IJERPH, Vol. 21, Pages 555: Public Dental Service Access Policies for People with Autism Spectrum Disorder (ASD) in Salvador, Bahia, Brazil: A Pre-Evaluation Study
This study sought to carry out a systematic and preliminary evaluation of the policies on access to public dental services for people with ASD in a Brazilian city. The study, conducted between November/2019 and February/2020, was developed through document analysis, the design of the theoretical logical model of the policies, and seven semi-structured interviews with key informants. The sample was intentionally selected. We also considered the answers to 108 questionnaires from a pilot study on the access of people with ASD to dental services applied to caregivers, dentists, and non-dental professionals. No refusals were r...
Source: International Journal of Environmental Research and Public Health - April 27, 2024 Category: Environmental Health Authors: Ednaldo de Jesus-Filho Sandra Garrido de Barros Maria Isabel Pereira Vianna Maria Cristina Teixeira Cangussu Tags: Article Source Type: research
Using a Video Activity Schedule to Teach Cooperative Games to Autistic Children in a Camp Setting
In this study, a non-concurrent multiple baseline design across participants was used to evaluate the effect of a video activity schedule to teach four dyads of autistic children how to play cooperative games during a summer day camp. Results indicate that all participants learned how to play the game, including during generalization and maintenance probes. A limitation within the study was a lack of data collected for social communication and social validity. Future research should collect social communication data and/or other measures like indices of happiness (e.g., smiling, laughing, etc.). (Source: Journal of Develop...
Source: Journal of Developmental and Physical Disabilities - April 27, 2024 Category: Disability Source Type: research
Autism Spectrum Disorder- and/or Intellectual Disability-Associated Semaphorin-5A Exploits the Mechanism by Which Dock5 Signalosome Molecules Control Cell Shape
Curr Issues Mol Biol. 2024 Apr 2;46(4):3092-3107. doi: 10.3390/cimb46040194.ABSTRACTAutism spectrum disorder (ASD) is a neurodevelopmental disorder that includes autism, Asperger's syndrome, and pervasive developmental disorder. Individuals with ASD may exhibit difficulties in social interactions, communication challenges, repetitive behaviors, and restricted interests. While genetic mutations in individuals with ASD can either activate or inactivate the activities of the gene product, impacting neuronal morphogenesis and causing symptoms, the underlying mechanism remains to be fully established. Herein, for the first time...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Miyu Okabe Takanari Sato Mikito Takahashi Asahi Honjo Maho Okawa Miki Ishida Mutsuko Kukimoto-Niino Mikako Shirouzu Yuki Miyamoto Junji Yamauchi Source Type: research
Autism Spectrum Disorder- and/or Intellectual Disability-Associated Semaphorin-5A Exploits the Mechanism by Which Dock5 Signalosome Molecules Control Cell Shape
Curr Issues Mol Biol. 2024 Apr 2;46(4):3092-3107. doi: 10.3390/cimb46040194.ABSTRACTAutism spectrum disorder (ASD) is a neurodevelopmental disorder that includes autism, Asperger's syndrome, and pervasive developmental disorder. Individuals with ASD may exhibit difficulties in social interactions, communication challenges, repetitive behaviors, and restricted interests. While genetic mutations in individuals with ASD can either activate or inactivate the activities of the gene product, impacting neuronal morphogenesis and causing symptoms, the underlying mechanism remains to be fully established. Herein, for the first time...
Source: Mol Biol Cell - April 26, 2024 Category: Molecular Biology Authors: Miyu Okabe Takanari Sato Mikito Takahashi Asahi Honjo Maho Okawa Miki Ishida Mutsuko Kukimoto-Niino Mikako Shirouzu Yuki Miyamoto Junji Yamauchi Source Type: research
Autistic Women's Experience of Motherhood: A Qualitative Analysis of Reddit
J Autism Dev Disord. 2024 Apr 26. doi: 10.1007/s10803-024-06312-7. Online ahead of print.ABSTRACTAutistic mothers remain under-represented in parental and autism research despite the associated physical and psychosocial challenges that accompany the transition to motherhood. Extant literature suggests autistic mothers experience sensory difficulties, communication challenges, stigma, and comorbidities as difficulties, but these studies have focused on autistic women in the perinatal period. The aim of this study was to examine reflections on motherhood from a Reddit community for autistic parents. Identified themes were Au...
