Data Pollution in Neuropsychiatry
This Viewpoint highlights several notable consequences of data pollution and identifies actionable steps that can be taken to address it. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - December 1, 2021 Category: Psychiatry Source Type: research

Failures in Perceptual Updating and the Severity of Psychosis in Schizophrenia
This case-control study assesses whether aberrant belief updating can be observed in a relatively simple motion direction estimation task in patients with schizophrenia or schizoaffective disorder compared with healthy control participants. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - December 1, 2021 Category: Psychiatry Source Type: research

Deletion of Loss-of-Function –Intolerant Genes and Risk of 5 Psychiatric Disorders
This study examines 2 gene-level metrics of variation constraint against protein-truncating variants —probability of loss-of-function intolerance and loss-of-function observed/expected upper bound fraction—and their association with the psychiatric consequences of both recurrent and nonrecurrent gene deletions. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - December 1, 2021 Category: Psychiatry Source Type: research

JAMA Psychiatry
Mission Statement: JAMA Psychiatry strives to publish original, state-of-the-art studies and commentaries of general interest to clinicians, scholars, and research scientists in psychiatry, mental health, behavioral science, and allied fields. The journal seeks to inform and to educate its readers as well as to stimulate debate and further exploration into the nature, causes, treatment, and public health importance of mental illness. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - December 1, 2021 Category: Psychiatry Source Type: research

Errors in Results Section and Figure 2
This article was corrected. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - December 1, 2021 Category: Psychiatry Source Type: research

Prevention of Incident and Recurrent Major Depression in Older Adults With Insomnia
This randomized clinical trial of adults without depression but with insomnia assesses whether insomnia treatment can prevent depression. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - November 24, 2021 Category: Psychiatry Source Type: research

Comparing Copy Number Variations in a Danish Case Cohort of Individuals With Psychiatric Disorders
This cohort study examines the prevalence and penetrance of copy number variants across the major recurrent copy number variants that are associated with risk for psychiatric disorders. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - November 24, 2021 Category: Psychiatry Source Type: research

Computational Psychiatry Across Species to Study the Biology of Hallucinations
This article explains methods for computational psychiatry to study hallucinations in humans and murine models. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - November 24, 2021 Category: Psychiatry Source Type: research

Limitations in Research on Maintenance Treatment for Individuals With Schizophrenia —Reply
In Reply Replication is the essence of science. It is therefore important that H øjlund and colleagues, who used a different meta-analytic method and slightly different inclusion criteria from ours, had similar findings in that standard doses (in our analysis, 5 mg risperidone equivalent) were more effective than lower ones (also see our Supplement where we applied the same typ e of analysis). Our results can be interpreted in the way Højlund et al suggest in their Letter. What dose-response meta-analysis adds is the shape of the dose response curve. As for acute schizophrenia, we found a hyperbolic pattern, ...
Source: JAMA Psychiatry - November 24, 2021 Category: Psychiatry Source Type: research

Errors in Relative Risks Reported in Figure 3 in a Network Meta-analysis of Cognitive Behavior Therapy Delivery Formats in Adults With Depression
To the Editor The authors regret to report that Figure 3B was not represented correctly in their Original Investigation, “Effectiveness and Acceptability of Cognitive Behavior Therapy Delivery Formats in Adults With Depression: A Network Meta-analysis,”1 published in the July 2019 issue. In reviewing the article for a presentation, a coauthor detected the errors. In the original Figure 3B, we had shown the dropout s of care as usual over each of the treatment formats, instead of dropouts of the formats over care as usual. But Figure 3B supposed care as usual to be the common comparator, so the correct represent...
Source: JAMA Psychiatry - November 24, 2021 Category: Psychiatry Source Type: research

Limitations in Research on Maintenance Treatment for Individuals With Schizophrenia
To the Editor Relapse prevention is paramount in managing schizophrenia. Leucht et al conducted a meta-analysis of randomized clinical trials comparing the association between different antipsychotic maintenance doses and risk of relapse and rehospitalization in individuals with schizophrenia by generating efficacy-related dose-response curves. Prevention of relapse and rehospitalization increased with up to 5 mg/d risperidone equivalent. Higher doses conferred little further advantage for reducing relapse or rehospitalization, but were associated with higher intolerability-related dropout rates. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - November 24, 2021 Category: Psychiatry Source Type: research

