Are Retrospective Self-reports Accurate Representations or Existential Recollections?
Child maltreatment is a serious public health problem that has substantial behavioral, clinical, social, and economic ramifications. In the United States, 3.5 million children were referred to child protection agencies for possible maltreatment in 2016 alone, and almost 700  000 were found to have experienced maltreatment. These cases represent documented cases. Because not all cases come to the attention of the authorities, there is a clear need to identify child maltreatment through other means, and that typically involves relying on retrospective self-reports. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - March 20, 2019 Category: Psychiatry Source Type: research

JAMA Psychiatry —The Year in Review, 2018
At the beginning of 2018, Stephan Heckers, MD, passed me the role of Editor in Chief ofJAMA Psychiatry. Although there is now a new team at the journal, there is also a good deal of continuity; I and Martin Paulus, MD, our current Deputy Editor, had the privilege of working with Dr Heckers during his tenure. We have added some new individuals to the team, including Helen Blair Simpson, MD, PhD, Columbia University, as Associate Editor and John Torous, MD, MBI, Beth Israel Deaconess Medical Center, as Web Editor. We are ably assisted by Sara DiBari, MFA, the journal ’s Editorial Manager. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - March 20, 2019 Category: Psychiatry Source Type: research

Association Timing of Onset of Maternal Mental Disorders With Completion of Primary Education in Offspring
This study examines the association between specific timing of maternal mental disorder onset and completion of primary education in offspring. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - March 20, 2019 Category: Psychiatry Source Type: research

Characteristics of Psychiatrists Associated With the Delivery of Telemental Health Visits in the Medicare Population
This observational study of Medicare fee-for-service claims data evaluates demographic characteristics of psychiatrists who deliver telemental health visits in the Medicare population. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - March 20, 2019 Category: Psychiatry Source Type: research

Agreement Between Prospective and Retrospective Measures of Childhood Maltreatment
This systematic review and meta-analysis assesses the agreement between prospective and retrospective measures of childhood maltreatment. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - March 20, 2019 Category: Psychiatry Source Type: research

Body Mass Index and Internalizing Symptoms in Childhood
This cohort study examines the comorbidity, codevelopment, and temporal precedence in body mass index and internalizing symptoms from early childhood to midadolescence and the sex differences and socioeconomic confounding in their association. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - March 20, 2019 Category: Psychiatry Source Type: research

Effectiveness of Self-guided App-Based Virtual Reality Cognitive Behavior Therapy for Acrophobia
This randomized clinical trial examines the effectiveness of a self-guided app-based virtual reality cognitive behavior therapy using low-cost goggles. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - March 20, 2019 Category: Psychiatry Source Type: research

JAMA Psychiatry Peer Reviewers in 2018
(Source: JAMA Psychiatry)
Source: JAMA Psychiatry - March 20, 2019 Category: Psychiatry Source Type: research

Error in Discussion Section
Discussion section. There are 413  326 young adult cases, not adolescent cases, of depression potentially attributable to cannabis exposure. The article has been corrected online. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - March 13, 2019 Category: Psychiatry Source Type: research

Why Less is Always More in the Treatment of Alcohol Use Disorders
Alcohol is a major risk factor for mortality and burden of disease and causally affects more than 200International Statistical Classification of Diseases and Related Health Problems (ICD)3-digit disease categories. Reducing the health harms of alcohol is therefore one of the most important medical goals in the world today. For most major causes of alcohol-attributable death, the risk associations between lifetime drinking and mortality are exponential. For all-cause mortality in high-income countries, depending on the distribution of causes of death in these countries, this means that the resulting risk association between...
Source: JAMA Psychiatry - March 13, 2019 Category: Psychiatry Source Type: research

Toward an Improved Understanding of Anhedonia
Anhedonia, the reduced ability to experience pleasure, has been critically implicated in a wide range of adolescent mental disorders and suicidal behaviors. Presently, medication as well as most first-line psychotherapeutic approaches do not sufficiently address motivational and reward-processing deficits that characterize anhedonia, and thus, treatment failure is common. To overcome limitations of a categorical nosologic system and improve treatments for core dysfunction, the National Institute of Mental Health ’s Research Domain Criteria initiative provides a framework for research focusing on core domains of funct...
Source: JAMA Psychiatry - March 13, 2019 Category: Psychiatry Source Type: research

