Nocardiosis in kidney transplant recipients: A tertiary care center experience
CONCLUSION: Nocardia may cause a late-manifesting infection beyond the traditional window. The cotrimoxazole prophylaxis may not be sufficient for Nocardia prevention.PMID:38537681 | DOI:10.1016/j.trim.2024.102041 (Source: Transplant Immunology)
Source: Transplant Immunology - March 27, 2024 Category: Transplant Surgery Authors: Rungmei Marak None Abdullah Manas Behera Anupma Kaul Dharmendra Bhaduaria Narayan Prasad Manas Patel Ravi Kushwaha Monika Yachha Source Type: research
Outer membrane vesicles as nanovaccine candidates against pathogenic Leptospira in experimental Guinea pig model
Biologicals. 2024 Mar 26;86:101764. doi: 10.1016/j.biologicals.2024.101764. Online ahead of print.ABSTRACTLeptospira interrogans serovar Hardjo is a long slender bacterium of size 0.1-0.3 μm × 5-50 μm. It is one of the major causes of bovine leptospirosis and is of economical importance because of the reproductive failure, still birth, abortion, and reduced productivity in cattle. It is also a zoonotic disease-causing infection in humans characterized by headaches, fever, chills, sweats and myalgia, lethargy, aching joints, pulmonary haemorrhages, and death in severe cases. Control of the disease involves antibiotic the...
Source: Biologicals : Journal of the International Association of Biological Standardization - March 27, 2024 Category: Biotechnology Authors: S David Inbaraj Sophia Subbaiyan Anbazhagan M Karikalan R Saravanan K Nagaleekar Viswas Prasad Thomas Pallab Chaudhuri Source Type: research
Outer membrane vesicles as nanovaccine candidates against pathogenic Leptospira in experimental Guinea pig model
Biologicals. 2024 Mar 26;86:101764. doi: 10.1016/j.biologicals.2024.101764. Online ahead of print.ABSTRACTLeptospira interrogans serovar Hardjo is a long slender bacterium of size 0.1-0.3 μm × 5-50 μm. It is one of the major causes of bovine leptospirosis and is of economical importance because of the reproductive failure, still birth, abortion, and reduced productivity in cattle. It is also a zoonotic disease-causing infection in humans characterized by headaches, fever, chills, sweats and myalgia, lethargy, aching joints, pulmonary haemorrhages, and death in severe cases. Control of the disease involves antibiotic the...
Source: Biologicals : Journal of the International Association of Biological Standardization - March 27, 2024 Category: Biotechnology Authors: S David Inbaraj Sophia Subbaiyan Anbazhagan M Karikalan R Saravanan K Nagaleekar Viswas Prasad Thomas Pallab Chaudhuri Source Type: research
Outer membrane vesicles as nanovaccine candidates against pathogenic Leptospira in experimental Guinea pig model
Biologicals. 2024 Mar 26;86:101764. doi: 10.1016/j.biologicals.2024.101764. Online ahead of print.ABSTRACTLeptospira interrogans serovar Hardjo is a long slender bacterium of size 0.1-0.3 μm × 5-50 μm. It is one of the major causes of bovine leptospirosis and is of economical importance because of the reproductive failure, still birth, abortion, and reduced productivity in cattle. It is also a zoonotic disease-causing infection in humans characterized by headaches, fever, chills, sweats and myalgia, lethargy, aching joints, pulmonary haemorrhages, and death in severe cases. Control of the disease involves antibiotic the...
Source: Biologicals : Journal of the International Association of Biological Standardization - March 27, 2024 Category: Biotechnology Authors: S David Inbaraj Sophia Subbaiyan Anbazhagan M Karikalan R Saravanan K Nagaleekar Viswas Prasad Thomas Pallab Chaudhuri Source Type: research
Outer membrane vesicles as nanovaccine candidates against pathogenic Leptospira in experimental Guinea pig model
Biologicals. 2024 Mar 26;86:101764. doi: 10.1016/j.biologicals.2024.101764. Online ahead of print.ABSTRACTLeptospira interrogans serovar Hardjo is a long slender bacterium of size 0.1-0.3 μm × 5-50 μm. It is one of the major causes of bovine leptospirosis and is of economical importance because of the reproductive failure, still birth, abortion, and reduced productivity in cattle. It is also a zoonotic disease-causing infection in humans characterized by headaches, fever, chills, sweats and myalgia, lethargy, aching joints, pulmonary haemorrhages, and death in severe cases. Control of the disease involves antibiotic the...
