Abnormalities in both stimulus-induced and baseline MEG alpha oscillations in the auditory cortex of children with Autism Spectrum Disorder
Brain Struct Funct. 2024 Apr 29. doi: 10.1007/s00429-024-02802-7. Online ahead of print.ABSTRACTThe neurobiology of Autism Spectrum Disorder (ASD) is hypothetically related to the imbalance between neural excitation (E) and inhibition (I). Different studies have revealed that alpha-band (8-12 Hz) activity in magneto- and electroencephalography (MEG and EEG) may reflect E and I processes and, thus, can be of particular interest in ASD research. Previous findings indicated alterations in event-related and baseline alpha activity in different cortical systems in individuals with ASD, and these abnormalities were associated wi...
Source: Brain Structure and Function - April 29, 2024 Category: Neuroscience Authors: Vardan Arutiunian Giorgio Arcara Irina Buyanova Makar Fedorov Elizaveta Davydova Darya Pereverzeva Alexander Sorokin Svetlana Tyushkevich Uliana Mamokhina Kamilla Danilina Olga Dragoy Source Type: research
Developing a pathway to clinical trials for < em > CACNA1A < /em > -related epilepsies: A patient organization perspective
Ther Adv Rare Dis. 2024 Apr 25;5:26330040241245725. doi: 10.1177/26330040241245725. eCollection 2024 Jan-Dec.ABSTRACTCACNA1A-related disorders are rare neurodevelopmental disorders linked to variants in the CACNA1A gene. This gene encodes the α1 subunit of the P/Q-type calcium channel Cav2.1, which is globally expressed in the brain and crucial for fast synaptic neurotransmission. The broad spectrum of CACNA1A-related neurological disorders includes developmental and epileptic encephalopathies, familial hemiplegic migraine type 1, episodic ataxia type 2, spinocerebellar ataxia type 6, together with unclassified presentati...
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Pangkong M Fox Sunitha Malepati Lisa Manaster Elsa Rossignol Jeffrey L Noebels Source Type: research
Abnormalities in both stimulus-induced and baseline MEG alpha oscillations in the auditory cortex of children with Autism Spectrum Disorder
Brain Struct Funct. 2024 Apr 29. doi: 10.1007/s00429-024-02802-7. Online ahead of print.ABSTRACTThe neurobiology of Autism Spectrum Disorder (ASD) is hypothetically related to the imbalance between neural excitation (E) and inhibition (I). Different studies have revealed that alpha-band (8-12 Hz) activity in magneto- and electroencephalography (MEG and EEG) may reflect E and I processes and, thus, can be of particular interest in ASD research. Previous findings indicated alterations in event-related and baseline alpha activity in different cortical systems in individuals with ASD, and these abnormalities were associated wi...
Source: Brain Structure and Function - April 29, 2024 Category: Neuroscience Authors: Vardan Arutiunian Giorgio Arcara Irina Buyanova Makar Fedorov Elizaveta Davydova Darya Pereverzeva Alexander Sorokin Svetlana Tyushkevich Uliana Mamokhina Kamilla Danilina Olga Dragoy Source Type: research
Abnormalities in both stimulus-induced and baseline MEG alpha oscillations in the auditory cortex of children with Autism Spectrum Disorder
AbstractThe neurobiology of Autism Spectrum Disorder (ASD) is hypothetically related to the imbalance between neural excitation (E) and inhibition (I). Different studies have revealed that alpha-band (8 –12 Hz) activity in magneto- and electroencephalography (MEG and EEG) may reflect E and I processes and, thus, can be of particular interest in ASD research. Previous findings indicated alterations in event-related and baseline alpha activity in different cortical systems in individuals with ASD, and these abnormalities were associated with core and co-occurring conditions of ASD. However, the knowledge on auditory alpha...