Source: Journal of Autism and Developmental Disorders - April 26, 2024 Category: Psychiatry Authors: Sandra Thom-Jones Imogen Melgaard Chloe S Gordon Source Type: research
Parent-Led Cognitive Behavioral Teletherapy for Anxiety in Autistic Youth: A Randomized Trial Comparing Two Levels of Therapist Support
In this study, 87 autistic youth (7 to 13 years old) with anxiety disorders and their parents were randomized to two forms of parent-led CBT in which parents led their child through a guided CBT workbook across 12 weeks: one with low therapist contact (four 30-minute telehealth calls), and one with standard therapist contact (ten 60-minute telehealth calls). Anxiety, functional impairment, and autism features significantly declined across therapy, without differences between groups. High satisfaction was reported in both groups, though significantly higher satisfaction ratings were reported in standard-contact CBT. Respond...
Source: Behavior Therapy - April 26, 2024 Category: Psychiatry & Psychology Authors: Andrew G Guzick Sophie C Schneider Minjee Kook Julia Rose Iacono Saira A Weinzimmer Troy Quast Sean M Olsen Killian Rainey Hughes Emily Jellinek-Russo Amanda Perozo Garcia Abigail Candelari Leandra N Berry Robin P Goin-Kochel Wayne K Goodman Eric A Storch Source Type: research
Autism Spectrum Disorder- and/or Intellectual Disability-Associated Semaphorin-5A Exploits the Mechanism by Which Dock5 Signalosome Molecules Control Cell Shape
Curr Issues Mol Biol. 2024 Apr 2;46(4):3092-3107. doi: 10.3390/cimb46040194.ABSTRACTAutism spectrum disorder (ASD) is a neurodevelopmental disorder that includes autism, Asperger's syndrome, and pervasive developmental disorder. Individuals with ASD may exhibit difficulties in social interactions, communication challenges, repetitive behaviors, and restricted interests. While genetic mutations in individuals with ASD can either activate or inactivate the activities of the gene product, impacting neuronal morphogenesis and causing symptoms, the underlying mechanism remains to be fully established. Herein, for the first time...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Miyu Okabe Takanari Sato Mikito Takahashi Asahi Honjo Maho Okawa Miki Ishida Mutsuko Kukimoto-Niino Mikako Shirouzu Yuki Miyamoto Junji Yamauchi Source Type: research
Autistic Women's Experience of Motherhood: A Qualitative Analysis of Reddit
J Autism Dev Disord. 2024 Apr 26. doi: 10.1007/s10803-024-06312-7. Online ahead of print.ABSTRACTAutistic mothers remain under-represented in parental and autism research despite the associated physical and psychosocial challenges that accompany the transition to motherhood. Extant literature suggests autistic mothers experience sensory difficulties, communication challenges, stigma, and comorbidities as difficulties, but these studies have focused on autistic women in the perinatal period. The aim of this study was to examine reflections on motherhood from a Reddit community for autistic parents. Identified themes were Au...
Source: Journal of Autism and Developmental Disorders - April 26, 2024 Category: Psychiatry Authors: Sandra Thom-Jones Imogen Melgaard Chloe S Gordon Source Type: research
Parent-Led Cognitive Behavioral Teletherapy for Anxiety in Autistic Youth: A Randomized Trial Comparing Two Levels of Therapist Support
In this study, 87 autistic youth (7 to 13 years old) with anxiety disorders and their parents were randomized to two forms of parent-led CBT in which parents led their child through a guided CBT workbook across 12 weeks: one with low therapist contact (four 30-minute telehealth calls), and one with standard therapist contact (ten 60-minute telehealth calls). Anxiety, functional impairment, and autism features significantly declined across therapy, without differences between groups. High satisfaction was reported in both groups, though significantly higher satisfaction ratings were reported in standard-contact CBT. Respond...
Source: Behavior Therapy - April 26, 2024 Category: Psychiatry & Psychology Authors: Andrew G Guzick Sophie C Schneider Minjee Kook Julia Rose Iacono Saira A Weinzimmer Troy Quast Sean M Olsen Killian Rainey Hughes Emily Jellinek-Russo Amanda Perozo Garcia Abigail Candelari Leandra N Berry Robin P Goin-Kochel Wayne K Goodman Eric A Storch Source Type: research
Autism Spectrum Disorder- and/or Intellectual Disability-Associated Semaphorin-5A Exploits the Mechanism by Which Dock5 Signalosome Molecules Control Cell Shape
Curr Issues Mol Biol. 2024 Apr 2;46(4):3092-3107. doi: 10.3390/cimb46040194.ABSTRACTAutism spectrum disorder (ASD) is a neurodevelopmental disorder that includes autism, Asperger's syndrome, and pervasive developmental disorder. Individuals with ASD may exhibit difficulties in social interactions, communication challenges, repetitive behaviors, and restricted interests. While genetic mutations in individuals with ASD can either activate or inactivate the activities of the gene product, impacting neuronal morphogenesis and causing symptoms, the underlying mechanism remains to be fully established. Herein, for the first time...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Miyu Okabe Takanari Sato Mikito Takahashi Asahi Honjo Maho Okawa Miki Ishida Mutsuko Kukimoto-Niino Mikako Shirouzu Yuki Miyamoto Junji Yamauchi Source Type: research
Parent-Led Cognitive Behavioral Teletherapy for Anxiety in Autistic Youth: A Randomized Trial Comparing Two Levels of Therapist Support
In this study, 87 autistic youth (7 to 13 years old) with anxiety disorders and their parents were randomized to two forms of parent-led CBT in which parents led their child through a guided CBT workbook across 12 weeks: one with low therapist contact (four 30-minute telehealth calls), and one with standard therapist contact (ten 60-minute telehealth calls). Anxiety, functional impairment, and autism features significantly declined across therapy, without differences between groups. High satisfaction was reported in both groups, though significantly higher satisfaction ratings were reported in standard-contact CBT. Respond...