Source: Biologicals : Journal of the International Association of Biological Standardization - March 27, 2024 Category: Biotechnology Authors: S David Inbaraj Sophia Subbaiyan Anbazhagan M Karikalan R Saravanan K Nagaleekar Viswas Prasad Thomas Pallab Chaudhuri Source Type: research
Outer membrane vesicles as nanovaccine candidates against pathogenic Leptospira in experimental Guinea pig model
Biologicals. 2024 Mar 26;86:101764. doi: 10.1016/j.biologicals.2024.101764. Online ahead of print.ABSTRACTLeptospira interrogans serovar Hardjo is a long slender bacterium of size 0.1-0.3 μm × 5-50 μm. It is one of the major causes of bovine leptospirosis and is of economical importance because of the reproductive failure, still birth, abortion, and reduced productivity in cattle. It is also a zoonotic disease-causing infection in humans characterized by headaches, fever, chills, sweats and myalgia, lethargy, aching joints, pulmonary haemorrhages, and death in severe cases. Control of the disease involves antibiotic the...
Source: Biologicals : Journal of the International Association of Biological Standardization - March 27, 2024 Category: Biotechnology Authors: S David Inbaraj Sophia Subbaiyan Anbazhagan M Karikalan R Saravanan K Nagaleekar Viswas Prasad Thomas Pallab Chaudhuri Source Type: research
Outer membrane vesicles as nanovaccine candidates against pathogenic Leptospira in experimental Guinea pig model
Biologicals. 2024 Mar 26;86:101764. doi: 10.1016/j.biologicals.2024.101764. Online ahead of print.ABSTRACTLeptospira interrogans serovar Hardjo is a long slender bacterium of size 0.1-0.3 μm × 5-50 μm. It is one of the major causes of bovine leptospirosis and is of economical importance because of the reproductive failure, still birth, abortion, and reduced productivity in cattle. It is also a zoonotic disease-causing infection in humans characterized by headaches, fever, chills, sweats and myalgia, lethargy, aching joints, pulmonary haemorrhages, and death in severe cases. Control of the disease involves antibiotic the...
Source: Biologicals : Journal of the International Association of Biological Standardization - March 27, 2024 Category: Biotechnology Authors: S David Inbaraj Sophia Subbaiyan Anbazhagan M Karikalan R Saravanan K Nagaleekar Viswas Prasad Thomas Pallab Chaudhuri Source Type: research
Outer membrane vesicles as nanovaccine candidates against pathogenic Leptospira in experimental Guinea pig model
Biologicals. 2024 Mar 26;86:101764. doi: 10.1016/j.biologicals.2024.101764. Online ahead of print.ABSTRACTLeptospira interrogans serovar Hardjo is a long slender bacterium of size 0.1-0.3 μm × 5-50 μm. It is one of the major causes of bovine leptospirosis and is of economical importance because of the reproductive failure, still birth, abortion, and reduced productivity in cattle. It is also a zoonotic disease-causing infection in humans characterized by headaches, fever, chills, sweats and myalgia, lethargy, aching joints, pulmonary haemorrhages, and death in severe cases. Control of the disease involves antibiotic the...
Source: Biologicals : Journal of the International Association of Biological Standardization - March 27, 2024 Category: Biotechnology Authors: S David Inbaraj Sophia Subbaiyan Anbazhagan M Karikalan R Saravanan K Nagaleekar Viswas Prasad Thomas Pallab Chaudhuri Source Type: research
Outer membrane vesicles as nanovaccine candidates against pathogenic Leptospira in experimental Guinea pig model
Biologicals. 2024 Mar 26;86:101764. doi: 10.1016/j.biologicals.2024.101764. Online ahead of print.ABSTRACTLeptospira interrogans serovar Hardjo is a long slender bacterium of size 0.1-0.3 μm × 5-50 μm. It is one of the major causes of bovine leptospirosis and is of economical importance because of the reproductive failure, still birth, abortion, and reduced productivity in cattle. It is also a zoonotic disease-causing infection in humans characterized by headaches, fever, chills, sweats and myalgia, lethargy, aching joints, pulmonary haemorrhages, and death in severe cases. Control of the disease involves antibiotic the...