Source: Anatomy and Embryology - April 29, 2024 Category: Anatomy Source Type: research
The Pediatric Autism Research Cohort (PARC) Study: protocol for a patient-oriented prospective study examining trajectories of functioning in children with autism
Introduction
The developmentally variable nature of autism poses challenges in providing timely services tailored to a child’s needs. Despite a recent focus on longitudinal research, priority-setting initiatives with stakeholders highlighted the importance of studying a child’s day-to-day functioning and social determinants of health to inform clinical care. To address this, we are conducting a pragmatic multi-site, patient-oriented longitudinal investigation: the Pediatric Autism Research Cohort (PARC) Study. In young children (<7 years of age) newly diagnosed with autism, we will: (1) examine variability i...
Source: BMJ Open - April 29, 2024 Category: General Medicine Authors: Kata, A., McPhee, P. G., Chen, Y.-J., Zwaigenbaum, L., Singal, D., Roncadin, C., Bennett, T., Carter, M., Di Rezze, B., Drmic, I., Duku, E., Fournier, S., Frei, J., Gentles, S. J., Georgiades, K., Hanlon-Dearman, A., Hoult, L., Kelley, E., Koller, J., de Tags: Open access, Paediatrics Source Type: research
Correction: An Emotional Skills Intervention for Elementary Children with Autism in China: A Pilot Study
(Source: Journal of Rational-Emotive and Cognitive-Behavior Therapy)
Source: Journal of Rational-Emotive and Cognitive-Behavior Therapy - April 29, 2024 Category: Psychiatry & Psychology Source Type: research
Preference for Prompting Procedures to Address Escape-Maintained Behavior in Autistic Adolescents
AbstractDifferential reinforcement of alternative behavior (DRA) is a common strategy for escape-maintained behaviors targeted for reduction (i.e., targeted behavior) exhibited by youth with intellectual and developmental disabilities. DRA often involves various methods of prompting to ensure the instruction or task remains in place until contingencies for the DRA are met. Currently, there is little research on client preference for these different prompting strategies in the context of DRA treatments. The current study includes four participants diagnosed with autism spectrum disorder (ASD) who exhibited targeted behavior...
Source: Journal of Developmental and Physical Disabilities - April 29, 2024 Category: Disability Source Type: research
Multi-kernel Learning Fusion Algorithm Based on RNN and GRU for ASD Diagnosis and Pathogenic Brain Region Extraction
AbstractAutism spectrum disorder (ASD) is a complex, severe disorder related to brain development. It impairs patient language communication and social behaviors. In recent years, ASD researches have focused on a single-modal neuroimaging data, neglecting the complementarity between multi-modal data. This omission may lead to poor classification. Therefore, it is important to study multi-modal data of ASD for revealing its pathogenesis. Furthermore, recurrent neural network (RNN) and gated recurrent unit (GRU) are effective for sequence data processing. In this paper, we introduce a novel framework for a Multi-Kernel Learn...
Source: Interdisciplinary Sciences, Computational Life Sciences - April 29, 2024 Category: Bioinformatics Source Type: research
The Effect of tDCS on Inhibitory Control and its Transfer Effect on Sustained Attention in Children with Autism Spectrum Disorder: An fNIRS Study
Individuals with autism spectrum disorder (ASD) have inhibitory control deficits. The combination of transcranial direct current stimulation (tDCS) and inhibitory control training produces good transfer effects and improves neuroplasticity. However, no studies have explored whether applying tDCS over the dlPFC improves inhibitory control and produces transfer effects in children with ASD. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - April 29, 2024 Category: Neurology Authors: Liu Chen, Bang Du, Ke Li, Kaiyun Li, TingTing Hou, Fanlu Jia, Li Li Source Type: research
A metagenome-wide association study of gut microbiome in patients with AMD, ASD, RA, T2D & amp; VKH diseases
Comput Biol Chem. 2024 Apr 20;110:108076. doi: 10.1016/j.compbiolchem.2024.108076. Online ahead of print.ABSTRACTClinical studies have already illustrated the associations between gut microbes and diseases, yet fundamental questions remain unclear that how we can universalize this knowledge. Considering the important role of human gut microbial composition in maintaining overall health, it is important to understand the microbial diversity and altered disease conditions of the human gut. Metagenomics provides a way to analyze and understand the microbes and their role in a community manner. It provides qualitative as well ...