Emergency Department Management of Deliberate Self-harm
This study provides estimates of how frequently evidence-based management practices are used by emergency departments when treating patients presenting for self-harm. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - March 13, 2019 Category: Psychiatry Source Type: research

Evaluation of Drinking Risk Levels as Outcomes in Alcohol Pharmacotherapy Trials
This secondary data analysis of data from clinical trials evaluates the sensitivity of World Health Organization risk level reduction of alcohol intake as outcomes in alcohol use disorder pharmacotherapy trials. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - March 13, 2019 Category: Psychiatry Source Type: research

Association of Brain Functions in Children With Anhedonia Mapped Onto Brain Imaging Measures
This cross-sectional study maps anhedonia in children and probes the specificity of changes against other clinical phenotypes (low mood, anxiety, and attention-deficit/hyperactivity disorder). (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - March 13, 2019 Category: Psychiatry Source Type: research

Association of Cohort and Individual Substance Use With Risk of Transitioning to Drug Use, Use Disorder, & amp; Remission
This multicountry study examines the association of the drug and alcohol use of an age cohort and the risk of an individual within that age cohort developing drug use, abuse, dependence, and remission from abuse and dependence. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - March 13, 2019 Category: Psychiatry Source Type: research

Prediction Models for Suicide Attempts and Death
This systematic review evaluates the diagnostic accuracy of suicide prediction models and simulates the effects of implementing such models using population-level estimates of suicide rates. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - March 13, 2019 Category: Psychiatry Source Type: research

Association of Early-Life Stress and Cytomegalovirus Infection
This study examines the association of cytomegalovirus infection in adults with major depressive disorder who experienced various forms of childhood stress. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - March 6, 2019 Category: Psychiatry Source Type: research

Autism Risk and Serotonin Reuptake Inhibitors
To the Editor In their article published in the December 2018 issue ofJAMA Psychiatryentitled “Association of Autism Spectrum Disorder With Prenatal Exposure to Medication Affecting Neurotransmitter Systems,” Janecka et al made several statements and conclusions that do not appear warranted. The problem stems from an inappropriate grouping of agents thought to affect the serotonin transp orter. Specifically, the decongestant pseudoephedrine was included in the group along with known selective and nonselective reuptake inhibitors. The inclusion of pseudoephedrine is clearly in error as pseudoephedrine has been s...
Source: JAMA Psychiatry - March 6, 2019 Category: Psychiatry Source Type: research

Autism Risk and Serotonin Reuptake Inhibitors —Reply
In Reply We thank Anderson for carefully reviewing our work and taking time to share his concerns about the classification of pseudoephedrine together with other medications that inhibit the reuptake of serotonin. We underscore that this classification is correct per 2 reputable pharmacological resources exploited in our article, DrugBank.ca and PubChem.com. Nevertheless, we also fully acknowledge that the medication is reported to have weak affinity to serotonin transporter. Although our method entailed inclusion of drugs with different affinities for any one target, below we explain how this impacted our findings and out...
Source: JAMA Psychiatry - March 6, 2019 Category: Psychiatry Source Type: research

Effectiveness of Training Therapists for Mental Health Intervention in Autism Spectrum Disorder
This cluster randomized trial evaluates the effectiveness of training community therapists in an individualized mental health intervention program vs usual care to address challenging behaviors across 18 months in children with autism spectrum disorder and to identify moderators and mediators of any intervention effects. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - March 6, 2019 Category: Psychiatry Source Type: research

Neuropsychiatric Disease After Exposure to Infection In Utero
This Swedish population-based cohort study estimates the risk of psychopathologic conditions imparted from fetal exposure to any maternal infection while hospitalized during pregnancy. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - March 6, 2019 Category: Psychiatry Source Type: research

