Traditional herbal medicine therapy of gallbladder ascariasis: a case report
ConclusionsConservative treatment of magnesium sulfate with Uyghur medicine treatment according to syndrome differentiation is proven to have curative effect. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - January 30, 2021 Category: General Medicine Source Type: research
Evaluation of crude adult Ascaris suum intestinal tract homogenate in inducing protective IgG production against A. suum larvae in BALB/c mice.
This study aims to measure antibody production and parasite load in male BALB/c mice immunized with crude Ascaris suum intestinal tract homogenate. Thirty-two (32) mice were randomized into: (1) unvaccinated, uninfected (UU); (2) unvaccinated, infected (UI); (3) vaccinated, uninfected (VU); and (4) vaccinated, infected (VI) groups. A 100-μL vaccine containing 50μg of homogenized A. suum intestines and Complete Freund's Adjuvant (1:1) were introduced intraperitoneally. Immunizations were done on days 0, 10, and 20. Oral gavage with 1000 embryonated eggs was done on day 30. Blood was obtained at day 40. To measure serum Ig...
Source: Experimental Parasitology - December 8, 2020 Category: Parasitology Authors: Girasol MJ, Grecia LR, Fabi JC, Fernandez AJ, Isabela Fernandez JN, Flores G, Flores R, Fontanilla EL, Fragante PJ, Genuino VC, Go SC, Gotico I, Gregorio ME, Grino MA, Guevarra PM, Guinal S, Guldam R, Infante GC, Jalandoni JP, Juyad IG, Valencia C, Makali Tags: Exp Parasitol Source Type: research
Quantitative lipidomic analysis of < i > Ascaris suum < /i >
by Tao Wang, Shuai Nie, Guangxu Ma, Johnny Vlaminck, Peter Geldhof, Nicholas A. Williamson, Gavin E. Reid, Robin B. GasserAscaris is a soil-transmitted nematode that causes ascariasis, a neglected tropical disease affecting predominantly children and adolescents in the tropics and subtropics. Approximately 0.8 billion people are affected worldwide, equating to 0.86 million disability-adjusted life-years (DALYs). Exploring the molecular biology ofAscaris is important to gain a better understanding of the host-parasite interactions and disease processes, and supports the development of novel interventions. Although advances ...
Source: PLoS Neglected Tropical Diseases - December 2, 2020 Category: Tropical Medicine Authors: Tao Wang Source Type: research
Vaccination with chimeric protein induces protection in murine model against ascariasis.
Abstract
An estimated 400 million people are infected by parasites of the genus Ascaris and the existing control measures are inefficient. Vaccine development using B cell antigens is a promising strategy for increased protection against this parasite. The present study aimed at developing a chimeric protein capable of conferring protection against infection by Ascaris sp. For this purpose, we performed B-cell epitope predictions on previously described vaccine candidate proteins from Ascaris suum and the corresponding peptides were used to construct a chimeric protein. Female BALB / c mice were immunized ...
Source: Vaccine - November 26, 2020 Category: Allergy & Immunology Authors: de Castro JC, de Almeida LV, Cardoso MS, Oliveira FMS, Nogueira DS, Reis-Cunha JL, Magalhaes LMD, Zhan B, Bottazzi ME, Hotez PJ, Bueno LL, Bartholomeu DC, Fujiwara RT Tags: Vaccine Source Type: research
Molecular evidence of hybridization between pig and human < i > Ascaris < /i > indicates an interbred species complex infecting humans
We report a 296 megabase (Mb) reference-quality genome comprised of 17,902 protein-coding genes derived from a single, representativeAscaris worm. An additional 68 worms were collected from 60 human hosts in Kenyan villages where pig husbandry is rare. Notably, the majority of these worms (63/68) possessed mitochondrial genomes that clustered closer to the pig parasiteAscaris suum than toA. lumbricoides. Comparative phylogenomic analyses identified over 11 million nuclear-encoded SNPs but just two distinct genetic types that had recombined across the genomes analyzed. The nuclear genomes had extensive heterozygosity, and a...
Source: eLife - November 6, 2020 Category: Biomedical Science Tags: Epidemiology and Global Health Genetics and Genomics Source Type: research
Ascariasis, Amebiasis and Giardiasis in Mexican children: distribution and geographical, environmental and socioeconomic risk factors
AbstractThe aim of this study is to provide an overview of the geographical distribution of Ascariasis, Amebiasis and Giardiasis, and to identify specific geographical, socioeconomic and environmental factors that are associated with the incidence of these infections in Mexican children. We made use of publicly available data that was reported by federal organizations in Mexico for the year 2010. The contribution of geographical, socioeconomic and environmental factors to the incidence of infections was assessed by a multivariable regression model using a backwards selection procedure.A. lumbricoides incidence was associat...
Source: Journal of Parasitic Diseases - October 30, 2020 Category: Parasitology Source Type: research
Ascariasis in common bile duct resulting in a subhepatic abscess.
CONCLUSIONS: Ascariasis should be considered in endemic areas and early endoscopic intervention and medical therapy can be effective for extrahepatic involvement.
PMID: 33094600 [PubMed - in process] (Source: Acta Gastro-Enterologica Belgica)
Source: Acta Gastro-Enterologica Belgica - October 24, 2020 Category: Gastroenterology Tags: Acta Gastroenterol Belg Source Type: research
Antibacterial and Antifungal Activities of the Leaf Exudate of Aloe megalacantha Baker.