Source: Computational Biology and Chemistry - April 28, 2024 Category: Bioinformatics Authors: Shivani Tyagi Pramod Katara Source Type: research
Randomized Feasibility Pilot of an Executive Functioning Intervention Adapted for Children's Mental Health Settings
J Autism Dev Disord. 2024 Apr 28. doi: 10.1007/s10803-024-06365-8. Online ahead of print.ABSTRACTThe critical role of executive functioning in autism as well as the co-occurring mental health challenges common among autistic youth support to the immense value of interventions targeting executive functioning for enhancing mental health services for autistic children. The goal of the present study was to conduct a randomized feasibility trial of Unstuck and On Target, an executive functioning intervention, adapted for delivery in children's community mental health setting. Mental health therapists (n = 26) enrolled with part...
Source: Journal of Autism and Developmental Disorders - April 28, 2024 Category: Psychiatry Authors: Kelsey S Dickson Megan Galligan Tana Holt Lauren Kenworthy Laura Anthony Scott Roesch Lauren Brookman-Frazee Source Type: research
Reliability, Validity and Acceptability of the PEDI-CAT with ASD Scales for Australian Children and Youth on the Autism Spectrum
CONCLUSION: The PEDI-CAT (ASD) had adequate psychometric properties and acceptability as a measure of Activities and Participation codes. However, it lacks comprehensiveness and relevance when compared to the ICF Core Sets for ASD and has the potential to overestimate functioning.PMID:38678516 | DOI:10.1007/s10803-024-06366-7 (Source: Journal of Autism and Developmental Disorders)
Source: Journal of Autism and Developmental Disorders - April 28, 2024 Category: Psychiatry Authors: Angela Chamberlain Emily D'Arcy Andrew Jo Whitehouse Kerry Wallace Maya Hayden-Evans Sonya Girdler Benjamin Milbourn Sven B ölte Kiah Evans Source Type: research
Infant Social Attention Associated with Elevated Likelihood for Autism Spectrum Disorder: A Multi-Method Comparison
CONCLUSION: Together, the findings support infant ET as a promising approach for identifying very early markers associated with ASD likelihood.PMID:38678515 | DOI:10.1007/s10803-024-06360-z (Source: Journal of Autism and Developmental Disorders)
Source: Journal of Autism and Developmental Disorders - April 28, 2024 Category: Psychiatry Authors: Xiaoxue Fu Emma Platt Frederick Shic Jessica Bradshaw Source Type: research
Prescriptions for Antipsychotics: Youth with Intellectual/Developmental Disabilities Compared to Youth without Intellectual/Developmental Disabilities
CONCLUSION: Compared to youth without IDD, youth with IDD were more frequently dispensed antipsychotics and metformin. These findings have important implications for the health of youth with IDD.PMID:38678514 | DOI:10.1007/s10803-024-06344-z (Source: Journal of Autism and Developmental Disorders)
Source: Journal of Autism and Developmental Disorders - April 28, 2024 Category: Psychiatry Authors: Sandra Marquis N Esm é Marquis Yona Lunsky Kimberlyn M McGrail Jennifer Baumbusch Source Type: research
A metagenome-wide association study of gut microbiome in patients with AMD, ASD, RA, T2D & amp; VKH diseases
Comput Biol Chem. 2024 Apr 20;110:108076. doi: 10.1016/j.compbiolchem.2024.108076. Online ahead of print.ABSTRACTClinical studies have already illustrated the associations between gut microbes and diseases, yet fundamental questions remain unclear that how we can universalize this knowledge. Considering the important role of human gut microbial composition in maintaining overall health, it is important to understand the microbial diversity and altered disease conditions of the human gut. Metagenomics provides a way to analyze and understand the microbes and their role in a community manner. It provides qualitative as well ...
Source: Computational Biology and Chemistry - April 28, 2024 Category: Bioinformatics Authors: Shivani Tyagi Pramod Katara Source Type: research