Monoamine Oxidase B Distribution Volume in the Prefrontal Cortex of Major Depressive Disorder
This case-control study investigates whether monoamine oxidase B distribution volume is elevated in the prefrontal cortex in major depressive episodes in patients with major depressive disorder. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - March 6, 2019 Category: Psychiatry Source Type: research

Typographical Error in Abstract
In the Original Investigation titled “Efficacy of a Home Visiting Enhancement for High-Risk Families Attending Parent Management Programs: A Randomized Superiority Clinical Trial,” published online January 23, 2019, and in the March print issue ofJAMA Psychiatry, there was an error in the Intervention section of the abstract. The parents were randomly assigned to receive IYP program plus HPS or IYP alone, not IYP program plus HPS or HPS alone. The article has been corrected online. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - March 1, 2019 Category: Psychiatry Source Type: research

March 2019 Highlights
(Source: JAMA Psychiatry)
Source: JAMA Psychiatry - March 1, 2019 Category: Psychiatry Source Type: research

JAMA Psychiatry
Mission Statement:JAMA Psychiatry strives to publish original, state-of-the-art studies and commentaries of general interest to clinicians, scholars, and research scientists in psychiatry, mental health, behavioral science, and allied fields. The journal seeks to inform and to educate its readers as well as to stimulate debate and further exploration into the nature, causes, treatment, and public health importance of mental illness. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - March 1, 2019 Category: Psychiatry Source Type: research

Omission of Additional Contributions
This article has been corrected online. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - February 27, 2019 Category: Psychiatry Source Type: research

Pharmacologic Intervention for the Treatment and Prevention of Delirium
The objective of the analyses was to ascertain if new agents or combinations of existing agents currently available can be substantiated as superior to placebo or widely used medications (eg, haloperidol) for the treatment and prevention of delirium. The authors perform an extensive review of the extant literature of well-designed and controlled clinical trials. Fifty-eight randomized clinical trials (RCTs) were included in the analyses, of which 20 RCTs with a total of 1435 participants compared the outcomes of treatment of delirium and 38 RCTs with a total of 8168 participants examined prevention. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - February 27, 2019 Category: Psychiatry Source Type: research

The Challenges and Opportunities of Small Effects
Explanations and accurate predictions are the fundamental deliverables for a mechanistic or pragmatic approach that academic psychiatric research can provide to stakeholders. Starting with this issue, we are publishing a series of Viewpoints describing the research boundaries and challenges to progress in our field. In this issue, Simon raises the need for better explanatory model using data from electronic health records. This Viewpoint acknowledges an important issue: variables or constructs that are used to help explain the current state of individuals or to generate predictions need to account for a substantial proport...
Source: JAMA Psychiatry - February 27, 2019 Category: Psychiatry Source Type: research

Omitted Acknowledgment of Local Contributors to Study
To the Editor On behalf of my coauthors, I write to explain a correction to the Additional Contributions section of our article, “Effect of Foster Care Intervention on Trajectories of General and Specific Psychopathology Among Children With Histories of Institutional Rearing: a Randomized Clinical Trial,” published online September 26, 2018, and in the November 2018 issue ofJAMA Psychiatry. We thank a reader for bringing this to our attention and appreciate the opportunity to acknowledge the indispensable work and commitment of our colleagues at the Tanner Foundation and the Institute of Child Development in Bu...
Source: JAMA Psychiatry - February 27, 2019 Category: Psychiatry Source Type: research

Association of Prenatal Vitamin Use With Risk for Autism Recurrence in Young Siblings
This cohort study examines the association between prenatal vitamin use in the early stages of pregnancy and the risk of autism in young children born into families who are genetically susceptible to autism spectrum disorder. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - February 27, 2019 Category: Psychiatry Source Type: research

Response and Safety of Pharmacological Interventions for the Management and Prevention of Delirium
This network meta-analysis evaluates evidence regarding pharmacological interventions for delirium treatment and prevention. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - February 27, 2019 Category: Psychiatry Source Type: research