Limitations in Research on Maintenance Treatment for Individuals With Schizophrenia
To the Editor We appreciate the clinical value of the dose-response meta-analysis performed by Leucht and colleagues. The interpretation provided was that doses above 5 mg/d risperidone equivalent do not provide additional protection against relapse, while the risk of relapse increases rapidly (and apparently hyperbolically) for doses less than 2.5 mg/d risperidone equivalent. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - November 24, 2021 Category: Psychiatry Source Type: research

Increasing the Impact of Prevention of Depression —New Opportunities
Depressive disorders are highly prevalent and are associated with a substantial loss of quality of life for patients and their relatives, with increased levels of morbidity and mortality and with enormous economic costs. Although effective pharmacologic and psychological treatments are available, the effects are modest, relapse rates are high, and many patients do not respond to treatments at all. Current treatments can reduce only an estimated one-third of the disease burden of depression at the population level and only under optimal conditions, assuming that all people with major depression receive an evidence-based tre...
Source: JAMA Psychiatry - November 24, 2021 Category: Psychiatry Source Type: research

Error in Results and in the Figure 3B Label and Plotted Values
This article has been corrected. This article was previously corrected on July 17, 2019, to fix a label error in Figure 3B. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - November 24, 2021 Category: Psychiatry Source Type: research

Lithium for Suicide-Related Outcome Prevention in Veterans With Major Depression or Bipolar Disorder
This randomized clinical trial assesses whether the addition of lithium to existing medication regimens would prevent or delay repeated suicide-related events and whether it could be used safely. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - November 17, 2021 Category: Psychiatry Source Type: research

Insights Into Mixing Fentanyl and Benzodiazepines From Canadian Drug Seizures
This cohort study uses data from the Drug Analysis Service of Health Canada to describe changes in the presence of benzodiazepines mixed with fentanyl in drug seizures in Canada from 2018 to 2021. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - November 17, 2021 Category: Psychiatry Source Type: research

Testing for Antisuicidal Effects of Lithium Treatment
The medical treatment of the propensity to suicide, whether prophylactic or therapeutic, differs not from that which is applicable in cases of ordinary insanity.George M. Burrows (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - November 17, 2021 Category: Psychiatry Source Type: research

Association of Single-Blind Placebo Run-in Periods With the Placebo Response in Antidepressant RCTs
This meta-analysis of 347 trials examines the association of the use of placebo run-in periods with the placebo response, drug response, and drug-placebo difference among randomized clinical trials of antidepressants. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - November 10, 2021 Category: Psychiatry Source Type: research

Advantages of Tax-Financed Universal Mental Health Care in Denmark
This Viewpoint illustrates tax-financed, universally available mental health care with experiences from Denmark. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - November 3, 2021 Category: Psychiatry Source Type: research

Association of Comorbid Behavioral and Medical Conditions With Cannabis Use Disorder in Pregnancy
This cross-sectional study examines the prevalence of co-occurring psychiatric and medical conditions in prenatal hospitalizations of individuals with and without cannabis use disorder by concomitant substance use disorders. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - November 3, 2021 Category: Psychiatry Source Type: research

Error in Table 1
This article was also corrected on June 9, 2021, for errors in statistical results. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - November 3, 2021 Category: Psychiatry Source Type: research

Add Open Access
The Original Investigation titled “Perturbations in Gut Microbiota Composition in Psychiatric Disorders: A Review and Meta-analysis,” published online September 15, 2021, in JAMA Psychiatry, was corrected to add indication of the open access license. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - November 3, 2021 Category: Psychiatry Source Type: research

