Data Errors in Results and Table 2
This article has been corrected online. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - February 19, 2020 Category: Psychiatry Source Type: research

Error in Abstract, Figure 3, and in Captions to Figures 1, 2, and 4
This article was corrected online. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - February 19, 2020 Category: Psychiatry Source Type: research

Where We Stand After Decades of Research to Develop More Personalized Treatments for Depression
Almost every clinician that has treated patients with major depressive disorder (MDD) will boldly proclaim that depression is not a single illness with a common causative mechanism, pathophysiology, prognosis, or response to treatment. Yet, despite decades of effort, it has been nearly impossible to delineate subgroupings within the disorder, beyond major depression with psychotic features, that can reliably add greater clinical meaning to the general diagnosis subsumed under the rubric of MDD. The inability to achieve what would appear to be such a simple task has frustrated the field for generations. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - February 19, 2020 Category: Psychiatry Source Type: research

Cognitive Impairment in Never-Medicated Individuals on the Schizophrenia Spectrum
This cohort study examines cognition in never-medicated individuals at different stages of the illness. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - February 19, 2020 Category: Psychiatry Source Type: research

Association of Individual Differences in Response to Antidepressants
This meta-analysis uses data from randomized clinical trials of antidepressants to investigate the assumption of systematic variability in symptomatic response to antidepressants and assesses whether this variability is associated with severity of major depressive disorder, antidepressant class, or year of study publication. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - February 19, 2020 Category: Psychiatry Source Type: research

Effort and Reward Decisions in Depression and Their Association With Relapse
This prognostic study examines whether the decision to invest effort for rewards represents a persistent depression process after remission, predicts relapse after remission, or is affected by antidepressant discontinuation. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - February 19, 2020 Category: Psychiatry Source Type: research

Notice of Retractions: Neumeister
These articles by Alexander Neumeister, MD, are being retracted. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - February 19, 2020 Category: Psychiatry Source Type: research

The Loss of Social Connectedness as a Major Contributor to Physician Burnout
This Viewpoint discusses social connectedness as a basic human need that when lost leads to burnout and outlines ways health care institutions can apply lessons from team and organizational literature to increase social connectedness and enhance well-being. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - February 19, 2020 Category: Psychiatry Source Type: research

Association of High Traditional Masculinity and Risk of Suicide Death
This cohort study explores the association between high traditional masculinity and suicide death among US men using data from the Add Health study. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - February 12, 2020 Category: Psychiatry Source Type: research

Association of a Reproducible Epigenetic Risk Profile for Schizophrenia With Brain Methylation and Function
This case-control study assesses the association between a blood DNA methylation signature with a reproducible differentiation of patients with schizophrenia from healthy controls and several other major neuropsychiatric disorders. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - February 12, 2020 Category: Psychiatry Source Type: research

Investigation of Psychosis Subgroups With Prognostic Validation and Exploration of Genetic Underpinnings
This cohort study aims to detect psychosis subgroups and examine their illness courses over 1.5 years and their polygenic scores for schizophrenia, bipolar disorder, major depression disorder, and educational achievement. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - February 12, 2020 Category: Psychiatry Source Type: research

Helping Families to Understand and Cope With Psychiatric Disorders in Childhood —Beyond Basic Facts
This article describes means of interacting with children with mental illness and their families in ways that move beyond simple information giving to enhance comprehension, coping, and group decision-making. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - February 5, 2020 Category: Psychiatry Source Type: research

Is Hippocampal Replay a Mechanism for Anxiety and Depression?
This article describes research on rodent models that may illuminate connections between hippocampal replay and anxiety and depression in humans. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - February 5, 2020 Category: Psychiatry Source Type: research

Exposure-Based Treatment for Co-occurring Substance Use Problems and Adolescent PTSD Symptoms
This randomized clinical trial assesses whether risk reduction through family therapy for adolescents with substance use problems and posttraumatic stress disorder symptoms results in improved outcomes relative to treatment as usual consisting primarily of trauma-focused cognitive behavioral therapy. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - February 5, 2020 Category: Psychiatry Source Type: research

Threat Conditioning and Its Extinction in Individuals With Anxiety Disorders
This cross-sectional study uses a threat conditioning and extinction protocol to conduct categorical (DSM-IV –based) and transdiagnostic dimensional (research domain criteria–based) assessments of psychophysiological, neural, and psychometric responses in adults with and without anxiety disorders. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - February 5, 2020 Category: Psychiatry Source Type: research