Severity and Variability of Depression Symptoms for Predicting Suicide Attempt
This study evaluates and follows up the children of parents with psychiatric disorders to assess their risks and likelihood for suicidal ideation and suicide attempts. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - February 27, 2019 Category: Psychiatry Source Type: research

Big Data From Health Records in Mental Health Care
This Viewpoint discusses the utility and limitations of big data analysis and machine learning in mental health care. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - February 27, 2019 Category: Psychiatry Source Type: research

Identifying Efficacious Treatment for Refractory Conditions, Such as Body Dysmorphic Disorder
Over the past 40 years, considerable evidence has accumulated in support of cognitive behavioral therapy (CBT) for various mental health disorders. Cognitive behavioral therapy has demonstrated efficacy on par with medication, significantly augmenting it and surpassing its durability. Despite this strong record, efficacy may be weaker if refractory elements (eg, rumination in patients with major depression) are not specifically targeted, and although no other psychosocial treatment has been studied as rigorously as CBT, a number of trials failed to include important high-quality indicators reflecting this rigor (eg, random...
Source: JAMA Psychiatry - February 20, 2019 Category: Psychiatry Source Type: research

Can Adjunctive Pharmacotherapy Reduce Hospitalization in Schizophrenia?
Two articles in this issue ofJAMA Psychiatry explore adjunctive treatments for individuals with schizophrenia using large, observational data sets. Results from randomized clinical trials (RCTs) of adjunctive pharmacologic treatments in schizophrenia have been inconsistent and often difficult to interpret because of poor quality. Although RCTs are the standard for evaluating the efficacy of an intervention, they are costly, are not always feasible, and the results may not be generalizable to typical clinical populations. In addition, high placebo response rates and heterogeneity of illness further limit our ability to dete...
Source: JAMA Psychiatry - February 20, 2019 Category: Psychiatry Source Type: research

Efficacy and Posttreatment Effects of Cognitive Behavioral Therapy vs Supportive Psychotherapy for Body Dysmorphic Disorder
This randomized clinical trial compares the symptom reduction and treatment gain durability between cognitive behavioral therapy or supportive psychotherapy for adults with body dysmorphic disorder. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - February 20, 2019 Category: Psychiatry Source Type: research

Association of Antipsychotic Polypharmacy vs Monotherapy With Rehospitalization in Schizophrenia
This national cohort study examines the use of polypharmacy vs monotherapy as maintenance treatment among adult patients with schizophrenia who have been rehospitalized for psychiatric treatment in Finland. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - February 20, 2019 Category: Psychiatry Source Type: research

Comparative Effectiveness of Adjunctive Psychotropic Medications in Patients With Schizophrenia
This cohort study uses US national Medicaid data to compare the effectiveness of different psychotropic medication strategies (antidepressant, benzodiazepine, mood stabilizer, or another antipsychotic) for adult patients with schizophrenia who are receiving antipsychotic treatment. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - February 20, 2019 Category: Psychiatry Source Type: research

Medical Devices to Prevent Opioid Use Disorder
This Viewpoint discusses the use of medical devices for preventing opioid use disorder and associated opportunities for addressing the opioid crisis in the United States. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - February 20, 2019 Category: Psychiatry Source Type: research

Reframing the Suicide Prevention Message for Military Personnel
Suicide is a major worldwide public health problem. In the United States, death rates by suicide have incrementally increased by about a third since 2000 to their 2017 levels of 23.6 per 100  000 men and 6.7 per 100 000 women. Approximately 50 000 US residents died by suicide in 2017. This increase has been greater in recent years in the civilian sector than the military sector, leading to an approximate equalization of the 2017 suicide death rate of civilians with that of active- duty military personnel. The military suicide death rate was higher than the age-matched and sex-matched civilian rate for the prior decad...
Source: JAMA Psychiatry - February 13, 2019 Category: Psychiatry Source Type: research