JAMA Psychiatry
Mission Statement: JAMA Psychiatry strives to publish original, state-of-the-art studies and commentaries of general interest to clinicians, scholars, and research scientists in psychiatry, mental health, behavioral science, and allied fields. The journal seeks to inform and to educate its readers as well as to stimulate debate and further exploration into the nature, causes, treatment, and public health importance of mental illness. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - November 1, 2021 Category: Psychiatry Source Type: research

Expanding Current Approaches to Solve the Opioid Crisis
This Viewpoint describes the opioid use disorder cascade of care model, which emcompasses prevention, identification, treatment, and recovery. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - October 27, 2021 Category: Psychiatry Source Type: research

Association Between Genetic Risk for Psychiatric Disorders and Living in Urban Settings
This cohort study uses UK Biobank data to examine genetic risk factors in persons with psychiatric disorders and their choice of urban vs rural residence. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - October 27, 2021 Category: Psychiatry Source Type: research

Use of the PsycheMERGE Network to Investigate Depression Scores and White Blood Cell Count
This genetic association study uses data from Vanderbilt University Medical Center and the PsycheMERGE network to investigate the association between inflammatory biomarkers, such as white blood cell count, and the genes that predispose an individual to depression. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - October 20, 2021 Category: Psychiatry Source Type: research

The Subjective Experience of Childhood Maltreatment in Psychopathology
This Viewpoint discusses future research and clinical directions regarding the subjective experience of childhood maltreatment and psychopathology. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - October 13, 2021 Category: Psychiatry Source Type: research

Improving Empowerment, Quality of Life, and Functioning in Severe Mental Illness
This randomized clinical trial investigates whether integrating a resource group model into community care has favorable effects on empowerment, quality of life, recovery, social functioning, and symptoms compared with community care as usual among people with severe mental illness. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - October 13, 2021 Category: Psychiatry Source Type: research

Addressing Structural Racism in Psychiatry With Steps to Improve Psychophysiologic Research
This Special Communication discusses how undersampling of racial and ethnic minority individuals has led to overgeneralized physiological findings, the implications for development of psychiatric treatments, and steps to improve service to racially diverse communities. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - October 6, 2021 Category: Psychiatry Source Type: research

Long-term Arrhythmia Detection in Patients Receiving Psychotropic Medication
This cohort study evaluates the incidence of arrhythmia in patients receiving psychotropic medication by monitoring of electrocardiographic findings using an implantable loop recorder. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - October 6, 2021 Category: Psychiatry Source Type: research

JAMA Psychiatry
Mission Statement: JAMA Psychiatry strives to publish original, state-of-the-art studies and commentaries of general interest to clinicians, scholars, and research scientists in psychiatry, mental health, behavioral science, and allied fields. The journal seeks to inform and to educate its readers as well as to stimulate debate and further exploration into the nature, causes, treatment, and public health importance of mental illness. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - October 1, 2021 Category: Psychiatry Source Type: research

Effect of Pain Reprocessing Therapy vs Placebo and Usual Care for Patients With Chronic Back Pain
This randomized clinical trial tests whether pain reprocessing therapy can provide durable and substantial relief from chronic back pain and investigates treatment mechanisms. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - September 29, 2021 Category: Psychiatry Source Type: research

Genetic Architecture of Depression in Individuals of East Asian Ancestry
This genetic association study investigates the genetics of depression across multiple data sets of individuals of East Asian and European descent living in different countries and within different nongenetic cultural contexts. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - September 29, 2021 Category: Psychiatry Source Type: research

Association of Alcohol With Cortical Thickness in Adolescents —Reply
In Reply We thank Kung et al for their thoughtful comments regarding the association of alcohol use with our findings. The potential confounding or interactive associations of alcohol use when investigating cannabis associations is a perennial challenge with human research, but a number of analyses lead us to conclude that the cortical thinning we reported was most strongly associated with cannabis exposure. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - September 29, 2021 Category: Psychiatry Source Type: research

Association of Alcohol With Cortical Thickness in Adolescents
To the Editor We read the excellent cohort study by Albaugh et al with great enthusiasm and appreciation. The authors reported that cannabis use during adolescence is associated with increased thinning in the left and right prefrontal cortices. This is an important study, and we wish to contribute a limitation. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - September 29, 2021 Category: Psychiatry Source Type: research