February 2020 Highlights
(Source: JAMA Psychiatry)
Source: JAMA Psychiatry - February 1, 2020 Category: Psychiatry Source Type: research

JAMA Psychiatry
Mission Statement: JAMA Psychiatry strives to publish original, state-of-the-art studies and commentaries of general interest to clinicians, scholars, and research scientists in psychiatry, mental health, behavioral science, and allied fields. The journal seeks to inform and to educate its readers as well as to stimulate debate and further exploration into the nature, causes, treatment, and public health importance of mental illness. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - February 1, 2020 Category: Psychiatry Source Type: research

Error in Figure 2 Curves and Revisions to Subtitle, Abstract, and Figure Titles and Captions
In the Original Investigation titled “Prevention of Recurrence After Recovery From a Major Depressive Episode With Antidepressant Medication Alone or in Combination With Cognitive Behavioral Therapy: Phase 2 of a 2-Phase Randomized Clinical Trial,” published online December 4, 2019, there was an error in the length of curve lines d epicted in Figure 2. For panel A and panel B, the line labeled Withdrawn stopped short of day 1096. Both lines should have reached the indicator for day 1096. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - January 29, 2020 Category: Psychiatry Source Type: research

Outcomes of Online Mindfulness-Based Cognitive Therapy for Patients With Residual Depressive Symptoms
This randomized clinical trial compares the efficacy and long-term outcomes of an online version of mindful-based cognitive therapy with usual depressive care for adults with residual depressive symptoms. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - January 29, 2020 Category: Psychiatry Source Type: research

Associations Between Depression, Arterial Stiffness, and Metabolic Syndrome Among Adults in the UK Biobank
This cohort study assesses the association of depression with elevated midlife arterial stiffness and investigates the extent to which this association is mediated by metabolic syndrome. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - January 29, 2020 Category: Psychiatry Source Type: research

The Origin of Our Modern Concept of Depression
This narrative review chronicles the evolution of the concept of melancholia to depression over 100 years from 1780 to 1880. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - January 29, 2020 Category: Psychiatry Source Type: research

Psychiatry on the Streets —Caring for Homeless Patients
This Viewpoint encourages the development of improvements in the availability and appeal of care for homeless people with mental illness in the United States. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - January 29, 2020 Category: Psychiatry Source Type: research

Policy Makers ’ Tough Choices for Psychological Interventions in Global Mental Health
More governments around the world are recognizing the importance of mental health in their national health, social welfare, development, and education plans. At the 2019 second global interministerial meeting held in Amsterdam, the Netherlands, 35 countries and organizations signed a declaration to integrate mental health and psychosocial support services in crisis situations. However, policy makers are left with the challenge of what psychological services to select and how to implement them. There is a growing range of psychological treatments, implementation modalities, and options to use nonspecialist paraprofessionals...
Source: JAMA Psychiatry - January 22, 2020 Category: Psychiatry Source Type: research

Effectiveness of Trauma-Focused Cognitive Behavioral Therapy for Children Who Experienced Parental Death
This randomized clinical trial examines the effectiveness of trauma-focused cognitive behavioral therapy for improving posttraumatic stress in children in Kenya and Tanzania who have experienced parental death. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - January 22, 2020 Category: Psychiatry Source Type: research

Digital Cognitive Behavioral Therapy for the Treatment of Prenatal Insomnia Symptoms
This randomized clinical trial examines the efficacy of digital cognitive behavioral therapy for insomnia compared with standard treatment among pregnant women with insomnia symptoms. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - January 22, 2020 Category: Psychiatry Source Type: research

When Deploying Predictive Algorithms, Are Summary Performance Measures Sufficient?
This Viewpoint assesses the performance measures of predictive algorithms in psychiatry. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - January 22, 2020 Category: Psychiatry Source Type: research

Error in Quiz Answer
This article has been corrected online. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - January 15, 2020 Category: Psychiatry Source Type: research

Violent Acts and Being the Target of Violence Among People With Mental Illness
Evidence has accumulated over the last 40 years indicating increased rates of violent perpetration and being the target of violence among people with mental illness. Landmark data collected in the early 1980s by the Epidemiologic Catchment Area study found a 12-month prevalence of 12% for any type of violence among people with mental disorders, which dropped to 7% if people with comorbid substance abuse (DSM-III) were excluded, compared with 2% in the general population. Similar magnitudes of increased risk have been found in subsequent studies and meta-analyses, although the absolute rates of violence vary, probably becau...
Source: JAMA Psychiatry - January 15, 2020 Category: Psychiatry Source Type: research