Source: Biologicals : Journal of the International Association of Biological Standardization - March 27, 2024 Category: Biotechnology Authors: S David Inbaraj Sophia Subbaiyan Anbazhagan M Karikalan R Saravanan K Nagaleekar Viswas Prasad Thomas Pallab Chaudhuri Source Type: research
Outer membrane vesicles as nanovaccine candidates against pathogenic Leptospira in experimental Guinea pig model
Biologicals. 2024 Mar 26;86:101764. doi: 10.1016/j.biologicals.2024.101764. Online ahead of print.ABSTRACTLeptospira interrogans serovar Hardjo is a long slender bacterium of size 0.1-0.3 μm × 5-50 μm. It is one of the major causes of bovine leptospirosis and is of economical importance because of the reproductive failure, still birth, abortion, and reduced productivity in cattle. It is also a zoonotic disease-causing infection in humans characterized by headaches, fever, chills, sweats and myalgia, lethargy, aching joints, pulmonary haemorrhages, and death in severe cases. Control of the disease involves antibiotic the...
Source: Biologicals : Journal of the International Association of Biological Standardization - March 27, 2024 Category: Biotechnology Authors: S David Inbaraj Sophia Subbaiyan Anbazhagan M Karikalan R Saravanan K Nagaleekar Viswas Prasad Thomas Pallab Chaudhuri Source Type: research
Klebsiella pneumoniae exhibiting a phenotypic hyper-splitting phenomenon including the formation of small colony variants
In this study, we characterized a Klebsiella pneumoniae strain in a patient with shrapnel hip injury, which resulted in multiple phenotypic changes, including the formation of a small colony variant (SCV) phenotype. Although already described since the 1960s, there is little knowledge about SCV phenotypes in Enterobacteriaceae. The formation of SCVs has been recognized as a bacterial strategy to evade host immune responses and compromise the efficacy of antimicrobial therapies, leading to persistent and recurrent courses of infections. In this case, 14 isolates with different resisto- and morpho-types were distinguished fr...
Source: Frontiers in cellular and infection microbiology - March 27, 2024 Category: Microbiology Source Type: research
Impact of Immunosuppressed Status on Prognosis of Carbapenem-Resistant Organisms Bloodstream Infections
ConclusionDespite the high mortality rate of CRO-BSI, immunosuppression did not affect the mortality. Appropriate antibiotic therapy is crucial for improving the prognosis of CRO-BSI, regardless of the immune status. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - March 27, 2024 Category: Infectious Diseases Source Type: research
Clinical impact and cost-consequence analysis of ePlex ® blood culture identification panels for the rapid diagnosis of bloodstream infections: a single-center randomized controlled trial
AbstractTo assess clinical impact and perform cost-consequence analysis of the broadest multiplex PCR panels available for the rapid diagnosis of bloodstream infections (BSI). Single-center, randomized controlled trial conducted from June 2019 to February 2021 at a French University hospital with an institutional antimicrobial stewardship program. Primary endpoint was the percentage of patients with optimized antimicrobial treatment 12 h after transmission of positivity and Gram stain results from the first positive BC. This percentage was significantly higher in the multiplex PCR (mPCR) group (90/105 = 85.7% %, CI95...
Source: European Journal of Clinical Microbiology and Infectious Diseases - March 27, 2024 Category: Microbiology Source Type: research
Impact of Immunosuppressed Status on Prognosis of Carbapenem-Resistant Organisms Bloodstream Infections
ConclusionDespite the high mortality rate of CRO-BSI, immunosuppression did not affect the mortality. Appropriate antibiotic therapy is crucial for improving the prognosis of CRO-BSI, regardless of the immune status. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - March 27, 2024 Category: Infectious Diseases Source Type: research
Evaluation of the Antimicrobial, Cytotoxic, and Physical Properties of Selected Nano-Complexes in Bovine Udder Inflammatory Pathogen Control
CONCLUSION: Synergistic effects of nanoparticles and no toxicity to bovine and human cells might, in the future, be an effective alternative in the fight against microorganisms responsible for mastitis, and the implementation of research results in practice would reduce the percentage of dairy cows suffering from mastitis. The problem of increasing antibiotic resistance is posing a global threat to human's and animal's health, and requires comprehensive research to evaluate the potential use of nanoparticles - especially their complexes - as well as to determine whether nanoparticles are safe for the breeders and the anima...
Source: Appl Human Sci - March 25, 2024 Category: Physiology Authors: Mateusz Wierzbicki Magdalena Kot Agata Lange Aleksandra Kali ńska Marcin Go łębiewski S ławomir Jaworski Source Type: research
