Genetic Liability for Bipolar Disorder and Major Depression and Risk for Mood, Anxiety, and Psychotic Disorders
This cohort study examines data from Swedish population registries to determine the relationship between genetic risk factors for major depression and bipolar disorder. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - September 21, 2022 Category: Psychiatry Source Type: research

Repetitive Transcranial Magnetic Stimulation vs Theta Burst Stimulation in Older Adults With Depression
This randomized noninferiority trial establishes the effectiveness and tolerability of theta burst stimulation compared with standard repetitive transcranial magnetic stimulation in older adults with treatment-resistant depression. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - September 21, 2022 Category: Psychiatry Source Type: research

Effectiveness of a Stand-alone Telephone-Delivered Intervention for Reducing Problem Alcohol Use
This randomized clinical trial investigates the effectiveness of the Ready2Change telephone-delivered intervention in reducing alcohol problem severity in individuals with alcohol use problems. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - September 21, 2022 Category: Psychiatry Source Type: research

Estimating the Prevalence of Substance Use Disorders in the US
This cross-sectional study estimates the prevalence of substance use disorders among adolescents and adults in the US. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - September 21, 2022 Category: Psychiatry Source Type: research

Error in Figure 2
This article has been corrected online and in print. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - September 21, 2022 Category: Psychiatry Source Type: research

Polygenic Risk Scores for Schizophrenia, Bipolar Disorder, and Depression in Veterans
This cross-sectional study benchmarks the penetrance of current neuropsychiatric polygenic risk scores in the Veterans Health Administration health care system, and explores associations between polygenic risk scores and broad categories of human disease via phenome-wide association studies. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - September 14, 2022 Category: Psychiatry Source Type: research

Characterizing and Coding Psychiatric Diagnoses Using EHR Data
In Reply Our recent article elicited letters raising several issues. Wright and colleagues provide important criticisms of the framing of our article. We agree that diagnosis is a more accurate description of phecodes derived from International Statistical Classification of Diseases, Ninth and Tenth Revisions, Clinical Modification (ICD-9/10-CM), billing codes in electronic health records (EHRs), and prevalence of diagnoses in EHRs is more accurate than prevalence. Though some recent work has shown that using 2 or more EHR codes has good sensitivity for a confirmed diagnosis of certain severe disorders, we cannot ensure th...
Source: JAMA Psychiatry - September 14, 2022 Category: Psychiatry Source Type: research

Characterizing and Coding Psychiatric Diagnoses Using EHR Data
To the Editor Barr et al were the first to report prevalence of major psychiatric diagnoses in the current All of Us cohort, including a detailed examination of co-occurrence and risk factors. One surprising result was the lower prevalence of psychiatric diagnoses than expected, and the authors suggest this may be due to a healthy participant bias and the association between health insurance and risk. However, 2 concerns may have compounded to decrease prevalence estimates. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - September 14, 2022 Category: Psychiatry Source Type: research

Characterizing and Coding Psychiatric Diagnoses Using EHR Data
To the Editor We are concerned with the recent article by Barr and colleagues, in which they characterize their study with the All of Us research program as research on “psychiatric disorders.” It is not; it is a study on who receives psychiatric diagnoses. These diagnoses were ascertained through electronic health records, not structured diagnostic assessment. This distinction is important because there are well-established sociological pressures and biases th at discourage assigning some diagnoses, particularly personality, substance use, and eating disorders. There is a real danger in the public, clinicians, trainee...
Source: JAMA Psychiatry - September 14, 2022 Category: Psychiatry Source Type: research

Error in Race and Ethnicity Data
The Original Investigation titled “Percentage of Heavy Drinking Days Following Psilocybin-Assisted Psychotherapy vs Placebo in the Treatment of Adult Patients With Alcohol Use Disorder: A Randomized Clinical Trial,” published online August 24, 2022, was corrected to fix the numbers of participants presented by race and ethnicity . (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - September 14, 2022 Category: Psychiatry Source Type: research

Errors in Terminology, Data Query, and Prevalence Rates
In the Brief Report “Prevalence, Comorbidity, and Sociodemographic Correlates of Psychiatric Diagnoses Reported in the All of Us Research Program,” published Online First on April 20, 2022, and in the June issue of JAMA Psychiatry, the authors had erroneously reported disorders when they should have used the term d iagnoses. In addition, their query of the All of Us database had erroneously identified 331 380 participants, but the correct number of participants with available EHR data using code developed by the All of Us workbench team was 214 206. The authors revised their analysis, as explained in their Letter, ...
Source: JAMA Psychiatry - September 14, 2022 Category: Psychiatry Source Type: research

Association of Psychological Distress Prior to Infection With Risk of Post –COVID-19 Conditions
This cohort study analyzes self-reported data from 3 large ongoing studies to determine whether high levels of psychological distress before SARS-CoV-2 infection are associated with increased risk of developing post –COVID-19 conditions, sometimes called long COVID. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - September 7, 2022 Category: Psychiatry Source Type: research

JAMA Psychiatry
Mission Statement: JAMA Psychiatry strives to publish original, state-of-the-art studies and commentaries of general interest to clinicians, scholars, and research scientists in psychiatry, mental health, behavioral science, and allied fields. The journal seeks to inform and to educate its readers as well as to stimulate debate and further exploration into the nature, causes, treatment, and public health importance of mental illness. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - September 1, 2022 Category: Psychiatry Source Type: research

Errors in Author Affiliations
This article was corrected online. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - September 1, 2022 Category: Psychiatry Source Type: research

Preparing for the Bursting of the Psychedelic Hype Bubble
This Viewpoint presents impediments to the clinical application of psychedelics created by extreme shifts in public perception while advocating further study and encouraging the dispute of claims not supported by available evidence. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - August 31, 2022 Category: Psychiatry Source Type: research