Cognitive and social adaptation in autism spectrum disorder: A prospective cohort study
CONCLUSION: Logic mathematics and memory promote better social insertion in children with autism spectrum disorder. General cognitive ability promotes communication.PMID:38655981 | DOI:10.1590/1516-3180.2023.0184.R1.16022024 (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - April 24, 2024 Category: General Medicine Authors: M árcia Regina Fumagalli Marteleto Jacy Perissinoto Source Type: research
Oxytocin, GABA, and dopamine interplay in autism
Endocr Regul. 2024 Apr 24;58(1):105-114. doi: 10.2478/enr-2024-0012. Print 2024 Jan 1.ABSTRACTOxytocin plays an important role in brain development and is associated with various neurotransmitter systems in the brain. Abnormalities in the production, secretion, and distribution of oxytocin in the brain, at least during some stages of the development, are critical for the pathogenesis of neuropsychiatric diseases, particularly in the autism spectrum disorder. The etiology of autism includes changes in local sensory and dopaminergic areas of the brain, which are also supplied by the hypothalamic sources of oxytocin. It is ve...
Source: Endocrine Regulations - April 24, 2024 Category: Endocrinology Authors: Tomas Havranek Zuzana Bacova Jan Bakos Source Type: research
Cognitive and social adaptation in autism spectrum disorder: A prospective cohort study
CONCLUSION: Logic mathematics and memory promote better social insertion in children with autism spectrum disorder. General cognitive ability promotes communication.PMID:38655981 | DOI:10.1590/1516-3180.2023.0184.R1.16022024 (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - April 24, 2024 Category: General Medicine Authors: M árcia Regina Fumagalli Marteleto Jacy Perissinoto Source Type: research
Oxytocin, GABA, and dopamine interplay in autism
Endocr Regul. 2024 Apr 24;58(1):105-114. doi: 10.2478/enr-2024-0012. Print 2024 Jan 1.ABSTRACTOxytocin plays an important role in brain development and is associated with various neurotransmitter systems in the brain. Abnormalities in the production, secretion, and distribution of oxytocin in the brain, at least during some stages of the development, are critical for the pathogenesis of neuropsychiatric diseases, particularly in the autism spectrum disorder. The etiology of autism includes changes in local sensory and dopaminergic areas of the brain, which are also supplied by the hypothalamic sources of oxytocin. It is ve...
Source: Endocrine Regulations - April 24, 2024 Category: Endocrinology Authors: Tomas Havranek Zuzana Bacova Jan Bakos Source Type: research
It is up to healthcare professionals to talk to us in a way that we can understand: informed consent processes in people with an intellectual disability
People with an intellectual disability form a sizeable minority group. Estimates of prevalence vary, depending on criteria used, but it is thought that intellectual disability affects around 1%–2% of the world population.1 2 Intellectual disability is present when the following three criteria are met: a significantly reduced ability to understand new or complex information, or to learn and apply new skills (impaired intelligence); a reduced ability to cope independently (impaired social functioning); and beginning before adulthood, with a lasting effect on development.3 4 Health inequities People with an intellectual...
Source: BMJ Quality and Safety - April 24, 2024 Category: General Medicine Authors: Ding, J., Keagan-Bull, R., Tuffrey-Wijne, I. Tags: Editorials Source Type: research
Effects of mini-basketball training program on social communication impairments and regional homogeneity of brain functions in preschool children with autism spectrum disorder
ConclusionsOur study underscores the effectiveness of a 12-week MBTP in ameliorating SCI and abnormalities in ReHo among preschool children with ASD.Trial registrationThe trial is retrospectively registered on the Chinese Clinical Trial Registry (ChiCTR1900024973; August 5, 2019). (Source: BMC Sports Science, Medicine and Rehabilitation)
Source: BMC Sports Science, Medicine and Rehabilitation - April 24, 2024 Category: Sports Medicine Source Type: research
Perspectives from the Autism Community on the Potential Utility of a Novel Measure of Suicide Risk and Mental Health Symptoms for Autistic Youth: A Pilot Study
AbstractBecause autistic youth experience increased suicide risk and there are no suicide risk screening tools for this population, existing measures need to be evaluated and then modified with input from the autism community. This pilot study obtained feedback from autistic youth, caregivers, and autism specialist clinicians (N = 14) on the applicability of a novel measure of suicide and mental health symptoms, theKiddie-Computerized Adaptive Test (K-CAT) scales, for use with autistic youth. While impressions were largely positive and several features support its use, participants identified several concerns that warr...