Student Substance Use Policies in US Allopathic Medical Schools
This quality improvement study examines US allopathic medical schools ’ student handbook policies on substance use and assesses their adherence to current Association of American Medical Colleges guidelines. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - September 29, 2021 Category: Psychiatry Source Type: research

Data Errors in Results
This article was corrected online. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - September 29, 2021 Category: Psychiatry Source Type: research

Ways That Mental Health Professionals Can Encourage COVID-19 Vaccination
This Viewpoint reviews what little is known about mental health and vaccination behavior and addresses 3 areas for intervention by mental health professionals, based on the Increasing Vaccination Model. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - September 23, 2021 Category: Psychiatry Source Type: research

Pragmatic Precision Psychiatry —A New Direction for Optimizing Treatment Selection
This Special Communication describes pragmatic precision psychiatry, which is the branch of precision psychiatry focused on matching patients to best currently available interventions. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - September 22, 2021 Category: Psychiatry Source Type: research

Methamphetamine Use, Use Disorder, and Overdose Deaths Among US Adults
This cross-sectional study reports the patterns of methamphetamine use (eg, with or without cocaine, frequency of use, and injected) among participants in the 2015 to 2019 National Survey on Drug Use and Health. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - September 22, 2021 Category: Psychiatry Source Type: research

Association Between Antipsychotic Use and COVID-19 Mortality in People With Serious Mental Illness
This cohort study investigates whether an association exists between antipsychotic use and mortality in patients with serious mental illness who are diagnosed with COVID-19. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - September 22, 2021 Category: Psychiatry Source Type: research

Two Hypotheses on the High Incidence of Dementia in Psychotic Disorders
This Viewpoint discusses 2 testable hypotheses for prevention of dementia and premature mortality after cognitive decline. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - September 15, 2021 Category: Psychiatry Source Type: research

Perturbations in Gut Microbiota Composition in Psychiatric Disorders
This systematic review and meta-analysis reviews gut microbiota alterations in general adult psychiatric populations and performs a within- and between-diagnostic comparison. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - September 15, 2021 Category: Psychiatry Source Type: research

Hypothyroidism and Clinical Depression
This systematic review and meta-analysis examines the association of hypothyroidism (subclinical or overt) with depression. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - September 15, 2021 Category: Psychiatry Source Type: research

Examining Power Relations to Understand and Address Social Determinants of Vaccine Uptake
This Viewpoint discusses 2 groups who experience vaccine inequality and have low uptake of the COVID-19 vaccine. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - September 8, 2021 Category: Psychiatry Source Type: research

Online 1-Day CBT-Based Workshops for Postpartum Depression
This randomized clinical trial assesses whether self-referred online 1-day cognitive behavioral therapy −based workshops plus treatment as usual improve postpartum depression in women with infants younger than 12 months compared with treatment as usual alone. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - September 8, 2021 Category: Psychiatry Source Type: research

Major Depressive Episode Severity Among Adults from Marginalized Racial and Ethnic Backgrounds in the US
This observational study analyzes nationally representative data to estimate differences in major depressive episode prevalence, persistence, and severity among racial and ethnic groups. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - September 8, 2021 Category: Psychiatry Source Type: research

Error in Author Name Presentation
This article has been corrected online. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - September 8, 2021 Category: Psychiatry Source Type: research

Applying Anti-racism to Clinical Care and Research
This Viewpoint provides a brief overview of the history of racism and its impact on the mental health field and suggest steps for engaging in anti-racism work through developing awareness of racial prejudices. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - September 1, 2021 Category: Psychiatry Source Type: research

Emergency Department Encounters Among Youth With Suicidal Thoughts or Behaviors During the COVID-19 Pandemic
This cross-sectional study characterizes population-level and relative change in suicide-related emergency department encounters among youth during the COVID-19 pandemic compared with 2019. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - September 1, 2021 Category: Psychiatry Source Type: research