Is There an Association Between Social Media Use and Mental Health? The Timing of Confounding Measurement Matters
To the Editor Riehm et al report an association between social media use and increased risk of internalizing and combined internalizing/externalizing problems 1 year later (between waves 2 and 3 of Population Assessment of Tobacco and Health study data), controlling for psychopathology and alcohol/marijuana use at wave 1. However, the analytic strategy is vulnerable to substantial residual confounding. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - January 15, 2020 Category: Psychiatry Source Type: research

Is There an Association Between Social Media Use and Mental Health? The Timing of Confounding Measurement Matters —Reply
In Reply In our study, we used 3 waves of data from the longitudinal Population Assessment of Tobacco and Health study to show that adolescents who report more frequent social media use report greater symptoms of psychopathology 1 year later. In their letter, Keyes and Kreski replicated our findings. They then showed that, after further adjusting for psychopathology measured concurrently with social media use, the prospective association we identified disappears, except for among the most frequent users of social media use. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - January 15, 2020 Category: Psychiatry Source Type: research

Risk of Subjection to and Perpetration of Violence in Persons With Psychiatric Disorders in Sweden
This nationwide Swedish cohort study examines the risks of subjection to violence and perpetration of violence among patients with psychiatric disorders compared with siblings and individuals from the general population without psychiatric disorders. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - January 15, 2020 Category: Psychiatry Source Type: research

Family-Focused Therapy vs Enhanced Care for Symptomatic Youths at High Risk for Bipolar Disorder
This randomized clinical trial compares the effects of family-focused therapy vs the standard therapy of enhanced care for symptomatic high-risk youths who have a family history of bipolar disorder. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - January 15, 2020 Category: Psychiatry Source Type: research

Leading the Next CBD Wave —Safety and Efficacy
This Viewpoint discusses why the quick rise in popularity of cannabidiol (CBD) necessitates policy changes that promote clinical trials to establish the next wave of CBD as a safe, efficacious regulated approved for use medicine. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - January 15, 2020 Category: Psychiatry Source Type: research

The Potential Role of Lumateperone
Antipsychotic medications are the primary pharmacologic treatment for schizophrenia and were initially discovered fortuitously in the early 1950s. Chlorpromazine was the prototype of this class of medications, retroactively noted as first-generation antipsychotics, which are primarily characterized by their high-affinity antagonism at the dopamine D2 receptor. The rediscovery of clozapine in 1989 heralded the initial era of second-generation antipsychotics, which extended through 2002. In general, second-generation antipsychotics have lower D2 affinity, along with high serotonin 5-HT2A antagonist affinity. Subsequently, se...
Source: JAMA Psychiatry - January 8, 2020 Category: Psychiatry Source Type: research

Shared Genetic Loci Between Body Mass Index and Major Psychiatric Disorders
This genome-wide association study examines the extent of overlap between the genetic architectures of major psychiatric disorders and body mass index and identifies common genetic loci. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - January 8, 2020 Category: Psychiatry Source Type: research

Efficacy and Safety of Lumateperone for Treatment of Schizophrenia
This randomized clinical trial examines the efficacy and safety of lumateperone for the short-term treatment of adults with schizophrenia. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - January 8, 2020 Category: Psychiatry Source Type: research

Overdose Reversals Save Lives
This Viewpoint argues that overdose reversals via naloxone administration should be considered saved lives. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - January 8, 2020 Category: Psychiatry Source Type: research

Open Access Change
For the Original Investigation titled “Association of Trauma Type, Age of Exposure, and Frequency in Childhood and Adolescence With Psychotic Experiences in Early Adulthood,” published online November 21, 2018, and in the January 2019 print issue of JAMA Psychiatry, the authors requested a change to the publication license from stan dard license to Open Access license. The article is now published under the Open Access license and has been corrected online. The article was previously corrected. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - January 2, 2020 Category: Psychiatry Source Type: research

Error in Abstract
The Original Investigation, “Effect of Stellate Ganglion Block Treatment on Posttraumatic Stress Disorder Symptoms: A Randomized Clinical Trial,” published online November 6, 2019, had an error in the Abstract. A sentence in the Design, Setting, and Participants subsection that referred to “anesthesiologists performing t he procedures” should have instead said “physicians performing the procedures”; the physicians involved were not all anesthesiologists. The article was corrected online. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - January 2, 2020 Category: Psychiatry Source Type: research