Source: Journal of Developmental and Physical Disabilities - April 24, 2024 Category: Disability Source Type: research
Clinical and molecular outcomes from the 5-Year natural history study of SSADH Deficiency, a model metabolic neurodevelopmental disorder
ConclusionsFindings from the SSADHD Natural History Study converge with iPSC and animal model work focused on a common disorder within our IDDRC, deepening our knowledge of the pathophysiology and longitudinal clinical course of a complex neurodevelopmental disorder. This further enables the identification of biomarkers and changes throughout development that will be essential for upcoming targeted trials of enzyme replacement and gene therapy. (Source: Journal of Neurodevelopmental Disorders)
Source: Journal of Neurodevelopmental Disorders - April 24, 2024 Category: Neurology Source Type: research
Diagnostic Evaluation of Autism Spectrum Disorder in Pediatric Primary Care
CONCLUSIONS: This model was successful in shortening the interval from referral to diagnosis resulting in significant decrease of age at diagnosis compared with the national average. Widespread implementation could improve access to timely diagnostic services and improve outcomes for children with ASD.PMID:38650542 | DOI:10.1177/21501319241247997 (Source: Primary Care)
Source: Primary Care - April 23, 2024 Category: Primary Care Authors: Arwa K Nasir Whitney Strong-Bak Marie Bernard Source Type: research
Analyzing the Quality of Life in Individuals with Fragile X Syndrome in Relation to Sleep and Mental Health
This study included 119 individuals with Fragile X Syndrome who were given different cognitive examinations by a neuropsychologist or by parent-proxy questionnaires. This study focused on the Pediatric Quality of Life Inventory (PedsQoL), the Anxiety, Depression and Mood Scale (ADAMS), the Children's Sleep Habits Questionnaire (CSHQ), but did include other cognitive tests (Vineland Adaptive Behaviour Scales, Nonverbal IQ, Autism Diagnostic Observation Schedule). We identified significant associations between decreases in emotional, social and school domains of PedsQoL and the ADAMS subtests of Generalized Anxiety, Manic/Hy...
Source: Journal of Autism and Developmental Disorders - April 23, 2024 Category: Psychiatry Authors: Amrita Minhas Kerri Whitlock Cory Rosenfelt Julie Shatto Brittany Finlay Jennifer Zwicker Sarah Lippe Sebastien Jacquemont Randi Hagerman Kara Murias Francois V Bolduc Source Type: research
Repetitive Behaviors in Autism and Obsessive-Compulsive Disorder: A Systematic Review
CONCLUSION: Further research into differences in the presentation of repetitive behaviors at a subscale and item level is required to inform clearer differentiation of specific behaviors in autism versus OCD. Understanding and more accurately differentiating is essential for efficient diagnosis, effective treatment, and better outcomes.PMID:38652373 | DOI:10.1007/s10803-024-06357-8 (Source: Journal of Autism and Developmental Disorders)
Source: Journal of Autism and Developmental Disorders - April 23, 2024 Category: Psychiatry Authors: Jessica O'Loghlen Matthew McKenzie Cathryne Lang Jessica Paynter Source Type: research
Gender Differences: Confirmatory Factor Analysis of the ADOS-II
CONCLUSION: The assumption of an identical latent factor structure for the ADOS-II Module 3 for males and females might not be justifiable. Possible diagnostic implications are discussed.PMID:38652372 | DOI:10.1007/s10803-024-06346-x (Source: Journal of Autism and Developmental Disorders)
Source: Journal of Autism and Developmental Disorders - April 23, 2024 Category: Psychiatry Authors: Ingrid S Tien Junok Kim Amanda R Johnson Jeffrey J Wood Source Type: research
Diagnostic Evaluation of Autism Spectrum Disorder in Pediatric Primary Care
CONCLUSIONS: This model was successful in shortening the interval from referral to diagnosis resulting in significant decrease of age at diagnosis compared with the national average. Widespread implementation could improve access to timely diagnostic services and improve outcomes for children with ASD.PMID:38650542 | PMC:PMC11036916 | DOI:10.1177/21501319241247997 (Source: Primary Care)
Source: Primary Care - April 23, 2024 Category: Primary Care Authors: Arwa K Nasir Whitney Strong-Bak Marie Bernard Source Type: research
What the Editors are Reading: Bladder Bowel Disorder
Gubbiotti M, Balzarro M, Zocante L, Di Gennaro G, Marchiafava M, Bedetti C, Rubilotta E. National Survey on bladder and bowel dysfunctions in Autism Spectrum Disorder population. Front. Psychiatry, March 2024 15:1140113. http://dx.doi.org/10.3389/fpsyt.2024.1140113 (Source: Journal of Pediatric Urology)
Source: Journal of Pediatric Urology - April 23, 2024 Category: Urology & Nephrology Authors: Ubirajara Barroso Source Type: research
Purinergic Signalling Mediates Aberrant Excitability of Developing Neuronal Circuits in the Fmr1 Knockout Mouse Model
In this study, we examined whether elevated astrocyte purinergic signalling also impacts neuronal morphology and connectivity ofFmr1 KO cortical neurons. Here, we found that conditioned media from primaryFmr1 KO astrocytes was sufficient to enhance neurite extension and complexity of both wildtype andFmr1 KO neurons to a similar degree as UTP-mediated outgrowth. Significantly enhanced firing was also observed inFmr1 KO neuron-astrocyte co-cultures grown on microelectrode arrays but was associated with large deficits in firing synchrony. The selective P2Y2 purinergic receptor antagonist AR-C 118925XX effectively normalized ...
Source: Molecular Neurobiology - April 23, 2024 Category: Neurology Source Type: research