Source: Behavior Therapy - April 26, 2024 Category: Psychiatry & Psychology Authors: Andrew G Guzick Sophie C Schneider Minjee Kook Julia Rose Iacono Saira A Weinzimmer Troy Quast Sean M Olsen Killian Rainey Hughes Emily Jellinek-Russo Amanda Perozo Garcia Abigail Candelari Leandra N Berry Robin P Goin-Kochel Wayne K Goodman Eric A Storch Source Type: research
Autism Spectrum Disorder- and/or Intellectual Disability-Associated Semaphorin-5A Exploits the Mechanism by Which Dock5 Signalosome Molecules Control Cell Shape
Curr Issues Mol Biol. 2024 Apr 2;46(4):3092-3107. doi: 10.3390/cimb46040194.ABSTRACTAutism spectrum disorder (ASD) is a neurodevelopmental disorder that includes autism, Asperger's syndrome, and pervasive developmental disorder. Individuals with ASD may exhibit difficulties in social interactions, communication challenges, repetitive behaviors, and restricted interests. While genetic mutations in individuals with ASD can either activate or inactivate the activities of the gene product, impacting neuronal morphogenesis and causing symptoms, the underlying mechanism remains to be fully established. Herein, for the first time...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Miyu Okabe Takanari Sato Mikito Takahashi Asahi Honjo Maho Okawa Miki Ishida Mutsuko Kukimoto-Niino Mikako Shirouzu Yuki Miyamoto Junji Yamauchi Source Type: research
GSE261454 MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons [ATAC-seq]
We describe here the first integrated CUT&Tag, transcriptome, and proteome analyses using human neurons with wild-type and mutant MECP2 molecules. MECP2 occupies CpG-rich promoter-proximal regions in over four thousand genes in human neurons, including a plethora of autism risk genes, together with RNA polymerase II (Pol II). MECP2 directly interacts with Pol II, and genes occupied by both proteins showed reduced expression in neurons with MECP2 patient mutations. We conclude that MECP2 acts as a positive cofactor for Pol II gene expression at many neuronal genes that harbor CpG-islands in promoter-proximal regions, and th...
Source: GEO: Gene Expression Omnibus - April 26, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
GSE247071 MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons. [CUT & Tag]
We describe here the first integrated CUT&Tag, transcriptome, and proteome analyses using human neurons with wild-type and mutant MECP2 molecules. MECP2 occupies CpG-rich promoter-proximal regions in over four thousand genes in human neurons, including a plethora of autism risk genes, together with RNA polymerase II (Pol II). MECP2 directly interacts with Pol II, and genes occupied by both proteins showed reduced expression in neurons with MECP2 patient mutations. We conclude that MECP2 acts as a positive cofactor for Pol II gene expression at many neuronal genes that harbor CpG-islands in promoter-proximal regions, and th...
Source: GEO: Gene Expression Omnibus - April 26, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
GSE230715 MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons [WGBS]
We describe here the first integrated CUT&Tag, transcriptome, and proteome analyses using human neurons with wild-type and mutant MECP2 molecules. MECP2 occupies CpG-rich promoter-proximal regions in over four thousand genes in human neurons, including a plethora of autism risk genes, together with RNA polymerase II (Pol II). MECP2 directly interacts with Pol II, and genes occupied by both proteins showed reduced expression in neurons with MECP2 patient mutations. We conclude that MECP2 acts as a positive cofactor for Pol II gene expression at many neuronal genes that harbor CpG-islands in promoter-proximal regions, and th...
Source: GEO: Gene Expression Omnibus - April 26, 2024 Category: Genetics & Stem Cells Tags: Methylation profiling by high throughput sequencing Homo sapiens Source Type: research