Error in Surname of Contributing Author
In the Original Investigation titled “Association of Maternal Eating Disorders With Pregnancy and Neonatal Outcomes,” published online November 20, 2019, the surname of the second author was inaccurate. Angelica Lindén Hirschberg should be referred to as Dr Hirschberg, not Dr Lindén Hirschberg. The error has been corrected. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - January 2, 2020 Category: Psychiatry Source Type: research

JAMA Psychiatry : Best of 2019
As a fan of popular music and sports, I am intrigued by top 10 rankings. Thus, I was glad to have a chance to select the 10 articles published in JAMA Psychiatry in 2019 that I think are particularly noteworthy. Of course, any such list, by necessity, excludes many important articles. What follows, with apologies to authors whose articles are not included, is a highly idiosyncratic view that reflects my thinking about the field and my teaching of the next generation of psychiatrists. Articles are grouped in 3 thematic areas for organization but are not a top 10 countdown or absolute ranking. In the sections below, I provid...
Source: JAMA Psychiatry - January 2, 2020 Category: Psychiatry Source Type: research

Electroencephalographic Biomarkers for Predicting Antidepressant Response
Medication selection in depression still relies primarily on trial and error, frustrating both patients and clinicians. Diagnostic tests that predict treatment response in advance could facilitate an informed approach and reduce suffering. Ideally, those tests would directly measure brain function. The primary research test of brain function, functional magnetic resonance imaging (fMRI), is too expensive to scale to routine care. Electroencephalography (EEG), however, is comparatively inexpensive and fast and could be made available in many settings. Plus, as a direct measure of localized brain activity, EEG is ideal for d...
Source: JAMA Psychiatry - January 2, 2020 Category: Psychiatry Source Type: research

Cortical Connectivity Moderators of Antidepressant vs Placebo Treatment Response in Depression
This secondary analysis of a randomized clinical trial examines whether electroencephalographic connectivity could reveal neural moderators of antidepressant treatment. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - January 2, 2020 Category: Psychiatry Source Type: research

January 2020 Highlights
(Source: JAMA Psychiatry)
Source: JAMA Psychiatry - January 1, 2020 Category: Psychiatry Source Type: research

JAMA Psychiatry
Mission Statement: JAMA Psychiatry strives to publish original, state-of-the-art studies and commentaries of general interest to clinicians, scholars, and research scientists in psychiatry, mental health, behavioral science, and allied fields. The journal seeks to inform and to educate its readers as well as to stimulate debate and further exploration into the nature, causes, treatment, and public health importance of mental illness. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - January 1, 2020 Category: Psychiatry Source Type: research

Limited Conclusions Can Be Reached From Danish Randomized Clinical Trial of Supported Employment
To the Editor We would like to point out several limitations of the study by Christensen et al comparing the effects of the individual placement and support (IPS) model of supported employment with IPS enhanced by cognitive remediation and social skills training (IPSE) and service as usual on work in persons with severe mental illness that preclude drawing firm conclusions about the potential benefits of augmenting IPS with cognitive remediation. Three sets of findings suggest problems implementing the IPS program. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - December 26, 2019 Category: Psychiatry Source Type: research

Limited Conclusions Can Be Reached From Danish Randomized Clinical Trial of Supported Employment —Reply
In Reply We thank Mueser and McGurk for the interest in this Danish randomized clinical trial investigating the effects of individual placement and support (IPS) and IPS supplemented with cognitive remediation and social skills training among 720 participants with severe mental illness. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - December 26, 2019 Category: Psychiatry Source Type: research

All-Cause and Cause-Specific Mortality Among People Using Extramedical Opioids
This systematic review and meta-analysis examines the mortality rates and key causes of excess mortality among people who use extramedical opioids. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - December 26, 2019 Category: Psychiatry Source Type: research

Association of Intrinsic Brain Architecture With Changes in Attentional and Mood Symptoms During Development
This cohort study examines the ability of resting-state networks to predict the developmental trajectory of symptoms associated with attention-deficit/hyperactivity disorder and major depressive disorder in US children. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - December 26, 2019 Category: Psychiatry Source Type: research

Ramifications of the VA MISSION Act of 2018 on Mental Health
This Viewpoint reviews the mental health implications of the VA MISSION Act of 2018, considers obstacles to expanding access with non –Veterans Affairs clinicians, and proposes solutions. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - December 26, 2019 Category: Psychiatry Source Type: research