Suicide Reduction and Research Efforts in Service Members and Veterans —Sobering Realities
The rate of death by suicide in the United States has risen 33% between 1999 and 2017, with a steeper climb in recent years and disproportionate increases in female and rural demographics. Particular concern has emerged for veterans, who experience a 50% higher incidence than the general adult population overall, with an 80% higher incidence in female veterans. Suicide incidence in service members is now comparable with the general population after decades of being significantly lower. These concerning trends have prompted an unprecedented expansion of suicide prevention, treatment, and research initiatives, with Departmen...
Source: JAMA Psychiatry - February 13, 2019 Category: Psychiatry Source Type: research

Cannabis Use in Adolescence and Risk of Depression, Anxiety, and Suicidality in Young Adulthood
This systematic review and meta-analysis examines the association of cannabis use during adolescence with risk of developing subsequent major depression, anxiety, and suicidal behavior in young adulthood. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - February 13, 2019 Category: Psychiatry Source Type: research

Effect of Augmenting Standard Care for Military Personnel With Brief Caring Text Messages for Suicide Prevention
This randomized clinical trial tests the effectiveness of using a series of simple text messages sent over 12 months to reduce suicidal thoughts and behaviors in military service members experiencing current suicidal ideation or suicide risk incidents. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - February 13, 2019 Category: Psychiatry Source Type: research

Attention to Prevention —Can We Stop Perinatal Depression Before it Starts?
This Editorial discusses current investigations into areas of need identified by the US Preventive Services Task Force recommendation statement on interventions to prevent perinatal depression as well as further topics of research focus. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - February 12, 2019 Category: Psychiatry Source Type: research

Importance of Variable Selection in Multimodal Prediction Models in Patients at Clinical High Risk for Psychosis and Recent-Onset Depression
To the Editor Koutsouleris and colleagues present a sophisticated and valuable analysis of functional outcomes in patients at clinical high risk for psychosis and recent-onset depression. Three machine learning prediction models (a clinical model, a neuroimaging model, and a combined model) were trained to predict social and role-functioning outcomes in these 2 samples. The models were also compared with expert rater prognosis of functional outcomes. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - February 6, 2019 Category: Psychiatry Source Type: research

Importance of Variable Selection in Multimodal Prediction Models in Patients at Clinical High Risk for Psychosis and Recent Onset Depression —Reply
In Reply We thank the authors for their interest in our Original Investigation published inJAMA Psychiatry. Nelson et al raised a query that our analysis was biased toward advocating structural magnetic resonance imaging for the prediction of functional outcomes in the clinical high-risk states for psychosis or in recent onset depression. More specifically, the colleagues were concerned that we had a priori picked just 8 functional baseline variables instead of using the full breadth of the clinical database available in our data. They suggest that the rationale of this strategy was to create a weak “straw man”...
Source: JAMA Psychiatry - February 6, 2019 Category: Psychiatry Source Type: research

Association of Fetal Growth With General and Specific Mental Health Conditions
This register-based study of pairs of siblings examines the associations between fetal growth and general and specific mental health conditions, controlling for familial factors. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - February 6, 2019 Category: Psychiatry Source Type: research

Association of a Youth-Nominated Support Team Intervention With Mortality
This secondary analysis of a randomized clinical trial compared mortality among suicidal adolescents who received a psychoeducational social support suicide prevention intervention with that among suicidal adolescents who received treatment as usual. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - February 6, 2019 Category: Psychiatry Source Type: research

Error in Results Sections
In the Original Investigation titled “Anxiety, Depression, and Insomnia Among Adults With Opioid Dependence Treated With Extended-Release Naltrexone vs Buprenorphine-Naloxone: A Randomized Clinical Trial and Follow-up Study,” published online December 19, 2018, and in the February print issue ofJAMA Psychiatry, there was an error in a 95% CI in the Results section of the abstract and the text. The 95% CI for the effect size for the insomnia score should be −0.61 to −0.02, not −0.65 to 0.02. The article has been corrected online. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - February 1, 2019 Category: Psychiatry Source Type: research

February 2019 Highlights
(Source: JAMA Psychiatry)
Source: JAMA Psychiatry - February 1, 2019 Category: Psychiatry Source Type: research