dopaminergic areas of the brain, which are also supplied by the hypothalamic sources of oxytocin. It is ve...
Source: Endocrine Regulations - April 24, 2024 Category: Endocrinology Authors: Tomas Havranek Zuzana Bacova Jan Bakos Source Type: research
Association of Breastfeeding Duration with Neurodevelopmental Outcomes in an Enriched Familial Likelihood Cohort for Autism Spectrum Disorder
This study aimed to compare the breastfeeding (BF) duration of the younger siblings of children with ASD in an enriched-likelihood cohort for autism spectrum disorder (ASD), and to determine whether longer BF duration was associated with differences in neurodevelopmental outcomes in this cohort. Information on BF practices was collected via surveys in the MARBLES (Markers of Autism Risk in Babies-Learning Early Signs) study. Developmental evaluations, including the Mullen Scales of Early Learning and the Autism Diagnostic Observation Schedule, were conducted by expert clinicians. Participants' neurodevelopmental outcome wa...
Source: Child Psychiatry and Human Development - April 24, 2024 Category: Child Development Authors: Ruchi Punatar Kathleen Angkustsiri Laura R Kair Daniel J Tancredi Danielle J Harvey Rebecca J Schmidt Source Type: research
Prenatal exposure to valproic acid reduces synaptic δ-catenin levels and disrupts ultrasonic vocalization in neonates
Neuropharmacology. 2024 Apr 23;253:109963. doi: 10.1016/j.neuropharm.2024.109963. Online ahead of print.ABSTRACTValproic acid (VPA) is an effective and commonly prescribed drug for epilepsy and bipolar disorder. However, children born from mothers treated with VPA during pregnancy exhibit an increased incidence of autism spectrum disorder (ASD). Although VPA may impair brain development at the cellular level, the mechanism of VPA-induced ASD has not been completely addressed. A previous study has found that VPA treatment strongly reduces δ-catenin mRNA levels in cultured human neurons. δ-catenin is important for the cont...
Source: Neuropharmacology - April 24, 2024 Category: Drugs & Pharmacology Authors: Seung Hyun Roh Hadassah Mendez-Vazquez Matheus F Sathler Michael J Doolittle Anastasiya Zaytseva Hannah Brown Morgan Sainsbury Seonil Kim Source Type: research
Cognitive and social adaptation in autism spectrum disorder: A prospective cohort study
CONCLUSION: Logic mathematics and memory promote better social insertion in children with autism spectrum disorder. General cognitive ability promotes communication.PMID:38655981 | DOI:10.1590/1516-3180.2023.0184.R1.16022024 (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - April 24, 2024 Category: General Medicine Authors: M árcia Regina Fumagalli Marteleto Jacy Perissinoto Source Type: research
Oxytocin, GABA, and dopamine interplay in autism
Endocr Regul. 2024 Apr 24;58(1):105-114. doi: 10.2478/enr-2024-0012. Print 2024 Jan 1.ABSTRACTOxytocin plays an important role in brain development and is associated with various neurotransmitter systems in the brain. Abnormalities in the production, secretion, and distribution of oxytocin in the brain, at least during some stages of the development, are critical for the pathogenesis of neuropsychiatric diseases, particularly in the autism spectrum disorder. The etiology of autism includes changes in local sensory and dopaminergic areas of the brain, which are also supplied by the hypothalamic sources of oxytocin. It is ve...
Source: Endocrine Regulations - April 24, 2024 Category: Endocrinology Authors: Tomas Havranek Zuzana Bacova Jan Bakos Source Type: research
Association of Breastfeeding Duration with Neurodevelopmental Outcomes in an Enriched Familial Likelihood Cohort for Autism Spectrum Disorder
This study aimed to compare the breastfeeding (BF) duration of the younger siblings of children with ASD in an enriched-likelihood cohort for autism spectrum disorder (ASD), and to determine whether longer BF duration was associated with differences in neurodevelopmental outcomes in this cohort. Information on BF practices was collected via surveys in the MARBLES (Markers of Autism Risk in Babies-Learning Early Signs) study. Developmental evaluations, including the Mullen Scales of Early Learning and the Autism Diagnostic Observation Schedule, were conducted by expert clinicians. Participants' neurodevelopmental outcome wa...
Source: Child Psychiatry and Human Development - April 24, 2024 Category: Child Development Authors: Ruchi Punatar Kathleen Angkustsiri Laura R Kair Daniel J Tancredi Danielle J Harvey Rebecca J Schmidt Source Type: research
Prenatal exposure to valproic acid reduces synaptic δ-catenin levels and disrupts ultrasonic vocalization in neonates
Neuropharmacology. 2024 Apr 23;253:109963. doi: 10.1016/j.neuropharm.2024.109963. Online ahead of print.ABSTRACTValproic acid (VPA) is an effective and commonly prescribed drug for epilepsy and bipolar disorder. However, children born from mothers treated with VPA during pregnancy exhibit an increased incidence of autism spectrum disorder (ASD). Although VPA may impair brain development at the cellular level, the mechanism of VPA-induced ASD has not been completely addressed. A previous study has found that VPA treatment strongly reduces δ-catenin mRNA levels in cultured human neurons. δ-catenin is important for the cont...
Source: Neuropharmacology - April 24, 2024 Category: Drugs & Pharmacology Authors: Seung Hyun Roh Hadassah Mendez-Vazquez Matheus F Sathler Michael J Doolittle Anastasiya Zaytseva Hannah Brown Morgan Sainsbury Seonil Kim Source Type: research
Cognitive and social adaptation in autism spectrum disorder: A prospective cohort study
CONCLUSION: Logic mathematics and memory promote better social insertion in children with autism spectrum disorder. General cognitive ability promotes communication.PMID:38655981 | DOI:10.1590/1516-3180.2023.0184.R1.16022024 (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - April 24, 2024 Category: General Medicine Authors: M árcia Regina Fumagalli Marteleto Jacy Perissinoto Source Type: research