Authors: Asmerom D, Kalay TH, Tafere GG
Abstract
Infectious diseases caused by fungi and bacteria are among the major causes of illness and death worldwide. This is mainly implicated by the antimicrobial resistance of the current treatment regimens. Since plant products are house stores of bioactive compounds, it is essential to screen plant-based antimicrobials to come up with novel medicines that counter the grave consequences of antimicrobial resistance. In the folk medicine of Ethiopia, Aloe megalacantha is used for the treatment of wound, dandruff, malaria, diabetes, impotence, colon cleansing, amoeba...
Source: International Journal of Microbiology - October 20, 2020 Category: Microbiology Tags: Int J Microbiol Source Type: research
Interactions between malnutrition, soil-transmitted helminthiasis and poverty among children living in periurban communities in Maranhao State, Northeastern Brazil.
In conclusion, the study describes the interactions between the dimensions of development represented by income, STHs and nutritional status revealing the importance of raising income levels to improve the living conditions of families in impoverished communities in Northeastern Brazil.
PMID: 33027397 [PubMed - in process] (Source: Revista do Instituto de Medicina Tropical de Sao Paulo)
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - October 9, 2020 Category: Tropical Medicine Authors: Almeida MM, Monteiro KJL, Bacelar PAA, Santos JPD, Freitas SPC, Evangelista BBC, Leal DN, Silva DAE, Cardoso AB, Nascimento EFD, Moraes Neto AHA, Carvalho-Costa FA Tags: Rev Inst Med Trop Sao Paulo Source Type: research
[Current Incidence and Contamination Sources of Ascariasis in Japan].
Authors: Sugiyama H, Morishima Y, Kagawa C, Araki J, Iwaki T, Ikuno H, Miguchi Y, Komatsu N, Kawakami Y, Asakura H
Abstract
Ascaris lumbricoides or roundworm is one of the key soil-transmitted helminths affecting humans. A small number of infections continue to occur in Japan, suggesting plant foodstuff contamination as the source of infection. To understand the current status of ascariasis incidence and to identify potential sources of infection, we extensively surveyed the available literature and collected data from testing facilities that examined clinical samples or foodstuffs. We observed that from 2...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - October 6, 2020 Category: Food Science Tags: Shokuhin Eiseigaku Zasshi Source Type: research
Trilateral Relationship: Ascaris, Microbiota, and Host Cells.
Abstract
Ascariasis is a globally spread intestinal nematode infection of humans and a considerable concern in pig husbandry. Ascaris accomplishes a complex body migration from the intestine via the liver and lung before returning to the intestine. Tissue migration and the habitat shared with a complex microbial community pose the question of how the nematode interacts with microbes and host cells from various tissues. This review addresses the current knowledge of the trilateral relationship between Ascaris, its microbial environment, and host cells, and discusses novel approaches targeting these interact...
Source: Trends in Parasitology - September 28, 2020 Category: Parasitology Authors: Midha A, Ebner F, Schlosser-Brandenburg J, Rausch S, Hartmann S Tags: Trends Parasitol Source Type: research
A first nation-wide assessment of soil-transmitted helminthiasis in Fijian primary schools, and factors associated with the infection, using a lymphatic filariasis transmission assessment survey as surveillance platform
ConclusionsAfter a decade of community-based LF-MDA, STH in school-age children in Fiji is now close to 10%, but localities of endemicity remain. Preventive chemotherapy should be maintained in areas with elevated STH prevalence alongside targeted delivery of integrated WASH interventions. LF-TAS has provided an opportunity to develop future public health surveillance platforms. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - September 24, 2020 Category: Tropical Medicine Authors: Sung Hye Kim Source Type: research
Human Ascariasis: An Updated Review.
CONCLUSION: The average cure rate with anthelminthic treatment is over 95%. Unfortunately, most treated patients in endemic areas become re-infected within months. Health education, personal hygiene, improved sanitary conditions, proper disposal of human excreta, and discontinuing the use of human fecal matter as a fertilizer are effective long-term preventive measures. Targeting deworming treatment and mass anthelminthic treatment should be considered in regions where A. lumbricoides is prevalent.
PMID: 32628606 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - July 7, 2020 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research
Triterpenoid and saponin rich Phytolacca dodecandra L'Herit(Endod): A review on its phytochemistry and pharmacological properties.
Abstract
Phytolacca dodecandra L'Herit (Endod) is the most extensively studied plant among 35 known species in the genus Phytolacca (Family: Phytolaccaceae). The plant has been used as a viable treatment for various ailments, such as malaria, rabies, ascariasis, and skin disorders, in many parts of Africa. In Ethiopia, the dried and powdered Endod berries have been used for a long period of time as a detergent to clean clothes. Since the discovery of the molluscicidal activities of its berries more than five decades ago, P. dodecandra has been a research focus worldwide and several phytochemicals mainly of...
Source: Mini Reviews in Medicinal Chemistry - June 16, 2020 Category: Chemistry Authors: Desta KT, El-Aty AMA Tags: Mini Rev Med Chem Source Type: research
Interactions between helminths and tuberculosis infections: Implications for tuberculosis diagnosis and vaccination in Africa
by Simeon I. Cadmus, Victor O. Akinseye, Babafemi O. Taiwo, Elena O. Pinelli, Dick van Soolingen, Shelley G. Rhodes
Africa is the second most populous continent and has perennial health challenges. Of the estimated 181 million school aged children in sub-Saharan Africa (SSA), nearly half suffer from ascariasis, trichuriasis, or a combination of these infections. Coupled with these is the problem of tuberculosis (TB) caused byMycobacterium tuberculosis (Mtb) infection, which is a leading cause of death in the region. Compared to the effect of the human immunodeficiency virus on the development of TB, the effect of chronic ...
Source: PLoS Neglected Tropical Diseases - June 3, 2020 Category: Tropical Medicine Authors: Simeon I. Cadmus Source Type: research
